Brief Information of the Compound and Protein
Compound Name
2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone
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PubChem ID
CID: 135398737
SID: 14826474
Canonical SMILES
CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
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Compound Formula C18H19ClN4
Compound Structure
Protein Name
Histamine H4 receptor
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Monoamine receptor
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Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
Ki = 501.19 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 199.53 nM
   TI
   LI
   LO
   TS
CL000074 SK-N-MC Homo sapiens (Human)  5
1
Kd = 11.9 nM
   TI
   LI
   LO
   TS
2
Kd = 14.5 nM
   TI
   LI
   LO
   TS
3
Kd = 20.9 nM
   TI
   LI
   LO
   TS
4
Kd = 70.2 nM
   TI
   LI
   LO
   TS
5
Ki = 177.83 nM
   TI
   LI
   LO
   TS