General Information of the Cell Line
Cell Line ID
CL000053
Cell Line Name
COS-7
Synonyms
Cos-7
COS 7
Cos 7
COS7
Cos7
CV-1 in Origin Simian-7
Category
Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0224
Tissue Information
Kidney
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01307, 5-hydroxytryptamine receptor 4
Compound ID Compound Name Compound Formula
CP0240582
Prx-03140
   Show/Hide
C19H27N3O3S
 1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
CP0484940
US9221790, 3
   Show/Hide
C25H31ClN4O2
 1
1
IC50 = 0.039 nM
   TI
   LI
   LO
   TS
CP0512209
US9221790, 7
   Show/Hide
C19H27ClN6O2
 1
1
IC50 = 0.067 nM
   TI
   LI
   LO
   TS
CP0491460
US9221790, 10
   Show/Hide
C24H29ClN4O2
 1
1
IC50 = 0.076 nM
   TI
   LI
   LO
   TS
CP0563225
US9221790, 6
   Show/Hide
C21H31ClN6O2
 1
1
IC50 = 0.103 nM
   TI
   LI
   LO
   TS
CP0531623
US9221790, 13
   Show/Hide
C21H25ClFN3O2
 1
1
IC50 = 0.134 nM
   TI
   LI
   LO
   TS
CP0539429
US9221790, 2
   Show/Hide
C18H26ClN7O2
 1
1
IC50 = 0.164 nM
   TI
   LI
   LO
   TS
CP0531621
US9221790, 8
   Show/Hide
C19H27ClN6O2
 1
1
IC50 = 0.182 nM
   TI
   LI
   LO
   TS
CP0484078
US9221790, 1
   Show/Hide
C19H27ClN6O2
 1
1
IC50 = 0.226 nM
   TI
   LI
   LO
   TS
CP0561399
US9221790, 4
   Show/Hide
C21H30ClN5O2
 1
1
IC50 = 0.229 nM
   TI
   LI
   LO
   TS
CP0491459
US9221790, 9
   Show/Hide
C20H25ClN4O2
 1
1
IC50 = 0.267 nM
   TI
   LI
   LO
   TS
CP0030226
4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl]-3-methoxy-piperidin-4-yl}-2-methoxy-benzamide
   Show/Hide
C23H29ClFN3O4
 1
1
IC50 = 0.362 nM
   TI
   LI
   LO
   TS
CP0412057
US9221790, 14
   Show/Hide
C21H26ClN3O3
 1
1
IC50 = 0.375 nM
   TI
   LI
   LO
   TS
CP0531622
US9221790, 12
   Show/Hide
C20H27ClN4O2
 1
1
IC50 = 0.421 nM
   TI
   LI
   LO
   TS
CP0479873
US9221790, 11
   Show/Hide
C18H24ClN5O2
 1
1
IC50 = 0.454 nM
   TI
   LI
   LO
   TS
CP0201648
4-[[(3R,4S)-4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-3-methoxypiperidin-1-yl]methyl]-N,N-dimethylpiperidine-1-carboxamide
   Show/Hide
C23H36ClN5O4
 1
1
IC50 = 52 nM
   TI
   LI
   LO
   TS
CP0364641
4-amino-N-[(3R,4S)-1-[3-(4-benzylpiperidin-1-yl)-3-oxopropyl]-3-methoxypiperidin-4-yl]-5-chloro-2-methoxybenzamide
   Show/Hide
C29H39ClN4O4
 1
1
IC50 = 66 nM
   TI
   LI
   LO
   TS
CP0573544
4-amino-5-chloro-2-methoxy-N-[(3S,4R)-3-methoxy-1-[[1-(2-methylpropanoyl)piperidin-4-yl]methyl]piperidin-4-yl]benzamide
   Show/Hide
C24H37ClN4O4
 1
1
IC50 = 68 nM
   TI
   LI
   LO
   TS
CP0127297
4-[[(3R,4S)-4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-3-methoxypiperidin-1-yl]methyl]-N-propan-2-ylpiperidine-1-carboxamide
   Show/Hide
C24H38ClN5O4
 1
1
IC50 = 73 nM
