Compound Information

General Information of the Compound

Compound ID

CP0025667

Compound Name

2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone

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Synonyms

3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine

8-Chloro-11-(4-methyl)-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine

8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine

8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine

Asaleptin

C 6305

CLOZARIL

Clopine (TN)

Clorazil

Clozapin

Clozapina

Clozapina [INN-Spanish]

Clozapine

Clozapine (JAN/USP/INN)

Clozapine [USAN:INN:BAN]

Clozapine(tautomer)

Clozapinum

Clozapinum [INN-Latin]

Clozaril (TN)

Denzapine (TN)

Fazaclo

Fazaclo (TN)

Fazaclo ODT

Froidir (TN)

HF-1854

HF1854

Iprox

KS-1166

Klozapol (TN)

LEX-123

LX 100-129

Leponex

Leponex (TN)

Lepotex

W-801

Zaponex (TN)

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Structure

Formula

C18H19ClN4

Molecular Weight

326.831

Canonical SMILES

CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12

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InChI

InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

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InChIKey

QZUDBNBUXVUHMW-UHFFFAOYSA-N

CAS

5786-21-0

Physicochemical Property

logP	3.7227
Rotatable Bonds	0
Heavy Atom Count	23
Polar Areas	30.87
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Complexity	23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID

CID: 135398737

SID: 14826474

ChEMBL ID

CHEMBL42

DrugBank ID

DB00363

Map of Molecular Bioactivity Related to the Compound

Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Compound

Protein ID: PT00819, 5-hydroxytryptamine receptor 1A

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	Ki = 100 nM Bioactivity Info	TI LI LO TS
2	Ki = 101 nM Bioactivity Info	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	2
1	Ki = 143 nM Bioactivity Info	TI LI LO TS
2	Ki = 180 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Ki = 6.38 nM
2	Ki = 8.9 nM
3	Ki = 140 nM
4	Ki = 160 nM
5	Ki = 270 nM
6	Ki = 416.87 nM
7	Ki = 710 nM
8	Ki = 1000 nM

Protein ID: PT00825, 5-hydroxytryptamine receptor 2A

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000234	AU-BEK Cell Line Info	Bos taurus (Bovine)	2
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
2	Ki = 5 nM Bioactivity Info	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	Ki = 4.84 nM Bioactivity Info	TI LI LO TS
2	Ki = 5.012 nM Bioactivity Info	TI LI LO TS
CL000065	HEK293-EBNA Cell Line Info	Homo sapiens (Human)	1
1	Ki = 9.6 nM Bioactivity Info	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	Ki = 13 nM Bioactivity Info	TI LI LO TS
2	Ki = 33 nM Bioactivity Info	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	2
1	Ki = 15 nM Bioactivity Info	TI LI LO TS
2	Ki = 18 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Activity = 5.4 nM
2	Ki = 1.4 nM
3	Ki = 2.692 nM
4	Ki = 3 nM
5	Ki = 3.03 nM
6	Ki = 3.3 nM
7	Ki = 4 nM
8	Ki = 5.35 nM
9	Ki = 6.3 nM
10	Ki = 7.8 nM
11	Ki = 8.57 nM
12	Ki = 8.9 nM
13	Ki = 9.12 nM
14	Ki = 9.6 nM
15	Ki = 10 nM
16	Ki = 15 nM
17	Ki = 24 nM
18	Ki = 230 nM

Protein ID: PT01019, 5-hydroxytryptamine receptor 2B

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 3.162 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	EC50 = 20 nM

Protein ID: PT00939, 5-hydroxytryptamine receptor 2C

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 7.943 nM Bioactivity Info	TI LI LO TS
CL000065	HEK293-EBNA Cell Line Info	Homo sapiens (Human)	1
1	Ki = 13 nM Bioactivity Info	TI LI LO TS
CL000027	tsA201 Cell Line Info	Homo sapiens (Human)	1
1	Ki = 15 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	EC50 = 250 nM
2	Ki = 2.884 nM
3	Ki = 4.8 nM
4	Ki = 5 nM
5	Ki = 5.012 nM
6	Ki = 10.47 nM
7	Ki = 13 nM
8	Ki = 15.85 nM
9	Ki = 17 nM
10	Ki = 21 nM
11	Ki = 23 nM
12	Ki = 24 nM
13	Ki = 100 nM

Protein ID: PT01354, 5-hydroxytryptamine receptor 6

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
2	Ki = 17 nM Bioactivity Info	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	5
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
2	Ki = 4 nM Bioactivity Info	TI LI LO TS
3	Ki = 4.8 nM Bioactivity Info	TI LI LO TS
4	Ki = 7.943 nM Bioactivity Info	TI LI LO TS
5	Ki = 17 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Ki = 4 nM
2	Ki = 9.5 nM
3	Ki = 10 nM
4	Ki = 11 nM
5	Ki < 50 nM
6	Ki = 100 nM

