Protein Information

General Information of the Protein

Protein ID	PT01161
Protein Name	D(4) dopamine receptor
Secondarily Protein Name	D(2C) dopamine receptor Dopamine D4 receptor
Gene Name	DRD4
Sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Dopamine receptor
Function	Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). Show/Hide
Uniprot ID	Primary ID: P21917 Secondarily ID: B0M0J7 Q7Z7Q5 Q8NGM5 Show/Hide
HGNC ID	HGNC:3025
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000901 , 661W

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0411059 Compound Info	(3S,4S)-4-ethyl-3-methyl-1-phenyl-2,4-dihydroquinolin-3-amine Show/Hide	C18H22N2	1
1	Ki = 1995.26 nM Bioactivity Info	TI LI LO TS
CP0387083 Compound Info	(3aS,9bS)-3a-methyl-5-phenyl-2,3,4,9b-tetrahydro-1H-pyrrolo[2,3-c]quinoline Show/Hide	C18H20N2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0391120 Compound Info	(1S,2R)-1-ethyl-7-methoxy-2-methyl-3,4-dihydro-1H-naphthalen-2-amine Show/Hide	C14H21NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0391121 Compound Info	(3S,4S)-4-ethyl-3,6-dimethyl-2,4-dihydrochromen-3-amine Show/Hide	C13H19NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0391154 Compound Info	(3aS,9bS)-7,9-dimethoxy-3a-methyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole Show/Hide	C14H19NO3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL001028 , CHO Pro-5