   TI
   LI
   LO
   TS
CP0181087
4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-1-[[1-(3-methylbutanoyl)piperidin-4-yl]methyl]piperidin-4-yl]benzamide
   Show/Hide
C25H39ClN4O4
 1
1
IC50 = 78 nM
   TI
   LI
   LO
   TS
CP0413839
4-amino-5-chloro-N-[(3R,4S)-1-[[1-(2,2-dimethylpropanoyl)piperidin-4-yl]methyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide
   Show/Hide
C25H39ClN4O4
 1
1
IC50 = 118 nM
   TI
   LI
   LO
   TS
CP0259049
propyl 4-[[(3R,4S)-4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-3-methoxypiperidin-1-yl]methyl]piperidine-1-carboxylate
   Show/Hide
C24H37ClN4O5
 1
1
IC50 = 134 nM
   TI
   LI
   LO
   TS
CP0568594
4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-1-[[1-(2-methylpropanethioyl)piperidin-4-yl]methyl]piperidin-4-yl]benzamide
   Show/Hide
C24H37ClN4O3S
 1
1
IC50 = 155 nM
   TI
   LI
   LO
   TS
CP0353451
4-amino-N-[(3R,4S)-1-[(1-butanoylpiperidin-4-yl)methyl]-3-methoxypiperidin-4-yl]-5-chloro-2-methoxybenzamide
   Show/Hide
C24H37ClN4O4
 1
1
IC50 = 178 nM
   TI
   LI
   LO
   TS
CP0364270
methyl 4-[[(3R,4S)-4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-3-methoxypiperidin-1-yl]methyl]piperidine-1-carboxylate
   Show/Hide
C22H33ClN4O5
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0059186
4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-1-[(1-propanoylpiperidin-4-yl)methyl]piperidin-4-yl]benzamide
   Show/Hide
C23H35ClN4O4
 1
1
IC50 = 329 nM
   TI
   LI
   LO
   TS
CP0127296
ethyl 4-[[(3R,4S)-4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-3-methoxypiperidin-1-yl]methyl]piperidine-1-carboxylate
   Show/Hide
C23H35ClN4O5
 1
1
IC50 = 377 nM
   TI
   LI
   LO
   TS
CP0163218
4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide
   Show/Hide
C23H29ClFN3O4
 1
1
IC50 = 483 nM
   TI
   LI
   LO
   TS
CP0259035
4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-1-[(1-propanoylpiperidin-3-yl)methyl]piperidin-4-yl]benzamide
   Show/Hide
C23H35ClN4O4
 1
1
IC50 = 493 nM
   TI
   LI
   LO
   TS
CP0353450
4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-1-(3-oxo-3-piperidin-1-ylpropyl)piperidin-4-yl]benzamide
   Show/Hide
C22H33ClN4O4
 1
1
IC50 = 560 nM
   TI
   LI
   LO
   TS
CP0201646
N-[(3R,4S)-1-[(1-acetylpiperidin-4-yl)methyl]-3-methoxypiperidin-4-yl]-4-amino-5-chloro-2-methoxybenzamide
   Show/Hide
C22H33ClN4O4
 1
1
IC50 = 592 nM
   TI
   LI
   LO
   TS
CP0201647
4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-1-[(1-propanethioylpiperidin-4-yl)methyl]piperidin-4-yl]benzamide
   Show/Hide
C23H35ClN4O3S
 1
1
IC50 = 593 nM
   TI
   LI
   LO
   TS
CP0261303
4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-1-(3-pyrrol-1-ylpropyl)piperidin-4-yl]benzamide
