Protein Information

General Information of the Protein

Protein ID	PT00897
Protein Name	Potassium voltage-gated channel subfamily H member 2
Secondarily Protein Name	Eag homolog Ether-a-go-go-related gene potassium channel 1 Voltage-gated potassium channel subunit Kv11.1
Gene Name	KCNH2
Secondarily Gene Name	ERG ERG1 HERG
Sequence	MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Ion channel > Voltage-gated ion channel > Potassium channels > Voltage-gated potassium channel
Function	Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661). Show/Hide
Uniprot ID	Primary ID: Q12809 Secondarily ID: A5H1P7 C4PFH9 D3DX04 O75418 O75680 Q708S9 Q9BT72 Q9BUT7 Q9H3P0 Show/Hide
HGNC ID	HGNC:6251
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000053 , COS-7

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0278751 Compound Info	BEPRIDIL HYDROCHLORIDE Show/Hide	C24H34N2O	1
1	IC50 = 550 nM Bioactivity Info	TI LI LO TS
CP0013607 Compound Info	2-methoxyacetic acid [(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methyl-amino]ethyl]-6-fluoro-1-isopropyl-tetralin-2-yl] ester;hydrate;hydrochloride Show/Hide	C29H38FN3O3	1
1	IC50 = 1430 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000695 , CHL

