Protein Information

General Information of the Protein

Protein ID	PT01354
Protein Name	5-hydroxytryptamine receptor 6
Secondarily Protein Name	Serotonin receptor 6
Gene Name	HTR6
Sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Serotonin receptor
Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611). Show/Hide
Uniprot ID	Primary ID: P50406 Secondarily ID: Q13640 Q5TGZ1 Show/Hide
Ensembl ID	ENSG00000158748
HGNC ID	HGNC:5301
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000094 , 1321N1

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0041613 Compound Info	Anapriline Show/Hide	C16H21NO2	2
1	EC50 > 5011.87 nM Bioactivity Info	TI LI LO TS
2	IC50 > 5011.87 nM Bioactivity Info	TI LI LO TS
CP0066236 Compound Info	1-(dimethylamino)-3-[(2-methyl-1H-1,2-benzazaborinin-8-yl)oxy]propan-2-ol Show/Hide	C14H21BN2O2	2
1	EC50 > 5011.87 nM Bioactivity Info	TI LI LO TS
2	IC50 > 5011.87 nM Bioactivity Info	TI LI LO TS
CP0366351 Compound Info	1-(dimethylamino)-3-[(2-methyl-1H-1,2-benzazaborinin-5-yl)oxy]propan-2-ol Show/Hide	C14H21BN2O2	2
1	EC50 > 5011.87 nM Bioactivity Info	TI LI LO TS
2	IC50 > 5011.87 nM Bioactivity Info	TI LI LO TS
CP0073333 Compound Info	3-benzenesulfonyl-8-piperazin-1-ylquinoline Show/Hide	C19H19N3O2S	1
1	IC50 = 2.8 nM Bioactivity Info	TI LI LO TS
CP0565805 Compound Info	1-(3-chlorophenyl)sulfonyl-4-piperazin-1-yl-2-propan-2-ylimidazo[4,5-c]pyridine Show/Hide	C19H22ClN5O2S	1
1	IC50 = 5.2 nM Bioactivity Info	TI LI LO TS
CP0515605 Compound Info	1-(3-chlorophenyl)sulfonyl-2-ethyl-4-piperazin-1-ylimidazo[4,5-c]pyridine Show/Hide	C18H20ClN5O2S	1
1	IC50 = 5.4 nM Bioactivity Info	TI LI LO TS
CP0537527 Compound Info	2-ethyl-1-(3-fluorophenyl)sulfonyl-4-piperazin-1-ylimidazo[4,5-c]pyridine Show/Hide	C18H20FN5O2S	1
1	IC50 = 6.4 nM Bioactivity Info	TI LI LO TS
CP0548230 Compound Info	1-(3-chlorophenyl)sulfonyl-4-piperazin-1-ylimidazo[4,5-c]pyridine Show/Hide	C16H16ClN5O2S	1
1	IC50 = 6.6 nM Bioactivity Info	TI LI LO TS
CP0552195 Compound Info	1-(3-chlorophenyl)sulfonyl-2-phenyl-4-piperazin-1-ylimidazo[4,5-c]pyridine Show/Hide	C22H20ClN5O2S	1
1	IC50 = 10.6 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000047 , 108CC15

