Protein Information

General Information of the Protein

Protein ID	PT01711
Protein Name	Histamine H4 receptor
Secondarily Protein Name	AXOR35 G-protein coupled receptor 105 GPRv53 Pfi-013 SP9144
Gene Name	HRH4
Secondarily Gene Name	GPCR105
Sequence	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Histamine receptor
Function	The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). Show/Hide
Uniprot ID	Primary ID: Q9H3N8 Secondarily ID: B0YJ19 B2KJ48 Q4G0I6 Q9GZQ0 Show/Hide
Ensembl ID	ENSG00000134489
HGNC ID	HGNC:17383
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0394325 Compound Info	2-[N-[(2R)-1-(1H-imidazol-5-yl)propan-2-yl]-C-phenylcarbonimidoyl]-5-methoxyphenol Show/Hide	C20H21N3O2	2
1	EC50 = 6750 nM Bioactivity Info	TI LI LO TS
2	Ki = 6750 nM Bioactivity Info	TI LI LO TS
CP0079896 Compound Info	2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-(3-hydroxy-propyl)-acetamide Show/Hide	C22H23ClN2O4	2
1	EC50 = 7780 nM Bioactivity Info	TI LI LO TS
2	Ki = 7780 nM Bioactivity Info	TI LI LO TS
CP0224333 Compound Info	4-[(E)-2-(3-chlorophenyl)ethenyl]-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine Show/Hide	C16H19ClN6	1
1	IC50 = 439 nM Bioactivity Info	TI LI LO TS
CP0209146 Compound Info	4-(4-chlorophenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine Show/Hide	C14H17ClN6	1
1	IC50 = 512 nM Bioactivity Info	TI LI LO TS
CP0411849 Compound Info	4-[(E)-2-(3-methylphenyl)ethenyl]-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine Show/Hide	C17H22N6	1
1	IC50 = 606 nM Bioactivity Info	TI LI LO TS
CP0319491 Compound Info	4-(4-bromophenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine Show/Hide	C14H17BrN6	1
1	IC50 = 1630 nM Bioactivity Info	TI LI LO TS
CP0092861 Compound Info	2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole Show/Hide	C15H20N2S	1
1	Ki = 1.1 nM Bioactivity Info	TI LI LO TS
CP0280476 Compound Info	[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(6-fluoro-1H-benzimidazol-2-yl)methanimine Show/Hide	C15H18FN5	1
1	Ki = 4.6 nM Bioactivity Info	TI LI LO TS
CP0388999 Compound Info	[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5-fluoro-4-methyl-1H-benzimidazol-2-yl)methanimine Show/Hide	C16H20FN5	1
1	Ki = 4.6 nM Bioactivity Info	TI LI LO TS
CP0327320 Compound Info	4-Benzyl-1H-imidazole derivative, 18 Show/Hide	C16H18N2	1
1	Ki = 5.623 nM Bioactivity Info	TI LI LO TS
CP0341974 Compound Info	1-[3-(1H-imidazol-4-ylmethyl)phenyl]-3,3-dimethylbutan-1-one Show/Hide	C16H20N2O	1
1	Ki = 5.623 nM Bioactivity Info	TI LI LO TS
CP0100102 Compound Info	[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(1H-benzimidazol-2-yl)methanimine Show/Hide	C15H19N5	1
1	Ki = 6.5 nM Bioactivity Info	TI LI LO TS
CP0041262 Compound Info	5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole Show/Hide	C14H16ClN3O	1
1	Ki = 8 nM Bioactivity Info	TI LI LO TS
CP0166950 Compound Info	2-[3-(1H-imidazol-4-ylmethyl)phenyl]-4,4,6-trimethyl-5,6-dihydro-4H-1,3-oxazine Show/Hide	C17H21N3O	1
1	Ki = 8.318 nM Bioactivity Info	TI LI LO TS
CP0077286 Compound Info	[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5,6-difluoro-1H-benzimidazol-2-yl)methanimine Show/Hide	C15H17F2N5	1
1	Ki = 9.5 nM Bioactivity Info	TI LI LO TS
CP0072183 Compound Info	[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5-chloro-1H-indol-2-yl)methanone Show/Hide	C16H18ClN3O	1
1	Ki = 16 nM Bioactivity Info	TI LI LO TS
CP0433154 Compound Info	N-(2,2-dimethylpropyl)-6-(4-methylpiperazin-1-yl)pyrimidin-4-amine Show/Hide	C14H25N5	1
1	Ki = 23.6 nM Bioactivity Info	TI LI LO TS
CP0077287 Compound Info	[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(6-chloro-1H-benzimidazol-2-yl)methanimine Show/Hide	C15H18ClN5	1
1	Ki = 26 nM Bioactivity Info	TI LI LO TS
CP0400871 Compound Info	4-N-(cyclopropylmethyl)-6-N-[2-(dimethylamino)ethyl]pyrimidine-4,6-diamine Show/Hide	C12H21N5	1
1	Ki = 32.4 nM Bioactivity Info	TI LI LO TS
CP0066043 Compound Info	(5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C13H15ClN4O	1
1	Ki = 47.7 nM Bioactivity Info	TI LI LO TS
CP0280475 Compound Info	[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,5-difluoro-1H-benzimidazol-2-yl)methanimine Show/Hide	C15H17F2N5	1
1	Ki = 49 nM Bioactivity Info	TI LI LO TS
CP0074914 Compound Info	[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5-fluoro-4-methyl-1H-benzimidazol-2-yl)methanone Show/Hide	C16H19FN4O	1
1	Ki = 52 nM Bioactivity Info	TI LI LO TS
CP0504043 Compound Info	6-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-N-(2,2-dimethylpropyl)pyrimidin-4-amine Show/Hide	C15H27N5	1
1	Ki = 58.9 nM Bioactivity Info	TI LI LO TS
CP0290795 Compound Info	[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,5,6-trifluoro-1H-benzimidazol-2-yl)methanimine Show/Hide	C15H16F3N5	1
