General Information of the Protein
Protein ID
PT03063
Protein Name
Peroxisome proliferator-activated receptor delta
Secondarily
Protein Name
Nuclear hormone receptor 1
Nuclear receptor subfamily 1 group C member 2
Peroxisome proliferator-activated receptor beta
Gene Name
PPARD
Secondarily
Gene Name
Nr1c2
Pparb
Sequence
MEQPQEETPEAREEEKEEVAMGDGAPELNGGPEHTLPSSSCADLSQNSSPSSLLDQLQMGCDGASGGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCDRICKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTASEGCQHNPQLADLKAFSKHIYNAYLKNFNMTKKKARSILTGKSSHNAPFVIHDIETLWQAEKGLVWKQLVNGLPPYNEISVHVFYRCQSTTVETVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTHEFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPQVEAIQDTILRALEFHLQVNHPDSQYLFPKLLQKMADLRQLVTEHAQMMQWLKKTESETLLHPLLQEIYKDMY
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Organism
Mus musculus, Mouse
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 1
>
Nuclear hormone receptor subfamily 1 group C
>
Nuclear hormone receptor subfamily 1 group C member 2
Function
Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues (PubMed:35675826). Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity).
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Uniprot ID
Primary ID:
P35396

Secondarily ID:
P37239
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Ensembl ID
ENSG00000112033
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000044 , CV-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0054286
 Compound Info 
2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylselanyl)phenoxy)acetic acid
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C21H18F3NO3SSe
  1
1
EC50 = 2.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0060839
 Compound Info 
2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid
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C21H17F4NO3S2
  1
1
EC50 <= 5.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0404578
 Compound Info 
2-(4-{2-[1-Cycloheptyl-3-(2,4-difluoro-phenyl)-ureido]-ethyl}-phenoxy)-2-methyl-propionic acid
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C26H32F2N2O4
  1
1
EC50 = 1400 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0170396
 Compound Info 
2-{[4-(2-{[(2,4-difluorophenyl)carbamoyl](heptyl)amino}ethyl)phenyl]sulfanyl}-2-methylpropanoic acid
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C26H34F2N2O3S
  1
1
EC50 = 2600 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0397728
 Compound Info 
2-(4-{2-[3-(2,4-Difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-propionic acid
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C26H34F2N2O4
  1
1
EC50 = 3200 nM
 Bioactivity Info 
   TI
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CP0374670
 Compound Info 
2-(4-{2-[3-(4-Fluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-propionic acid
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C26H35FN2O4
  1
1
EC50 = 5500 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0083167
 Compound Info 
4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid
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C33H30N4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0429811
 Compound Info 
4'-((2,3-dimethyl-5-(1-phenylpropylcarbamoyl)-1H-indol-1-yl)methyl)biphenyl-2-carboxylic acid
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C34H32N2O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0447683
 Compound Info 
4'-((6-(1-phenylpropylcarbamoyl)-2-propyl-1H-benzo[d]imidazol-1-yl)methyl)biphenyl-2-carboxylic acid
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C34H33N3O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0380009
 Compound Info 
2-[4-[[2-propyl-5-(1-propylbenzimidazol-2-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl]phenyl]benzoic acid
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C34H32N4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0380010
 Compound Info 
2-[4-[[5-(1-butylbenzimidazol-2-yl)-2-propylindazol-3-yl]methyl]phenyl]benzoic acid
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C35H34N4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0421159
 Compound Info 
2-propyl-5-(1-propylbenzimidazol-2-yl)-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrazolo[1,5-a]pyridine
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C34H32N8
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0425898
 Compound Info 
N-(1-phenylpropyl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrazolo[1,5-a]pyridine-5-carboxamide
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C34H33N7O
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0430042
 Compound Info 
2-[4-[[5-(1-phenylpropylcarbamoyl)-2-propylindazol-3-yl]methyl]phenyl]benzoic acid
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C34H33N3O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0432277
 Compound Info 
5-(1-butylbenzimidazol-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]indazole
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C35H34N8
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0432279
 Compound Info 
2-[4-[[5-(1-phenylpropylcarbamoyl)-2-propylpyrazolo[1,5-a]pyridin-3-yl]methyl]phenyl]benzoic acid
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C34H33N3O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0439849
 Compound Info 
2-[4-[[1-methoxy-5-(1-phenylpropylcarbamoyl)-2-propylindol-3-yl]methyl]phenyl]benzoic acid
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C36H36N2O4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0403631
 Compound Info 
2-(4-{2-[1-(5-Cyclohexyl-pentyl)-3-(4-fluoro-phenyl)-ureido]-ethyl}-phenoxy)-2-methyl-propionic acid
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C30H41FN2O4
  1
1
EC50 = 23000 nM
 Bioactivity Info 
   TI
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CP0378531
 Compound Info 
(S)-2-(5-(3-((2-(4-ethylphenyl)-5-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C28H33N3O3
  1
1
IC50 = 370 nM
 Bioactivity Info 
   TI
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CP0427747
 Compound Info 
(S)-2-(5-(3-((2-(4-isopropylphenyl)-5-methylpyrimidin-4-yl)(methyl)amino)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C29H35N3O3
  1
1
IC50 = 610 nM
 Bioactivity Info 
   TI
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CP0427720
 Compound Info 
2-((S)-5-(3-(5-(5-acetyl-4-methylthiazol-2-yl)pyridin-2-yloxy)propoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
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C25H26N2O5S
  1
1
IC50 = 1390 nM
 Bioactivity Info 
   TI
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Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0039118
 Compound Info 
2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid
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C21H18F3NO3S2
  1
1 EC50 = 20 nM
CP0060839
 Compound Info 
2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid
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C21H17F4NO3S2
  1
1 EC50 = 30 nM
CP0109272
 Compound Info 
(Z)-2-(2-bromophenyl)-3-[4-(4-methylpiperazin-1-yl)phenyl]prop-2-enenitrile
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C20H20BrN3
  1
1 IC50 = 26.9 nM
CP0146189
 Compound Info 
(Z)-2-(2-chlorophenyl)-3-[4-(dimethylamino)phenyl]prop-2-enenitrile
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C17H15ClN2
  1
1 IC50 = 180 nM
CP0177179
 Compound Info 
methyl 3-[(4-anilino-2-methoxyphenyl)sulfamoyl]thiophene-2-carboxylate
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C19H18N2O5S2
  1
1 IC50 >= 300 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT00909 Peroxisome proliferator-activated receptor delta Homo sapiens, Human
 Protein Info