   Show/Hide
C21H29ClN4O3
 1
1
IC50 = 648 nM
   TI
   LI
   LO
   TS
CP0127187
4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-1-[2-(1-propanoylpiperidin-4-yl)ethyl]piperidin-4-yl]benzamide
   Show/Hide
C24H37ClN4O4
 1
1
IC50 = 805 nM
   TI
   LI
   LO
   TS
CP0259034
4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-1-(3-oxo-3-pyrrolidin-1-ylpropyl)piperidin-4-yl]benzamide
   Show/Hide
C21H31ClN4O4
 1
1
IC50 = 920 nM
   TI
   LI
   LO
   TS
CP0201644
4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-1-(3-morpholin-4-yl-3-oxopropyl)piperidin-4-yl]benzamide
   Show/Hide
C21H31ClN4O5
 1
1
IC50 = 954 nM
   TI
   LI
   LO
   TS
CP0203842
4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-1-[3-(tetrazol-2-yl)propyl]piperidin-4-yl]benzamide
   Show/Hide
C18H26ClN7O3
 1
1
IC50 = 1121 nM
   TI
   LI
   LO
   TS
CP0203841
4-amino-5-chloro-N-[(3R,4S)-1-(3-imidazol-1-ylpropyl)-3-methoxypiperidin-4-yl]-2-methoxybenzamide
   Show/Hide
C20H28ClN5O3
 1
1
IC50 = 1165 nM
   TI
   LI
   LO
   TS
CP0109667
4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-1-[3-(1,2,4-triazol-1-yl)propyl]piperidin-4-yl]benzamide
   Show/Hide
C19H27ClN6O3
 1
1
IC50 = 1271 nM
   TI
   LI
   LO
   TS
CP0261301
4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-1-(2-pyrrol-1-ylethyl)piperidin-4-yl]benzamide
   Show/Hide
C20H27ClN4O3
 1
1
IC50 = 5759 nM
   TI
   LI
   LO
   TS
CP0123097
3H-GR113808
   Show/Hide
C19H27N3O4S
 4
1
Ki = 0.078 nM
   TI
   LI
   LO
   TS
2
Ki = 0.33 nM
   TI
   LI
   LO
   TS
3
Ki = 0.41 nM
   TI
   LI
   LO
   TS
4
Ki = 0.53 nM
   TI
   LI
   LO
   TS
CP0373139
4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyrimidin-2-yl-piperazin-1-yl)-ethyl ester
   Show/Hide
C18H22ClN5O3
 4
1
Ki = 2.47 nM
   TI
   LI
   LO
   TS
2
Ki = 3.5 nM
   TI
   LI
   LO
   TS
3
Ki = 7.03 nM
   TI
   LI
   LO
   TS
4
Ki = 8.1 nM
   TI
   LI
   LO
   TS
CP0290551
2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate
   Show/Hide
C15H21ClN2O3
 4
1
Ki = 3.69 nM
   TI
   LI
   LO
   TS
2
Ki = 7.98 nM
   TI
   LI
   LO
   TS
3
Ki = 8.4 nM
   TI
   LI
   LO
   TS
4
Ki = 10.7 nM
   TI
   LI
   LO
   TS
CP0448968
4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-phenyl-piperazin-1-yl)-ethyl ester
   Show/Hide
C20H24ClN3O3
 4
1
Ki = 12.5 nM
   TI
   LI
   LO
   TS
2
Ki = 23 nM
   TI
   LI
   LO
   TS
3
Ki = 32 nM
   TI
   LI
   LO
   TS
4
Ki = 55 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0240380
4-[(E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
   Show/Hide
C26H29NO2  1
1
IC50 = 8690 nM
   TI
   LI
   LO
   TS
CP0317701
(E)-N-(2-aminoethyl)-3-[4-[(Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]prop-2-enamide;2,2,2-trifluoroacetic acid