Cell Line Info

Cell Line ID: CL000901 , 661W

Cell Line Info

Cell Line ID: CL000051 , BHK-21

Cell Line Info

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000065 , HEK293-EBNA

Cell Line Info

Cell Line ID: CL000131 , HEK293-F

Cell Line Info

Cell Line ID: CL000017 , HeLa

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0153460 Compound Info	2-(5-chloro-2-methyl-1H-indol-3-yl)-N,N-dimethylethanamine Show/Hide	C13H17ClN2	1
1	EC50 = 44.8 nM
CP0175237 Compound Info	5-(benzenesulfonyl)-N,11-dimethyl-2,3,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7-tetraen-4-amine Show/Hide	C17H19N5O2S	2
1	IC50 = 0.837 nM
2	Ki = 0.389 nM
CP0226262 Compound Info	4-(benzenesulfonyl)-N,8,11-trimethyl-2,6,7,11-tetrazatricyclo[7.4.0.03,7]trideca-1,3,5,8-tetraen-5-amine Show/Hide	C18H21N5O2S	2
1	IC50 = 1.43 nM
2	Ki = 0.662 nM
CP0329025 Compound Info	5-(benzenesulfonyl)-N,8,11-trimethyl-2,3,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7-tetraen-4-amine Show/Hide	C18H21N5O2S	2
1	IC50 = 1.48 nM
2	Ki = 0.685 nM
CP0037955 Compound Info	METHIOTHEPIN Show/Hide	C20H24N2S2	2
1	IC50 = 2.4 nM
2	Ki = 0.4 nM
CP0304087 Compound Info	2-(benzenesulfonyl)-N-ethyl-5-piperazin-1-ylaniline Show/Hide	C18H23N3O2S	1
1	IC50 = 2.7 nM
CP0043132 Compound Info	3-Benzenesulfonyl-2-methylsulfanyl-pyrido[1,2-a]pyrimidin-(4E)-ylideneamine Show/Hide	C15H13N3O2S2	2
1	IC50 = 4 nM
2	Ki = 3.981 nM
CP0219258 Compound Info	5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine Show/Hide	C15H15N3O2S2	5
1	IC50 = 4.61 nM
2	IC50 = 30 nM
3	Ki = 2 nM
4	Ki = 2.1 nM
5	Ki = 2.14 nM
CP0016259 Compound Info	4-(benzenesulfonyl)-N,11-dimethyl-2,6,7,11-tetrazatricyclo[7.4.0.03,7]trideca-1,3,5,8-tetraen-5-amine Show/Hide	C17H19N5O2S	2
1	IC50 = 7.02 nM
2	Ki = 3.26 nM
CP0077916 Compound Info	5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole Show/Hide	C14H15ClN2	1
1	IC50 = 7.4 nM
CP0326089 Compound Info	3-(4-fluorophenyl)sulfonyl-5,7-dimethyl-2-methylsulfanylpyrazolo[1,5-a]pyrimidine Show/Hide	C15H14FN3O2S2	2
1	IC50 < 10 nM
2	IC50 = 112 nM
CP0513900 Compound Info	5-(benzenesulfonyl)-4,11-dimethyl-2,3,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7-tetraene Show/Hide	C17H18N4O2S	2
1	IC50 = 13 nM
2	Ki = 60 nM
CP0073332 Compound Info	2-ethyl-3-[(3-fluorophenyl)methyl]-7-piperazin-1-ylimidazo[4,5-b]pyridine Show/Hide	C19H22FN5	2
1	IC50 = 17.6 nM
2	Ki = 6 nM
CP0126985 Compound Info	3-(3-chlorophenyl)sulfonyl-5,7-dimethyl-2-methylsulfanylpyrazolo[1,5-a]pyrimidine Show/Hide	C15H14ClN3O2S2	1
1	IC50 = 20 nM
CP0126984 Compound Info	3-(3-fluorophenyl)sulfonyl-5,7-dimethyl-2-methylsulfanylpyrazolo[1,5-a]pyrimidine Show/Hide	C15H14FN3O2S2	1
1	IC50 = 25 nM
CP0118951 Compound Info	4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-benzenesulfonamide Show/Hide	C12H16N6O2S	5
1	IC50 = 26.3 nM
2	Ki = 50.12 nM
3	Ki = 54.95 nM
4	Ki = 55 nM
5	Ki = 58 nM
CP0001238 Compound Info	14C-5-hydroxy tryptamine creatinine disulfate Show/Hide	C10H12N2O	11
1	IC50 = 27.5 nM
2	IC50 = 100 nM
3	IC50 = 180 nM
4	IC50 = 200 nM
5	IC50 = 262 nM
6	Ki = 50 nM
7	Ki = 65 nM
8	Ki = 70 nM
9	Ki = 84 nM
10	Ki = 93 nM
11	Ki = 100 nM
CP0126986 Compound Info	3-(3-chloro-4-fluorophenyl)sulfonyl-5,7-dimethyl-2-methylsulfanylpyrazolo[1,5-a]pyrimidine Show/Hide	C15H13ClFN3O2S2	1
1	IC50 = 46 nM
CP0175239 Compound Info	5,7-Dimethyl-2-(ethylthio)-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidine Show/Hide	C16H17N3O2S2	1
1	IC50 = 50 nM
CP0306929 Compound Info	3-Benzenesulfonyl-2-methylsulfanyl-pyrimido[2,1-a]isoquinolin-(4Z)-ylideneamine Show/Hide	C19H15N3O2S2	1
1	IC50 = 68.9 nM
CP0154123 Compound Info	3-Benzenesulfonyl-8-ethyl-2-methylsulfanyl-pyrido[1,2-a]pyrimidin-(4Z)-ylideneamine Show/Hide	C17H17N3O2S2	1
1	IC50 = 70.1 nM
CP0293425 Compound Info	5-(benzenesulfonyl)-11-methyl-4-methylsulfanyl-2,3,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7-tetraene Show/Hide	C17H18N4O2S2	2
1	IC50 = 76.9 nM
2	Ki = 35.7 nM
CP0063547 Compound Info	2-Methylsulfanyl-3-(naphthalene-2-sulfonyl)-pyrido[1,2-a]pyrimidin-(4Z)-ylideneamine Show/Hide	C19H15N3O2S2	1
1	IC50 = 79.2 nM