1	Ki = 70 nM Bioactivity Info	TI LI LO TS
CP0072184 Compound Info	[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,5-difluoro-1H-benzimidazol-2-yl)methanone Show/Hide	C15H16F2N4O	1
1	Ki = 74 nM Bioactivity Info	TI LI LO TS
CP0399210 Compound Info	N-(3,3-dimethylbutyl)-6-(4-methylpiperazin-1-yl)pyrimidin-4-amine Show/Hide	C15H27N5	1
1	Ki = 82 nM Bioactivity Info	TI LI LO TS
CP0292148 Compound Info	[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(6-fluoro-1H-benzimidazol-2-yl)methanone Show/Hide	C15H17FN4O	1
1	Ki = 83 nM Bioactivity Info	TI LI LO TS
CP0493786 Compound Info	[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)methanone Show/Hide	C15H17ClN4O	1
1	Ki = 83 nM Bioactivity Info	TI LI LO TS
CP0074915 Compound Info	[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(1H-benzimidazol-2-yl)methanone Show/Hide	C15H18N4O	1
1	Ki = 102 nM Bioactivity Info	TI LI LO TS
CP0367164 Compound Info	4-(4-Iodo-phenyl)-butyric acid 3-(1H-imidazol-4-yl)-propyl ester Show/Hide	C16H19IN2O2	1
1	Ki = 118 nM Bioactivity Info	TI LI LO TS
CP0036302 Compound Info	N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]quinolin-2-amine Show/Hide	C23H26Cl2N4	1
1	Ki = 125 nM Bioactivity Info	TI LI LO TS
CP0074916 Compound Info	[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5,6-difluoro-1H-benzimidazol-2-yl)methanone Show/Hide	C15H16F2N4O	1
1	Ki = 128 nM Bioactivity Info	TI LI LO TS
CP0074913 Compound Info	[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(6-chloro-1H-benzimidazol-2-yl)methanone Show/Hide	C15H17ClN4O	1
1	Ki = 129 nM Bioactivity Info	TI LI LO TS
CP0470833 Compound Info	N-(1H-benzimidazol-2-ylmethyl)-2-[(1S,2R)-2-(1H-imidazol-5-yl)cyclopropyl]ethanamine Show/Hide	C16H19N5	1
1	Ki = 166 nM Bioactivity Info	TI LI LO TS
CP0505945 Compound Info	N-(3,3-dimethylbutyl)-6-piperazin-1-ylpyrimidin-4-amine Show/Hide	C14H25N5	1
1	Ki = 201 nM Bioactivity Info	TI LI LO TS
CP0508788 Compound Info	N-benzyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-amine Show/Hide	C16H21N5	1
1	Ki = 207 nM Bioactivity Info	TI LI LO TS
CP0390750 Compound Info	N-(2,3-dihydro-1H-inden-2-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-4-amine Show/Hide	C18H23N5	1
1	Ki = 212 nM Bioactivity Info	TI LI LO TS
CP0378856 Compound Info	benzyl 2-[[2-(acetylsulfanylmethyl)-3-(1,3-benzodioxol-5-yl)propanoyl]amino]acetate Show/Hide	C22H23NO6S	1
1	Ki = 214 nM Bioactivity Info	TI LI LO TS
CP0400869 Compound Info	N-(2,2-dimethylpropyl)-6-(4-methyl-1,4-diazepan-1-yl)pyrimidin-4-amine Show/Hide	C15H27N5	1
1	Ki = 235 nM Bioactivity Info	TI LI LO TS
CP0109671 Compound Info	4-(3-Trityloxy-propyl)-1H-imidazole Show/Hide	C25H24N2O	1
1	Ki = 240 nM Bioactivity Info	TI LI LO TS
CP0481811 Compound Info	2-[[(1S,2R)-2-(1H-imidazol-5-yl)cyclopropyl]methyl]-1H-benzimidazole Show/Hide	C14H14N4	1
1	Ki = 295 nM Bioactivity Info	TI LI LO TS
CP0456415 Compound Info	6-N-(3,3-dimethylbutyl)-4-N-[(3S)-pyrrolidin-3-yl]pyrimidine-4,6-diamine Show/Hide	C14H25N5	1
1	Ki = 502 nM Bioactivity Info	TI LI LO TS
CP0513416 Compound Info	6-N-(3,3-dimethylbutyl)-4-N-[(3S)-1-methylpyrrolidin-3-yl]pyrimidine-4,6-diamine Show/Hide	C15H27N5	1
1	Ki = 593 nM Bioactivity Info	TI LI LO TS
CP0400870 Compound Info	6-(4-cyclohexylpiperazin-1-yl)-N-(3,3-dimethylbutyl)pyrimidin-4-amine Show/Hide	C20H35N5	1
1	Ki = 601 nM Bioactivity Info	TI LI LO TS
CP0475649 Compound Info	(1R,5R)-6-[6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-6-azabicyclo[3.1.1]heptane Show/Hide	C15H23N5	1
1	Ki = 860 nM Bioactivity Info	TI LI LO TS
CP0387450 Compound Info	6-methyl-2-(2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl)pyridine-3-carbonitrile Show/Hide	C14H18N4	1
1	Ki = 930 nM Bioactivity Info	TI LI LO TS
CP0432970 Compound Info	6-N-(3,3-dimethylbutyl)-4-N-[(3R)-pyrrolidin-3-yl]pyrimidine-4,6-diamine Show/Hide	C14H25N5	1
1	Ki = 939 nM Bioactivity Info	TI LI LO TS
CP0403671 Compound Info	[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(1H-pyrrolo[2,3-b]pyridin-2-yl)methanone Show/Hide	C15H18N4O	1
1	Ki = 973 nM Bioactivity Info	TI LI LO TS
CP0381178 Compound Info	2-(4-Methyl-piperazin-1-yl)-quinoxaline Show/Hide	C13H16N4	1
1	Ki = 1060 nM Bioactivity Info	TI LI LO TS
CP0408107 Compound Info	4-(1H-imidazol-5-yl)-N-naphthalen-1-ylpiperidine-1-carboxamide Show/Hide	C19H20N4O	1
1	Ki = 1090 nM Bioactivity Info	TI LI LO TS
CP0390749 Compound Info	4-[2-(1H-imidazol-5-yl)ethylamino]-1-[(2-methoxyphenyl)methyl]pyrimidin-2-one Show/Hide	C17H19N5O2	1
1	Ki = 1600 nM Bioactivity Info	TI LI LO TS
CP0169952 Compound Info	[(3aS,6aR)-2-ethyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(6-chloro-1H-benzimidazol-2-yl)methanone Show/Hide	C16H19ClN4O	1
1	Ki = 1960 nM Bioactivity Info	TI LI LO TS