Protein ID: PT00941, 5-hydroxytryptamine receptor 7

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	8
1	Ki = 11.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 18 nM Bioactivity Info	TI LI LO TS
3	Ki = 21 nM Bioactivity Info	TI LI LO TS
4	Ki = 25 nM Bioactivity Info	TI LI LO TS
5	Ki = 37 nM Bioactivity Info	TI LI LO TS
6	Ki = 45.5 nM Bioactivity Info	TI LI LO TS
7	Ki = 47.4 nM Bioactivity Info	TI LI LO TS
8	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 19.95 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Ki = 9 nM
2	Ki = 12.59 nM
3	Ki = 39.81 nM
4	Ki = 40 nM
5	Ki = 45.5 nM
6	Ki = 48 nM
7	Ki = 100 nM

Protein ID: PT01195, D(1A) dopamine receptor

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	Ki = 44 nM Bioactivity Info	TI LI LO TS
2	Ki = 132 nM Bioactivity Info	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	Ki = 89 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Ki = 7.5 nM
2	Ki = 21.38 nM
3	Ki = 31.62 nM
4	Ki = 44 nM
5	Ki = 53 nM
6	Ki = 180 nM
7	Ki = 290 nM
8	Ki = 540 nM
9	Ki = 1000 nM

Protein ID: PT01358, D(1A) dopamine receptor

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 420 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Ki = 420 nM

Protein ID: PT01169, D(1B) dopamine receptor

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	Ki = 198 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Ki = 780 nM
2	Ki = 1000 nM

Protein ID: PT01005, D(2) dopamine receptor

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	10
1	Ki = 28 nM Bioactivity Info	TI LI LO TS
2	Ki = 39 nM Bioactivity Info	TI LI LO TS
3	Ki = 41 nM Bioactivity Info	TI LI LO TS
4	Ki = 74 nM Bioactivity Info	TI LI LO TS
5	Ki = 83 nM Bioactivity Info	TI LI LO TS
6	Ki = 125.89 nM Bioactivity Info	TI LI LO TS
7	Ki = 155 nM Bioactivity Info	TI LI LO TS
8	Ki = 208 nM Bioactivity Info	TI LI LO TS
9	Ki = 254 nM Bioactivity Info	TI LI LO TS
10	Ki = 389 nM Bioactivity Info	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	3
1	Ki = 71 nM Bioactivity Info	TI LI LO TS
2	Ki = 72 nM Bioactivity Info	TI LI LO TS
3	Ki = 150 nM Bioactivity Info	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 91 nM Bioactivity Info	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	Ki = 220 nM Bioactivity Info	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	Ki = 372 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Activity = 256 nM
2	IC50 = 9 nM
3	IC50 = 113 nM
4	IC50 = 230 nM
5	IC50 = 260 nM
6	Ki = 7.11 nM
7	Ki = 28 nM
8	Ki = 31.62 nM
9	Ki = 41 nM
10	Ki = 69 nM
11	Ki = 72 nM
12	Ki = 77.62 nM
13	Ki = 113 nM
14	Ki = 130 nM
15	Ki = 134.9 nM
16	Ki = 138 nM
17	Ki = 144 nM
18	Ki = 150 nM
19	Ki = 157 nM
20	Ki = 190 nM
21	Ki = 210 nM
22	Ki = 220 nM
23	Ki = 223.87 nM
24	Ki = 250 nM
25	Ki = 260 nM
26	Ki = 389 nM
27	Ki = 1000 nM
28	Ki > 100 nM

Protein ID: PT00957, D(2) dopamine receptor

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	2
1	Ki = 63.1 nM Bioactivity Info	TI LI LO TS
2	Ki = 64.2 nM Bioactivity Info	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	Ki = 190 nM Bioactivity Info	TI LI LO TS
2	Ki = 260 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 132 nM
2	IC50 = 290 nM
3	IC50 = 330 nM
4	IC50 = 410 nM
5	IC50 = 440 nM
6	IC50 = 830 nM
7	IC50 = 2108 nM
8	Ki = 34 nM
9	Ki = 45.71 nM
10	Ki = 53.6 nM
11	Ki = 82 nM
12	Ki = 210 nM
13	Ki = 250 nM
14	Ki = 251.19 nM
15	Ki = 263.03 nM
16	Ki = 319 nM

Protein ID: PT00943, D(3) dopamine receptor

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	6
1	Ki = 88 nM Bioactivity Info	TI LI LO TS
2	Ki = 100 nM Bioactivity Info	TI LI LO TS
3	Ki = 200 nM Bioactivity Info	TI LI LO TS
4	Ki = 295 nM Bioactivity Info	TI LI LO TS
5	Ki = 454 nM Bioactivity Info	TI LI LO TS
6	Ki = 960 nM Bioactivity Info	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	Ki = 200 nM Bioactivity Info	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 222 nM Bioactivity Info	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	Ki = 319 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 450 nM
2	Ki = 239.88 nM
3	Ki = 240 nM
4	Ki = 242 nM
5	Ki = 280 nM
6	Ki = 319 nM
7	Ki = 360 nM
8	Ki = 372.3 nM
9	Ki = 912.01 nM
10	Ki = 960 nM
11	Ki = 1000 nM