CP0099428 Compound Info	5-Methoxy-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole Show/Hide	C15H18N2O	1
1	IC50 = 80 nM
CP0080534 Compound Info	2-ethyl-5-methoxy-N,N-dimethyltryptamine Show/Hide	C15H22N2O	3
1	IC50 = 85 nM
2	Ki = 16 nM
3	Ki < 50 nM
CP0281465 Compound Info	3-Benzenesulfonyl-7-fluoro-2-methylsulfanyl-pyrido[1,2-a]pyrimidin-(4Z)-ylideneamine Show/Hide	C15H12FN3O2S2	1
1	IC50 = 87.6 nM
CP0172993 Compound Info	2,5,7-Triimethyl-phenylsulfonyl-pyrazolo[1,5-a]pyrimidine Show/Hide	C15H15N3O2S	2
1	IC50 = 147 nM
2	Ki = 68.4 nM
CP0172992 Compound Info	3-(4-chlorophenyl)sulfonyl-5,7-dimethyl-2-methylsulfanylpyrazolo[1,5-a]pyrimidine Show/Hide	C15H14ClN3O2S2	1
1	IC50 = 230 nM
CP0363770 Compound Info	3-Benzenesulfonyl-9-bromo-7-methyl-2-methylsulfanyl-pyrido[1,2-a]pyrimidin-(4Z)-ylideneamine Show/Hide	C16H14BrN3O2S2	1
1	IC50 = 269 nM
CP0293306 Compound Info	3-(4-methoxyphenyl)sulfonyl-5,7-dimethyl-2-methylsulfanylpyrazolo[1,5-a]pyrimidine Show/Hide	C16H17N3O3S2	1
1	IC50 = 440 nM
CP0223269 Compound Info	2-{[5,7-Dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidin-2-yl]oxy}ethanol Show/Hide	C16H17N3O4S	3
1	IC50 = 477 nM
2	Ki = 22.2 nM
3	Ki = 222 nM
CP0211753 Compound Info	5,7-Dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidine Show/Hide	C14H13N3O2S	3
1	IC50 = 510 nM
2	IC50 > 1000 nM
3	Ki = 237 nM
CP0321822 Compound Info	4-(benzenesulfonyl)-11-methyl-5-methylsulfanyl-2,6,7,11-tetrazatricyclo[7.4.0.03,7]trideca-1,3,5,8-tetraene Show/Hide	C17H18N4O2S2	2
1	IC50 = 801 nM
2	Ki = 372 nM
CP0513899 Compound Info	4-(4-fluorophenyl)sulfonyl-11-methyl-5-methylsulfanyl-2,6,7,11-tetrazatricyclo[7.4.0.03,7]trideca-1,3,5,8-tetraene Show/Hide	C17H17FN4O2S2	1
1	IC50 > 1000 nM
CP0216239 Compound Info	3-(benzenesulfonyl)-N,5,7-trimethylpyrazolo[1,5-a]pyrimidin-2-amine Show/Hide	C15H16N4O2S	1
1	Ki = 0.2 nM
CP0073333 Compound Info	3-benzenesulfonyl-8-piperazin-1-ylquinoline Show/Hide	C19H19N3O2S	4
1	Ki = 0.23 nM
2	Ki = 0.234 nM
3	Ki = 0.25 nM
4	Ki = 0.28 nM
CP0523047 Compound Info	1-(benzenesulfonyl)-2-methyl-4-piperazin-1-ylbenzimidazole Show/Hide	C18H20N4O2S	2
1	Ki = 0.5 nM
2	Ki = 0.53 nM
CP0214694 Compound Info	2-(2,6-difluorophenyl)-6-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]pyridazin-3-one Show/Hide	C25H23F3N4O3	1
1	Ki = 0.5 nM
CP0339112 Compound Info	4-phenyl-N-(4-piperazin-1-ylquinolin-6-yl)benzenesulfonamide Show/Hide	C25H24N4O2S	1
1	Ki = 0.5012 nM
CP0043595 Compound Info	(3R)-N,N-Dimethyl-1-[3-(1-naphthylsulfonyl)-1H-indazol-5-yl]pyrrolidin-3-amine Show/Hide	C23H24N4O2S	1
1	Ki = 0.51 nM
CP0265775 Compound Info	6-chloro-N-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]imidazo[2,1-b][1,3]thiazole-5-sulfonamide Show/Hide	C17H18ClN5O2S2	3
1	Ki = 0.58 nM
2	Ki = 2.2 nM
3	Ki = 312 nM
CP0113176 Compound Info	5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide Show/Hide	C21H24ClN3O3S2	2
1	Ki = 0.6 nM
2	Ki = 0.631 nM
CP0081712 Compound Info	4-tert-butyl-N-(4-piperazin-1-ylquinolin-6-yl)benzenesulfonamide Show/Hide	C23H28N4O2S	1
1	Ki = 0.631 nM
CP0041243 Compound Info	5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide hydrochloride Show/Hide	C20H22ClN3O3S2	3
1	Ki = 0.66 nM
2	Ki = 1 nM
3	Ki = 1.259 nM
CP0294753 Compound Info	9-methyl-2-(methylthio)-3-(phenylsulfonyl)-5,6,7,8-tetrahydropyrazolo[5,1-b]quinazoline Show/Hide	C18H19N3O2S2	1
1	Ki = 0.68 nM
CP0037941 Compound Info	2-[1-(Naphthalene-1-sulfonyl)-1H-indol-6-yl]-octahydro-pyrrolo[1,2-a]pyrazine Show/Hide	C25H25N3O2S	1
1	Ki = 0.7 nM
CP0309013 Compound Info	5-chloro-N-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]naphthalene-2-sulfonamide Show/Hide	C22H22ClN3O2S	1
1	Ki = 0.7 nM
CP0199114 Compound Info	SB-399885 Show/Hide	C18H21Cl2N3O4S	2
1	Ki = 0.7762 nM
2	Ki = 0.8 nM
CP0165719 Compound Info	N-[3-[(8aR)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-4-methoxyphenyl]-5-chloro-3-methyl-1-benzothiophene-2-sulfonamide Show/Hide	C23H26ClN3O3S2	1
1	Ki = 0.7943 nM
CP0183577 Compound Info	5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid ((S)-3-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-4-methoxy-phenyl)-amide Show/Hide	C23H26ClN3O3S2	2
1	Ki = 0.7943 nM
2	Ki = 0.8 nM