CP0403672 Compound Info	[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(6-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)methanone Show/Hide	C15H17ClN4O	1
1	Ki = 2090 nM Bioactivity Info	TI LI LO TS
CP0304519 Compound Info	[5-[[3-[[6-(3,3-dimethylbutylamino)pyrimidin-4-yl]amino]pyrrolidin-1-yl]methyl]furan-2-yl]methanol Show/Hide	C20H31N5O2	1
1	Ki = 2110 nM Bioactivity Info	TI LI LO TS
CP0388998 Compound Info	[(3aR,6aS)-2-propan-2-yl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(6-chloro-1H-benzimidazol-2-yl)methanone Show/Hide	C17H21ClN4O	1
1	Ki = 2670 nM Bioactivity Info	TI LI LO TS
CP0378894 Compound Info	ethyl 2-[(4R)-4-[[2-benzyl-3-(hydroxyamino)-3-oxopropanoyl]amino]-3-oxo-4,5-dihydro-1H-2-benzazepin-2-yl]acetate Show/Hide	C24H27N3O6	1
1	Ki = 3018 nM Bioactivity Info	TI LI LO TS
CP0378092 Compound Info	(4-methylpiperazin-1-yl)-(1H-pyrrolo[2,3-b]pyridin-2-yl)methanone Show/Hide	C13H16N4O	1
1	Ki = 3100 nM Bioactivity Info	TI LI LO TS
CP0305101 Compound Info	(6-chloroimidazo[1,2-a]pyridin-2-yl)-(4-methylpiperazin-1-yl)methanone Show/Hide	C13H15ClN4O	1
1	Ki = 3170 nM Bioactivity Info	TI LI LO TS
CP0475647 Compound Info	2-(3-methoxyphenyl)-1-(2-methylphenoxy)-3-(4-methylpiperazin-1-yl)propan-2-ol Show/Hide	C22H30N2O3	1
1	Ki = 3240 nM Bioactivity Info	TI LI LO TS
CP0378896 Compound Info	N-[4-[4-(2-fluorophenyl)piperazin-1-yl]butyl]-5,6-dimethoxy-3-methyl-1H-indene-2-carboxamide Show/Hide	C27H34FN3O3	1
1	Ki = 3800 nM Bioactivity Info	TI LI LO TS
CP0474872 Compound Info	2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-(3-imidazol-1-ylpropyl)acetamide Show/Hide	C25H25ClN4O3	1
1	Ki = 4200 nM Bioactivity Info	TI LI LO TS
CP0292149 Compound Info	[(3aS,6aR)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl]-(6-chloro-1H-benzimidazol-2-yl)methanone Show/Hide	C14H15ClN4O	1
1	Ki = 5080 nM Bioactivity Info	TI LI LO TS
CP0555638 Compound Info	phenyl-[4-(5-pyrrolidin-1-ylpentoxy)phenyl]methanone Show/Hide	C22H27NO2	1
1	Ki = 13000 nM Bioactivity Info	TI LI LO TS
CP0109672 Compound Info	1-[4-[[4-[(3-methylpiperidin-1-yl)methyl]phenyl]methoxy]phenyl]ethanone Show/Hide	C22H27NO2	1
1	Ki = 16400 nM Bioactivity Info	TI LI LO TS
CP0259576 Compound Info	oxalic acid;1-[5-(4-phenylphenoxy)pentyl]piperidine Show/Hide	C24H31NO5	1
1	Ki = 19900 nM Bioactivity Info	TI LI LO TS
CP0428320 Compound Info	6-N-(3,3-dimethylbutyl)-4-N-[(3S)-1-[[5-(methoxymethyl)furan-2-yl]methyl]pyrrolidin-3-yl]pyrimidine-4,6-diamine Show/Hide	C21H33N5O2	1
1	Ki = 20000 nM Bioactivity Info	TI LI LO TS
CP0433153 Compound Info	2-[[(3S)-3-[[6-(3,3-dimethylbutylamino)pyrimidin-4-yl]amino]pyrrolidin-1-yl]methyl]-6-fluorophenol Show/Hide	C21H30FN5O	1
1	Ki = 20000 nM Bioactivity Info	TI LI LO TS
CP0503441 Compound Info	imidazo[1,2-a]pyrazin-2-yl-(4-methylpiperazin-1-yl)methanone Show/Hide	C12H15N5O	1
1	Ki = 20100 nM Bioactivity Info	TI LI LO TS
CP0343761 Compound Info	oxalic acid;1-[5-(4-phenylphenoxy)pentyl]azepane Show/Hide	C25H33NO5	1
1	Ki = 21800 nM Bioactivity Info	TI LI LO TS
CP0539975 Compound Info	2-N-[2-[4-(3-piperidin-1-ylpropoxy)phenyl]ethyl]pyridine-2,5-diamine Show/Hide	C21H30N4O	1
1	Ki = 30000 nM Bioactivity Info	TI LI LO TS
CP0391666 Compound Info	6-(4-methylpiperazin-1-yl)-N-[[3-(trifluoromethyl)phenyl]methyl]pyrimidine-4-carboxamide Show/Hide	C18H20F3N5O	1
1	Ki = 34900 nM Bioactivity Info	TI LI LO TS
CP0470832 Compound Info	1-[(1R,2R)-2-(6-chloro-1H-benzimidazol-2-yl)cyclopropyl]-N-[(4-chlorophenyl)methyl]methanamine Show/Hide	C18H17Cl2N3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0481809 Compound Info	1-[(1R,2S)-2-(5-chloro-1H-indol-2-yl)cyclopropyl]-N-[(4-chlorophenyl)methyl]methanamine Show/Hide	C19H18Cl2N2	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0481810 Compound Info	2-[(1S,2S)-2-(5-chloro-1H-indol-2-yl)cyclopropyl]-N-[(4-chlorophenyl)methyl]ethanamine Show/Hide	C20H20Cl2N2	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0492070 Compound Info	2-[(1S,2R)-2-(6-chloro-1H-benzimidazol-2-yl)cyclopropyl]-N-[(4-chlorophenyl)methyl]ethanamine Show/Hide	C19H19Cl2N3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0532518 Compound Info	N-[(4-chlorophenyl)methyl]-2-[(1S,2R)-2-(4-methylpiperazin-1-yl)cyclopropyl]ethanamine Show/Hide	C17H26ClN3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0534664 Compound Info	N-[(4-chlorophenyl)methyl]-1-[(1R,2R)-2-(4-methylpiperazin-1-yl)cyclopropyl]methanamine Show/Hide	C16H24ClN3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0557339 Compound Info	N-[(4-chlorophenyl)methyl]-2-[(1S,2R)-2-piperazin-1-ylcyclopropyl]ethanamine Show/Hide	C16H24ClN3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0578830 Compound Info	N-[(4-chlorophenyl)methyl]-1-[(1R,2R)-2-piperazin-1-ylcyclopropyl]methanamine Show/Hide	C15H22ClN3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000065 , HEK293-EBNA