Cell Line Info

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000082 , HEL

Cell Line Info

Cell Line ID: CL000083 , MCF-7

Cell Line Info

Cell Line ID: CL000309 , NCTC clone 929

Cell Line Info

Cell Line ID: CL000700 , VCaP

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0040184 Compound Info	1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-1,3-benzodiazol-2-amine Show/Hide	C28H31FN4O	7
1	EC50 = 1.9 nM
2	IC50 = 0.9 nM
3	IC50 = 1.5 nM
4	IC50 = 3.31 nM
5	IC50 = 10 nM
6	IC50 = 11.48 nM
7	Ki = 20 nM
CP0218850 Compound Info	6-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one Show/Hide	C24H26N4O2	2
1	EC50 = 7.943 nM
2	Ki = 63.1 nM
CP0052474 Compound Info	(4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine-4-carbonyl}-phenyl)-methanesulfonamide Show/Hide	C21H27N3O3S	8
1	EC50 = 25 nM
2	IC50 = 1.2 nM
3	IC50 = 7.82 nM
4	IC50 = 12.02 nM
5	IC50 = 19.95 nM
6	IC50 = 20 nM
7	IC50 = 21 nM
8	IC50 = 24.2 nM
CP0046703 Compound Info	1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one Show/Hide	C24H26ClFN4O	4
1	IC50 = 3 nM
2	IC50 = 10 nM
3	IC50 = 14.7 nM
4	IC50 = 14.79 nM
CP0305866 Compound Info	1-(3-(4-(3-methylbenzo[b][1,4]oxathiin-2-yl)phenoxy)propyl)pyrrolidine Show/Hide	C22H25NO2S	1
1	IC50 = 4.4 nM
CP0253731 Compound Info	1-[3-[4-[(2R,3S)-3-methyl-2,3-dihydro-1,4-benzoxathiin-2-yl]phenoxy]propyl]pyrrolidine Show/Hide	C22H27NO2S	1
1	IC50 = 5 nM
CP0371449 Compound Info	1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidine-2-thione Show/Hide	C24H27FN4S	1
1	IC50 = 6.166 nM
CP0030226 Compound Info	4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl]-3-methoxy-piperidin-4-yl}-2-methoxy-benzamide Show/Hide	C23H29ClFN3O4	4
1	IC50 = 6.7 nM
2	IC50 = 6.761 nM
3	IC50 = 39.81 nM
4	IC50 = 47 nM
CP0171480 Compound Info	(Lu 23-086)1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one Show/Hide	C24H27FN4O	1
1	IC50 = 6.918 nM
CP0289652 Compound Info	7-fluoro-N-[1-[(3-fluoro-4-methoxyphenyl)methyl]piperidin-4-yl]-4-oxochromene-2-carboxamide Show/Hide	C23H22F2N2O4	1
1	IC50 = 8.5 nM
CP0356295 Compound Info	4-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C21H24N4O2	1
1	IC50 = 9 nM
CP0002229 Compound Info	(Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-phenyl)-ethyl]-methylamino}-ethoxy)-phenyl]-methanesulfonamide Show/Hide	C19H27N3O5S2	3
1	IC50 = 10 nM
2	IC50 = 30 nM
3	IC50 = 200 nM
CP0237326 Compound Info	N-[4-[4-[ethyl(heptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide Show/Hide	C20H36N2O3S	3
1	IC50 = 10 nM
2	IC50 = 15.14 nM
3	IC50 = 20 nM
CP0198230 Compound Info	1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-3,6-dihydro-2H-pyridin-1-yl}-ethyl)-imidazolidin-2-one Show/Hide	C24H24ClFN4O	1
1	IC50 = 10 nM
CP0008601 Compound Info	4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) Show/Hide	C21H23ClFNO2	5
1	IC50 = 10 nM
2	IC50 = 26.8 nM
3	IC50 = 26.92 nM
4	IC50 = 30.2 nM
5	IC50 = 1400 nM
CP0035258 Compound Info	N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine Show/Hide	C17H18F3NO	4
1	IC50 = 10 nM
2	IC50 = 457.09 nM
3	IC50 = 1513.56 nM
4	IC50 > 10000 nM
CP0036382 Compound Info	CAS_52-53-9 Show/Hide	C27H38N2O4	4
1	IC50 = 10 nM
2	IC50 = 141.25 nM
3	IC50 = 400 nM
4	IC50 = 3100 nM
CP0041749 Compound Info	1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile Show/Hide	C20H21FN2O	2
1	IC50 = 10 nM
2	IC50 = 3981.07 nM
CP0292876 Compound Info	1-[5-chloro-1-(4-fluorophenyl)indol-3-yl]-N,N-dimethylmethanamine Show/Hide	C17H16ClFN2	1
1	IC50 = 10.96 nM
CP0253729 Compound Info	1-[3-[4-[(2R,3S)-3-ethyl-2,3-dihydro-1,4-benzoxathiin-2-yl]phenoxy]propyl]pyrrolidine Show/Hide	C23H29NO2S	1
1	IC50 = 11 nM
CP0648622 Compound Info	N-(4-(1-(2-(6-methylpyridin-2-yl)ethyl)piperidine-4-carbonyl)phenyl)methanesulfonamide dihydrochloride Show/Hide	C21H29Cl2N3O3S	2
1	IC50 = 11 nM
2	IC50 = 18.1 nM
CP0231382 Compound Info	1-[3-[4-[(2R,3S)-3-phenyl-2,3-dihydro-1,4-benzoxathiin-2-yl]phenoxy]propyl]pyrrolidine Show/Hide	C27H29NO2S	1
1	IC50 = 12 nM
CP0007317 Compound Info	(+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl)-p-cresol Show/Hide	C22H31NO	1
1	IC50 = 16.98 nM
CP0027419 Compound Info	1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one Show/Hide	C28H29F2N3O	5
1	IC50 = 18 nM
2	IC50 = 50.12 nM
3	IC50 = 54.6 nM
4	IC50 = 54.95 nM
5	IC50 = 1700 nM
CP0311464 Compound Info	N-[1'-(6-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)-4-hydroxyspiro[3,4-dihydrochromene-2,4'-piperidine]-6-yl]methanesulfonamide Show/Hide	C25H29N3O4S	1
1	IC50 = 20.89 nM
CP0278751 Compound Info	BEPRIDIL HYDROCHLORIDE Show/Hide	C24H34N2O	3
1	IC50 = 22.91 nM
2	IC50 = 430 nM
3	IC50 = 549.54 nM
CP0298427 Compound Info	1-(2-{4-[1-(4-Fluoro-phenyl)-2,3-dihydro-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one Show/Hide	C24H29FN4O	1
1	IC50 = 23.44 nM
CP0282547 Compound Info	1-[3-[4-[(2R,3R)-3-methyl-2,3-dihydro-1,4-benzoxathiin-2-yl]phenoxy]propyl]pyrrolidine Show/Hide	C22H27NO2S	1
1	IC50 = 25 nM
CP0040487 Compound Info	1-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-N-methyl-N-((tetrahydro-2H-pyran-4-yl)methyl)piperidin-4-amine Show/Hide	C26H33FN4O	1
1	IC50 = 29 nM
CP0264620 Compound Info	(S)-1-(2-(chroman-4-yl)ethyl)-4-(3,4-dimethoxyphenyl)piperidine Show/Hide	C24H31NO3	2
1	IC50 = 30 nM
2	IC50 = 251.19 nM
CP0163218 Compound Info	4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide Show/Hide	C23H29ClFN3O4	3
1	IC50 = 31.55 nM
2	IC50 = 270 nM
3	IC50 < 1000 nM
CP0040196 Compound Info	1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazol-2(3H)-one Show/Hide	C22H22FN3O2	1
1	IC50 = 32.36 nM
CP0035893 Compound Info	(Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine Show/Hide	C21H26N2S2	4
1	IC50 = 33.2 nM
2	IC50 = 95.5 nM
3	IC50 = 190.55 nM
4	IC50 = 191 nM
CP0306020 Compound Info	4-(5-Chloro-3-{1-[2-(2-oxo-imidazolidin-1-yl)-ethyl]-piperidin-4-yl}-indol-1-yl)-benzoic acid methyl ester Show/Hide	C26H29ClN4O3	1
1	IC50 = 36.31 nM
CP0104272 Compound Info	1-[1,3-bis(chloranyl)-6-(trifluoromethyl)phenanthren-9-yl]-3-(dibutylamino)propan-1-ol;hydrochloride Show/Hide	C26H30Cl2F3NO	4
1	IC50 = 40 nM
2	IC50 = 156 nM
3	IC50 = 194.98 nM
4	IC50 = 199.53 nM
CP0033565 Compound Info	(+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol Show/Hide	C32H41NO2	8
1	IC50 = 50 nM
2	IC50 = 56 nM
3	IC50 = 199.53 nM
4	IC50 = 213 nM
5	IC50 = 213.8 nM
6	Ki = 56 nM
7	Ki = 78 nM
8	Ki = 320 nM
CP0056747 Compound Info	4-[(4-Chlorophenyl)methyl]-2-({(2R)-1-[4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl]-2-pyrrolidinyl}methyl)-1(2H)-phthalazinone Show/Hide	C39H49ClN4O2	1
1	IC50 = 50.12 nM
CP0237321 Compound Info	1-{2-[4-(5-Chloro-1-phenyl-1H-indol-3-yl)-piperidin-1-yl]-ethyl}-imidazolidin-2-one Show/Hide	C24H27ClN4O	1
1	IC50 = 87.1 nM
CP0294233 Compound Info	4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-phthalazin-1-one Show/Hide	C22H24ClN3O	1
1	IC50 = 100 nM
CP0290006 Compound Info	(R)-2-(6-methyl-2-phenylpyrimidin-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C27H28N4	1
1	IC50 = 120 nM
CP0056386 Compound Info	5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one Show/Hide	C21H21ClN4OS	4
1	IC50 = 120.23 nM
2	IC50 = 125 nM
3	IC50 = 125.89 nM
4	IC50 < 1000 nM
CP0530506 Compound Info	6-[[[1-[2-[6-methoxy-3-(trifluoromethyl)-1,5-naphthyridin-4-yl]ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C27H28F3N5O4	1
1	IC50 = 130 nM
CP0029932 Compound Info	CHEMBL1614712 Show/Hide	C27H29N5O	1
1	IC50 = 130 nM
CP0297101 Compound Info	methyl 2-[4-[5-chloro-3-[1-[2-(2-oxoimidazolidin-1-yl)ethyl]piperidin-4-yl]indol-1-yl]phenyl]acetate Show/Hide	C27H31ClN4O3	1
1	IC50 = 131.83 nM
CP0334084 Compound Info	1-{2-[4-(5-Chloro-1-cyclohexyl-1H-indol-3-yl)-piperidin-1-yl]-ethyl}-imidazolidin-2-one Show/Hide	C24H33ClN4O	1
1	IC50 = 138.04 nM
CP0039958 Compound Info	(risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one Show/Hide	C23H27FN4O2	7
1	IC50 = 147.91 nM
2	IC50 = 148 nM
3	IC50 = 167 nM
4	IC50 = 260 nM
5	IC50 = 778 nM
6	IC50 = 1070 nM
7	IC50 = 1330 nM
CP0077311 Compound Info	1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one Show/Hide	C22H24ClN5O2	1
1	IC50 = 162.18 nM
CP0068895 Compound Info	ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate Show/Hide	C22H23ClN2O2	2
1	IC50 = 169.82 nM
2	IC50 = 173.78 nM
CP0232071 Compound Info	3-benzyl-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)quinazolin-4(3H)-one Show/Hide	C29H31N3O2	1
1	IC50 = 170 nM
CP0117618 Compound Info	2-fluoro-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C23H24FN3O2	1
1	IC50 = 170 nM
CP0045063 Compound Info	2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine Show/Hide	C17H20N4S	3
1	IC50 = 181 nM
2	IC50 = 181.97 nM
3	IC50 = 231.3 nM
CP0327634 Compound Info	1-(2-Chroman-4-yl-ethyl)-4-(3,4-dimethoxy-phenyl)-piperidine Show/Hide	C24H31NO3	1
1	IC50 = 199.53 nM
CP0110939 Compound Info	5-Chloro-1-(4-fluoro-phenyl)-3-piperidin-4-yl-1H-indole Show/Hide	C19H18ClFN2	1
1	IC50 = 204.17 nM
CP0347887 Compound Info	(5R)-31-oxo-20-oxa-2,6,11,13-tetraazahexacyclo[19.6.2.1^{2,5}.1^{15,19}.0^{9,13}.0^{24,28}]hentriaconta-1(27),9,11,15,17,19(30),21(29),22,24(28),25-decaene-18-carbonitrile Show/Hide	C27H23N5O2	1
1	IC50 = 210 nM
CP0356157 Compound Info	1-(4-chlorophenyl)-2-[3-(4-fluorophenoxy)propyl]guanidine Show/Hide	C16H17ClFN3O	1
1	IC50 = 216 nM
CP0040625 Compound Info	N-[3-[4-[4-[(4-methylphenyl)sulfonylamino]butyl]piperazin-1-yl]phenyl]acetamide Show/Hide	C23H32N4O3S	1
1	IC50 = 300 nM
CP0567161 Compound Info	6-[[[1-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-8-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C27H30FN5O4	1
1	IC50 = 300 nM
CP0294516 Compound Info	10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulfinyl)-10H-phenothiazine Show/Hide	C21H26N2OS2	3
1	IC50 = 316.23 nM
2	IC50 = 320 nM
3	IC50 = 549.54 nM
CP0025667 Compound Info	2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone Show/Hide	C18H19ClN4	5
1	IC50 = 320 nM
2	IC50 = 323.59 nM
3	IC50 = 901 nM
4	IC50 = 3200 nM
5	IC50 = 3981.07 nM
CP0003832 Compound Info	N'-hydroxy-N-phenyloctanediamide Show/Hide	C14H20N2O3	2
1	IC50 = 322 nM
2	IC50 > 30000 nM
CP0034615 Compound Info	(6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol Show/Hide	C20H24N2O2	1
1	IC50 = 323.59 nM
CP0125124 Compound Info	1-Methyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester Show/Hide	C15H21NO2	2
1	IC50 = 323.59 nM
2	IC50 = 74131.02 nM
CP0035515 Compound Info	(2R)-N-[6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-4-yl]-2-hydroxypropanamide Show/Hide	C25H23Cl3N2O3	1
1	IC50 = 340 nM
CP0041757 Compound Info	1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol Show/Hide	C24H26N2O4	3
1	IC50 = 350 nM
2	IC50 = 10471.29 nM
3	IC50 = 12589.25 nM
CP0231514 Compound Info	2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-3-methyl-8-(trifluoromethyl)quinazolin-4(3H)-one Show/Hide	C25H26F3N3O2	1
1	IC50 = 350 nM
CP0313614 Compound Info	2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-8-(trifluoromethyl)-4(3H)-quinazolinone Show/Hide	C23H24F3N3O2	1
1	IC50 = 350 nM
CP0076698 Compound Info	(1R,3R)-1-(oxan-4-yl)-3-(5-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole Show/Hide	C25H26N4O	2
1	IC50 = 380 nM
2	Ki = 369 nM
CP0720695 Compound Info	Azimilide Show/Hide	C23H28ClN5O3	3
1	IC50 = 400 nM
2	IC50 = 562.34 nM
3	IC50 = 1412.54 nM
CP0046135 Compound Info	4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C23H25N3O2	1
1	IC50 = 430 nM