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000880 , COS

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000065 , HEK293-EBNA

Cell Line Info

Cell Line ID: CL000806 , HEK298

Cell Line Info

Cell Line ID: CL000041 , LTK-

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0200483 Compound Info	2-[4-(2-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-benzoimidazole Show/Hide	C18H19ClN4	2
1	EC50 = 1 nM
2	Ki = 8.5 nM
CP0364830 Compound Info	2-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-1H-benzoimidazole Show/Hide	C19H22N4O	2
1	EC50 = 5.6 nM
2	Ki = 4.3 nM
CP0268831 Compound Info	2-(4-Phenyl-piperazin-1-ylmethyl)-1H-benzoimidazole Show/Hide	C18H20N4	2
1	EC50 = 10.1 nM
2	Ki = 52 nM
CP0193372 Compound Info	5-Fluoro-2-(4-pyridin-2-yl-piperazin-1-ylmethyl)-1H-indole Show/Hide	C18H19FN4	2
1	EC50 = 32 nM
2	Ki = 3.6 nM
CP0052067 Compound Info	2-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-pyrazolo[1,5-a]pyridine Show/Hide	C18H19ClN4	4
1	EC50 = 154 nM
2	Ki = 2.2 nM
3	Ki = 2.7 nM
4	Ki = 3.1 nM
CP0046420 Compound Info	CAS_3853 Show/Hide	C18H19ClN4	4
1	EC50 = 2230 nM
2	Ki = 0.4 nM
3	Ki = 0.43 nM
4	Ki = 0.6 nM
CP0031347 Compound Info	2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole Show/Hide	C17H19N5	5
1	EC50 ~ 12.4 nM
2	Ki = 167 nM
3	Ki ~ 46.8 nM
4	Ki ~ 57.5 nM
5	Ki ~ 63.6 nM
CP0062789 Compound Info	3-Methoxy-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-benzamide Show/Hide	C21H27N3O3	2
1	IC50 = 1 nM
2	Ki = 1.1 nM
CP0008601 Compound Info	4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) Show/Hide	C21H23ClFNO2	19
1	IC50 = 1.3 nM
2	IC50 = 5 nM
3	IC50 = 6.5 nM
4	Ki = 0.74 nM
5	Ki = 1 nM
6	Ki = 1.4 nM
7	Ki = 1.585 nM
8	Ki = 1.9 nM
9	Ki = 2.3 nM
10	Ki = 3.3 nM
11	Ki = 3.8 nM
12	Ki = 5 nM
13	Ki = 7 nM
14	Ki = 7.3 nM
15	Ki = 7.94 nM
16	Ki = 10 nM
17	Ki = 10.47 nM
18	Ki = 11 nM
19	Ki = 12.7 nM
CP0049653 Compound Info	2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-((R)-2-methyl-2,3-dihydro-indol-1-yl)-ethanone Show/Hide	C23H29N3O	2
1	IC50 = 2 nM
2	Ki = 2 nM
CP0213669 Compound Info	1-(3-Methoxy-phenyl)-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butan-1-one Show/Hide	C22H28N2O3	1
1	IC50 = 3.1 nM
CP0681671 Compound Info	1-(2,4-Dimethyl-phenyl)-4-(2-phenyl-cyclopropylmethyl)-piperazine hydrobromide Show/Hide	C22H29BrN2	1
1	IC50 = 8 nM
CP0076121 Compound Info	13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,9,12,14-heptaene Show/Hide	C18H18ClN3O	1
1	IC50 = 14 nM
CP0025667 Compound Info	2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone Show/Hide	C18H19ClN4	28
1	IC50 = 17 nM
2	IC50 = 23 nM
3	IC50 = 32 nM
4	IC50 = 40 nM
5	IC50 = 52 nM
6	IC50 = 110 nM
7	IC50 = 120 nM
8	IC50 = 138 nM
9	IC50 = 156 nM
10	Ki = 10 nM
11	Ki = 15 nM
12	Ki = 15.85 nM
13	Ki = 16 nM
14	Ki = 17 nM
15	Ki = 21 nM
16	Ki = 28.4 nM
17	Ki = 30 nM
18	Ki = 30.4 nM
19	Ki = 39 nM
20	Ki = 40 nM
21	Ki = 44 nM
22	Ki = 53.7 nM
23	Ki = 54 nM
24	Ki = 60 nM
25	Ki = 71 nM
26	Ki = 72 nM
27	Ki = 100 nM
28	Ki = 9000 nM
CP0052226 Compound Info	1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-propyl]-piperazine Show/Hide	C25H34N2O2	1
1	IC50 = 60 nM
CP0355375 Compound Info	6-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine Show/Hide	C19H21BrN4O	1
1	Ki = 0.25 nM
CP0077360 Compound Info	N-[2-(3-chlorophenoxy)ethyl]-3-phenoxypropan-1-amine Show/Hide	C17H20ClNO2	1