Cell Line Info

Cell Line ID: CL000903 , HEK293-SF-hH4R-His6-CRE-Luc

Cell Line Info

Cell Line ID: CL000912 , HEK293T-beta-arr2-hH4R

Cell Line Info

Cell Line ID: CL000909 , HEK293T-SF-His6-CRE-Luc

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Cell Line ID: CL000004 , SH-SY5Y

Cell Line Info

Cell Line ID: CL000074 , SK-N-MC

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0137852 Compound Info	N-[N'-[3-(1H-imidazol-5-yl)propyl]carbamimidoyl]propanamide Show/Hide	C10H17N5O	1
1	EC50 = 4.467 nM
CP0036920 Compound Info	2-(1H-imidazol-4-yl)ethan-1-amine Show/Hide	C5H9N3	7
1	EC50 = 7.413 nM
2	EC50 = 75 nM
3	Kd = 5 nM
4	Ki = 1.6 nM
5	Ki = 4.8 nM
6	Ki = 8 nM
7	Ki = 60 nM
CP0041262 Compound Info	5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole Show/Hide	C14H16ClN3O	9
1	EC50 = 12.59 nM
2	IC50 = 86 nM
3	Kd = 10 nM
4	Ki = 4 nM
5	Ki = 4.5 nM
6	Ki = 5 nM
7	Ki = 6 nM
8	Ki = 35.48 nM
9	Ki = 50.12 nM
CP0041493 Compound Info	Clobenpropit Show/Hide	C14H17ClN4S	1
1	EC50 = 22.39 nM
CP0202795 Compound Info	2-(diaminomethylideneamino)ethyl carbamimidothioate Show/Hide	C4H11N5S	1
1	EC50 = 38.02 nM
CP0098027 Compound Info	2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide Show/Hide	C6H10N4S	1
1	EC50 = 51 nM
CP0361321 Compound Info	4-(3-aminoazetidin-1-yl)-6-cyclopentylpyrimidin-2-amine Show/Hide	C12H19N5	1
1	EC50 = 1300 nM
CP0060466 Compound Info	4-(1-adamantyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine Show/Hide	C19H29N5	1
1	EC50 > 10000 nM
CP0115846 Compound Info	4-[(4aR,7aR)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-6-cyclopentylpyrimidin-2-amine Show/Hide	C16H25N5	1
1	EC50 > 10000 nM
CP0115847 Compound Info	(3S,4S)-1-(2-amino-6-cyclopentylpyrimidin-4-yl)-4-(methylamino)pyrrolidin-3-ol Show/Hide	C14H23N5O	1
1	EC50 > 10000 nM
CP0129069 Compound Info	4-cyclopentyl-6-piperazin-1-ylpyrimidin-2-amine Show/Hide	C13H21N5	2
1	EC50 > 10000 nM
2	Ki = 1 nM
CP0173430 Compound Info	4-cyclopentyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine Show/Hide	C14H23N5	1
1	EC50 > 10000 nM
CP0244888 Compound Info	4-cyclopentyl-6-[(3S)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine Show/Hide	C14H23N5	1
1	EC50 > 10000 nM
CP0247768 Compound Info	4-ethyl-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine Show/Hide	C11H19N5	2
1	EC50 > 10000 nM
2	Ki = 21 nM
CP0251187 Compound Info	4-[(3aR,6aR)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[2,3-c]pyrrol-5-yl]-6-cyclopentylpyrimidin-2-amine Show/Hide	C15H23N5	1
1	EC50 > 10000 nM
CP0316739 Compound Info	4-[(4aR,7aR)-3,4,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazin-6-yl]-6-cyclopentylpyrimidin-2-amine Show/Hide	C15H23N5O	1
1	EC50 > 10000 nM
CP0340876 Compound Info	4-cyclopentyl-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine Show/Hide	C14H23N5	1
1	EC50 > 10000 nM
CP0340877 Compound Info	4-tert-butyl-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine Show/Hide	C13H23N5	1
1	EC50 > 10000 nM
CP0361319 Compound Info	4-[(3S)-3-aminopyrrolidin-1-yl]-6-cyclopentylpyrimidin-2-amine Show/Hide	C13H21N5	1
1	EC50 > 10000 nM
CP0361322 Compound Info	4-cyclopentyl-6-(1,7-diazaspiro[4.4]nonan-7-yl)pyrimidin-2-amine Show/Hide	C16H25N5	1
1	EC50 > 10000 nM
CP0361354 Compound Info	4-benzyl-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine Show/Hide	C16H21N5	1
1	EC50 > 10000 nM
CP0361356 Compound Info	4-cyclohexyl-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine Show/Hide	C15H25N5	1
1	EC50 > 10000 nM
CP0361357 Compound Info	4-[(3R)-3-aminopyrrolidin-1-yl]-6-tert-butylpyrimidin-2-amine Show/Hide	C12H21N5	1
1	EC50 > 10000 nM
CP0368406 Compound Info	4-cyclopropyl-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine Show/Hide	C12H19N5	1
1	EC50 > 10000 nM
CP0369772 Compound Info	4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-6-propan-2-ylpyrimidin-2-amine Show/Hide	C12H21N5	1
1	EC50 > 10000 nM
CP0382706 Compound Info	4-[(3R)-3-aminopyrrolidin-1-yl]-6-cyclopentylpyrimidin-2-amine Show/Hide	C13H21N5	1
1	EC50 > 10000 nM
CP0382709 Compound Info	4-[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-6-cyclopentylpyrimidin-2-amine Show/Hide	C16H25N5	1
1	EC50 > 10000 nM
CP0480123 Compound Info	4-cyclobutyl-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine Show/Hide	C13H21N5	1