CP0146498 Compound Info	2-((1-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidin-4-yl)(methyl)amino)pyrimidin-4(3H)-one Show/Hide	C24H25FN6O	1
1	IC50 = 436.52 nM
CP0002230 Compound Info	4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide Show/Hide	C28H22F3N7O	1
1	IC50 = 450 nM
CP0313890 Compound Info	4-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-1-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-butan-1-ol Show/Hide	C31H39NO3	1
1	IC50 = 457.09 nM
CP0232074 Compound Info	3-phenyl-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)quinazolin-4(3H)-one Show/Hide	C28H29N3O2	1
1	IC50 = 460 nM
CP0042240 Compound Info	1-{3-[4-(3-Methyl-4,4-dioxo-4H-4lambda6-benzo[1,4]oxathiin-2-yl)-phenoxy]-propyl}-pyrrolidine Show/Hide	C22H25NO4S	1
1	IC50 = 470 nM
CP0184098 Compound Info	2-(1-adamantyl)-1-(4-iodophenyl)guanidine Show/Hide	C17H22IN3	1
1	IC50 = 491.4 nM
CP0020486 Compound Info	6-methoxy-4-[2-[4-([1,3]oxathiolo[5,4-c]pyridin-6-ylmethylamino)piperidin-1-yl]ethyl]quinoline-3-carbonitrile Show/Hide	C25H27N5O2S	1
1	IC50 = 500 nM
CP0002211 Compound Info	N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide Show/Hide	C22H27FN4O2	1
1	IC50 = 500 nM
CP0567047 Compound Info	6-[[[1-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-7,8-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C28H32FN5O4	1
1	IC50 = 500 nM
CP0132905 Compound Info	Rilpivirine Show/Hide	C22H18N6	1
1	IC50 = 500 nM
CP0444610 Compound Info	CHEMBL4870418 Show/Hide	C24H23ClN4O	1
1	IC50 = 500 nM
CP0070817 Compound Info	N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine Show/Hide	C20H22F3N5O	3
1	IC50 = 511 nM
2	IC50 = 980 nM
3	IC50 = 1000 nM
CP0557813 Compound Info	CHEMBL4849414 Show/Hide	C22H20ClF2N3O	1
1	IC50 = 520 nM
CP0177352 Compound Info	6-[[[1-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C26H29N5O4	1
1	IC50 = 560 nM
CP0170290 Compound Info	2-[4-[5-chloro-3-[1-[2-(2-oxoimidazolidin-1-yl)ethyl]piperidin-4-yl]indol-1-yl]phenyl]acetic acid Show/Hide	C26H29ClN4O3	1
1	IC50 = 575.44 nM
CP0013607 Compound Info	2-methoxyacetic acid [(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methyl-amino]ethyl]-6-fluoro-1-isopropyl-tetralin-2-yl] ester;hydrate;hydrochloride Show/Hide	C29H38FN3O3	4
1	IC50 = 580 nM
2	IC50 = 806 nM
3	IC50 = 1400 nM
4	IC50 = 1445.44 nM
CP0048052 Compound Info	4-(4-(2-(cyclopropylmethoxy)-5-(methylsulfonyl)benzoyl)piperazin-1-yl)-3-fluorobenzonitrile Show/Hide	C23H24FN3O4S	1
1	IC50 = 600 nM
CP0043996 Compound Info	(R)-2-(1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C26H26Cl2N4	1
1	IC50 = 600 nM
CP0349959 Compound Info	1-cyclopropyl-3-[4-(1-phenylpyrrolo[2,3-c]pyridin-3-yl)pyridin-2-yl]urea Show/Hide	C22H19N5O	1
1	IC50 = 600 nM
CP0042927 Compound Info	7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one Show/Hide	C23H27Cl2N3O2	5
1	IC50 = 630.96 nM
2	IC50 = 896.5 nM
3	IC50 = 3860 nM
4	IC50 < 1000 nM
5	Ki = 598 nM
CP0635260 Compound Info	eltrombopag Show/Hide	C25H22N4O4	1
1	IC50 = 690 nM
CP0231381 Compound Info	3-(4-{[3-(1-Pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C21H23N3O2	1
1	IC50 = 710 nM
CP0240846 Compound Info	GS-333126 Show/Hide	C25H14F7N5	1
1	IC50 = 794.33 nM
CP0011846 Compound Info	1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one Show/Hide	C21H27NO3	1
1	IC50 = 800 nM
CP0040489 Compound Info	1-(4-fluorobenzyl)-2-(4-(4-methyl-1H-pyrazol-1-yl)piperidin-1-yl)-1H-benzo[d]imidazole Show/Hide	C23H24FN5	1
1	IC50 = 809 nM
CP0000082 Compound Info	CAS_68647 Show/Hide	C18H19N3O	1
1	IC50 = 812.83 nM
CP0165991 Compound Info	(R)-3-bromo-5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)isoxazole Show/Hide	C19H20BrN3O	1
1	IC50 = 880 nM
CP0068493 Compound Info	(2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine Show/Hide	C25H29I2NO3	2
1	IC50 = 1000 nM
2	IC50 = 10000 nM
CP0341378 Compound Info	(+/-)-1-{3-[4-(6-Methoxy-3-methyl-4,4-dioxo-3,4-dihydro-2H-4lambda6-benzo[1,4]oxathiin-2-yl)-phenoxy]-propyl}-pyrrolidine Show/Hide	C23H29NO5S	1
1	IC50 = 1000 nM
CP0445227 Compound Info	6-[[[1-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-7-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C27H30FN5O4	1
1	IC50 = 1000 nM
CP0087489 Compound Info	6-(4-(3,4-dimethoxybenzoyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one Show/Hide	C22H25N3O4	2
1	IC50 = 1096.48 nM
2	IC50 = 18000 nM
CP0044035 Compound Info	1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine Show/Hide	C16H19ClN2	2
1	IC50 = 1100 nM
2	IC50 = 20892.96 nM
CP0232075 Compound Info	2-Phenyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C27H27N3O2	1
1	IC50 = 1100 nM
CP0296278 Compound Info	8-chloro-2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-3-methylquinazolin-4(3H)-one Show/Hide	C24H26ClN3O2	1
1	IC50 = 1100 nM
CP0007430 Compound Info	IBRUTINIB Show/Hide	C25H24N6O2	2
1	IC50 = 1100 nM
2	Ki = 1100 nM
CP0176864 Compound Info	CHEMBL4853672 Show/Hide	C24H22F2N4O	1
1	IC50 = 1100 nM
CP0676878 Compound Info	6-((1-(2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-2-oxoethyl)-2-oxabicyclo[2.2.2]octan-4-ylamino)methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one Show/Hide	C26H26FN5O5	1
1	IC50 = 1200 nM
CP0010656 Compound Info	3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one Show/Hide	C23H27FN4O3	2
1	IC50 = 1288.25 nM
2	IC50 = 1300 nM
CP0343389 Compound Info	CHEMBL4846783 Show/Hide	C23H20F2N4O	1
1	IC50 = 1300 nM
CP0093801 Compound Info	(R)-5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-2-phenylthiazole Show/Hide	C25H25N3S	1
1	IC50 = 1360 nM
CP0055808 Compound Info	3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine Show/Hide	C18H22N2	2
1	IC50 = 1380.38 nM
2	IC50 = 1390 nM
CP0074740 Compound Info	[(8R)-3-[2-(2,4-difluorophenyl)-1,3-thiazol-4-yl]-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(4-thiophen-2-ylphenyl)methanone Show/Hide	C26H19F2N5OS2	1
1	IC50 = 1400 nM
CP0177354 Compound Info	6-[[[1-[2-[3-(hydroxymethyl)-6-methoxy-1,5-naphthyridin-4-yl]ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C27H31N5O5	1
1	IC50 = 1440 nM
CP0033479 Compound Info	(chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Show/Hide	C17H19ClN2S	1
1	IC50 = 1479.11 nM
CP0151323 Compound Info	(R)-4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-2-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)thiazole Show/Hide	C26H25F3N4OS	1
1	IC50 = 1520 nM
CP0213280 Compound Info	6-[[[1-[2-(6-methoxy-3-methylsulfonyl-1,5-naphthyridin-4-yl)ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C27H31N5O6S	1
1	IC50 = 1550 nM
CP0142753 Compound Info	2,8-Dimethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O2	1
1	IC50 = 1600 nM
CP0164837 Compound Info	(R)-3-(4-chlorophenyl)-5-methyl-4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)isoxazole Show/Hide	C26H26ClN3O	1
1	IC50 = 1600 nM
CP0194592 Compound Info	(R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofuran-5-yl)benzonitrile Show/Hide	C22H22N2O	1
1	IC50 = 1600 nM
CP0235590 Compound Info	(R)-4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-2-phenylthiazole Show/Hide	C25H25N3S	1
1	IC50 = 1600 nM
CP0081096 Compound Info	2-methoxy-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C24H27N3O3	1
1	IC50 = 1600 nM
CP0479605 Compound Info	CHEMBL4845961 Show/Hide	C23H22ClF2N3O	1
1	IC50 = 1600 nM
CP0194289 Compound Info	(S)-1-(6-((diethylamino)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-4-(3-(trifluoromethyl)phenethyl)piperazin-2-one Show/Hide	C28H36F3N3O	1
1	IC50 = 1700 nM
CP0042239 Compound Info	(+/-)-1-{3-[4-(7-Methoxy-3-methyl-4,4-dioxo-3,4-dihydro-2H-4lambda6-benzo[1,4]oxathiin-2-yl)-phenoxy]-propyl}-pyrrolidine Show/Hide	C23H29NO5S	1
1	IC50 = 1700 nM
CP0272546 Compound Info	3-ethyl-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)quinazolin-4(3H)-one Show/Hide	C24H29N3O2	1
1	IC50 = 1700 nM
CP0226201 Compound Info	(R)-3-methyl-2-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)benzo[d]thiazolo[3,2-a]imidazole Show/Hide	C26H26N4S	1
1	IC50 = 1720 nM
CP0296280 Compound Info	2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-3-propylquinazolin-4(3H)-one Show/Hide	C25H31N3O2	1
1	IC50 = 1800 nM
CP0005212 Compound Info	US8987315, Ketoconazole Show/Hide	C26H28Cl2N4O4	2
1	IC50 = 1900 nM
2	IC50 = 1905.46 nM
CP0081972 Compound Info	(R)-N-(1-(3-(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)propyl)piperidin-4-yl)-N-ethyl-2-(4-(methylsulfonyl)phenyl)acetamide Show/Hide	C32H38F2N2O5S2	2
1	IC50 = 1900 nM
2	IC50 = 7300 nM
CP0200768 Compound Info	CHEMBL85606 Show/Hide	C28H30N4O	2
1	IC50 = 1995.26 nM
2	Ki = 630.96 nM
CP0043968 Compound Info	7-(2,5-dimethylpyrazol-3-yl)-3-[3-[[4-methyl-5-(2-methylquinolin-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-1,2,4,5-tetrahydro-3-benzazepine Show/Hide	C31H35N7S	1
1	IC50 = 1995.26 nM
CP0013001 Compound Info	(+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-indan-1-one Show/Hide	C24H29NO3	1
1	IC50 = 1995.26 nM
CP0035188 Compound Info	(R)-2-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)benzo[d]thiazole Show/Hide	C23H23N3S	1
1	IC50 = 2000 nM
CP0142752 Compound Info	2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-3,8-dimethylquinazolin-4(3H)-one Show/Hide	C25H29N3O2	1
1	IC50 = 2000 nM
CP0191293 Compound Info	(R)-3-(4-chlorophenyl)-4-methyl-5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)isoxazole Show/Hide	C26H26ClN3O	1
1	IC50 = 2000 nM
CP0198938 Compound Info	(R)-2-(5'-methyl-2,2'-bithiophen-5-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C25H26N2S2	1
1	IC50 = 2000 nM
CP0235588 Compound Info	(R)-5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)thiophene-2-carbonitrile Show/Hide	C21H21N3S	1
1	IC50 = 2000 nM
CP0282425 Compound Info	1-[2-(3-chloro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-N-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)piperidin-4-amine Show/Hide	C24H28ClN5O3	1
1	IC50 = 2000 nM
CP0183196 Compound Info	6-[[[1-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C26H28FN5O4	2
1	IC50 = 2000 nM
2	IC50 = 2100 nM
CP0420173 Compound Info	5-[2-[1-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperidin-4-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C23H24N6O3	1
1	IC50 = 2000 nM
CP0547955 Compound Info	CHEMBL4864639 Show/Hide	C24H25ClFN3O	1
1	IC50 = 2050 nM
CP0069651 Compound Info	7-methoxy-N-(piperidin-4-ylmethyl)-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amine Show/Hide	C19H21F3N6O2	1
1	IC50 = 2100 nM
CP0547938 Compound Info	CHEMBL4863359 Show/Hide	C23H23Cl2N3O	1
1	IC50 = 2300 nM
CP0534438 Compound Info	CHEMBL4861332 Show/Hide	C23H22ClF2N3O	2
1	IC50 = 2400 nM
2	IC50 = 11000 nM
CP0029912 Compound Info	Aralen Show/Hide	C18H26ClN3	2
1	IC50 = 2500 nM
2	IC50 = 2511.89 nM
CP0218857 Compound Info	6-Fluoro-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C22H24FN3O2	1
1	IC50 = 2500 nM
CP0232078 Compound Info	(+/-)-(S)-1-{3-[4-(8-Methoxy-3-methyl-4,4-dioxo-3,4-dihydro-2H-4lambda6-benzo[1,4]oxathiin-2-yl)-phenoxy]-propyl}-3-methyl-piperidine Show/Hide	C25H33NO5S	1
1	IC50 = 2500 nM
CP0056899 Compound Info	(2-Benzhydryloxy-ethyl)-dimethyl-amine Show/Hide	C17H21NO	2
1	IC50 = 2570.4 nM
2	IC50 = 26915.35 nM
CP0064841 Compound Info	(2,8-Bis-trifluoromethyl-quinolin-4-yl)-(1-methyl-piperidin-2-yl)-methanol Show/Hide	C17H16F6N2O	3
1	IC50 = 2600 nM
2	IC50 = 5495.41 nM
3	IC50 = 5623.41 nM
CP0297753 Compound Info	2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-7-(trifluoromethyl)-4(3H)-quinazolinone Show/Hide	C23H24F3N3O2	1