1	Ki = 0.309 nM
CP0040671 Compound Info	8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C23H26FN3O2	3
1	Ki = 0.33 nM
2	Ki = 0.45 nM
3	Ki = 1.4 nM
CP0099175 Compound Info	N-[1-[(4-iodophenyl)methyl]piperidin-4-yl]-N-methyl-3-propan-2-yloxypyridin-2-amine Show/Hide	C21H28IN3O	1
1	Ki = 0.33 nM
CP0395310 Compound Info	6-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine Show/Hide	C19H21IN4O	1
1	Ki = 0.33 nM
CP0059512 Compound Info	N-[2-(3,4-dimethylphenoxy)ethyl]-3-phenoxypropan-1-amine Show/Hide	C19H25NO2	1
1	Ki = 0.3467 nM
CP0776339 Compound Info	SID50106618 Show/Hide	C18H20Cl2N4	1
1	Ki = 0.43 nM
CP0059544 Compound Info	(3-Phenoxy-propyl)-(2-m-tolyloxy-ethyl)-amine Show/Hide	C18H23NO2	1
1	Ki = 0.4571 nM
CP0059618 Compound Info	N-[2-(4-chlorophenoxy)ethyl]-3-phenoxypropan-1-amine Show/Hide	C17H20ClNO2	1
1	Ki = 0.5248 nM
CP0077362 Compound Info	N-[2-(3-chloro-4-methylphenoxy)ethyl]-3-phenoxypropan-1-amine Show/Hide	C18H22ClNO2	1
1	Ki = 0.5248 nM
CP0178983 Compound Info	(3-Phenoxy-propyl)-(2-p-tolyloxy-ethyl)-amine Show/Hide	C18H23NO2	1
1	Ki = 0.5248 nM
CP0079550 Compound Info	N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]pyrazolo[1,5-a]pyridine-3-carboxamide Show/Hide	C21H25N5O2	1
1	Ki = 0.67 nM
CP0088145 Compound Info	1-(2-Methoxy-phenyl)-4-(1-phenyl-1H-pyrrol-3-ylmethyl)-piperazine Show/Hide	C22H25N3O	2
1	Ki = 0.7 nM
2	Ki = 1.3 nM
CP0161149 Compound Info	2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-N-m-tolyl-acetamide Show/Hide	C20H25N3O2	2
1	Ki = 0.7 nM
2	Ki = 1.8 nM
CP0339664 Compound Info	CHEBI:64217 Show/Hide	C21H26ClN3O2	1
1	Ki = 0.75 nM
CP0159469 Compound Info	N-[2-(4-chlorophenoxy)ethyl]-3-(4-fluorophenoxy)propan-1-amine Show/Hide	C17H19ClFNO2	1
1	Ki = 0.8318 nM
CP0059517 Compound Info	3-(4-fluorophenoxy)-N-[2-(4-methylphenoxy)ethyl]propan-1-amine Show/Hide	C18H22FNO2	1
1	Ki = 0.955 nM
CP0240039 Compound Info	2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine Show/Hide	C18H18Cl2N4	1
1	Ki = 0.99 nM
CP0059513 Compound Info	(2-p-Tolyloxy-ethyl)-(3-o-tolyloxy-propyl)-amine Show/Hide	C19H25NO2	1
1	Ki = 1.096 nM
CP0154475 Compound Info	3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-indole Show/Hide	C19H20ClN3	1
1	Ki = 1.1 nM
CP0036921 Compound Info	3-HYDROXYTYRAMINE HYDROCHLORIDE Show/Hide	C8H11NO2	4
1	Ki = 1.2 nM
2	Ki = 57 nM
3	Ki = 62 nM
4	Ki = 97 nM
CP0141761 Compound Info	(2-p-Tolyloxy-ethyl)-(3-m-tolyloxy-propyl)-amine Show/Hide	C19H25NO2	1
1	Ki = 1.202 nM
CP0052064 Compound Info	2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-1H-benzoimidazole Show/Hide	C20H24N4	1
1	Ki = 1.5 nM
CP0059535 Compound Info	(2-Phenoxy-ethyl)-(3-phenoxy-propyl)-amine Show/Hide	C17H21NO2	1
1	Ki = 1.995 nM
CP0084794 Compound Info	3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyrazolo[1,5-a]pyridine Show/Hide	C18H19ClN4	2
1	Ki = 2 nM
2	Ki = 3.6 nM
CP0099174 Compound Info	4-[5-(4-Chloro-phenyl)-4-methyl-isoxazol-3-yl]-1-phenethyl-piperidine Show/Hide	C23H25ClN2O	2
1	Ki = 2.5 nM
2	Ki = 3.5 nM
CP0146487 Compound Info	(2-Phenoxy-ethyl)-(3-p-tolyloxy-propyl)-amine Show/Hide	C18H23NO2	1
1	Ki = 2.692 nM
CP0050806 Compound Info	2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide derivative Show/Hide	C20H22N4O	2
1	Ki = 2.7 nM
2	Ki = 14.5 nM
CP0133352 Compound Info	(2S)-2-[(5-chloro-2-methoxyphenoxy)methyl]-4-[(4-chlorophenyl)methyl]morpholine Show/Hide	C19H21Cl2NO3	1