1	EC50 > 10000 nM
CP0510462 Compound Info	4-[(3R)-3-aminopyrrolidin-1-yl]-6-ethylpyrimidin-2-amine Show/Hide	C10H17N5	1
1	EC50 > 10000 nM
CP0536915 Compound Info	4-butyl-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine Show/Hide	C13H23N5	1
1	EC50 > 10000 nM
CP0541017 Compound Info	4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinazolin-2-amine Show/Hide	C13H21N5	1
1	EC50 > 10000 nM
CP0128727 Compound Info	8-chloro-4-(4-methylpiperazin-1-yl)benzofuro[3,2-d]pyrimidine Show/Hide	C15H15ClN4O	3
1	IC50 = 19 nM
2	Ki = 4.7 nM
3	Ki = 19 nM
CP0056899 Compound Info	(2-Benzhydryloxy-ethyl)-dimethyl-amine Show/Hide	C17H21NO	2
1	IC50 = 11000 nM
2	Ki = 11000 nM
CP0058845 Compound Info	4-[(3R)-3-aminopyrrolidin-1-yl]-6-propan-2-ylpyrimidin-2-amine Show/Hide	C11H19N5	4
1	Kd = 12.59 nM
2	Ki = 12 nM
3	Ki = 12.5 nM
4	Ki > 10000 nM
CP0361360 Compound Info	4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-6-(trifluoromethyl)pyrimidin-2-amine Show/Hide	C10H14F3N5	2
1	Kd > 100000 nM
2	Ki > 10000 nM
CP0242759 Compound Info	(R)-N2-isobutyl-4-(3-(methylamino)pyrrolidin-1-yl)pyridine-2,6-diamine Show/Hide	C14H25N5	1
1	Ki = 0.2 nM
CP0270460 Compound Info	3-[4-(5-fluoro-4-methyl-1H-benzimidazol-2-yl)-3-methylphenoxy]-N-[2-(1H-imidazol-5-yl)ethyl]propan-1-amine Show/Hide	C23H26FN5O	1
1	Ki = 0.21 nM
CP0272050 Compound Info	N-(2-bicyclo[2.2.1]heptanyl)-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine Show/Hide	C16H25N5	1
1	Ki = 0.8 nM
CP0282159 Compound Info	(R)-N2-cyclopentyl-4-(3-(methylamino)pyrrolidin-1-yl)pyridine-2,6-diamine Show/Hide	C15H25N5	1
1	Ki = 0.9 nM
CP0171841 Compound Info	4-N-cyclopentyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine Show/Hide	C14H24N6	1
1	Ki = 1 nM
CP0292387 Compound Info	(R)-N2-isobutyl-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine Show/Hide	C13H24N6	1
1	Ki = 1 nM
CP0386871 Compound Info	N-(2-bicyclo[2.2.1]heptanyl)-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridin-2-amine Show/Hide	C17H26N4	1
1	Ki = 1 nM
CP0207351 Compound Info	6-(4-methylpiperazin-1-yl)-4-N-(2-methylpropyl)pyrimidine-2,4-diamine Show/Hide	C13H24N6	1
1	Ki = 2 nM
CP0242755 Compound Info	4-(4-methylpiperazin-1-yl)-6-N-(2-methylpropyl)pyridine-2,6-diamine Show/Hide	C14H25N5	1
1	Ki = 2 nM
CP0116622 Compound Info	4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-N-(2-methylpropyl)pyrimidin-2-amine Show/Hide	C13H23N5	1
1	Ki = 2 nM
CP0116623 Compound Info	4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-N-(2-methylpropyl)pyridin-2-amine Show/Hide	C14H24N4	1
1	Ki = 2 nM
CP0130122 Compound Info	N-cyclopentyl-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine Show/Hide	C14H23N5	1
1	Ki = 2 nM
CP0220828 Compound Info	4-N-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine Show/Hide	C13H22N6	1
1	Ki = 2.4 nM
CP0242757 Compound Info	6-N-cyclopentyl-4-(4-methylpiperazin-1-yl)pyridine-2,6-diamine Show/Hide	C15H25N5	1
1	Ki = 3 nM
CP0257100 Compound Info	(R)-N4-isopropyl-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine Show/Hide	C12H22N6	1
1	Ki = 3 nM
CP0337591 Compound Info	(R)-N2-isopropyl-4-(3-(methylamino)pyrrolidin-1-yl)pyridine-2,6-diamine Show/Hide	C13H23N5	2
1	Ki = 3 nM
2	Ki = 3.1 nM
CP0346009 Compound Info	6-(4-methylpiperazin-1-yl)-4-N-propan-2-ylpyrimidine-2,4-diamine Show/Hide	C12H22N6	1
1	Ki = 3 nM
CP0089117 Compound Info	N-butyl-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine Show/Hide	C13H23N5	1
1	Ki = 3 nM
CP0213380 Compound Info	5-(3-(4-(5-fluoro-4-methyl-1H-benzo[d]imidazol-2-yl)-3-methylphenoxy)propyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine Show/Hide	C24H26FN5O	1
1	Ki = 3.3 nM
CP0044460 Compound Info	N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide Show/Hide	C15H24N4S	4
1	Ki = 3.981 nM
2	Ki = 27 nM
3	Ki = 124 nM
4	Ki = 125.89 nM
CP0207352 Compound Info	(R)-N4-isobutyl-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine Show/Hide	C13H24N6	1
1	Ki = 4 nM
CP0089118 Compound Info	N-cyclopentyl-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridin-2-amine Show/Hide	C15H24N4	1
1	Ki = 4 nM
CP0233670 Compound Info	(4,5-Dichloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C14H15Cl2N3O	1
1	Ki = 5 nM