CP0258948 Compound Info	4-(3-(2-(dimethylamino)ethyl)-1H-indol-1-ylsulfonyl)benzenamine Show/Hide	C18H21N3O2S	1
1	Ki = 0.8 nM
CP0217150 Compound Info	IDALOPIRDINE Show/Hide	C20H19F5N2O	1
1	Ki = 0.83 nM
CP0093674 Compound Info	3-(3-bromo-benzenesulfonyl)-1-(1-methyl-pyrrolidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C18H18BrN3O2S	1
1	Ki = 0.8913 nM
CP0279831 Compound Info	2-(5-methoxy-1-naphthalen-1-ylsulfonylindol-3-yl)-N,N-dimethylethanamine Show/Hide	C23H24N2O3S	1
1	Ki = 0.9 nM
CP0111551 Compound Info	5-chloro-N-(4-piperazin-1-ylquinolin-6-yl)naphthalene-2-sulfonamide Show/Hide	C23H21ClN4O2S	1
1	Ki = 1 nM
CP0208303 Compound Info	5-chloro-2-methyl-N-(4-piperazin-1-ylquinolin-6-yl)-1-benzothiophene-3-sulfonamide Show/Hide	C22H21ClN4O2S2	1
1	Ki = 1 nM
CP0306083 Compound Info	5-chloro-3-methyl-N-[4-(4-methylpiperazin-1-yl)quinolin-6-yl]-1-benzothiophene-2-sulfonamide Show/Hide	C23H23ClN4O2S2	1
1	Ki = 1 nM
CP0039674 Compound Info	1-(2-bromophenyl)sulfonyl-3-(1-methylpyrrolidin-3-yl)indole Show/Hide	C19H19BrN2O2S	1
1	Ki = 1 nM
CP0777252 Compound Info	2-Iodo-N-(3-(R)-1-pyrrolidin-2-ylmethyl-1H-indol-5-yl)-benzenesulfonamide Show/Hide	C20H22IN3O2S	1
1	Ki = 1 nM
CP0144979 Compound Info	1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-indole Show/Hide	C18H19N3O2S	1
1	Ki = 1 nM
CP0237538 Compound Info	2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole Show/Hide	C21H24N2	1
1	Ki = 1.2 nM
CP0113794 Compound Info	3-[(5-chlorothien-2-yl)sulfonyl]-1-piperidin-3-yl-1H-pyrrolo[2,3-b]pyridine Show/Hide	C16H16ClN3O2S2	1
1	Ki = 1.202 nM
CP0082421 Compound Info	5-chloro-3-methyl-N-(2-methyl-4-piperazin-1-ylquinolin-6-yl)-1-benzothiophene-2-sulfonamide Show/Hide	C23H23ClN4O2S2	1
1	Ki = 1.259 nM
CP0170807 Compound Info	5-chloro-3-ethyl-N-(4-piperazin-1-ylquinolin-6-yl)-1-benzothiophene-2-sulfonamide Show/Hide	C23H23ClN4O2S2	1
1	Ki = 1.259 nM
CP0343547 Compound Info	5-chloro-3-methyl-N-[4-[(3S)-3-methylpiperazin-1-yl]quinolin-6-yl]-1-benzothiophene-2-sulfonamide Show/Hide	C23H23ClN4O2S2	1
1	Ki = 1.259 nM
CP0281706 Compound Info	6-(1,2,3,5,8,8a-Hexahydro-indolizin-7-yl)-1-(naphthalene-1-sulfonyl)-1H-indole Show/Hide	C26H24N2O2S	1
1	Ki = 1.259 nM
CP0302411 Compound Info	3-(3-bromo-benzenesulfonyl)-1-pyrrolidin-3-yl-1Hpyrrolo[2,3-b]pyridine Show/Hide	C17H16BrN3O2S	1
1	Ki = 1.288 nM
CP0309906 Compound Info	3-[(3-chlorophenyl)sulfonyl]-1-piperidin-3-yl-1Hpyrrolo[2,3-b]pyridine Show/Hide	C18H18ClN3O2S	1
1	Ki = 1.288 nM
CP0325789 Compound Info	1-pyrrolidin-3-yl-3-(3-trifluoromethyl-benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C18H16F3N3O2S	1
1	Ki = 1.288 nM
CP0286684 Compound Info	(2-{2-[3-(3-Methoxy-benzyl)-[1,2,4]oxadiazol-5-yl]-1H-indol-3-yl}-ethyl)-dimethyl-amine Show/Hide	C22H24N4O2	1
1	Ki = 1.3 nM
CP0080114 Compound Info	Cerlapirdine Show/Hide	C22H23N3O3S	1
1	Ki = 1.3 nM
CP0318500 Compound Info	5-(1,4-diazepan-1-yl)-2-(4-fluorophenylsulfonyl)-N-methylbenzenamine Show/Hide	C18H22FN3O2S	1
1	Ki = 1.4 nM
CP0045070 Compound Info	1-Benzenesulfonyl-5-chloro-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indole Show/Hide	C20H21ClN2O2S	2
1	Ki = 1.4 nM
2	Ki < 50 nM
CP0302413 Compound Info	3-(3-fluoro-benzenesulfonyl)-1-(1-methyl-pyrrolidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C18H18FN3O2S	1
1	Ki = 1.413 nM
CP0148437 Compound Info	(9-Benzenesulfonyl-6-methoxy-2,3,4,9-tetrahydro-1H-carbazol-4-ylmethyl)-dimethyl-amine Show/Hide	C22H26N2O3S	2
1	Ki = 1.5 nM
2	Ki = 2.3 nM
CP0330654 Compound Info	2-[1-(benzenesulfonyl)indol-4-yl]-N,N-dimethylethanamine Show/Hide	C18H20N2O2S	1
1	Ki = 1.5 nM
CP0275252 Compound Info	3-(3-chloro-benzenesulfonyl)-1-pyrrolidin-3-yl-1Hpyrrolo[2,3-b]pyridine Show/Hide	C17H16ClN3O2S	1
1	Ki = 1.514 nM
CP0288554 Compound Info	3-(3-chloro-benzenesulfonyl)-1-(1-methyl-pyrrolidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C18H18ClN3O2S	1
1	Ki = 1.514 nM
CP0152148 Compound Info	2-(5-methoxy-1-naphthalen-2-ylsulfonylindol-3-yl)-N,N-dimethylethanamine Show/Hide	C23H24N2O3S	1
1	Ki = 1.6 nM
CP0076188 Compound Info	1-(benzenesulfonyl)-4,5-dihydro-3H-benzo[cd]indol-4-amine Show/Hide	C17H16N2O2S	1
1	Ki = 1.6 nM
