General Information of the Compound
Compound ID
CP0647677
Compound Name
2,5-Dimethyl-8-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride
    Show/Hide
Structure
Formula
C19H21ClN2O2S
Molecular Weight
376.909
Canonical SMILES
CN1CCc2c(c3cc(S(=O)(=O)c4ccccc4)ccc3n2C)C1.Cl
    Show/Hide
InChI
InChI=1S/C19H20N2O2S.ClH/c1-20-11-10-19-17(13-20)16-12-15(8-9-18(16)21(19)2)24(22,23)14-6-4-3-5-7-14;/h3-9,12H,10-11,13H2,1-2H3;1H
    Show/Hide
InChIKey
LFLUHLCPXQWQKW-UHFFFAOYSA-N
Physicochemical Property
logP
3.4208
Rotatable Bonds
2
Heavy Atom Count
25
Polar Areas
42.31
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 45113656
SID: 92302706
ChEMBL ID
CHEMBL1095274
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 78 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 5.7 nM