CP0130185 Compound Info	N-(2-bicyclo[2.2.1]heptanyl)-5-[(3S)-3-(methylamino)pyrrolidin-1-yl]pyridazin-3-amine Show/Hide	C16H25N5	1
1	Ki = 5 nM
CP0288245 Compound Info	3-(4-(5-fluoro-4-methyl-1H-benzo[d]imidazol-2-yl)-3-methylphenoxy)-N-(pyridin-3-ylmethyl)propan-1-amine Show/Hide	C24H25FN4O	1
1	Ki = 5.3 nM
CP0171496 Compound Info	(R)-N2-cyclopentyl-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine Show/Hide	C14H24N6	1
1	Ki = 6 nM
CP0171840 Compound Info	4-(4-Methylpiperazin-1-yl)-6-pyrrolidin-1-ylpyrimidin-2-ylamine Show/Hide	C13H22N6	1
1	Ki = 6 nM
CP0296515 Compound Info	(R)-N2-isopropyl-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine Show/Hide	C12H22N6	1
1	Ki = 6 nM
CP0247767 Compound Info	4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-N-propan-2-ylpyrimidin-2-amine Show/Hide	C12H21N5	2
1	Ki = 6 nM
2	Ki = 8 nM
CP0054275 Compound Info	N-cyclopentyl-5-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridazin-3-amine Show/Hide	C14H23N5	1
1	Ki = 6 nM
CP0398277 Compound Info	N-(2-bicyclo[2.2.1]heptanyl)-4-[(3S)-3-(methylamino)pyrrolidin-1-yl]pyridin-2-amine Show/Hide	C17H26N4	1
1	Ki = 6 nM
CP0114132 Compound Info	(7-Methyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C15H19N3O	1
1	Ki = 7 nM
CP0089184 Compound Info	N-butyl-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridin-2-amine Show/Hide	C14H24N4	1
1	Ki = 7 nM
CP0347010 Compound Info	(1R,2S)-trans-2-[2-(4-chlorobenzylamino)ethyl]-1-(1H-imidazol-4-yl)cyclopropane Show/Hide	C15H18ClN3	1
1	Ki = 7.6 nM
CP0160979 Compound Info	(7-Amino-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C14H18N4O	1
1	Ki = 8 nM
CP0193887 Compound Info	(5-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C14H16BrN3O	1
1	Ki = 8 nM
CP0292394 Compound Info	4-(piperazin-1-yl)-6-(pyrrolidin-1-yl)pyrimidin-2-amine Show/Hide	C12H20N6	1
1	Ki = 8 nM
CP0119547 Compound Info	N-(2-bicyclo[2.2.1]heptanyl)-4-[(3S)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine Show/Hide	C16H25N5	1
1	Ki = 8 nM
CP0130186 Compound Info	N-(2-bicyclo[2.2.1]heptanyl)-5-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridazin-3-amine Show/Hide	C16H25N5	1
1	Ki = 8 nM
CP0257102 Compound Info	(R)-N4-cyclopentyl-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine Show/Hide	C14H24N6	1
1	Ki = 9 nM
CP0163641 Compound Info	12-chloro-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]-8-oxa-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-4-amine Show/Hide	C14H15ClN6O	2
1	Ki = 9 nM
2	Ki = 9.4 nM
CP0303224 Compound Info	2-N-cyclopentyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine Show/Hide	C14H24N6	1
1	Ki = 10 nM
CP0114131 Compound Info	(5,7-Dichloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C14H15Cl2N3O	1
1	Ki = 11 nM
CP0186261 Compound Info	2-[3-(1H-imidazol-5-yl)propyl]-1-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine Show/Hide	C14H23N7S	1
1	Ki = 12.3 nM
CP0823737 Compound Info	SID50106398 Show/Hide	C5H11Cl2N3	1
1	Ki = 12.59 nM
CP0297628 Compound Info	3-(1H-imidazol-5-yl)propyl N'-[2-(4-iodophenyl)ethyl]carbamimidothioate Show/Hide	C15H19IN4S	1
1	Ki = 12.59 nM
CP0071088 Compound Info	(5,7-Difluoro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C14H15F2N3O	1
1	Ki = 14 nM
CP0288244 Compound Info	5-fluoro-4-methyl-2-(2-methyl-4-(3-((4aR,7aR)-tetrahydro-1H-pyrrolo[3,4-b]pyridin-6(2H,7H,7aH)-yl)propoxy)phenyl)-1H-benzo[d]imidazole Show/Hide	C25H31FN4O	1
1	Ki = 14 nM
CP0071086 Compound Info	(5-Fluoro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C14H16FN3O	1
1	Ki = 15 nM
CP0231594 Compound Info	(5-Amino-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C14H18N4O	1
1	Ki = 15 nM
CP0311383 Compound Info	6-(4-methylpiperazin-1-yl)-2-N-(2-methylpropyl)pyrimidine-2,4-diamine Show/Hide	C13H24N6	1
1	Ki = 15 nM
CP0249606 Compound Info	(1H-Indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C14H17N3O	2
1	Ki = 17 nM
2	Ki = 38 nM
CP0114129 Compound Info	(7-Chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C14H16ClN3O	1
1	Ki = 19 nM
CP0090040 Compound Info	4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-N-propan-2-ylpyridin-2-amine Show/Hide	C13H22N4	1
1	Ki = 19 nM
CP0221940 Compound Info	1-(3-(4-(5-fluoro-4-methyl-1H-benzo[d]imidazol-2-yl)-3-methylphenoxy)propyl)-N-methylpyrrolidin-3-amine Show/Hide	C23H29FN4O	1