CP0287755 Compound Info	3-[(5-chlorothien-2-yl)sulfonyl]-1-(1-methylpiperidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C17H18ClN3O2S2	1
1	Ki = 1.905 nM
CP0173778 Compound Info	5-chloro-3-methyl-N-(4-piperazin-1-ylquinolin-6-yl)-1-benzothiophene-2-sulfonamide Show/Hide	C22H21ClN4O2S2	1
1	Ki = 1.995 nM
CP0310111 Compound Info	6-Chloro-imidazo[2,1-b]thiazole-5-sulfonic acid [1-(2-dimethylamino-ethyl)-1H-indol-5-yl]-amide Show/Hide	C17H18ClN5O2S2	1
1	Ki = 1.995 nM
CP0277694 Compound Info	3-[(2-fluorophenyl)sulfonyl]-1-piperidin-3-yl-1Hpyrrolo[2,3-b]pyridine Show/Hide	C18H18FN3O2S	1
1	Ki = 1.995 nM
CP0325786 Compound Info	3-(2-fluoro-benzenesulfonyl)-1-pyrrolidin-3-yl-1Hpyrrolo[2,3-b]pyridine Show/Hide	C17H16FN3O2S	1
1	Ki = 1.995 nM
CP0045069 Compound Info	2-[1-(benzenesulfonyl)-5-methoxyindol-3-yl]-N,N-dimethylethanamine Show/Hide	C19H22N2O3S	5
1	Ki = 2 nM
2	Ki = 2.1 nM
3	Ki = 2.3 nM
4	Ki = 2.512 nM
5	Ki < 50 nM
CP0144949 Compound Info	2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulfonyl)-1H-indol-3-yl]ethan-1-amine Show/Hide	C15H13ClN4O2S2	2
1	Ki = 2 nM
2	Ki = 2.2 nM
CP0093677 Compound Info	3-{[3-(trifluoromethyl)phenyl]sulfonyl}-1-(1-methylpiperidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C20H20F3N3O2S	1
1	Ki = 2.089 nM
CP0648533 Compound Info	N-(3-Fluorophenyl)-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-sulfonamide hydrochloride Show/Hide	C18H19ClFN3O2S	1
1	Ki = 2.1 nM
CP0357075 Compound Info	3-(2-Chloro-benzenesulfonyl)-1-(1-methyl-pyrrolidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C18H18ClN3O2S	1
1	Ki = 2.188 nM
CP0271608 Compound Info	3-[(3-fluorophenyl)sulfonyl]-1-piperidin-3-yl-1Hpyrrolo[2,3-b]pyridine Show/Hide	C18H18FN3O2S	1
1	Ki = 2.399 nM
CP0310110 Compound Info	SB-258585 Show/Hide	C18H22IN3O3S	1
1	Ki = 2.512 nM
CP0325791 Compound Info	3-benzenesulfonyl-1-(1-methyl-pyrrolidin-3-yl)-1Hpyrrolo[2,3-b]pyridine Show/Hide	C18H19N3O2S	1
1	Ki = 2.512 nM
CP0276427 Compound Info	10-(benzenesulfonyl)-11-methylsulfanyl-2-piperazin-1-yl-1,8,12-triazatricyclo[7.3.0.03,7]dodeca-2,7,9,11-tetraene Show/Hide	C20H23N5O2S2	1
1	Ki = 2.512 nM
CP0316409 Compound Info	3-(3-fluoro-benzenesulfonyl)-1-pyrrolidin-3-yl-1Hpyrrolo[2,3-b]pyridine Show/Hide	C17H16FN3O2S	1
1	Ki = 2.692 nM
CP0285245 Compound Info	2-(1-benzyl-1H-inden-3-yl)-N,N-dimethylethanamine Show/Hide	C20H23N	1
1	Ki = 3 nM
CP0099906 Compound Info	N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide Show/Hide	C17H18Br2FN3O3S	2
1	Ki = 3 nM
2	Ki = 3.162 nM
CP0277626 Compound Info	(3S)-1-[3-(1-Naphthylsulfonyl)-1H-indazol-5-yl]pyrrolidin-3-amine Show/Hide	C21H20N4O2S	1
1	Ki = 3.06 nM
CP0255950 Compound Info	2-[1-(benzenesulfonyl)indol-3-yl]-N,N-dimethylethanamine Show/Hide	C18H20N2O2S	2
1	Ki = 3.162 nM
2	Ki = 4.1 nM
CP0326103 Compound Info	1-(1-ethylpiperidin-3-yl)-3-[(5-chlorothien-2-yl)-sulfonyl]-1H-pyrrolo[2,3-b]pyridine Show/Hide	C18H20ClN3O2S2	1
1	Ki = 3.236 nM
CP0093676 Compound Info	3-(3-chloro-benzenesulfonyl)-1-(1-ethyl-pyrrolidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C19H20ClN3O2S	1
1	Ki = 3.311 nM
CP0143099 Compound Info	3-[(3-fluorophenyl)sulfonyl]-1-(1-isopropylpiperidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C21H24FN3O2S	1
1	Ki = 3.388 nM
CP0277627 Compound Info	1-[3-(1-Naphthylsulfonyl)-1H-indazol-5-yl]azetidin-3-amine Show/Hide	C20H18N4O2S	1
1	Ki = 3.55 nM
CP0148007 Compound Info	1-{3-[(4-Methyl-1-naphthyl)sulfonyl]-1H-indazol-5-yl}piperidin-4-amine Show/Hide	C23H24N4O2S	1
1	Ki = 3.62 nM
CP0427370 Compound Info	1-(1-ethylpiperidin-3-yl)-3-(phenylsulfonyl)-1Hpyrrolo[2,3-b]pyridine Show/Hide	C20H23N3O2S	1
1	Ki = 3.631 nM
CP0291339 Compound Info	3-[(2-chlorophenyl)sulfonyl]-1-piperidin-3-yl-1Hpyrrolo[2,3-b]pyridine Show/Hide	C18H18ClN3O2S	1
1	Ki = 3.715 nM
CP0295962 Compound Info	3-[(3-bromophenyl)sulfonyl]-1-piperidin-3-yl-1Hpyrrolo[2,3-b]pyridine Show/Hide	C18H18BrN3O2S	1
1	Ki = 3.802 nM
CP0287714 Compound Info	3-[(3,5-dichlorophenyl)sulfonyl]-1-(1-methylpiperidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C19H19Cl2N3O2S	1
1	Ki = 3.89 nM
CP0025667 Compound Info	2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone Show/Hide	C18H19ClN4	6
