General Information of the Compound
Compound ID
CP0133264
Compound Name
A-56268
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Synonyms
(14R)-14-Hydroxyclarithromycin
6-O-Methylerythromycin
6-O-Methylerythromycin a
A-56268
ANX-015
Abbotic
Abbott-56268
Adel
Astromen
Biaxin
Biaxin (TN)
Biaxin HP
Biaxin XL
Biaxin filmtab
Biaxin xl filmtab
Bicrolid
CLM & IL-12
CRL-1605 & Clarithromycin
CTY
Clacee
Clacid
Clacid (TN)
Clacine
Clambiotic
Clarem
Claribid
Claricide
Claridar
Claridar (TN)
Claripen
Claripen (TN)
Clarith
Clarithromycin
Clarithromycin & Interleukin-12
Clarithromycin (JP15/USP/INN)
Clarithromycin [USAN:INN:BAN:JAN]
Clarithromycin extended release
Clarithromycin suspension or tablets
Clarithromycina
Clarithromycine
Clarithromycine [INN-French]
Clarithromycinum
Clarithromycinum [INN-Latin]
Claritromicina
Claritromicina [INN-Spanish]
Clathromycin
Crixan
Crixan (TN)
Cyllid
Cyllind
DRG-0099
Erythromycin, 6-O-methyl-
Fromilid
Fromilid (TN);Infex (TN)
Helas
Heliclar
Hydro-2H-pyran-2-yl]oxy}-7-methoxy-3,5,7,9,11,13-hexame
Klabax
Klabax (TN)
Klacid
Klaciped
Klaricid
Klaricid (TN)
Klaricid H.P
Klaricid H.PKlaricid Pediatric
Klaricid XL
Klarid
Klarin
Klax
Kofron
Lactoferrin B & Clarithromycin
Lactoferrin H & Clarithromycin
Mabicrol
Macladin
Maclar
Mavid
Naxy
Naxy;Veclam
O(6)-methylerythromycin
SDP-015
TE-031
TE031
Veclam
Vikrol (TN)
Zeclar
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Structure
Formula
C38H69NO13
Molecular Weight
747.964
Canonical SMILES
CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O)OC
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InChI
InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
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InChIKey
AGOYDEPGAOXOCK-KCBOHYOISA-N
CAS
81103-11-9
116836-41-0
Physicochemical Property
logP
2.4397
Rotatable Bonds
8
Heavy Atom Count
52
Polar Areas
182.91
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
14
Complexity
52

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 84029
SID: 14937909
ChEMBL ID
CHEMBL1741
DrugBank ID
DB01211
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01546, ATP-dependent translocase ABCB1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000167 NIH-3T3-G185 Mus musculus (Mouse)  7
1
IC50 = 3800 nM
   TI
   LI
   LO
   TS
2
IC50 = 7200 nM
   TI
   LI
   LO
   TS
3
IC50 = 15100 nM
   TI
   LI
   LO
   TS
4
IC50 = 23800 nM
   TI
   LI
   LO
   TS
5
IC50 = 50200 nM
   TI
   LI
   LO
   TS
6
IC50 = 56100 nM
   TI
   LI
   LO
   TS
7
IC50 = 86700 nM
   TI
   LI
   LO
   TS
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 58884.37 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 46000 nM
2 IC50 = 58884.37 nM
Protein ID: PT03566, Solute carrier organic anion transporter family member 1B1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 3090.3 nM
   TI
   LI
   LO
   TS
Protein ID: PT03657, Solute carrier organic anion transporter family member 1B3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 3311.31 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Clarithromycin )
Drug Name Clarithromycin
Company Abbott Laboratories
Indication
Bacterial infection
Approved
Drug 2 ( Clarithromycin )
Drug Name Clarithromycin
Indication
Coronavirus Disease 2019 (COVID-19)
Phase 2