1	IC50 = 2600 nM
CP0126643 Compound Info	(R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(4-(piperidin-1-yl)phenyl)quinoline Show/Hide	C27H33N3	1
1	IC50 = 2800 nM
CP0135721 Compound Info	2-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl)-6-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C25H25F2N5	1
1	IC50 = 2800 nM
CP0202877 Compound Info	2-Propyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C24H29N3O2	1
1	IC50 = 2800 nM
CP0219814 Compound Info	(R)-6-methyl-5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)thiazolo[3,2-b][1,2,4]triazole Show/Hide	C21H23N5S	1
1	IC50 = 2800 nM
CP0231379 Compound Info	3-methyl-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)quinazolin-4(3H)-one Show/Hide	C23H27N3O2	1
1	IC50 = 2800 nM
CP0072232 Compound Info	(R)-5-methyl-3-(4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)thiazol-2-yl)isoxazole Show/Hide	C23H24N4OS	1
1	IC50 = 2840 nM
CP0102830 Compound Info	3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)quinazolin-4(3H)-one Show/Hide	C22H25N3O2	1
1	IC50 = 2900 nM
CP0253727 Compound Info	2-(4-(1-cyclopentylpiperidin-4-yloxy)phenyl)-3-methylquinazolin-4(3H)-one Show/Hide	C25H29N3O2	1
1	IC50 = 2900 nM
CP0282224 Compound Info	(+/-)-(R)-1-{3-[4-(8-Methoxy-3-methyl-4,4-dioxo-3,4-dihydro-2H-4lambda6-benzo[1,4]oxathiin-2-yl)-phenoxy]-propyl}-2-methyl-pyrrolidine Show/Hide	C24H31NO5S	1
1	IC50 = 2900 nM
CP0305860 Compound Info	3-isopropyl-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)quinazolin-4(3H)-one Show/Hide	C25H31N3O2	1
1	IC50 = 3000 nM
CP0048166 Compound Info	2-[[5-cyano-4-[2,4-dichloro-5-[2-(diethylamino)ethoxy]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]sulfanyl]-N-methylacetamide Show/Hide	C22H24Cl2N6O2S	1
1	IC50 = 3140 nM
CP0071568 Compound Info	5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrid[4,3-b]indol-1-one;hydrochloride Show/Hide	C17H18N4O	2
1	IC50 = 3200 nM
2	IC50 = 3235.94 nM
CP0044008 Compound Info	(R)-4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)benzonitrile Show/Hide	C23H23N3	1
1	IC50 = 3200 nM
CP0060491 Compound Info	10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene Show/Hide	C20H23N	2
1	IC50 = 3290 nM
2	IC50 = 10000 nM
CP0045223 Compound Info	(S)-4-(4-chlorophenethyl)-1-(6-((diethylamino)-methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)piperazin-2-one Show/Hide	C27H36ClN3O	1
1	IC50 = 3300 nM
CP0010658 Compound Info	5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one Show/Hide	C22H30N6O4S	2
1	IC50 = 3300 nM
2	IC50 = 3311.31 nM
CP0036757 Compound Info	3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine Show/Hide	C19H24N2	1
1	IC50 = 3388.44 nM
CP0090824 Compound Info	(R)-2-(4H-benzo[d][1,3]dioxin-6-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C24H26N2O2	1
1	IC50 = 3600 nM
CP0282484 Compound Info	(R)-2-(6-chloropyridin-3-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C21H22ClN3	1
1	IC50 = 3600 nM
CP0002793 Compound Info	(BRL 43694)1-Methyl-1H-indazole-3-carboxylic acid (9-methyl-9-aza-bicyclo[3.3.1]non-3-yl)-amide Show/Hide	C18H24N4O	2
1	IC50 = 3715.35 nM
2	IC50 = 3801.89 nM
CP0044093 Compound Info	(R)-4-methyl-5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-2-(thiophen-2-yl)thiazole Show/Hide	C24H25N3S2	1
1	IC50 = 3720 nM
CP0039091 Compound Info	N-[3-[4-[4-(cyclohexylmethylsulfonylamino)butyl]piperazin-1-yl]phenyl]acetamide Show/Hide	C23H38N4O3S	2
1	IC50 = 3800 nM
2	Ki > 2000 nM
CP0042238 Compound Info	2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-6-methoxy-3-methylquinazolin-4(3H)-one Show/Hide	C25H29N3O3	1
1	IC50 = 3800 nM
CP0231998 Compound Info	(+/-)-(S)-1-{3-[4-(8-Methoxy-3-methyl-4,4-dioxo-3,4-dihydro-2H-4lambda6-benzo[1,4]oxathiin-2-yl)-phenoxy]-propyl}-2-methyl-pyrrolidine Show/Hide	C24H31NO5S	1
1	IC50 = 3800 nM
CP0179956 Compound Info	N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide Show/Hide	C17H20F6N2O3	1
1	IC50 = 3890.45 nM
CP0305864 Compound Info	2-Isopropyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C24H29N3O2	1
1	IC50 = 3900 nM
CP0225649 Compound Info	2-amino-1-[3-(4-fluoroanilino)-2-(4-fluorophenyl)-6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl]-2-methylpropan-1-one Show/Hide	C22H23F2N5O	1
1	IC50 = 3950 nM
CP0062100 Compound Info	(-)-(R)-2-(1-(2-(2-(azetidin-1-yl)ethyl)benzo[b]thiophen-3-yl)ethyl)pyridine Show/Hide	C20H22N2S	1
1	IC50 = 4200 nM
CP0231378 Compound Info	2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-7-methoxy-3-methylquinazolin-4(3H)-one Show/Hide	C25H29N3O3	1
1	IC50 = 4300 nM
CP0128076 Compound Info	8-Chloro-11-piperazin-1-yl-5H-dibenzo[b,e][1,4]diazepine Show/Hide	C17H17ClN4	2
1	IC50 = 4490 nM
2	IC50 = 31622.78 nM
CP0069452 Compound Info	5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C23H24N6O3	2
1	IC50 = 4500 nM
2	IC50 = 14000 nM
CP0459494 Compound Info	5-[2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C22H23N7O3	1
1	IC50 = 4500 nM
CP0027141 Compound Info	3-oxo-2-(2-pyridin-2-ylethyl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindole-1-carboxamide Show/Hide	C24H20F3N3O3	1
1	IC50 = 4600 nM
CP0077040 Compound Info	4-Amino-5-chloro-2-ethoxy-N-[4-(4-fluoro-benzyl)-morpholin-2-ylmethyl]-benzamide; citrate(AS-4370) Show/Hide	C21H25ClFN3O3	1
1	IC50 = 4786.3 nM
CP0003146 Compound Info	5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide Show/Hide	C22H21Cl3N4O	1
1	IC50 = 4800 nM
CP0073733 Compound Info	(+/-)-1-{3-[4-(8-Methoxy-3-methyl-4,4-dioxo-3,4-dihydro-2H-4lambda6-benzo[1,4]oxathiin-2-yl)-phenoxy]-propyl}-piperidine Show/Hide	C24H31NO5S	1
1	IC50 = 4800 nM
CP0093794 Compound Info	(R)-4-methyl-5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-2-(pyridin-4-yl)thiazole Show/Hide	C25H26N4S	1
1	IC50 = 4800 nM
CP0231698 Compound Info	(R)-ethyl 5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)thiophene-2-carbimidate Show/Hide	C23H27N3OS	1
1	IC50 = 4800 nM
CP0270573 Compound Info	2-Phenyl-3-piperidin-3-yl-1H-indole Show/Hide	C19H20N2	2
1	IC50 = 4897.79 nM
2	Ki = 4900 nM
CP0151774 Compound Info	1-{3-[4-((2S,3S)-8-Methoxy-3-methyl-4,4-dioxo-3,4-dihydro-2H-4lambda6-benzo[1,4]oxathiin-2-yl)-phenoxy]-propyl}-pyrrolidine Show/Hide	C23H29NO5S	1
1	IC50 = 4900 nM
CP0170167 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-4-methylbenzenesulfonamide Show/Hide	C22H31N3O3S	1
1	IC50 = 5000 nM
CP0291530 Compound Info	2-Ethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O2	1
1	IC50 = 5000 nM
CP0205340 Compound Info	N-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-1-[2-(3-fluoro-6-methoxyquinolin-4-yl)ethyl]piperidin-4-amine Show/Hide	C25H29FN4O3	1
1	IC50 = 5000 nM
CP0658097 Compound Info	5-(1H-indol-7-ylamino)-3-((1R,2S)-2-aminocyclohexylamino)-1,2,4-triazine-6-carboxamide Show/Hide	C18H22N8O	1
1	IC50 = 5000 nM
CP0309072 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C22H25N3O4S	1
1	IC50 = 5000 nM
CP0367992 Compound Info	4-[3-[2-[[(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl]methyl]-4-(trifluoromethyl)phenyl]-4-chlorophenyl]-3-methylbenzoic acid Show/Hide	C34H23ClF9NO4	1
1	IC50 = 5000 nM
CP0126140 Compound Info	2-fluoro-N-[3-methoxy-4-[5-(3-piperidin-1-ylpropylamino)-1,3,4-oxadiazol-2-yl]phenyl]benzamide Show/Hide	C24H28FN5O3	2
1	IC50 = 5011.87 nM
2	IC50 = 16982.44 nM
CP0418474 Compound Info	CHEMBL4848514 Show/Hide	C24H23ClN4O	1
1	IC50 = 5300 nM
CP0202876 Compound Info	2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-3-methylquinazolin-4(3H)-one Show/Hide	C24H27N3O2	1
1	IC50 = 5600 nM
CP0177353 Compound Info	6-[[[1-[2-[3-(difluoromethyl)-6-methoxy-1,5-naphthyridin-4-yl]ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C27H29F2N5O4	1
1	IC50 = 5850 nM
CP0073728 Compound Info	7-Fluoro-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C22H24FN3O2	1
1	IC50 = 6000 nM
CP0238238 Compound Info	(R)-4-methyl-5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-2-(pyridin-3-yl)thiazole Show/Hide	C25H26N4S	1
1	IC50 = 6000 nM
CP0271584 Compound Info	(R)-2-(5-chloro-1-methyl-3-phenyl-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C26H27ClN4	1
1	IC50 = 6000 nM
CP0232076 Compound Info	1-{3-[4-((2R,3R)-8-Methoxy-3-methyl-4,4-dioxo-3,4-dihydro-2H-4lambda6-benzo[1,4]oxathiin-2-yl)-phenoxy]-propyl}-pyrrolidine Show/Hide	C23H29NO5S	1
1	IC50 = 6200 nM
CP0253728 Compound Info	(+/-)-1-{3-[4-(5-Methoxy-3-methyl-4,4-dioxo-3,4-dihydro-2H-4lambda6-benzo[1,4]oxathiin-2-yl)-phenoxy]-propyl}-pyrrolidine Show/Hide	C23H29NO5S	1
1	IC50 = 6300 nM
CP0185942 Compound Info	(R)-5-methyl-4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-3-phenylisoxazole Show/Hide	C26H27N3O	1
1	IC50 = 6400 nM
CP0206060 Compound Info	2,5-Dimethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O2	1
1	IC50 = 6600 nM
CP0402857 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methyl-1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C23H27N3O4S	1
1	IC50 = 6600 nM
CP0074461 Compound Info	(2S,6R)-2,6-dimethyl-N-[4-[1-(oxan-4-yl)pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl]morpholine-4-carboxamide Show/Hide	C24H29N5O3	1
1	IC50 = 6600 nM
CP0090649 Compound Info	2,7-Dimethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O2	1
1	IC50 = 6700 nM
CP0042236 Compound Info	(R)-2-tert-butyl-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C20H28N2	1
1	IC50 = 6800 nM
CP0064169 Compound Info	5-hydroxy-2-(4-hydroxyphenyl)-N-methyl-4-(piperidin-1-ylmethyl)-1-benzofuran-3-carboxamide Show/Hide	C22H24N2O4	1
1	IC50 = 6900 nM
CP0780095 Compound Info	1-{3-[4-(8-Methoxy-3-methyl-4,4-dioxo-3,4-dihydro-2H-4lambda6-benzo[1,4]oxathiin-2-yl)-phenoxy]-propyl}-pyrrolidine Show/Hide	C23H29NO5S	1
1	IC50 = 7000 nM
CP0035807 Compound Info	Cocaine Show/Hide	C17H21NO4	1
1	IC50 = 7244.36 nM
CP0062495 Compound Info	(Z)-2-butenedioic acid;2-(2,2-dicyclohexylethyl)piperidine Show/Hide	C19H35N	1
1	IC50 = 7762.47 nM
CP0043999 Compound Info	2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-8-fluoro-3-methylquinazolin-4(3H)-one Show/Hide	C24H26FN3O2	1
1	IC50 = 7900 nM
CP0350333 Compound Info	(3R,4S)-4-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)-1-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]piperidin-3-ol Show/Hide	C24H28FN5O4	1
1	IC50 = 7900 nM
CP0191294 Compound Info	(R)-2-(2-methylimidazo[1,2-a]pyridin-3-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C24H26N4	1
1	IC50 = 8000 nM
CP0114969 Compound Info	[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(4-thiophen-2-ylphenyl)methanone Show/Hide	C20H18N6OS2	1
1	IC50 = 8000 nM
CP0062279 Compound Info	(S)-1-(6-((diethylamino)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-4-(4-fluorophenethyl)piperazin-2-one Show/Hide	C27H36FN3O	1
1	IC50 = 8100 nM
CP0029449 Compound Info	(5S)-31-oxo-20-oxa-2,6,11,13-tetraazahexacyclo[19.6.2.1^{2,5}.1^{15,19}.0^{9,13}.0^{24,28}]hentriaconta-1(27),9,11,15,17,19(30),21(29),22,24(28),25-decaene-18-carbonitrile Show/Hide	C27H23N5O2	1
1	IC50 = 8100 nM
CP0290003 Compound Info	5-Chloro-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C22H24ClN3O2	1
1	IC50 = 8100 nM
CP0013593 Compound Info	1-(3-Hydroxy-propyl)-5-((R)-2-{2-[2-(2,2,2-trifluoro-ethoxy)-phenoxy]-ethylamino}-propyl)-2,3-dihydro-1H-indole-7-carboxylic acid amide Show/Hide	C25H32F3N3O4	1
1	IC50 = 8200 nM
CP0132553 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(2-methoxypyrimidin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C24H28N4O5	1
1	IC50 = 8200 nM
