Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
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 PubChem ID
CID: 10446295
SID: 15467241
Canonical SMILES
CN1CCN(CC1)C(=O)c1nc2ccc(Cl)cc2[nH]1
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Compound Formula C13H15ClN4O
Compound Structure
Protein Name
 Protein Info 
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
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Monoamine receptor
>
Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 47.7 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
Ki = 26 nM
   TI
   LI
   LO
   TS
2
Ki = 39.6 nM
   TI
   LI
   LO
   TS
CL000074 SK-N-MC
 Cell Line Info 
Homo sapiens (Human)  4
1
Kd = 19.95 nM
   TI
   LI
   LO
   TS
2
Ki = 20 nM
   TI
   LI
   LO
   TS
3
Ki = 26 nM
   TI
   LI
   LO
   TS
4
Ki = 79.43 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 26 nM