1	Ki = 20 nM
CP0171842 Compound Info	4-N-benzyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine Show/Hide	C16H22N6	1
1	Ki = 20 nM
CP0071085 Compound Info	(5-Hydroxy-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C14H17N3O2	1
1	Ki = 23 nM
CP0332121 Compound Info	4-N-methyl-6-(4-methylpiperazin-1-yl)-4-N-propan-2-ylpyrimidine-2,4-diamine Show/Hide	C13H24N6	1
1	Ki = 24 nM
CP0213377 Compound Info	(+/-)-5-fluoro-2-(4-(3-(hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)propoxy)-2-methylphenyl)-4-methyl-1H-benzo[d]imidazole Show/Hide	C24H29FN4O	1
1	Ki = 26 nM
CP0224450 Compound Info	2-arylbenzimidazole derivative, 6 Show/Hide	C26H35ClN4O	1
1	Ki = 26 nM
CP0066043 Compound Info	(5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C13H15ClN4O	1
1	Ki = 26 nM
CP0332122 Compound Info	4-(4-methylpiperazin-1-yl)-6-N-propan-2-ylpyridine-2,6-diamine Show/Hide	C13H23N5	1
1	Ki = 28 nM
CP0114128 Compound Info	(5,7-Dimethyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C16H21N3O	1
1	Ki = 31 nM
CP0659380 Compound Info	S-(2-guanidylethyl)-isothiourea dihydrobromide Show/Hide	C4H12BrN5S	1
1	Ki = 31.62 nM
CP0037128 Compound Info	(4-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C14H16BrN3O	1
1	Ki = 32 nM
CP0288241 Compound Info	5-fluoro-4-methyl-2-(2-methyl-4-(3-(4-methylpiperazin-1-yl)propoxy)phenyl)-1H-benzo[d]imidazole Show/Hide	C23H29FN4O	1
1	Ki = 32 nM
CP0052696 Compound Info	N-cyclopentyl-4-[(3S)-3-(methylamino)pyrrolidin-1-yl]pyridin-2-amine Show/Hide	C15H24N4	1
1	Ki = 33 nM
CP0337586 Compound Info	(R)-4-(3-(methylamino)pyrrolidin-1-yl)-6-(pyrrolidin-1-yl)pyrimidin-2-amine Show/Hide	C13H22N6	1
1	Ki = 36 nM
CP0081592 Compound Info	(1S,2R)-trans-2-[2-(4-chlorobenzylamino)ethyl]-1-(1H-imidazol-4-yl)cyclopropane Show/Hide	C15H18ClN3	1
1	Ki = 37.2 nM
CP0308219 Compound Info	(1H-Indol-2-yl)-piperazin-1-yl-methanone Show/Hide	C13H15N3O	1
1	Ki = 38 nM
CP0274705 Compound Info	(+/-)-5-fluoro-4-methyl-2-(2-methyl-4-(3-(tetrahydro-1H-pyrrolo[3,4-b]pyridin-6(2H,7H,7aH)-yl)propoxy)phenyl)-1H-benzo[d]imidazole Show/Hide	C25H31FN4O	1
1	Ki = 42 nM
CP0071089 Compound Info	(5-methyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C15H19N3O	1
1	Ki = 46 nM
CP0365453 Compound Info	5-[(3R)-3-(methylamino)pyrrolidin-1-yl]-N-(2-methylpropyl)pyridazin-3-amine Show/Hide	C13H23N5	1
1	Ki = 55 nM
CP0386870 Compound Info	N-butyl-4-(4-methylpiperazin-1-yl)pyrimidin-2-amine Show/Hide	C13H23N5	1
1	Ki = 55 nM
CP0074614 Compound Info	4-(4-methylpiperazin-1-yl)-[1]benzofuro[3,2-d]pyrimidine Show/Hide	C15H16N4O	1
1	Ki = 56 nM
CP0071087 Compound Info	(7-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C14H16BrN3O	1
1	Ki = 61 nM
CP0115852 Compound Info	N-cyclopentyl-4-(4-methylpiperazin-1-yl)pyrimidin-2-amine Show/Hide	C14H23N5	1
1	Ki = 63 nM
CP0316391 Compound Info	2-arylbenzimidazole derivative, 7 Show/Hide	C25H33ClN4O	1
1	Ki = 65 nM
CP0371150 Compound Info	4-(4-methylpiperazin-1-yl)-N-(2-methylpropyl)pyrimidin-2-amine Show/Hide	C13H23N5	1
1	Ki = 69 nM
CP0305706 Compound Info	1-(3-(4-(5-fluoro-4-methyl-1H-benzo[d]imidazol-2-yl)-3-methylphenoxy)propyl)piperidin-3-amine Show/Hide	C23H29FN4O	1
1	Ki = 72 nM
CP0068025 Compound Info	(+/-)-5-fluoro-4-methyl-2-(2-methyl-4-(3-(3-methyl-3,6-diazabicyclo[3.1.0]hexan-6-yl)propoxy)phenyl)-1H-benzo[d]imidazole Show/Hide	C23H27FN4O	1
1	Ki = 77 nM
CP0171499 Compound Info	(R)-4-(3-(methylamino)pyrrolidin-1-yl)-6-(pyrrolidin-1-yl)pyridin-2-amine Show/Hide	C14H23N5	1
1	Ki = 77 nM
CP0064316 Compound Info	(12S,17S)-6-(piperazin-1-yl)-11-oxa-3,5-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]heptadeca-1(10),2(7),3,5-tetraen-4-amine Show/Hide	C18H25N5O	1
1	Ki = 79.43 nM
CP0198951 Compound Info	2,4-diamino-5,6-disubstituted pyrimidine, 9 Show/Hide	C17H21N5	1
1	Ki = 79.43 nM
CP0213376 Compound Info	1-(3-(4-(5-fluoro-4-methyl-1H-benzo[d]imidazol-2-yl)-3-methylphenoxy)propyl)pyrrolidin-3-amine Show/Hide	C22H27FN4O	1
1	Ki = 80 nM
CP0221941 Compound Info	1-(3-(4-(5-fluoro-4-methyl-1H-benzo[d]imidazol-2-yl)-3-methylphenoxy)propyl)-N,N-dimethylpyrrolidin-3-amine Show/Hide	C24H31FN4O	1
1	Ki = 84 nM
CP0398278 Compound Info	N-(2-bicyclo[2.2.1]heptanyl)-4-(4-methylpiperazin-1-yl)pyrimidin-2-amine Show/Hide	C16H25N5	1