CP0219813 Compound Info	(R)-6-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)quinoxaline Show/Hide	C24H24N4	1
1	IC50 = 8400 nM
CP0004985 Compound Info	2-(4-fluorophenyl)-N-[6-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]-1-methylbenzimidazol-4-amine Show/Hide	C24H21FN6O	1
1	IC50 = 8500 nM
CP0093554 Compound Info	BIIB-057 Show/Hide	C19H23N9O	2
1	IC50 = 8600 nM
2	IC50 = 9100 nM
CP0091000 Compound Info	(R)-2-(2,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C24H27N5	1
1	IC50 = 8800 nM
CP0561521 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methyl-1,2,4-thiadiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C22H26N4O4S	1
1	IC50 = 9000 nM
CP0016164 Compound Info	(3R,4R)-1-[3-(2,5-difluorophenyl)cyclobutyl]-4-[(3S)-3-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]piperidine-3-carboxylic acid Show/Hide	C29H32F2N2O4	1
1	IC50 = 9970 nM
CP0072374 Compound Info	BAY-E-5009 Show/Hide	C18H20N2O6	1
1	IC50 = 10000 nM
CP0162544 Compound Info	5-tert-Butyl-1-(4-fluoro-phenyl)-1H-indole Show/Hide	C18H18FN	1
1	IC50 = 10000 nM
CP0224890 Compound Info	1-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-ethanone Show/Hide	C16H11ClFNO	1
1	IC50 = 10000 nM
CP0297102 Compound Info	5-Chloro-1-(4-fluoro-phenyl)-3-isopropyl-1H-indole Show/Hide	C17H15ClFN	1
1	IC50 = 10000 nM
CP0036394 Compound Info	2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-8-methoxy-3-methylpyrido[3,4-d]pyrimidin-4(3H)-one Show/Hide	C24H28N4O3	1
1	IC50 = 10000 nM
CP0164197 Compound Info	2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-5-(trifluoromethyl)-4(3H)-quinazolinone Show/Hide	C23H24F3N3O2	1
1	IC50 = 10000 nM
CP0206057 Compound Info	5-Fluoro-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C22H24FN3O2	1
1	IC50 = 10000 nM
CP0206059 Compound Info	6-Methoxy-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O3	1
1	IC50 = 10000 nM
CP0218851 Compound Info	2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-8-methoxy-3-methylquinazolin-4(3H)-one Show/Hide	C25H29N3O3	1
1	IC50 = 10000 nM
CP0218853 Compound Info	2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-5-methoxy-3-methylquinazolin-4(3H)-one Show/Hide	C25H29N3O3	1
1	IC50 = 10000 nM
CP0231995 Compound Info	2,6-Dimethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O2	1
1	IC50 = 10000 nM
CP0296479 Compound Info	8-Methoxy-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone trifluoroacetate Show/Hide	C23H27N3O3	1
1	IC50 = 10000 nM
CP0305862 Compound Info	8-Fluoro-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C22H24FN3O2	1
1	IC50 = 10000 nM
CP0305863 Compound Info	5-Methoxy-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O3	1
1	IC50 = 10000 nM
CP0305865 Compound Info	2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C22H25N3O2	1
1	IC50 = 10000 nM
CP0310817 Compound Info	7-Methoxy-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O3	1
1	IC50 = 10000 nM
CP0044706 Compound Info	(2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl}phenyl)prop-2-enamide Show/Hide	C22H25N3O3	1
1	IC50 = 10300 nM
CP0455805 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methoxy-1,2,4-thiadiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C22H26N4O5S	1
1	IC50 = 10300 nM
CP0090976 Compound Info	(R)-2-(4-methyl-2-(pyrrolidin-1-yl)pyrimidin-5-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C25H31N5	1
1	IC50 = 10400 nM
CP0198937 Compound Info	(R)-2-(1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C26H30N6O	1
1	IC50 = 10400 nM
CP0165503 Compound Info	2-amino-4-fluoro-5-(4-hydroxypiperidin-1-yl)sulfonyl-N-(3,4,5-trifluorophenyl)benzamide Show/Hide	C18H17F4N3O4S	1
1	IC50 = 10900 nM
CP0126599 Compound Info	N-[1-[(3R)-3-(3,5-difluorophenyl)-3-(1-methylsulfonylpiperidin-4-yl)propyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide Show/Hide	C31H43F2N3O5S2	1
1	IC50 = 11000 nM
CP0289830 Compound Info	(R)-4-methyl-5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-2-(pyridin-2-yl)thiazole Show/Hide	C25H26N4S	1
1	IC50 = 11200 nM
CP0165988 Compound Info	(R)-2-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)thiazole Show/Hide	C19H21N3S	1
1	IC50 = 11600 nM
CP0194663 Compound Info	7-[[[1-[[(3R)-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-1H-pyrido[3,4-b][1,4]oxazin-2-one Show/Hide	C26H26FN5O5	1
1	IC50 = 11700 nM
CP0414064 Compound Info	5-[(1R)-1-hydroxy-2-[2-(5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one Show/Hide	C25H31N3O5S	1
1	IC50 = 11700 nM
CP0049757 Compound Info	4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide Show/Hide	C21H29N3O	2
1	IC50 = 12000 nM
2	IC50 = 91201.08 nM
CP0222016 Compound Info	(R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(pyridin-3-yl)quinoline Show/Hide	C21H23N3	1
1	IC50 = 12000 nM
CP0264622 Compound Info	Anzemet Cinv Show/Hide	C19H20N2O3	1
1	IC50 = 12022.64 nM
CP0327633 Compound Info	MDL-74156 Show/Hide	C19H22N2O3	1
1	IC50 = 12022.64 nM
CP0165987 Compound Info	(R)-2'-methyl-4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-2,4'-bithiazole Show/Hide	C23H24N4S2	1
1	IC50 = 12400 nM
CP0100241 Compound Info	2-Methyl-10-piperazin-1-yl-4H-3-thia-4,9-diaza-benzo[f]azulene Show/Hide	C16H18N4S	1
1	IC50 = 12589.25 nM
CP0209320 Compound Info	2-fluoro-N-[4-[5-(4-piperidin-1-ylbutylamino)-1,3,4-oxadiazol-2-yl]phenyl]benzamide Show/Hide	C24H28FN5O2	1
1	IC50 = 12589.25 nM
CP0095971 Compound Info	4-methyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H26N6O3	2
1	IC50 = 13000 nM
2	IC50 = 20000 nM
CP0088540 Compound Info	(+/-)-1-Cyclobutyl-4-[4-(8-methoxy-3-methyl-4,4-dioxo-3,4-dihydro-2H-4lambda6-benzo[1,4]oxathiin-2-yl)-phenoxy]-piperidine Show/Hide	C25H31NO5S	1
1	IC50 = 14000 nM
CP0145132 Compound Info	AZD7762 Show/Hide	C17H19FN4O2S	1
1	IC50 = 15000 nM
CP0312988 Compound Info	3-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-pentan-3-ol Show/Hide	C19H19ClFNO	1
1	IC50 = 15848.93 nM
CP0033646 Compound Info	AZD-9291 Show/Hide	C28H33N7O2	1
1	IC50 = 16200 nM
CP0091072 Compound Info	(R)-2-(5-methyl-1-(6-methyl-4-(trifluoromethyl)pyridin-2-yl)-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C27H28F3N5	1
1	IC50 = 16800 nM
CP0046632 Compound Info	US9056859, 72 Show/Hide	C23H25N7O3	1
1	IC50 = 17000 nM
CP0077731 Compound Info	(+)-cis-Diltiazem Show/Hide	C22H26N2O4S	1
1	IC50 = 17378.01 nM
CP0567159 Compound Info	6-[[[1-[2-[6-(2-aminoethoxy)-3-fluoro-1,5-naphthyridin-4-yl]ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C27H31FN6O4	1
1	IC50 = 17500 nM
CP0090975 Compound Info	(R)-2-(3-methyl-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C20H24N4	1
1	IC50 = 17600 nM
CP0218860 Compound Info	(R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(pyridin-2-yl)quinoline Show/Hide	C21H23N3	1
1	IC50 = 18000 nM
CP0232572 Compound Info	(R)-N,N-dimethyl-6-(5-methyl-4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-1H-pyrazol-1-yl)pyridazin-3-amine Show/Hide	C26H31N7	1
1	IC50 = 18000 nM
CP0082827 Compound Info	AT-4140 Show/Hide	C19H22F2N4O3	1
1	IC50 = 18197.01 nM
CP0146499 Compound Info	2-fluoro-N-[3-fluoro-4-[5-(4-morpholin-4-ylbutylamino)-1,3,4-oxadiazol-2-yl]phenyl]benzamide Show/Hide	C23H25F2N5O3	1
1	IC50 = 18620.87 nM
CP0361823 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-pyridin-4-yl-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C24H27N3O4	1
1	IC50 = 19500 nM
CP0181333 Compound Info	US9206199, 22 Show/Hide	C24H25N7O4	1
1	IC50 = 19700 nM
CP0024122 Compound Info	(3R,4R)-4-[(3S)-3-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-(2-thiophen-2-ylsulfanylethyl)piperidine-3-carboxylic acid Show/Hide	C25H30N2O4S2	2
1	IC50 = 19700 nM
2	IC50 = 21000 nM
CP0044007 Compound Info	(R)-1-(4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)phenyl)pyridin-4(1H)-one Show/Hide	C27H27N3O	1
1	IC50 = 20000 nM
CP0044094 Compound Info	(R)-2-(5-methyl-1-(pyridin-2-yl)-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C25H27N5	1
1	IC50 = 20000 nM
CP0126641 Compound Info	(R)-2-(2,6-dimethylpyridin-3-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C23H27N3	1
1	IC50 = 20000 nM
CP0309069 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C24H28N4O5	2
1	IC50 = 20000 nM
2	IC50 > 90000 nM
CP0073725 Compound Info	(R)-2,4-dimethyl-5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)thiazole Show/Hide	C21H25N3S	1
1	IC50 = 20400 nM
CP0091071 Compound Info	(R)-2-(2,6-dichloropyridin-4-yl)-4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)thiazole Show/Hide	C24H22Cl2N4S	1
1	IC50 = 20400 nM
CP0242688 Compound Info	(R)-4-(4-methyl-5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)thiazol-2-yl)morpholine Show/Hide	C24H30N4OS	1
1	IC50 = 20400 nM
CP0160930 Compound Info	PILSICAINIDE Show/Hide	C17H24N2O	1
1	IC50 = 20417.38 nM
CP0090825 Compound Info	(R)-2-([1,2,4]triazolo[1,5-a]pyrimidin-5-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C21H22N6	1
1	IC50 = 20800 nM
CP0376890 Compound Info	5-[1-fluoro-2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one Show/Hide	C23H24FN7O3	1
1	IC50 = 22000 nM
CP0689663 Compound Info	5-(((3R,4R)-3-aminotetrahydro-2H-pyran-4-yl)amino)-3-(4-methoxy-1H-indol-2-yl)pyrazine-2-carboxamide Show/Hide	C19H22N6O3	1
1	IC50 = 22000 nM
CP0189728 Compound Info	US9018211, 2A Show/Hide	C26H30N2O6	2
1	IC50 = 22000 nM
2	IC50 = 23000 nM
CP0686385 Compound Info	(S)-3-(4-(3-(4-chlorobenzyl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)piperidin-1-yl)-1H-1,2,4-triazol-5-amine Show/Hide	C23H27ClN6O	1
1	IC50 = 22000 nM
CP0165984 Compound Info	(R)-2-(4-methylpiperidin-1-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C22H31N3	1
1	IC50 = 22400 nM
CP0216065 Compound Info	(R)-2-(2-methoxypyrimidin-5-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C21H24N4O	1
1	IC50 = 22400 nM
CP0441184 Compound Info	5-[(1R)-1-hydroxy-2-[2-(5-methylsulfonylpyrazin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one Show/Hide	C24H30N4O5S	1
1	IC50 = 22700 nM
CP0025032 Compound Info	2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid Show/Hide	C32H39NO4	2
1	IC50 = 22908.68 nM
2	Ki = 23000 nM
CP0011242 Compound Info	(3R,4R)-4-[(3S)-3-(3-fluoro-6-methoxyquinolin-4-yl)-3-hydroxypropyl]-1-(2-thiophen-2-ylsulfanylethyl)piperidine-3-carboxylic acid Show/Hide	C25H29FN2O4S2	1
1	IC50 = 23600 nM
CP0088854 Compound Info	[(8R)-8-methyl-3-(2-methyl-1,3-thiazol-4-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(4-thiophen-2-ylphenyl)methanone Show/Hide	C21H19N5OS2	1
1	IC50 = 24000 nM
CP0051541 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-3-one Show/Hide	C25H29N3O6S	1
1	IC50 = 24000 nM
CP0349958 Compound Info	N-[4-[1-(oxan-4-yl)pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl]morpholine-4-carboxamide Show/Hide	C22H25N5O3	1
1	IC50 = 24100 nM
CP0126642 Compound Info	(R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C21H26N4	1
1	IC50 = 24800 nM
CP0126699 Compound Info	(R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(pyrazin-2-yl)quinoline Show/Hide	C20H22N4	1
1	IC50 = 24800 nM
CP0183353 Compound Info	6-[[(3R,4R)-3-aminooxan-4-yl]amino]-8-(1H-indol-7-ylamino)-2H-2,7-naphthyridin-1-one Show/Hide	C21H22N6O2	1
1	IC50 = 24900 nM
CP0017287 Compound Info	(3R,4R)-4-[(3S)-3-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-(3-phenylcyclobutyl)piperidine-3-carboxylic acid Show/Hide	C29H34N2O4	1
1	IC50 = 24900 nM
CP0184986 Compound Info	6-[[[1-[2-[3-fluoro-6-(2-hydroxyethoxy)-1,5-naphthyridin-4-yl]ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C27H30FN5O5	1