1	Ki = 4 nM
2	Ki = 9.5 nM
3	Ki = 10 nM
4	Ki = 11 nM
5	Ki < 50 nM
6	Ki = 100 nM
CP0033479 Compound Info	(chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Show/Hide	C17H19ClN2S	2
1	Ki = 4 nM
2	Ki < 50 nM
CP0379692 Compound Info	3-(4-methylpiperazin-1-yl)-1-(phenylsulfonyl)-1H-indole Show/Hide	C19H21N3O2S	1
1	Ki = 4 nM
CP0424546 Compound Info	N-[1-(5-chloro-2,3-dimethoxyphenyl)ethyl]-2-methylsulfonyl-5-piperazin-1-ylaniline Show/Hide	C21H28ClN3O4S	1
1	Ki = 4 nM
CP0089877 Compound Info	3-(4-chloro-benzenesulfonyl)-1-(1-methyl-pyrrolidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C18H18ClN3O2S	1
1	Ki = 4.169 nM
CP0093693 Compound Info	3-(4-bromo-benzenesulfonyl)-1-pyrrolidin-3-yl-1Hpyrrolo[2,3-b]pyridine Show/Hide	C17H16BrN3O2S	1
1	Ki = 4.266 nM
CP0309914 Compound Info	1-[3-(1-Naphthylsulfonyl)-1H-indazol-5-yl]piperidin-4-amine Show/Hide	C22H22N4O2S	1
1	Ki = 4.27 nM
CP0061587 Compound Info	1-(1-ethylpiperidin-3-yl)-3-[(3-fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine Show/Hide	C20H22FN3O2S	1
1	Ki = 4.365 nM
CP0038773 Compound Info	(3R)-1-[3-(1-Naphthylsulfonyl)-1H-indazol-5-yl]pyrrolidin-3-amine Show/Hide	C21H20N4O2S	1
1	Ki = 4.46 nM
CP0039675 Compound Info	6-chloro-N-[3-[2-(dimethylamino)ethyl]-2-methyl-1H-inden-5-yl]imidazo[2,1-b][1,3]thiazole-5-sulfonamide Show/Hide	C19H21ClN4O2S2	1
1	Ki = 4.5 nM
CP0062984 Compound Info	1-{3-[(5-Chloro-1-naphthyl)sulfonyl]-1H-indazol-5-yl}piperidin-4-amine Show/Hide	C22H21ClN4O2S	1
1	Ki = 4.52 nM
CP0295961 Compound Info	3-{[3-(trifluoromethyl)phenyl]sulfonyl}-1-piperidin-3-yl-1H-pyrrolo[2,3-b]pyridine Show/Hide	C19H18F3N3O2S	1
1	Ki = 4.571 nM
CP0158829 Compound Info	3-[(3-fluorophenyl)sulfonyl]-1-(1-methylpiperidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C19H20FN3O2S	1
1	Ki = 4.677 nM
CP0271606 Compound Info	3-(phenylsulfonyl)sulfonyl]-1-piperidin-3-yl-1Hpyrrolo[2,3-b]pyridine Show/Hide	C18H19N3O2S	1
1	Ki = 4.898 nM
CP0285020 Compound Info	2-(7-methoxy-1-naphthalen-2-ylsulfonylindol-3-yl)-N,N-dimethylethanamine Show/Hide	C23H24N2O3S	1
1	Ki = 5 nM
CP0185590 Compound Info	4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-benzenesulfonamide Show/Hide	C18H22BrN3O3S	1
1	Ki = 5 nM
CP0287843 Compound Info	3-(4-fluoro-benzenesulfonyl)-1-(1-methyl-pyrrolidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C18H18FN3O2S	1
1	Ki = 5.012 nM
CP0325788 Compound Info	3-(4-chloro-benzenesulfonyl)-1-pyrrolidin-3-yl-1Hpyrrolo[2,3-b]pyridine Show/Hide	C17H16ClN3O2S	1
1	Ki = 5.495 nM
CP0218398 Compound Info	6-[5-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]pentanoyl]-1-azatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-trien-11-one Show/Hide	C28H30FN3O3	1
1	Ki = 5.55 nM
CP0317149 Compound Info	6-[4-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]butanoyl]-1-azatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-trien-11-one Show/Hide	C27H28FN3O3	1
1	Ki = 5.6 nM
CP0277693 Compound Info	3-(2-fluoro-benzenesulfonyl)-1-(1-methyl-pyrrolidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C18H18FN3O2S	1
1	Ki = 5.623 nM
CP0647677 Compound Info	2,5-Dimethyl-8-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride Show/Hide	C19H21ClN2O2S	1
1	Ki = 5.7 nM
CP0269589 Compound Info	8-(1-pyrrolidin-3-yl-1H-pyrrolo[2,3-b]pyridine-3-sulfonyl)-quinoline Show/Hide	C20H18N4O2S	1
1	Ki = 5.754 nM
CP0149650 Compound Info	2-(1-benzyl-1H-indol-3-yl)-N,N-dimethylethanamine Show/Hide	C19H22N2	1
1	Ki = 6 nM
CP0294388 Compound Info	3-[(3,5-dichlorophenyl)sulfonyl]-1-piperidin-3-yl-1H-pyrrolo[2,3-b]pyridine Show/Hide	C18H17Cl2N3O2S	1
1	Ki = 6.166 nM
CP0045725 Compound Info	(4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide Show/Hide	C20H25N3O	1
1	Ki = 6.9 nM
CP0186950 Compound Info	(4S,5S)-4-Dimethylamino-1-(toluene-4-sulfonyl)-1,3,4,5-tetrahydro-benzo[cd]indol-5-ol Show/Hide	C20H22N2O3S	2
1	Ki = 7.2 nM
2	Ki = 7.943 nM
CP0271607 Compound Info	3-[(4-chlorophenyl)sulfonyl]-1-piperidin-3-yl-1Hpyrrolo[2,3-b]pyridine Show/Hide	C18H18ClN3O2S	1
1	Ki = 7.586 nM
CP0087260 Compound Info	3-[1-(benzenesulfonyl)indol-4-yl]-N,N-dimethylpropan-1-amine Show/Hide	C19H22N2O2S	1