   Show/Hide
C33H31F9N2O8  1
1
IC50 = 5950 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Kidney)
Cell Line Name Organism Disease
G-402 Homo sapiens (Human) Kidney neoplasm
A-498 Homo sapiens (Human) Renal cell carcinoma
786-O Homo sapiens (Human) Renal cell carcinoma
SN12C Homo sapiens (Human) Renal cell carcinoma
G-401 Homo sapiens (Human) Rhabdoid tumor of the kidney
AU-BEK Bos taurus (Bovine) -
MDCK Canis lupus familiaris (Dog) -
MDCK-II Canis lupus familiaris (Dog) -
MDCK-I Canis lupus familiaris (Dog) -
MDCK-MDR1 Canis lupus familiaris (Dog) -
MDCKII-LE Canis lupus familiaris (Dog) -
DK Canis lupus familiaris (Dog) -
MDCK2/BCRP Canis lupus familiaris (Dog) -
MDCK-Net6 Canis lupus familiaris (Dog) -
MDCK-UT-A1-AQP1-YFP Canis lupus familiaris (Dog) -
CV-1 Chlorocebus aethiops (Green monkey) -
COS-1 Chlorocebus aethiops (Green monkey) -
COS-M6 Chlorocebus aethiops (Green monkey) -
COS Chlorocebus aethiops (Green monkey) -
OAT1-COS7 Chlorocebus aethiops (Green monkey) -
BS-C-1 Chlorocebus pygerythrus (Vervet monkey) -
Vero Chlorocebus sabaeus (Green monkey) -
OK Didelphis virginiana (North American opossum) -
HEK293 Homo sapiens (Human) -
HEK-293T Homo sapiens (Human) -
tsA201 Homo sapiens (Human) -
HEK293-A Homo sapiens (Human) -
T-REx-293 Homo sapiens (Human) -
HEK293-EBNA Homo sapiens (Human) -
Expi293F Homo sapiens (Human) -
Flp-In-293 Homo sapiens (Human) -
HEK293S Homo sapiens (Human) -
HEK293-F Homo sapiens (Human) -
HEK293-EBNA1-6E Homo sapiens (Human) -
AD-293 Homo sapiens (Human) -
HEK293-H Homo sapiens (Human) -
HEK-Blue hNOD2 Homo sapiens (Human) -
HEK293T/17 Homo sapiens (Human) -
293T/ACE2 [Japan 2021] Homo sapiens (Human) -
GripTite 293 MSR Homo sapiens (Human) -
HL-2 Homo sapiens (Human) -
HEK-Blue hTLR8 Homo sapiens (Human) -
PathHunter HEK 293 EDG1 Total GPCR Internalization Homo sapiens (Human) -
Flp-In-T-REx-293 Homo sapiens (Human) -
HEKR2 Homo sapiens (Human) -
HEK-Blue IL-6 Homo sapiens (Human) -
HK-2 [Human kidney] Homo sapiens (Human) -
HEK293-FT Homo sapiens (Human) -
HEK-2 Homo sapiens (Human) -
HEK-Blue hTLR2 Homo sapiens (Human) -
HEK-Blue hTLR4 Homo sapiens (Human) -
HEK-Blue CD40L Homo sapiens (Human) -
Expi293F GnTI- Homo sapiens (Human) -
HEK-Blue hNOD1 Homo sapiens (Human) -
pEAK Rapid Homo sapiens (Human) -
HEK-Blue hTLR9 Homo sapiens (Human) -
HEK-Blue hTLR7 Homo sapiens (Human) -
293Ta Homo sapiens (Human) -
293-Dual hSTING-R232 Homo sapiens (Human) -
HEK293-CNG Homo sapiens (Human) -
FreeStyle 293-F Homo sapiens (Human) -
PrecisION hnAChR alpha7/ric3-HEK Homo sapiens (Human) -
GeneBLAzer ERbeta-UAS-bla GripTite 293 Homo sapiens (Human) -