1	IC50 = 25000 nM
CP0337894 Compound Info	(1R)-2-[4-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]-1-(6-methoxy-1,5-naphthyridin-4-yl)ethanol Show/Hide	C24H29N5O4	1
1	IC50 = 25100 nM
CP0091001 Compound Info	(R)-2-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-4,5-dihydrothiazole Show/Hide	C19H23N3S	1
1	IC50 = 25200 nM
CP0058434 Compound Info	6-[[[1-[(1S)-2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1-hydroxyethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C26H28FN5O5	1
1	IC50 = 26000 nM
CP0232570 Compound Info	(R)-2-(6-methylpyridin-3-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C22H25N3	1
1	IC50 = 26400 nM
CP0366397 Compound Info	6-[[[1-[2-(6-methoxy-3-methyl-1,5-naphthyridin-4-yl)ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C27H31N5O4	1
1	IC50 = 27430 nM
CP0051539 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-methylsulfonylpyrazin-2-yl)-2,8-diazaspiro[4.5]decan-3-one Show/Hide	C24H28N4O6S	1
1	IC50 = 27800 nM
CP0135717 Compound Info	(R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(pyridin-4-yl)quinoline Show/Hide	C21H23N3	1
1	IC50 = 28000 nM
CP0124168 Compound Info	2-fluoro-N-[4-[5-(4-morpholin-4-ylbutylamino)-1,3,4-oxadiazol-2-yl]phenyl]benzamide Show/Hide	C23H26FN5O3	1
1	IC50 = 29512.09 nM
CP0389764 Compound Info	5-[(1R)-1-hydroxy-2-[2-(6-methylsulfonylpyridin-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one Show/Hide	C25H31N3O5S	1
1	IC50 = 29600 nM
CP0366449 Compound Info	6-[[[1-[(1S)-2-[3-fluoro-6-(2-hydroxyethoxy)-1,5-naphthyridin-4-yl]-1-hydroxyethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C27H30FN5O6	1
1	IC50 = 29700 nM
CP0358870 Compound Info	4-methyl-5-[1-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]propan-2-yl]-3H-2-benzofuran-1-one Show/Hide	C24H27N7O3	1
1	IC50 = 30000 nM
CP0150720 Compound Info	2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid Show/Hide	C21H25ClN2O3	2
1	IC50 = 30199.52 nM
2	IC50 = 31622.78 nM
CP0242687 Compound Info	(R)-4-methyl-5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-2-(pyrazin-2-yl)thiazole Show/Hide	C24H25N5S	1
1	IC50 = 32000 nM
CP0055087 Compound Info	(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione Show/Hide	C37H67NO13	1
1	IC50 = 39000 nM
CP0230989 Compound Info	3-[4-[(3S)-3-[(4-chlorophenyl)methyl]morpholin-4-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine Show/Hide	C18H25ClN6O	1
1	IC50 = 39000 nM
CP0044006 Compound Info	(R)-2-methyl-3-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-1,8-naphthyridine Show/Hide	C25H26N4	1
1	IC50 = 40000 nM
CP0090662 Compound Info	(R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C16H20N2	1
1	IC50 = 40000 nM
CP0090980 Compound Info	(R)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C21H26N4	1
1	IC50 = 40000 nM
CP0091002 Compound Info	(R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(1H-pyrazol-5-yl)quinoline Show/Hide	C19H22N4	1
1	IC50 = 40000 nM
CP0206064 Compound Info	(R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(pyrimidin-5-yl)quinoline Show/Hide	C20H22N4	1
1	IC50 = 40000 nM
CP0218968 Compound Info	(R)-2-(1,5-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C21H26N4	1
1	IC50 = 40000 nM
CP0232571 Compound Info	(R)-3-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-2-(trifluoromethyl)pyridin-4-ol Show/Hide	C22H22F3N3O	1
1	IC50 = 40000 nM
CP0232574 Compound Info	(R)-6-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-2,3-dihydroimidazo[2,1-b]thiazole Show/Hide	C21H24N4S	1
1	IC50 = 40000 nM
CP0232575 Compound Info	(R)-6-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-[1,3]dioxolo[4,5-b]pyridine Show/Hide	C22H23N3O2	1
1	IC50 = 40000 nM
CP0232579 Compound Info	(R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(1H-pyrazol-4-yl)quinoline Show/Hide	C19H22N4	1
1	IC50 = 40000 nM
CP0253726 Compound Info	(R)-2,4-dimethyl-5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)oxazole Show/Hide	C21H25N3O	1
1	IC50 = 40000 nM
CP0567336 Compound Info	(1S,2S)-2-[[7-fluoro-8-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]ethyl]-1,5-naphthyridin-2-yl]oxymethyl]cyclopropane-1-carboxylic acid Show/Hide	C30H32FN5O6	1
1	IC50 = 43400 nM
CP0222014 Compound Info	(R)-2-cyclopropyl-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C19H24N2	1
1	IC50 = 44000 nM
CP0181203 Compound Info	1-[2-[4-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]ethyl]-2-oxoquinoline-7-carbonitrile Show/Hide	C25H27N5O3	1
1	IC50 = 44000 nM
CP0133264 Compound Info	A-56268 Show/Hide	C38H69NO13	2
1	IC50 = 46000 nM
2	IC50 = 58884.37 nM
CP0027239 Compound Info	(3R,4R)-1-[3-(2,6-difluorophenyl)cyclobutyl]-4-[(3S)-3-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]piperidine-3-carboxylic acid Show/Hide	C29H32F2N2O4	1
1	IC50 = 47600 nM
CP0052206 Compound Info	1-Cyclopropyl-6-fluoro-5-methyl-7-(3-methyl-piperazin-1-yl)-4-oxo-1,4,4a,8a-tetrahydro-quinoline-3-carboxylic acid (Grepafloxacin) Show/Hide	C19H22FN3O3	2
1	IC50 = 50000 nM
2	IC50 = 50118.72 nM
CP0126108 Compound Info	(4-fluorophenyl)-[(8R)-8-(2-hydroxyethyl)-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone Show/Hide	C17H17FN6O2S	1
1	IC50 = 50000 nM
CP0147959 Compound Info	[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-phenylmethanone Show/Hide	C16H16N6OS	1
1	IC50 = 50000 nM
CP0046619 Compound Info	Adalat Show/Hide	C17H18N2O6	1
1	IC50 = 50118.72 nM
CP0108552 Compound Info	4-methyl-5-[2-[4-[2-[3-methyl-5-(tetrazol-1-yl)pyridin-2-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H27N7O3	1
1	IC50 = 52000 nM
CP0237307 Compound Info	US9206199, 21 Show/Hide	C24H25N7O4	1
1	IC50 = 56500 nM
CP0212153 Compound Info	(4-chlorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone Show/Hide	C16H15ClN6OS	1
1	IC50 = 66000 nM
CP0002800 Compound Info	1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea Show/Hide	C23H28ClN3O5S	2
1	IC50 = 74000 nM
2	IC50 = 74131.02 nM
CP0322115 Compound Info	4-(5-Chloro-3-{1-[2-(2-oxo-imidazolidin-1-yl)-ethyl]-piperidin-4-yl}-indol-1-yl)-benzoic acid Show/Hide	C25H27ClN4O3	1
1	IC50 = 74131.02 nM
CP0333449 Compound Info	US9206199, 23 Show/Hide	C24H25N7O4	1
1	IC50 = 74900 nM
CP0205342 Compound Info	(1R)-2-[4-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]-1-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethanol Show/Hide	C24H28FN5O4	1
1	IC50 = 79400 nM
CP0308131 Compound Info	9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine Show/Hide	C16H15N3	1
1	IC50 = 91201.08 nM
CP0039577 Compound Info	9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)-[1,2,4]triazolo[3,4-f][1,6]naphthyridine Show/Hide	C34H29N9	1
1	IC50 > 10000 nM
CP0049926 Compound Info	(R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide Show/Hide	C20H21F3N2O2	1
1	IC50 > 10000 nM
CP0134600 Compound Info	5-(4-methylsulfonylphenyl)-3-[6-(trifluoromethyl)pyridin-3-yl]pyridin-2-amine Show/Hide	C18H14F3N3O2S	1
1	IC50 > 10000 nM
CP0262055 Compound Info	N-[3-[(2S,5R)-6-amino-5-ethylsulfonyl-2-(fluoromethyl)-5-methyl-3,4-dihydropyridin-2-yl]-4-fluorophenyl]-2,2-difluoro-[1,3]dioxolo[4,5-c]pyridine-6-carboxamide Show/Hide	C22H22F4N4O5S	1
1	IC50 > 10000 nM
CP0057972 Compound Info	2-[[4-(2-chloro-4,5-dimethoxyphenyl)-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-2-yl]sulfanyl]-N,N-dimethylacetamide Show/Hide	C19H18ClN5O3S	1
1	IC50 > 30000 nM
CP0086081 Compound Info	2-[[4-(2-chloro-5-hydroxy-4-methoxyphenyl)-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-2-yl]sulfanyl]-N,N-dimethylacetamide Show/Hide	C18H16ClN5O3S	1
1	IC50 > 30000 nM
CP0118574 Compound Info	7-[[(1R,2S)-2-aminocyclohexyl]amino]-5-(1H-indol-7-ylamino)-3H-pyrido[4,3-d]pyrimidin-4-one Show/Hide	C21H23N7O	1
1	IC50 > 30000 nM
CP0068661 Compound Info	CHEMBL3355987 Show/Hide	C21H25ClN4O	1
1	IC50 > 30000 nM
CP0114551 Compound Info	CHEMBL3355552 Show/Hide	C22H25F3N4O	1
1	IC50 > 30000 nM
CP0114708 Compound Info	CHEMBL3355544 Show/Hide	C19H19F3N4O2	1
1	IC50 > 30000 nM
CP0177776 Compound Info	CHEMBL3355550 Show/Hide	C19H19F3N4O	1
1	IC50 > 30000 nM
CP0074483 Compound Info	4-ethyl-N-[4-[1-(oxan-4-yl)pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl]piperazine-1-carboxamide Show/Hide	C24H30N6O2	1
1	IC50 > 30000 nM
CP0270792 Compound Info	CHEMBL4640031 Show/Hide	C26H33N5O3	1
1	IC50 > 30000 nM
CP0390388 Compound Info	1-(oxan-4-yl)-3-pyridin-4-ylpyrrolo[2,3-c]pyridine Show/Hide	C17H17N3O	1
1	IC50 > 30000 nM
CP0042443 Compound Info	(S)-1-(5-phenyl-3-(piperidin-3-ylcarbamoyl)thiophen-2-yl)urea Show/Hide	C17H20N4O2S	1
1	IC50 > 31600 nM
CP0098301 Compound Info	1-[(1R,2R)-1,2-diphenyl-2-piperidin-1-ylethyl]piperidine Show/Hide	C24H32N2	1
1	IC50 > 33000 nM
CP0123212 Compound Info	(3R)-3-[[4-[(5-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C27H27ClFN3O5	1
1	IC50 > 60000 nM
CP0194662 Compound Info	6-[[[1-[[(3R)-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-7-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C27H28FN5O5	1
1	IC50 > 60000 nM
CP0194683 Compound Info	(3R)-3-[[4-[(8-chloro-2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C26H26ClFN4O5	1
1	IC50 > 60000 nM
CP0194684 Compound Info	(3R)-5-fluoro-3-hydroxy-3-[[4-(1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C26H29FN6O3	1
1	IC50 > 60000 nM
CP0257060 Compound Info	(3R)-5-fluoro-3-hydroxy-3-[[4-[(3-methyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C27H29FN4O5	1
1	IC50 > 60000 nM
CP0257224 Compound Info	(3R)-3-[[4-(1,3-benzodioxol-5-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C26H26FN3O5	1
1	IC50 > 60000 nM
CP0257248 Compound Info	(3R)-5-fluoro-3-[[4-[(6-fluoro-2,3-dihydro-1,4-benzodioxin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C27H27F2N3O5	1
1	IC50 > 60000 nM
CP0286018 Compound Info	(3R)-5-fluoro-3-hydroxy-3-[[4-[(2-methyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C27H29FN4O5	1
1	IC50 > 60000 nM
CP0286019 Compound Info	(3R)-3-[[4-[(1,1-dioxo-2,3-dihydro-[1,4]oxathiino[2,3-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C26H27FN4O6S	1
1	IC50 > 60000 nM
CP0286020 Compound Info	(3R)-5-fluoro-3-hydroxy-3-[[4-[(4-methyl-2,3-dihydropyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C27H30FN5O4	1
1	IC50 > 60000 nM
CP0347527 Compound Info	(3R)-3-[[4-(6,7-dihydro-[1,4]dioxino[2,3-c]pyridazin-3-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C25H26FN5O5	1
1	IC50 > 60000 nM
CP0362596 Compound Info	7-[[[1-[[(3R)-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-8-carbonitrile Show/Hide	C27H26FN5O5	1
1	IC50 > 60000 nM
CP0367924 Compound Info	(3R)-3-[[4-[(5,8-dichloro-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C27H26Cl2FN3O5	1
1	IC50 > 60000 nM
CP0463213 Compound Info	(3R)-3-[[4-[(6-chloro-2,3-dihydro-1,4-benzodioxin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C27H27ClFN3O5	1
1	IC50 > 60000 nM
CP0511464 Compound Info	(3R)-3-[[4-(2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-6-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C26H27FN4O5	1
1	IC50 > 60000 nM
CP0511465 Compound Info	(3R)-3-[[4-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C26H28FN5O4	1
1	IC50 > 60000 nM
CP0557192 Compound Info	(3R)-3-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C27H28FN3O5	1
1	IC50 > 60000 nM
CP0560825 Compound Info	7-ethyl-6-[[[1-[[(3R)-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Show/Hide	C28H30FN5O5	1
1	IC50 > 60000 nM
CP0560826 Compound Info	(3R)-3-[[4-(2,3-dihydro-[1,4]oxathiino[3,2-c]pyridin-7-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C26H27FN4O4S	1