1	Ki = 7.9 nM
CP0282297 Compound Info	1-(3-(3-chlorophenylsulfonyl)-1H-indazol-5-yl)piperidin-4-amine Show/Hide	C18H19ClN4O2S	1
1	Ki = 8.04 nM
CP0113787 Compound Info	1-(1-ethyl-pyrrolidin-3-yl)-3-(3-fluoro-benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C19H20FN3O2S	1
1	Ki = 8.318 nM
CP0143094 Compound Info	3-(4-fluoro-benzenesulfonyl)-1-pyrrolidin-3-yl-1Hpyrrolo[2,3-b]pyridine Show/Hide	C17H16FN3O2S	1
1	Ki = 8.511 nM
CP0104220 Compound Info	3-[(3-bromophenyl)sulfonyl]-1-(1-isopropylpiperidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C21H24BrN3O2S	1
1	Ki = 9.333 nM
CP0039676 Compound Info	4-indol-1-ylsulfonylaniline Show/Hide	C14H12N2O2S	1
1	Ki = 10 nM
CP0174706 Compound Info	6-chloro-N-[3-[2-(dimethylamino)ethyl]-1H-inden-5-yl]imidazo[2,1-b][1,3]thiazole-5-sulfonamide Show/Hide	C18H19ClN4O2S2	1
1	Ki = 10 nM
CP0045063 Compound Info	2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine Show/Hide	C17H20N4S	3
1	Ki = 10 nM
2	Ki = 10.7 nM
3	Ki < 50 nM
CP0291338 Compound Info	3-benzenesulfonyl-1-(1-ethyl-pyrrolidin-3-yl)-1Hpyrrolo[2,3-b]pyridine Show/Hide	C19H21N3O2S	1
1	Ki = 10.96 nM
CP0143098 Compound Info	3-[(4-chlorophenyl)sulfonyl]-1-(1-isopropylpiperidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C21H24ClN3O2S	1
1	Ki = 11.22 nM
CP0093694 Compound Info	3-[(4-chlorophenyl)sulfonyl]-1-(1-methylpiperidin-3-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C19H20ClN3O2S	1
1	Ki = 11.48 nM
CP0080436 Compound Info	4-Amino-N-(2,6-bis-methylamino-pyridin-4-yl)-benzenesulfonamide Show/Hide	C13H17N5O2S	2
1	Ki = 12 nM
2	Ki = 15.85 nM
CP0297596 Compound Info	3-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperidin-3-yl-1H-pyrrolo[2,3-b]pyridine Show/Hide	C19H18F3N3O2S	1
1	Ki = 12.02 nM
CP0214619 Compound Info	1-{3-[(4-Isopropylphenyl)sulfonyl]-1H-indazol-5-yl}piperidin-4-amine Show/Hide	C21H26N4O2S	1
1	Ki = 13.09 nM
CP0295963 Compound Info	1-(1-ethylpiperidin-3-yl)-3-[(3,5-dichlorophenyl)-sulfonyl]-1H-pyrrolo[2,3-b]pyridine Show/Hide	C20H21Cl2N3O2S	1
1	Ki = 13.49 nM
CP0229727 Compound Info	(3R)-1-[1-(1-Methylethyl)-3-(naphthalen-1-ylsulfonyl)-1H-indazol-5-yl]pyrrolidin-3-amine Show/Hide	C24H26N4O2S	1
1	Ki = 13.7 nM
CP0071154 Compound Info	2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamine Show/Hide	C13H18N2O	2
1	Ki = 16 nM
2	Ki = 70 nM
CP0102529 Compound Info	[3-[2-(dimethylamino)ethyl]-5-methoxyindol-1-yl]-phenylmethanone Show/Hide	C20H22N2O2	2
1	Ki = 18 nM
2	Ki = 25.12 nM
CP0073585 Compound Info	1-[3-(2-Naphthylsulfonyl)-1H-indazol-5-yl]piperidin-4-amine Show/Hide	C22H22N4O2S	1
1	Ki = 18.22 nM
CP0135451 Compound Info	2-(5-methoxy-2-phenyl-1H-indol-3-yl)-N,N-dimethylethanamine Show/Hide	C19H22N2O	2
1	Ki = 20 nM
2	Ki = 50.12 nM
CP0318039 Compound Info	3-(2-Dimethylamino-ethyl)-1H-indole-2-carboxylic acid ethyl ester Show/Hide	C15H20N2O2	1
1	Ki = 20 nM
CP0148894 Compound Info	(3R)-1-[1-Methyl-3-(naphthalen-1-ylsulfonyl)-1H-indazol-5-yl]pyrrolidin-3-amine Show/Hide	C22H22N4O2S	1
1	Ki = 21.1 nM
CP0148893 Compound Info	(3S)-N,N-Dimethyl-1-[3-(1-naphthylsulfonyl)-1H-indazol-5-yl]pyrrolidin-3-amine Show/Hide	C23H24N4O2S	1
1	Ki = 24.4 nM
CP0017601 Compound Info	2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole Show/Hide	C21H25N3	2
1	Ki = 26 nM
2	Ki = 34 nM
CP0292029 Compound Info	1-Benzenesulfonyl-3-(2-dimethylamino-ethyl)-1H-indol-5-ol Show/Hide	C18H20N2O3S	1
1	Ki = 28 nM
CP0268549 Compound Info	4-(1,2,3,4-Tetrahydro-carbazole-9-sulfonyl)-phenylamine Show/Hide	C18H18N2O2S	1
1	Ki = 31.62 nM
CP0291340 Compound Info	1-(1-ethylpiperidin-3-yl)-3-[(4-chlorophenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine Show/Hide	C20H22ClN3O2S	1
1	Ki = 33.11 nM
CP0073491 Compound Info	(3R)-1-[1-(2-Methylpropyl)-3-(naphthalen-1-ylsulfonyl)-1Hindazol-5-yl]pyrrolidin-3-amine Show/Hide	C25H28N4O2S	1
1	Ki = 36.9 nM
CP0022455 Compound Info	2-Me 5-HT Show/Hide	C11H14N2O	2
1	Ki = 46 nM
2	Ki = 400 nM
CP0043596 Compound Info	(3R)-1-[2-(1-Methylethyl)-3-(naphthalen-1-ylsulfonyl)-2Hindazol-5-yl]pyrrolidin-3-amine Show/Hide	C24H26N4O2S	1
1	Ki = 48.7 nM
CP0034894 Compound Info	2-(5-methoxy-1H-indol-3-yl)ethanamine Show/Hide	C11H14N2O	1