Protein ID: PT01366, D(3) dopamine receptor

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	2
1	Ki = 161 nM Bioactivity Info	TI LI LO TS
2	Ki = 188 nM Bioactivity Info	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 230 nM Bioactivity Info	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	Ki = 319 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Ki = 500 nM

Protein ID: PT01161, D(4) dopamine receptor

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	10
1	IC50 = 41 nM Bioactivity Info	TI LI LO TS
2	IC50 = 58 nM Bioactivity Info	TI LI LO TS
3	Ki = 10 nM Bioactivity Info	TI LI LO TS
4	Ki = 16 nM Bioactivity Info	TI LI LO TS
5	Ki = 17 nM Bioactivity Info	TI LI LO TS
6	Ki = 30 nM Bioactivity Info	TI LI LO TS
7	Ki = 39 nM Bioactivity Info	TI LI LO TS
8	Ki = 39.81 nM Bioactivity Info	TI LI LO TS
9	Ki = 47 nM Bioactivity Info	TI LI LO TS
10	Ki = 70 nM Bioactivity Info	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	Ki = 10 nM Bioactivity Info	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	2
1	Ki = 13 nM Bioactivity Info	TI LI LO TS
2	Ki = 18 nM Bioactivity Info	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 16 nM Bioactivity Info	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	Ki = 21 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 17 nM
2	IC50 = 23 nM
3	IC50 = 32 nM
4	IC50 = 40 nM
5	IC50 = 52 nM
6	IC50 = 110 nM
7	IC50 = 120 nM
8	IC50 = 138 nM
9	IC50 = 156 nM
10	Ki = 10 nM
11	Ki = 15 nM
12	Ki = 15.85 nM
13	Ki = 16 nM
14	Ki = 17 nM
15	Ki = 21 nM
16	Ki = 28.4 nM
17	Ki = 30 nM
18	Ki = 30.4 nM
19	Ki = 39 nM
20	Ki = 40 nM
21	Ki = 44 nM
22	Ki = 53.7 nM
23	Ki = 54 nM
24	Ki = 60 nM
25	Ki = 71 nM
26	Ki = 72 nM
27	Ki = 100 nM
28	Ki = 9000 nM

Protein ID: PT01206, Histamine H1 receptor

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 2.38 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Activity = 1.2 nM
2	EC50 = 0.4 nM
3	Kd = 3.1 nM
4	Ki = 1 nM
5	Ki = 1.1 nM
6	Ki = 1.8 nM
7	Ki = 2.1 nM
8	Ki = 10 nM
9	Ki = 17 nM

Protein ID: PT01194, Histamine H3 receptor

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS

Protein ID: PT01711, Histamine H4 receptor

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000074	SK-N-MC Cell Line Info	Homo sapiens (Human)	5
1	Kd = 11.9 nM Bioactivity Info	TI LI LO TS
2	Kd = 14.5 nM Bioactivity Info	TI LI LO TS
3	Kd = 20.9 nM Bioactivity Info	TI LI LO TS
4	Kd = 70.2 nM Bioactivity Info	TI LI LO TS
5	Ki = 177.83 nM Bioactivity Info	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	Ki = 199.53 nM Bioactivity Info	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	1
1	Ki = 501.19 nM Bioactivity Info	TI LI LO TS

Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000156	HT-1080 Cell Line Info	Homo sapiens (Human)	1
1	Potency ~ 10322.5 nM Bioactivity Info	TI LI LO TS

Protein ID: PT01310, Muscarinic acetylcholine receptor M1

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 6.31 nM Bioactivity Info	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	IC50 = 9.4 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Ki = 0.98 nM
2	Ki = 1.8 nM
3	Ki = 100 nM

Protein ID: PT01198, Muscarinic acetylcholine receptor M2

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Ki = 100 nM

Protein ID: PT01266, Muscarinic acetylcholine receptor M3

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Ki = 100 nM

Protein ID: PT01156, Muscarinic acetylcholine receptor M4

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	Ki = 12.59 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Ki = 100 nM

Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000083	MCF-7 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 190.55 nM Bioactivity Info	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	5
1	IC50 = 191 nM Bioactivity Info	TI LI LO TS
2	IC50 = 650 nM Bioactivity Info	TI LI LO TS
3	Ki = 3080 nM Bioactivity Info	TI LI LO TS
4	Ki = 4060 nM Bioactivity Info	TI LI LO TS
5	Ki = 17000 nM Bioactivity Info	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	IC50 = 323.59 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 320 nM
2	IC50 = 323.59 nM
3	IC50 = 901 nM
4	IC50 = 3200 nM
5	IC50 = 3981.07 nM

Clinical Information about the Compound

Drug 1 ( Clozapine )

Drug Name	Clozapine
Company	Sandoz
Indication	Schizophrenia Approved
Target(s)	Dopamine D4 receptor (D4R) Target Info Modulator

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han