1	Ki = 86 nM
CP0221946 Compound Info	(+/-)-5-fluoro-4-methyl-2-(2-methyl-4-(3-(6-methyl-3,6-diazabicyclo[3.1.0]hexan-3-yl)propoxy)phenyl)-1H-benzo[d]imidazole Show/Hide	C23H27FN4O	1
1	Ki = 89 nM
CP0346013 Compound Info	4-(4-methylpiperazin-1-yl)-6-(pyrrolidin-1-yl)pyridin-2-amine Show/Hide	C14H23N5	1
1	Ki = 100 nM
CP0371151 Compound Info	4-(4-methylpiperazin-1-yl)-N-propan-2-ylpyrimidin-2-amine Show/Hide	C12H21N5	1
1	Ki = 117 nM
CP0100890 Compound Info	1-cyano-3-[[(2R,5R)-5-(1H-imidazol-5-yl)oxolan-2-yl]methyl]-2-methylguanidine Show/Hide	C11H16N6O	1
1	Ki = 125.89 nM
CP0192538 Compound Info	(1S,2R)-trans-2-[2-(cyclohexylmethylamino)ethyl]-1-(1H-imidazol-4-yl)cyclopropane Show/Hide	C15H25N3	1
1	Ki = 127 nM
CP0047136 Compound Info	(2R)-1-(1H-imidazol-5-yl)propan-2-amine Show/Hide	C6H11N3	1
1	Ki = 146 nM
CP0267304 Compound Info	(6-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C14H16BrN3O	1
1	Ki = 147 nM
CP0057002 Compound Info	1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea Show/Hide	C9H16N4S	1
1	Ki = 180 nM
CP0279022 Compound Info	1-cyano-3-[[(2S,5R)-5-(1H-imidazol-5-yl)oxolan-2-yl]methyl]-2-methylguanidine Show/Hide	C11H16N6O	1
1	Ki = 223.87 nM
CP0224451 Compound Info	1-{3-[4-(5-tert-butyl-1H-1,3-benzodiazol-2-yl)-2-chlorophenoxy]propyl}-N,N-dimethylpyrrolidin-3-amine Show/Hide	C26H35ClN4O	1
1	Ki = 250 nM
CP0172969 Compound Info	5-[(2R,5S)-5-(phenylmethoxymethyl)oxolan-2-yl]-1H-imidazole Show/Hide	C15H18N2O2	1
1	Ki = 436.52 nM
CP0130853 Compound Info	Imifuramine Show/Hide	C8H13N3O	1
1	Ki = 891.25 nM
CP0348117 Compound Info	5-[(2R,5R)-5-(phenylmethoxymethyl)oxolan-2-yl]-1H-imidazole Show/Hide	C15H18N2O2	1
1	Ki = 1047.13 nM
CP0304519 Compound Info	[5-[[3-[[6-(3,3-dimethylbutylamino)pyrimidin-4-yl]amino]pyrrolidin-1-yl]methyl]furan-2-yl]methanol Show/Hide	C20H31N5O2	1
1	Ki = 2110 nM
CP0182141 Compound Info	[(2S,5R)-5-(1H-imidazol-5-yl)oxolan-2-yl]methanamine Show/Hide	C8H13N3O	1
1	Ki = 2511.89 nM
CP0192798 Compound Info	(5-Methoxy-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C15H19N3O2	1
1	Ki = 3000 nM
CP0097151 Compound Info	[(2R,5S)-5-(1H-imidazol-5-yl)oxolan-2-yl]methanamine Show/Hide	C8H13N3O	1
1	Ki = 6456.54 nM
CP0099909 Compound Info	1-cyano-3-[[(2R,5S)-5-(1H-imidazol-5-yl)oxolan-2-yl]methyl]-2-methylguanidine Show/Hide	C11H16N6O	1
1	Ki = 8128.31 nM
CP0154225 Compound Info	[(2R,5R)-5-(1H-imidazol-5-yl)-2,5-dihydrofuran-2-yl]methanamine Show/Hide	C8H11N3O	1
1	Ki = 11748.98 nM
CP0038430 Compound Info	[(2R,5S)-5-(1H-imidazol-5-yl)-2,5-dihydrofuran-2-yl]methanamine Show/Hide	C8H11N3O	1
1	Ki = 12022.64 nM
CP0154610 Compound Info	[(2S,5S)-5-(1H-imidazol-5-yl)oxolan-2-yl]methanamine Show/Hide	C8H13N3O	1
1	Ki = 12882.5 nM
CP0122622 Compound Info	5-[(2S,5R)-5-(phenylmethoxymethyl)oxolan-2-yl]-1H-imidazole Show/Hide	C15H18N2O2	1
1	Ki = 13489.63 nM
CP0195654 Compound Info	1-cyano-3-[[(2S,5S)-5-(1H-imidazol-5-yl)oxolan-2-yl]methyl]-2-methylguanidine Show/Hide	C11H16N6O	1
1	Ki = 20417.38 nM
CP0309840 Compound Info	5-[(2S,5S)-5-(phenylmethoxymethyl)oxolan-2-yl]-1H-imidazole Show/Hide	C15H18N2O2	1
1	Ki = 21379.62 nM
CP0055652 Compound Info	[(2S,5R)-5-(1H-imidazol-5-yl)-2,5-dihydrofuran-2-yl]methanamine Show/Hide	C8H11N3O	1
1	Ki = 21877.62 nM
CP0100889 Compound Info	[(2S,5S)-5-(1H-imidazol-5-yl)-2,5-dihydrofuran-2-yl]methanamine Show/Hide	C8H11N3O	1
1	Ki < 100000 nM
CP0119048 Compound Info	1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine Show/Hide	C17H26ClNO	1
1	Ki > 100000 nM

Clinical Information about the Protein

Target 1 ( Histamine H4 receptor (H4R) )

Target Type	Clinical trial Target
Disease	4 Target-related Diseases				4
1	Rheumatoid arthritis [ICD-11: FA20]
2	Atopic dermatitis [ICD-11: EA80]
3	Cognitive impairment [ICD-11: 6D71]
4	Inflammation [ICD-11: 1A00-CA43.1]
Clinical Trial Drug(s)	2 Clinical Trial Drugs				2
1	JNJ-38518168	Drug Info	Phase 2	Rheumatoid arthritis
2	PF-3893787	Drug Info	Phase 2	Atopic dermatitis
Discontinued Drug(s)	1 Discontinued Drug				1
1	Thioperamide	Drug Info	Terminated	Cognitive impairment
Investigative Drug(s)	1 Investigative Drug				1
1	[3H]JNJ 7777120	Drug Info	Investigative	Inflammation

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han