1	Ki < 50 nM
CP0080535 Compound Info	5-fluoro-3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1-naphthalen-1-ylsulfonylindole Show/Hide	C24H21FN2O2S	1
1	Ki < 50 nM
CP0099907 Compound Info	6-Chloro-imidazo[2,1-b]thiazole-5-sulfonic acid [1-(2-pyrrolidin-1-yl-ethyl)-1H-indol-6-yl]-amide Show/Hide	C19H20ClN5O2S2	1
1	Ki = 50.12 nM
CP0310112 Compound Info	4-(2,6-dibromopyridin-4-yl)sulfonylaniline Show/Hide	C11H8Br2N2O2S	1
1	Ki = 50.12 nM
CP0330836 Compound Info	(3R)-1-[2-Methyl-3-(naphthalen-1-ylsulfonyl)-2H-indazol-5-yl]pyrrolidin-3-amine Show/Hide	C22H22N4O2S	1
1	Ki = 54.3 nM
CP0036840 Compound Info	2-(5-methoxy-2-methyl-1H-indol-3-yl)-N,N-dimethylethanamine Show/Hide	C14H20N2O	1
1	Ki = 60 nM
CP0056386 Compound Info	5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one Show/Hide	C21H21ClN4OS	2
1	Ki = 61 nM
2	Ki = 76 nM
CP0069200 Compound Info	1H-indole-3-ethanamine Show/Hide	C10H12N2	1
1	Ki = 70 nM
CP0208161 Compound Info	(3R)-1-[2-(2-Methylpropyl)-3-(naphthalen-1-ylsulfonyl)-2Hindazol-5-yl]pyrrolidin-3-amine Show/Hide	C25H28N4O2S	1
1	Ki = 75.8 nM
CP0277471 Compound Info	N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-nitrobenzenesulfonamide Show/Hide	C18H22N4O5S	1
1	Ki = 79.43 nM
CP0087385 Compound Info	2-(5-Methoxy-2-methyl-1H-indol-3-yl)-ethylamine Show/Hide	C12H16N2O	1
1	Ki = 80 nM
CP0086335 Compound Info	4-[(2S)-2-[2-[4-(1-benzothiophen-4-yl)piperazin-1-yl]ethyl]pyrrolidin-1-yl]sulfonylisoquinoline Show/Hide	C27H30N4O2S2	1
1	Ki = 116 nM
CP0378964 Compound Info	4-(4-chlorophenyl)sulfonyl-5-(3,4-dihydro-1H-isoquinolin-2-yl)-2-ethylsulfonyl-1,3-thiazole Show/Hide	C20H19ClN2O4S3	1
1	Ki = 119 nM
CP0359400 Compound Info	(9-Benzyl-6-methoxy-2,3,4,9-tetrahydro-1H-carbazol-4-ylmethyl)-dimethyl-amine Show/Hide	C23H28N2O	1
1	Ki = 136 nM
CP0228753 Compound Info	(6-Methoxy-2,3,4,9-tetrahydro-1H-carbazol-4-ylmethyl)-dimethyl-amine Show/Hide	C16H22N2O	1
1	Ki = 168 nM
CP0076852 Compound Info	2-(5-methoxy-2-propyl-1H-indol-3-yl)-N,N-dimethylethanamine Show/Hide	C16H24N2O	1
1	Ki = 185 nM
CP0042927 Compound Info	7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one Show/Hide	C23H27Cl2N3O2	2
1	Ki = 318 nM
2	Ki > 1000 nM
CP0099712 Compound Info	3-(2-aminoethyl)-1H-indole-5-carboxamide Show/Hide	C11H13N3O	1
1	Ki = 720 nM
CP0370109 Compound Info	6-Chloro-imidazo[2,1-b]thiazole-5-sulfonic acid [1-(3-piperidin-1-yl-propyl)-1H-indol-5-yl]-amide Show/Hide	C21H24ClN5O2S2	1
1	Ki = 1000 nM
CP0039958 Compound Info	(risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one Show/Hide	C23H27FN4O2	4
1	Ki = 1190 nM
2	Ki = 1329.2 nM
3	Ki = 2000 nM
4	Ki > 1000 nM
CP0008601 Compound Info	4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) Show/Hide	C21H23ClFNO2	2
1	Ki = 6000 nM
2	Ki > 5000 nM
CP0370584 Compound Info	4-(2-bromo-6-piperazin-1-ylpyridin-4-yl)sulfonylaniline Show/Hide	C15H17BrN4O2S	1
1	Ki ~ 0.1 nM
CP0370117 Compound Info	4-(2-Bromo-6-pyrrolidin-1-yl-pyridine-4-sulfonyl)-phenylamine Show/Hide	C15H16BrN3O2S	1
1	Ki ~ 1 nM
CP0096286 Compound Info	(R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidin-1-ylsulfonyl)phenol Show/Hide	C18H28N2O3S	1
1	Ki > 10000 nM

Clinical Information about the Protein

Target 1 ( 5-HT 6 receptor (HTR6) )

Target Type	Clinical trial Target
Disease	5 Target-related Diseases				5
1	Schizophrenia [ICD-11: 6A20]
2	Alzheimer disease [ICD-11: 8A20]
3	Neurological disorder [ICD-11: 6B60]
4	Parkinson disease [ICD-11: 8A00.0]
5	Anxiety disorder [ICD-11: 6B00-6B0Z]
Clinical Trial Drug(s)	5 Clinical Trial Drugs				5
1	LU AE58054	Drug Info	Phase 3	Schizophrenia
2	SAM-531	Drug Info	Phase 2	Alzheimer disease
3	SB-742457	Drug Info	Phase 3	Alzheimer disease
4	SUVN-502	Drug Info	Phase 2	Neurological disorder
5	SYN120	Drug Info	Phase 2	Parkinson disease
Discontinued Drug(s)	1 Discontinued Drug				1
1	WAY-181187	Drug Info	Discontinued in Phase 1	Anxiety disorder

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT02228	5-hydroxytryptamine receptor 6	Rattus norvegicus, Rat	Protein Info
PT06956	5-hydroxytryptamine receptor 6	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han