General Information of the Compound
Compound ID
CP0370109
Compound Name
6-Chloro-imidazo[2,1-b]thiazole-5-sulfonic acid [1-(3-piperidin-1-yl-propyl)-1H-indol-5-yl]-amide
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Structure
Formula
C21H24ClN5O2S2
Molecular Weight
478.043
Canonical SMILES
Clc1nc2sccn2c1S(=O)(=O)Nc1ccc2n(CCCN3CCCCC3)ccc2c1
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InChI
InChI=1S/C21H24ClN5O2S2/c22-19-20(27-13-14-30-21(27)23-19)31(28,29)24-17-5-6-18-16(15-17)7-12-26(18)11-4-10-25-8-2-1-3-9-25/h5-7,12-15,24H,1-4,8-11H2
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InChIKey
FGBNGCFMRUCMAW-UHFFFAOYSA-N
Physicochemical Property
logP
4.6807
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
71.64
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11408954
SID: 16504640
ChEMBL ID
CHEMBL407860
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 1000 nM