1	Ki = 2.8 nM
CP0058895 Compound Info	2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine Show/Hide	C19H22N4O	1
1	Ki = 2.8 nM
CP0094782 Compound Info	2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide Show/Hide	C23H24FN3O2S	1
1	Ki = 2.9 nM
CP0156986 Compound Info	4-(4-Benzyl-piperazin-1-yl)-1,3-dihydro-indol-2-one Show/Hide	C19H21N3O	1
1	Ki = 3 nM
CP0077361 Compound Info	4-[2-(3-Phenoxy-propylamino)-ethoxy]-phenol Show/Hide	C17H21NO3	1
1	Ki = 3.09 nM
CP0099176 Compound Info	CAS_188942 Show/Hide	C18H20N6	1
1	Ki = 3.6 nM
CP0050117 Compound Info	N-[2-(2-chlorophenoxy)ethyl]-3-phenoxypropan-1-amine Show/Hide	C17H20ClNO2	1
1	Ki = 4.365 nM
CP0269451 Compound Info	N-[2-(4-nitrophenoxy)ethyl]-3-phenoxypropan-1-amine Show/Hide	C17H20N2O4	1
1	Ki = 4.365 nM
CP0269449 Compound Info	4-Chloro-N-[4-(2-chloro-phenyl)-piperazin-1-ylmethyl]-benzamide Show/Hide	C18H19Cl2N3O	1
1	Ki = 5.248 nM
CP0098943 Compound Info	N-[2-(4-methoxyphenoxy)ethyl]-3-phenoxypropan-1-amine Show/Hide	C18H23NO3	1
1	Ki = 5.37 nM
CP0269450 Compound Info	4-Chloro-N-[4-(2-cyano-phenyl)-piperazin-1-ylmethyl]-benzamide Show/Hide	C19H19ClN4O	1
1	Ki = 5.495 nM
CP0169831 Compound Info	4-[5-(4-Chloro-phenyl)-1H-pyrazol-3-yl]-1-phenethyl-piperidine Show/Hide	C22H24ClN3	1
1	Ki = 5.5 nM
CP0159467 Compound Info	N-[2-(4-chlorophenoxy)ethyl]-3-(4-methylphenoxy)propan-1-amine Show/Hide	C18H22ClNO2	1
1	Ki = 5.623 nM
CP0178951 Compound Info	N-[[4-(2-cyanophenyl)piperazin-1-yl]methyl]-4-methylbenzamide Show/Hide	C20H22N4O	1
1	Ki = 6.457 nM
CP0076889 Compound Info	N-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-3-methylbenzamide Show/Hide	C20H25N3O2	1
1	Ki = 6.761 nM
CP0129571 Compound Info	2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo[1,2-a]pyridine Show/Hide	C18H19ClN4	1
1	Ki = 7 nM
CP0215268 Compound Info	N-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-4-methylbenzamide Show/Hide	C20H25N3O2	1
1	Ki = 7.762 nM
CP0083554 Compound Info	(S)-3-{2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-yl]-ethyl}-2,3-dihydro-isoindol-1-one Show/Hide	C22H27N3O	1
1	Ki = 7.8 nM
CP0091842 Compound Info	N-[2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl]-2,2-dimethylbutanamide Show/Hide	C18H28ClN3O	1
1	Ki = 8 nM
CP0103405 Compound Info	3-(4-Phenyl-piperazin-1-ylmethyl)-1H-indole Show/Hide	C19H21N3	1
1	Ki = 8 nM
CP0127400 Compound Info	(-)-Pramipexole Show/Hide	C10H17N3S	1
1	Ki = 8.5 nM
CP0039958 Compound Info	(risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one Show/Hide	C23H27FN4O2	3
1	Ki = 8.5 nM
2	Ki = 16 nM
3	Ki = 100 nM
CP0159532 Compound Info	N-[[4-(2-cyanophenyl)piperazin-1-yl]methyl]-3-methylbenzamide Show/Hide	C20H22N4O	2
1	Ki = 8.71 nM
2	Ki = 9 nM
CP0188439 Compound Info	4-(4-Benzyl-piperazin-1-yl)-5-chloro-1,3-dihydro-indol-2-one Show/Hide	C19H20ClN3O	1
1	Ki = 8.8 nM
CP0113655 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-7-carboxamide Show/Hide	C23H29N5O2	1
1	Ki = 8.9 nM
CP0146505 Compound Info	(2-p-Tolyloxy-ethyl)-(3-p-tolyloxy-propyl)-amine Show/Hide	C19H25NO2	1
1	Ki = 10.96 nM
CP0059819 Compound Info	11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(18),3(8),4,6,14,16-hexaen-6-ol Show/Hide	C18H21NO	1
1	Ki = 11.3 nM
CP0269448 Compound Info	N-[[4-(2-chlorophenyl)piperazin-1-yl]methyl]-4-methylbenzamide Show/Hide	C19H22ClN3O	1