1	IC50 > 60000 nM
CP0566821 Compound Info	(3R)-3-[[4-[(4,4-dioxo-2,3-dihydro-[1,4]oxathiino[3,2-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one Show/Hide	C26H27FN4O6S	1
1	IC50 > 60000 nM
CP0272596 Compound Info	N-[1-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]-N-methyl-3-oxo-4H-pyrido[3,2-b][1,4]oxazine-6-carboxamide Show/Hide	C27H28FN5O5	1
1	IC50 > 60000 nM
CP0453242 Compound Info	N-[1-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]-3-oxo-4H-pyrido[3,2-b][1,4]oxazine-6-carboxamide Show/Hide	C26H26FN5O5	1
1	IC50 > 60000 nM
CP0528791 Compound Info	(1R,2S)-2-[[7-fluoro-8-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]ethyl]-1,5-naphthyridin-2-yl]oxymethyl]cyclopropane-1-carboxylic acid Show/Hide	C30H32FN5O6	1
1	IC50 > 60000 nM
CP0066063 Compound Info	N-[2-[[(1S,2R,4R)-2-(benzenesulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide Show/Hide	C27H34F3N3O4S	1
1	IC50 > 80000 nM
CP0188530 Compound Info	6-(4-chlorophenyl)-3-[6-(4-hydroxypiperidin-1-yl)pyridin-3-yl]pyrrolo[2,1-f][1,2,4]triazin-4-one Show/Hide	C22H20ClN5O2	1
1	IC50 > 80000 nM
CP0112422 Compound Info	(4-fluorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone Show/Hide	C16H15FN6OS	1
1	IC50 > 100000 nM
CP0002598 Compound Info	US9493448, 122 Show/Hide	C20H21ClFN5O3S	1
1	IC50 > 100000 nM
CP0538171 Compound Info	1-({4-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenylcarbamoyl]-phenyl}-imino-methyl)-piperidine-3-carboxylic acid ethyl ester Show/Hide	C28H27Cl2N5O4	1
1	Ki = 16 nM
CP0371094 Compound Info	1'-(2,4-difluorophenethyl)-6-methoxyspiro[3,4-dihydro-2H-chromene-2,4'-(hexahydropyridine)] Show/Hide	C22H25F2NO2	1
1	Ki = 20 nM
CP0447444 Compound Info	1'-(2,4-difluorophenethyl)spiro[1,2,3,4-tetrahydronaphthalene-2,4'-(hexahydropyridine)] Show/Hide	C22H25F2N	1
1	Ki = 69 nM
CP0345223 Compound Info	3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole Show/Hide	C27H28N2	1
1	Ki = 80 nM
CP0045013 Compound Info	(3R)-1-cyclohexyl-3-(5-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole Show/Hide	C26H28N4	1
1	Ki = 80 nM
CP0039097 Compound Info	1'-(2,4-difluorophenethyl)spiro[3,4-dihydro-2H-chromene-2,4'-(hexahydropyridine)] Show/Hide	C21H23F2NO	1
1	Ki = 110 nM
CP0891260 Compound Info	(3R,4R)-6-Fluoro-3-(4-fluoropiperidin-3-yl)-2-naphthalen-2-yl-1H-indole Show/Hide	C23H20F2N2	1
1	Ki = 110 nM
CP0091025 Compound Info	5-chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N-dimethyl-carbamimidoyl)-benzoylamino]-benzamide Show/Hide	C22H19Cl2N5O2	1
1	Ki = 110 nM
CP0511470 Compound Info	4-(4-Chloro-benzenesulfonyl)-1-[2-(2,4-difluoro-phenyl)-ethyl]-piperidine Show/Hide	C19H20ClF2NO2S	1
1	Ki = 150 nM
CP0094782 Compound Info	2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide Show/Hide	C23H24FN3O2S	1
1	Ki = 200 nM
CP0304607 Compound Info	N-[2-[(5-chloropyridin-2-yl)carbamoyl]-4-methoxyphenyl]-4-(N,N-dimethylcarbamimidoyl)-2-piperidin-1-ylbenzamide Show/Hide	C28H31ClN6O3	1
1	Ki = 200 nM
CP0262775 Compound Info	3-(1-Benzyl-piperidin-3-yl)-2-phenyl-1H-indole Show/Hide	C26H26N2	1
1	Ki = 290 nM
CP0829637 Compound Info	(3R,4R)-6-Fluoro-3-(4-fluoropiperidin-3-yl)-2-naphthalen-1-yl-1H-indole Show/Hide	C23H20F2N2	1
1	Ki = 500 nM
CP0347876 Compound Info	3-(1-(2-Phenylethyl)piperidin-3-yl)-2-phenyl-1H-indole Show/Hide	C27H28N2	1
1	Ki = 530 nM
CP0347888 Compound Info	4-[[1-(2-(2,4-Difluorophenyl)ethyl)-4-piperidinyl]sulfonyl]benzonitrile Show/Hide	C20H20F2N2O2S	1
1	Ki = 560 nM
CP0345192 Compound Info	1'-[2-(2,4-Difluorophenyl)ethyl]-3,4-dihydrospiro[2H-1-benzothiopyran-2,4'-piperidine]-1,1-dioxide Show/Hide	C21H23F2NO2S	1
1	Ki = 570 nM
CP0044329 Compound Info	1-(2,4-difluorophenethyl)-4-(4-fluorophenylsulfonyl)piperidine Show/Hide	C19H20F3NO2S	1
1	Ki = 710 nM
CP0126585 Compound Info	4-methyl-6-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-1,4-benzoxazin-3-one Show/Hide	C25H28N4O2	1
1	Ki = 794.33 nM
CP0701507 Compound Info	(3R,4R)-6-Fluoro-3-(4-fluoropiperidin-3-yl)-1H-indole-2-carboxylic acid phenylamide Show/Hide	C20H19F2N3O	1
1	Ki = 930 nM
CP0040626 Compound Info	1-(2,4-difluorophenethyl)-4-(phenylsulfonyl)piperidine Show/Hide	C19H21F2NO2S	1
1	Ki = 1000 nM
CP0075436 Compound Info	(2,3-Dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol Show/Hide	C22H28FNO3	1
1	Ki = 1100 nM
CP0746305 Compound Info	3-((3R,4R)-4-fluoropiperidin-3-yl)-2-phenyl-1H-indole Show/Hide	C19H19FN2	1
1	Ki = 1100 nM
CP0371095 Compound Info	1'-phenethylspiro[1,2,3,4-tetrahydronaphthalene-2,4'-(hexahydropyridine)]-1-ol; hydrochloride Show/Hide	C22H27NO	1
1	Ki = 1200 nM
CP0311380 Compound Info	6-Fluoro-2-(4-fluoro-phenyl)-3-piperidin-3-yl-1H-indole Show/Hide	C19H18F2N2	1
1	Ki = 1300 nM
CP0371096 Compound Info	4-[[1-(2-(2,4-Difluorophenyl)ethyl)-4-piperidinyl]sulfonyl]benzamide Show/Hide	C20H22F2N2O3S	1
1	Ki = 1300 nM
CP0647510 Compound Info	(3R,4R)-6-Chloro-3-(4-fluoropiperidin-3-yl)-2-phenyl-1H-indole Show/Hide	C19H18ClFN2	1
1	Ki = 1400 nM
CP0829638 Compound Info	(3R,4R)-6-Fluoro-3-(4-fluoropiperidin-3-yl)-2-thiophen-3-yl-1H-indole Show/Hide	C17H16F2N2S	1
1	Ki = 1500 nM
CP0844291 Compound Info	(3R,4R)-6-Fluoro-2-(4-fluorophenyl)-3-(4-fluoropiperidin-3-yl)-1H-indole Show/Hide	C19H17F3N2	1
1	Ki = 1600 nM
CP0039099 Compound Info	1-(2-Phenylethyl)-4-(phenylsulfonyl)piperidine Show/Hide	C19H23NO2S	1
1	Ki = 1800 nM
CP0037570 Compound Info	BEVYXXA Show/Hide	C23H22ClN5O3	1
1	Ki = 1800 nM
CP0430154 Compound Info	3-[[1-(2-(2,4-Difluorophenyl)ethyl)-4-piperidinyl]sulfonyl]benzonitrile Show/Hide	C20H20F2N2O2S	1
1	Ki = 1900 nM
CP0826952 Compound Info	(3R,4R)-7-Chloro-3-(4-fluoropiperidin-3-yl)-2-phenyl-1H-indole Show/Hide	C19H18ClFN2	1
1	Ki = 2100 nM
CP0042313 Compound Info	N-[2-[(5-chloropyridin-2-yl)carbamoyl]-4-methoxyphenyl]-4-(N,N-dimethylcarbamimidoyl)-2-fluorobenzamide Show/Hide	C23H21ClFN5O3	1
1	Ki = 2100 nM
CP0289001 Compound Info	1-(3-Phenylpropyl)-4-(phenylsulfonyl)piperidine Show/Hide	C20H25NO2S	1
1	Ki = 2500 nM
CP0916293 Compound Info	(3R,4R)-6-Fluoro-3-(4-fluoro-piperidin-3-yl)-2-pyridin-3-yl-1H-indole Show/Hide	C18H17F2N3	1
1	Ki = 2500 nM
CP0275239 Compound Info	(-)-(R)-2-(3-(1-(5-fluoropyridin-2-yl)ethyl)benzo[b]thiophen-2-yl)-N,N-dimethylethanamine Show/Hide	C19H21FN2S	1
1	Ki = 2500 nM
CP0283739 Compound Info	8-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one Show/Hide	C24H26N4O2	1
1	Ki = 2511.89 nM
CP0907832 Compound Info	(3R,4R)-7-Fluoro-3-(4-fluoropiperidin-3-yl)-2-phenyl-1H-indole Show/Hide	C19H18F2N2	1
1	Ki = 3000 nM
CP0040490 Compound Info	(R)-1-(4-fluorobenzyl)-2-(1-methylpiperidin-3-yl)-1H-benzo[d]imidazole Show/Hide	C20H22FN3	1
1	Ki = 3900 nM
CP0270386 Compound Info	4-methyl-8-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-1,4-benzoxazin-3-one Show/Hide	C25H28N4O2	1
1	Ki = 3981.07 nM
CP0039100 Compound Info	2-[[1-(2-(2,4-Difluorophenyl)ethyl)-4-piperidinyl]sulfonyl]benzonitrile Show/Hide	C20H20F2N2O2S	1
1	Ki = 4000 nM
CP0802170 Compound Info	6-Fluoro-3-(4-fluoro-piperidin-3-yl)-2-phenyl-1H-indole Show/Hide	C19H18F2N2	1
1	Ki = 4000 nM
CP0647511 Compound Info	2-Cyclohexyl-3-(4-fluoro-piperidin-3-yl)-1H-indole Show/Hide	C19H24F2N2	1
1	Ki = 5400 nM
CP0152373 Compound Info	1-(2,4-difluorophenethyl)-4-fluoro-4-(4-fluorophenylsulfonyl)piperidine Show/Hide	C19H19F4NO2S	1
1	Ki = 5561 nM
CP0245025 Compound Info	2-Phenyl-3-piperidin-4-yl-1H-indole Show/Hide	C19H20N2	1
1	Ki = 5700 nM
CP0039034 Compound Info	2-(1-methylpiperidin-3-yl)-1-(2-phenoxyethyl)-1H-benzo[d]imidazole Show/Hide	C21H25N3O	1
1	Ki = 5900 nM
CP0245024 Compound Info	1-(4-Fluorophenyl)-2-[4-(phenylsulfonyl)-1-piperidinyl]-ethanone Show/Hide	C19H20FNO3S	1
1	Ki = 6800 nM
CP0311378 Compound Info	3-(1-Methyl-piperidin-2-yl)-2-phenyl-1H-indole Show/Hide	C20H22N2	1
1	Ki = 7000 nM
CP0816404 Compound Info	(3R,4R)-5-Fluoro-3-(4-fluoropiperidin-3-yl)-2-phenyl-1H-indole Show/Hide	C19H18F2N2	1
1	Ki = 7000 nM
CP0816405 Compound Info	(3R,4R)-5-Chloro-3-(4-fluoropiperidin-3-yl)-2-phenyl-1H-indole Show/Hide	C19H18ClFN2	1
1	Ki = 7000 nM
CP0345222 Compound Info	3-[[1-(2-(2,4-Difluorophenyl)ethyl)-4-piperidinyl]sulfonyl]benzamide Show/Hide	C20H22F2N2O3S	1
1	Ki = 7143.01 nM
CP0844290 Compound Info	(3R,4R)-6-Fluoro-3-(4-fluoropiperidin-3-yl)-1H-indole-2-carboxylic Acid Methyl Ester Show/Hide	C15H16F2N2O2	1
1	Ki = 8200 nM
CP0371098 Compound Info	3-(1-Methyl-piperidin-3-yl)-2-phenyl-1H-indole Show/Hide	C20H22N2	1
1	Ki = 9599.99 nM
CP0036238 Compound Info	(-)-(R)-N,N-dimethyl-2-(3-(1-(pyridin-2-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine Show/Hide	C19H22N2S	1
1	Ki > 5 nM
CP0056536 Compound Info	N,N-dimethyl-2-[3-(pyrazin-2-ylmethyl)-1H-inden-2-yl]ethanamine Show/Hide	C18H21N3	1
1	Ki > 3000 nM
CP0101717 Compound Info	(-)-Dimethyl-{2-[3-((R)-1-pyrazin-2-yl-ethyl)-1H-inden-2-yl]-ethyl}-amine Show/Hide	C19H23N3	1
1	Ki > 3000 nM
CP0092749 Compound Info	(-)-(R)-N,N-dimethyl-2-(3-(1-(pyridin-3-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine Show/Hide	C19H22N2S	1
1	Ki > 5000 nM
CP0147331 Compound Info	(-)-(R)-N-methyl-2-(3-(1-(pyridin-2-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine Show/Hide	C18H20N2S	1
1	Ki > 5000 nM
CP0147381 Compound Info	(-)-(R)-N,N-dimethyl-2-(3-(1-(3-methylpyridin-2-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine Show/Hide	C20H24N2S	1
1	Ki > 5000 nM
CP0156538 Compound Info	(-)-(R)-2-(3-(1-(2-fluoropyridin-3-yl)ethyl)benzo[b]thiophen-2-yl)-N,N-dimethylethanamine Show/Hide	C19H21FN2S	1
1	Ki > 5000 nM
CP0156608 Compound Info	(-)-(S)-2-(3-(1-(2-chloropyridin-3-yl)ethyl)benzo[b]thiophen-2-yl)-N,N-dimethylethanamine Show/Hide	C19H21ClN2S	1
1	Ki > 5000 nM
CP0204086 Compound Info	(-)-(R)-2-(3-(1-(1H-pyrazol-1-yl)ethyl)benzo[b]thiophen-2-yl)-N,N-dimethylethanamine Show/Hide	C17H21N3S	1
1	Ki > 5000 nM
CP0214258 Compound Info	(-)-(R)-2-(3-(1-(3-fluoropyridin-2-yl)ethyl)benzo[b]thiophen-2-yl)-N,N-dimethylethanamine Show/Hide	C19H21FN2S	1
1	Ki > 5000 nM
CP0214261 Compound Info	(+)-(R)-2-(3-(1-(3-methoxypyridin-2-yl)ethyl)benzo[b]thiophen-2-yl)-N,N-dimethylethanamine Show/Hide	C20H24N2OS	1
1	Ki > 5000 nM
CP0244950 Compound Info	(-)-(R)-2-(3-(1-(2-methoxypyridin-3-yl)ethyl)benzo[b]thiophen-2-yl)-N,N-dimethylethanamine Show/Hide	C20H24N2OS	1
1	Ki > 5000 nM
CP0275228 Compound Info	(-)-(R)-N,N-dimethyl-2-(3-(1-(thiazol-4-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine Show/Hide	C17H20N2S2	1
1	Ki > 5000 nM
CP0099167 Compound Info	(4-(2,4-difluorophenethyl)piperidin-1-yl)(2-fluorophenyl)methanone Show/Hide	C20H20F3NO	1
1	Ki > 9000 nM
CP0042315 Compound Info	1-(2-(2-(5-chloropyridin-2-ylcarbamoyl)-4-methoxyphenylcarbamoyl)-5-(N,N-dimethylcarbamimidoyl)phenyl)piperidine-4-carboxylic acid Show/Hide	C29H31ClN6O5	1
1	Ki > 10000 nM
CP0163484 Compound Info	2-(3-(5-chloropyridin-2-ylcarbamoyl)-4-(4-(N,N-dimethylcarbamimidoyl)benzamido)phenoxy)acetic acid Show/Hide	C24H22ClN5O5	1
1	Ki > 10000 nM
CP0065988 Compound Info	1-(4-fluorobenzyl)-2-(1-methylpiperidin-3-yl)-1H-benzo[d]imidazole Show/Hide	C20H22FN3	1
1	Ki > 10000 nM
CP0134298 Compound Info	1-({4-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenylcarbamoyl]-phenyl}-imino-methyl)-piperidine-3-carboxylic acid Show/Hide	C26H23Cl2N5O4	1
1	Ki > 10000 nM
CP0208472 Compound Info	N-(2-amino-5-thiophen-2-ylphenyl)-6-(2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-yl)pyridine-3-carboxamide Show/Hide	C23H23N5O3S	1
1	Ki > 30000 nM