HEK385-7 Homo sapiens (Human) -
HEK2935 Homo sapiens (Human) -
ACTOne CXCR4 Homo sapiens (Human) -
HEK298 Homo sapiens (Human) -
HEK273 Homo sapiens (Human) -
293/GFP Homo sapiens (Human) -
HEK293 AequoScreen Homo sapiens (Human) -
HEK-Blue Null1-v Homo sapiens (Human) -
HEK-GIRK-M4 Homo sapiens (Human) -
HTLA Homo sapiens (Human) -
HEK293/Galpha15 Homo sapiens (Human) -
HEK293-SF-hH4R-His6-CRE-Luc Homo sapiens (Human) -
HEK293-SF-mH4R-His6-CRE-Luc Homo sapiens (Human) -
293AD Homo sapiens (Human) -
HEK293T/Galpha16-gustducin 44 Homo sapiens (Human) -
CellSensor SBE-bla HEK 293T Homo sapiens (Human) -
NRK1-HEK293T Homo sapiens (Human) -
HEK293T-SF-His6-CRE-Luc Homo sapiens (Human) -
HEK293T-beta-arr2-rH4R Homo sapiens (Human) -
HEK293T-beta-arr2-mH4R Homo sapiens (Human) -
HEK293T-beta-arr2-hH4R Homo sapiens (Human) -
HEK293T-SP-FLAG-hH3R-CRE-CBR Homo sapiens (Human) -
293/AP1-luc Homo sapiens (Human) -
293GT Homo sapiens (Human) -
GeneBLAzer AR-UAS-bla Griptite 293 Homo sapiens (Human) -
UAS-MR-bla HEK293 Homo sapiens (Human) -
HEK293-DR-GFP Homo sapiens (Human) -
PSC-HEK293 Homo sapiens (Human) -
HEK-293-A2B Homo sapiens (Human) -
HEK293-SF-rH4R-His6-CRE-Luc Homo sapiens (Human) -
Hana3A Homo sapiens (Human) -
HEK293S GnTI- Homo sapiens (Human) -
GeneBLAzer UAS-bla GripTite 293 Homo sapiens (Human) -
GeneBLAzer UAS-bla HEK 293H Homo sapiens (Human) -
GeneBLAzer UAS-bla HEK 293T Homo sapiens (Human) -
HEKMSR2 Homo sapiens (Human) -
HEK-hNET Homo sapiens (Human) -
HEK-hDAT Homo sapiens (Human) -
HEK-hSERT Homo sapiens (Human) -
EE-HEK293 Homo sapiens (Human) -
HEK-A2A Homo sapiens (Human) -
HEK293EM Homo sapiens (Human) -
293-NB2 Homo sapiens (Human) -
HEK-SEAP Homo sapiens (Human) -
HEK293/Gal4 Homo sapiens (Human) -
Octn2-HEK Homo sapiens (Human) -
Octn1-HEK Homo sapiens (Human) -
Octn3-HEK Homo sapiens (Human) -
HEK293superTOP Homo sapiens (Human) -
HEK293T-ARRB1 Homo sapiens (Human) -
HEK293T-ARRB2 Homo sapiens (Human) -
HEK293T-qs5-HA Homo sapiens (Human) -
EDG3-Ga15-bla HEK293T Homo sapiens (Human) -
LLC-MK2 Macaca mulatta (Rhesus macaque) -
BHK-21 Mesocricetus auratus (Golden hamster) -
BHK-21 clone 13 Mesocricetus auratus (Golden hamster) -
BHK570 Mesocricetus auratus (Golden hamster) -
TK-TS 13 Mesocricetus auratus (Golden hamster) -
BHK/AC9 Mesocricetus auratus (Golden hamster) -
mIMCD-3 Mus musculus (Mouse) -
RK3E Rattus norvegicus (Rat) -
KNRK Rattus norvegicus (Rat) -
NRK-52E Rattus norvegicus (Rat) -
SKPT-0193 Cl.2 Rattus norvegicus (Rat) -
RKE Rattus norvegicus (Rat) -
LLC-PK1 Sus scrofa (Pig) -
LLC-GA5-CoL150 Sus scrofa (Pig) -
PK-15 Sus scrofa (Pig) -
HKRK-B28 Sus scrofa (Pig) -
PK15NTD Sus scrofa (Pig) -