1	Ki = 12.02 nM
CP0100739 Compound Info	N-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]pyrazolo[1,5-a]pyridine-3-carboxamide Show/Hide	C22H27N5O2	1
1	Ki = 14 nM
CP0140964 Compound Info	2-[4-(4-Bromo-2-cyano-phenyl)-piperazin-1-yl]-N-(4-bromo-3-methyl-phenyl)-acetamide Show/Hide	C20H20Br2N4O	2
1	Ki = 14 nM
2	Ki = 54.2 nM
CP0110881 Compound Info	4-Chloro-N-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-benzamide Show/Hide	C19H22ClN3O2	1
1	Ki = 14.13 nM
CP0122849 Compound Info	4-(4-Benzyl-piperazin-1-yl)-1,3-dihydro-benzoimidazol-2-one Show/Hide	C18H20N4O	1
1	Ki = 14.4 nM
CP0104676 Compound Info	Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C24H29N3O2S	1
1	Ki = 15 nM
CP0178952 Compound Info	3-Chloro-N-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-benzamide Show/Hide	C19H22ClN3O2	1
1	Ki = 15.14 nM
CP0080249 Compound Info	4-[4-(4-Chloro-phenyl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one; hydrochloride Show/Hide	C20H22ClFN2O	2
1	Ki = 17 nM
2	Ki = 17.5 nM
CP0045063 Compound Info	2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine Show/Hide	C17H20N4S	4
1	Ki = 19 nM
2	Ki = 28 nM
3	Ki = 50 nM
4	Ki = 100 nM
CP0046703 Compound Info	1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one Show/Hide	C24H26ClFN4O	1
1	Ki = 21 nM
CP0311650 Compound Info	N-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]benzamide Show/Hide	C19H23N3O2	1
1	Ki = 21.88 nM
CP0348803 Compound Info	3-(4-Phenyl-piperidin-1-ylmethyl)-1H-indole Show/Hide	C20H22N2	1
1	Ki = 25 nM
CP0141757 Compound Info	N-[[4-(2-cyanophenyl)piperazin-1-yl]methyl]benzamide Show/Hide	C19H20N4O	1
1	Ki = 26.92 nM
CP0178940 Compound Info	N-[[4-(2-chlorophenyl)piperazin-1-yl]methyl]-3-methylbenzamide Show/Hide	C19H22ClN3O	1
1	Ki = 26.92 nM
CP0077364 Compound Info	3-(4-bromophenoxy)-N-[2-(4-methylphenoxy)ethyl]propan-1-amine Show/Hide	C18H22BrNO2	1
1	Ki = 26.92 nM
CP0045037 Compound Info	Benzofuran-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C24H29N3O3	1
1	Ki = 30 nM
CP0171882 Compound Info	N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]pyrazolo[1,5-a]pyridine-2-carboxamide Show/Hide	C21H25N5O2	1
1	Ki = 30 nM
CP0056386 Compound Info	5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one Show/Hide	C21H21ClN4OS	2
1	Ki = 32 nM
2	Ki = 39 nM
CP0110876 Compound Info	N-[[4-(2-chlorophenyl)piperazin-1-yl]methyl]benzamide Show/Hide	C18H20ClN3O	1
1	Ki = 32.36 nM
CP0040962 Compound Info	3-Chloro-N-[4-(2-cyano-phenyl)-piperazin-1-ylmethyl]-benzamide Show/Hide	C19H19ClN4O	1
1	Ki = 33.88 nM
CP0159468 Compound Info	3-(4-bromophenoxy)-N-[2-(4-chlorophenoxy)ethyl]propan-1-amine Show/Hide	C17H19BrClNO2	1
1	Ki = 38.02 nM
CP0071762 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]naphthalene-2-carboxamide Show/Hide	C26H31N3O2	1
1	Ki = 39 nM
CP0302767 Compound Info	2-[4-(3-Methoxy-phenyl)-piperazin-1-yl]-N-m-tolyl-acetamide Show/Hide	C20H25N3O2	2
1	Ki = 39.1 nM
2	Ki = 46 nM
CP0374678 Compound Info	3-Chloro-N-[4-(2-chloro-phenyl)-piperazin-1-ylmethyl]-benzamide Show/Hide	C18H19Cl2N3O	1
1	Ki = 40.74 nM
CP0089965 Compound Info	N-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]pyrazolo[1,5-a]pyridine-2-carboxamide Show/Hide	C22H27N5O2	1
1	Ki = 41 nM
CP0085020 Compound Info	N-[2-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)ethyl]-N-pyridin-2-ylcyclohexanecarboxamide Show/Hide	C25H31N3O	1