Clinical Information about the Protein

Target 1 ( Voltage-gated potassium channel Kv11.1 (KCNH2) )

Target Type	Successful Target
Disease	6 Target-related Diseases				6
1	Cardiac failure [ICD-11: BD10-BD13]
2	Sleep-wake disorder [ICD-11: 7A00-7B2Z]
3	Pain [ICD-11: MG30-MG3Z]
4	Malaria [ICD-11: 1F40-1F45]
5	Cardiac arrhythmias [ICD-11: BC9Z]
6	Ovarian cancer [ICD-11: 2C73]
Approved Drug(s)	1 Approved Drug				1
1	VESNARINONE	Drug Info	Approved	Cardiac failure
Clinical Trial Drug(s)	4 Clinical Trial Drugs				4
1	M100907	Drug Info	Phase 3	Sleep-wake disorder
2	ABT-229	Drug Info	Phase 2	Pain
3	NITD609	Drug Info	Phase 2	Malaria
4	ISOQUINE	Drug Info	Phase 1	Malaria
Discontinued Drug(s)	1 Discontinued Drug				1
1	MK-499	Drug Info	Discontinued in Phase 2	Cardiac arrhythmias
Investigative Drug(s)	1 Investigative Drug				1
1	6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-N-(HYDROXYMETHYL)-1,2,2-TRIMETHYL-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX)	Drug Info	Investigative	Ovarian cancer

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT06976	Potassium voltage-gated channel subfamily H member 2	Canis lupus familiaris, Dog, Canis familiaris	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han