Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone
    Show/Hide
 PubChem ID
CID: 135398737
SID: 14826474
Canonical SMILES
CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
    Show/Hide
Compound Formula C18H19ClN4
Compound Structure
Protein Name
 Protein Info 
D(4) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Uniprot ID
P21917
Gene Name
DRD4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  10
1
IC50 = 41 nM
   TI
   LI
   LO
   TS
2
IC50 = 58 nM
   TI
   LI
   LO
   TS
3
Ki = 10 nM
   TI
   LI
   LO
   TS
4
Ki = 16 nM
   TI
   LI
   LO
   TS
5
Ki = 17 nM
   TI
   LI
   LO
   TS
6
Ki = 30 nM
   TI
   LI
   LO
   TS
7
Ki = 39 nM
   TI
   LI
   LO
   TS
8
Ki = 39.81 nM
   TI
   LI
   LO
   TS
9
Ki = 47 nM
   TI
   LI
   LO
   TS
10
Ki = 70 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 16 nM
   TI
   LI
   LO
   TS
CL000053 COS-7
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
Ki = 21 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 10 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
Ki = 13 nM
   TI
   LI
   LO
   TS
2
Ki = 18 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 17 nM
2 IC50 = 23 nM
3 IC50 = 32 nM
4 IC50 = 40 nM
5 IC50 = 52 nM
6 IC50 = 110 nM
7 IC50 = 120 nM
8 IC50 = 138 nM
9 IC50 = 156 nM
10 Ki = 10 nM
11 Ki = 15 nM
12 Ki = 15.85 nM
13 Ki = 16 nM
14 Ki = 17 nM
15 Ki = 21 nM
16 Ki = 28.4 nM
17 Ki = 30 nM
18 Ki = 30.4 nM
19 Ki = 39 nM
20 Ki = 40 nM
21 Ki = 44 nM
22 Ki = 53.7 nM
23 Ki = 54 nM
24 Ki = 60 nM
25 Ki = 71 nM
26 Ki = 72 nM
27 Ki = 100 nM
28 Ki = 9000 nM