1	Ki = 55 nM
CP0183485 Compound Info	1-(4-Chloro-benzyl)-4-[5-(4-chloro-phenyl)-1H-pyrazol-3-yl]-piperidine Show/Hide	C21H21Cl2N3	1
1	Ki = 61 nM
CP0155036 Compound Info	2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-N-m-tolyl-acetamide Show/Hide	C19H22FN3O	2
1	Ki = 61.9 nM
2	Ki = 90.7 nM
CP0097278 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-5-carboxamide Show/Hide	C23H29N5O2	1
1	Ki = 67 nM
CP0190893 Compound Info	N-[5-[4-(2-methoxyphenyl)piperazin-1-yl]pentyl]pyrazolo[1,5-a]pyridine-3-carboxamide Show/Hide	C24H31N5O2	1
1	Ki = 68 nM
CP0059541 Compound Info	(3-Phenoxy-propyl)-(2-o-tolyloxy-ethyl)-amine Show/Hide	C18H23NO2	1
1	Ki = 74.13 nM
CP0171880 Compound Info	N-[5-[4-(2-methoxyphenyl)piperazin-1-yl]pentyl]pyrazolo[1,5-a]pyridine-2-carboxamide Show/Hide	C24H31N5O2	1
1	Ki = 78 nM
CP0125988 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-4-carboxamide Show/Hide	C23H29N5O2	1
1	Ki = 87 nM
CP0310037 Compound Info	2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-N-m-tolyl-acetamide Show/Hide	C20H25N3O2	2
1	Ki = 88.9 nM
2	Ki = 101 nM
CP0061859 Compound Info	(+/-)-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline Show/Hide	C16H15NO3	1
1	Ki = 90 nM
CP0041389 Compound Info	Benzofuran-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C23H25Cl2N3O2	1
1	Ki = 93 nM
CP0074631 Compound Info	6-methyl-4,5,6,7,8,13-hexahydrothieno[2,3-f][3]benzazecine Show/Hide	C16H19NS	1
1	Ki = 99 nM
CP0082972 Compound Info	11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{15,20}]henicosa-1(14),3(8),4,6,15,17,19-heptaene Show/Hide	C20H22N2	1
1	Ki = 108 nM
CP0140966 Compound Info	2-[4-(4-Bromo-2-cyano-phenyl)-piperazin-1-yl]-N-(2,4,6-tribromo-3-methyl-phenyl)-acetamide Show/Hide	C20H18Br4N4O	2
1	Ki = 113.5 nM
2	Ki = 936 nM
CP0681805 Compound Info	(R)-2-[(Benzylamino)methyl]chroman-7-ol oxalate Show/Hide	C19H21NO6	1
1	Ki = 116 nM
CP0045034 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-2-carboxamide Show/Hide	C23H29N5O2	1
1	Ki = 130 nM
CP0175178 Compound Info	11-methyl-11-aza-tricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaene Show/Hide	C18H21N	1
1	Ki = 148 nM
CP0277858 Compound Info	2-[4-(4-Benzhydryl-phenyl)-piperazin-1-yl]-N-m-tolyl-acetamide Show/Hide	C32H33N3O	1
1	Ki = 174.5 nM
CP0078330 Compound Info	7-[4-[4-(2,3-dichlorophenyl)-1,4-diazepan-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one Show/Hide	C24H29Cl2N3O2	1
1	Ki = 200 nM
CP0077378 Compound Info	4-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-ynyl]-phenylamine Show/Hide	C21H22N2	1
1	Ki = 229.09 nM
CP0139060 Compound Info	N-[2-(4-phenylpiperazin-1-yl)ethyl]-N-pyridin-2-ylcyclohexanecarboxamide Show/Hide	C24H32N4O	1
1	Ki = 246 nM
CP0042927 Compound Info	7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one Show/Hide	C23H27Cl2N3O2	3
1	Ki = 251 nM
2	Ki = 510 nM
3	Ki = 1000 nM
CP0211927 Compound Info	5-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-ynyl]-pyridin-2-ylamine Show/Hide	C20H21N3	1
1	Ki = 275.42 nM
CP0043442 Compound Info	Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C23H25Cl2N3OS	1
1	Ki = 340 nM
CP0073517 Compound Info	6-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-ynyl]-pyridin-3-ylamine Show/Hide	C20H21N3	1
1	Ki = 371.54 nM
CP0061556 Compound Info	N-[(E)-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]-4-pyridin-2-ylbenzamide Show/Hide	C26H26Cl2N4O	1
1	Ki = 375 nM
CP0345574 Compound Info	3-(4-Methyl-piperidin-1-ylmethyl)-1H-indole Show/Hide	C15H20N2	1
1	Ki = 570 nM
CP0275169 Compound Info	4-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-ynyl]-pyridine Show/Hide	C20H20N2	1
1	Ki = 575.44 nM
CP0266687 Compound Info	1-(2-methoxyphenyl)-4-[4-(4-phenyltriazol-1-yl)butyl]piperazine Show/Hide	C23H29N5O	1
1	Ki = 639.3 nM
CP0216424 Compound Info	3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-ynyl]-pyridine Show/Hide	C20H20N2	1
1	Ki = 676.08 nM
CP0065124 Compound Info	9H-Fluorene-2-carboxylic acid {(E)-4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-but-2-enyl}-amide Show/Hide	C28H27Cl2N3O	1
1	Ki = 1020 nM
CP0044765 Compound Info	Benzofuran-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-but-2-enyl}-amide Show/Hide	C23H23Cl2N3O2	1
1	Ki = 1070 nM
CP0041232 Compound Info	1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperidin-4-ol Show/Hide	C20H21ClN2O	2
1	Ki = 1100 nM
2	Ki = 1520.7 nM
CP0040250 Compound Info	2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol Show/Hide	C21H25N3O2S	3
1	Ki = 1600 nM
2	Ki = 2200 nM
3	Ki > 1000 nM
CP0047599 Compound Info	Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-but-2-enyl}-amide Show/Hide	C23H23Cl2N3OS	1
1	Ki = 1770 nM
CP0183672 Compound Info	9-Oxo-9H-fluorene-4-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C28H27Cl2N3O2	1
1	Ki = 1850 nM
CP0045385 Compound Info	CAS_15676-16-1 Show/Hide	C15H23N3O4S	1
1	Ki = 2100 nM
CP0046343 Compound Info	(6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexahydro-6H-7-aza-benzo[6,7]cyclohepta[1,2-a]naphthalen-12-ol Show/Hide	C19H20ClNO	1
1	Ki = 5515 nM
CP0073485 Compound Info	1-benzyl-4-(3-hydroxyphenyl)piperazine Show/Hide	C17H20N2O	1
1	Ki > 400 nM
CP0042204 Compound Info	1H-Indole-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C23H26Cl2N4O	1
1	Ki > 800 nM
CP0184444 Compound Info	Biphenylene-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C27H27Cl2N3O	1
1	Ki > 5000 nM
CP0082340 Compound Info	2-(4-Pyridin-4-yl-piperazin-1-yl)-N-m-tolyl-acetamide Show/Hide	C18H22N4O	1
1	Ki > 10000 nM
CP0276844 Compound Info	2-(4-Biphenyl-4-yl-piperazin-1-yl)-N-m-tolyl-acetamide Show/Hide	C25H27N3O	1
1	Ki > 10000 nM
CP0277857 Compound Info	2-[4-(4-Benzyl-phenyl)-piperazin-1-yl]-N-m-tolyl-acetamide Show/Hide	C26H29N3O	1
1	Ki > 10000 nM

Clinical Information about the Protein

Target 1 ( Dopamine D4 receptor (D4R) )

Target Type	Successful Target
Disease	4 Target-related Diseases				4
1	Schizophrenia [ICD-11: 6A20]
2	Allergy [ICD-11: 4A80-4A85]
3	Psychotic disorder [ICD-11: 6A20-6A25]
4	Erectile dysfunction [ICD-11: HA01.1]
Approved Drug(s)	2 Approved Drugs				2
1	Clozapine	Drug Info	Approved	Schizophrenia
2	Phenyltoloxamine	Drug Info	Approved	Allergy
Clinical Trial Drug(s)	2 Clinical Trial Drugs				2
1	L-745,870	Drug Info	Phase 2	Psychotic disorder
2	NGD 94-1	Drug Info	Phase 1	Schizophrenia
Discontinued Drug(s)	3 Discontinued Drugs				3
1	ABT-724	Drug Info	Discontinued in Phase 2	Erectile dysfunction
2	Sonepiprazole	Drug Info	Terminated	Schizophrenia
3	YM-43611	Drug Info	Terminated	Psychotic disorder
Preclinical Drug(s)	1 Preclinical Drug				1
1	PD-165167	Drug Info	Preclinical	Schizophrenia

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han