Compound Information

General Information of the Compound

Compound ID

CP0003832

Compound Name

Vorinostat

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Synonyms

M344

MK-0683

MK0683

Merck brand of Vorinostat

N'-hydroxy-N-phenyloctanediamide

N-Hydroxy-N'-phenyl octanediamide

N-Hyrdroxy-N'-phenyloctanediamide

N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide

N-hydroxy-N'-phenyloctanediamide

N1-hydroxy-N8-phenyloctanediamide

NHNPODA

OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE

SAHA

SAHA cpd

SAHA, Suberoylanilide hydroxamic acid

SHH

SKI390

SW-064652

Suberanilohydroxamic acid

Suberoylanilide hydroxamic acid

Vorinostat

Vorinostat (HDAC inhibitor)

Vorinostat (JAN/USAN)

Vorinostat MSD

Vorinostat [USAN]

WIN64652

Zolinza

Zolinza (TN)

Zolinza, MK-0683, SAHA

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Structure

Formula

C14H20N2O3

Molecular Weight

264.325

Canonical SMILES

ONC(=O)CCCCCCC(=O)Nc1ccccc1

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InChI

InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)

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InChIKey

WAEXFXRVDQXREF-UHFFFAOYSA-N

CAS

149647-78-9

Physicochemical Property

logP	2.4711
Rotatable Bonds	8
Heavy Atom Count	19
Polar Areas	78.43
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Complexity	19

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID

CID: 5311

SID: 14823867

ChEMBL ID

CHEMBL98

DrugBank ID

DB02546

Map of Molecular Bioactivity Related to the Compound

Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Compound

Protein ID: PT02011, 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000068	A-549 Cell Line Info	Homo sapiens (Human)	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 > 10000 nM

Protein ID: PT01462, Bromodomain-containing protein 4

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000018	HL-60 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 740 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 10 nM
2	IC50 = 43.13 nM
3	IC50 > 10000 nM
4	IC50 > 50000 nM

Protein ID: PT00285, Histone deacetylase

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000090	Schneider 2 Cell Line Info	Drosophila melanogaster (Fruit fly)	1
1	IC50 = 59 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 130 nM

Protein ID: PT00991, Histone deacetylase 1

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	25
1	IC50 = 5.5 nM Bioactivity Info	TI LI LO TS
2	IC50 = 9.1 nM Bioactivity Info	TI LI LO TS
3	IC50 = 10 nM Bioactivity Info	TI LI LO TS
4	IC50 = 11 nM Bioactivity Info	TI LI LO TS
5	IC50 = 13 nM Bioactivity Info	TI LI LO TS
6	IC50 = 19 nM Bioactivity Info	TI LI LO TS
7	IC50 = 23 nM Bioactivity Info	TI LI LO TS
8	IC50 = 25 nM Bioactivity Info	TI LI LO TS
9	IC50 = 26 nM Bioactivity Info	TI LI LO TS
10	IC50 = 31 nM Bioactivity Info	TI LI LO TS
11	IC50 = 32 nM Bioactivity Info	TI LI LO TS
12	IC50 = 33 nM Bioactivity Info	TI LI LO TS
13	IC50 = 35 nM Bioactivity Info	TI LI LO TS
14	IC50 = 44 nM Bioactivity Info	TI LI LO TS
15	IC50 = 45 nM Bioactivity Info	TI LI LO TS
16	IC50 = 50.12 nM Bioactivity Info	TI LI LO TS
17	IC50 = 63.5 nM Bioactivity Info	TI LI LO TS
18	IC50 = 79 nM Bioactivity Info	TI LI LO TS
19	IC50 = 80 nM Bioactivity Info	TI LI LO TS
20	IC50 = 81 nM Bioactivity Info	TI LI LO TS
21	IC50 = 85 nM Bioactivity Info	TI LI LO TS
22	IC50 = 99 nM Bioactivity Info	TI LI LO TS
23	IC50 = 101 nM Bioactivity Info	TI LI LO TS
24	IC50 = 110 nM Bioactivity Info	TI LI LO TS
25	IC50 = 111 nM Bioactivity Info	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	7
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
2	IC50 = 20 nM Bioactivity Info	TI LI LO TS
3	IC50 = 21 nM Bioactivity Info	TI LI LO TS
4	IC50 = 30 nM Bioactivity Info	TI LI LO TS
5	IC50 = 33 nM Bioactivity Info	TI LI LO TS
6	IC50 = 122 nM Bioactivity Info	TI LI LO TS
7	IC50 = 240 nM Bioactivity Info	TI LI LO TS
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	3
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
2	IC50 = 38 nM Bioactivity Info	TI LI LO TS
3	IC50 = 119 nM Bioactivity Info	TI LI LO TS
CL000162	HeLa S3 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 33 nM Bioactivity Info	TI LI LO TS
CL000023	BTI-Tn-5B1-4 Cell Line Info	Trichoplusia ni (Cabbage looper)	7
1	IC50 = 90 nM Bioactivity Info	TI LI LO TS
2	IC50 = 93.34 nM Bioactivity Info	TI LI LO TS
3	IC50 = 100 nM Bioactivity Info	TI LI LO TS
4	IC50 = 120 nM Bioactivity Info	TI LI LO TS
5	IC50 = 180 nM Bioactivity Info	TI LI LO TS
6	IC50 = 195 nM Bioactivity Info	TI LI LO TS
7	IC50 = 210.98 nM Bioactivity Info	TI LI LO TS
CL000034	Caco-2 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 119 nM Bioactivity Info	TI LI LO TS
CL000012	Sf21 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	IC50 = 306 nM Bioactivity Info	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CL000163	COLO 205 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 2200 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 4 nM
2	IC50 = 5 nM
3	IC50 = 5.2 nM
4	IC50 = 7 nM
5	IC50 = 8.9 nM
6	IC50 = 9 nM
7	IC50 = 9.7 nM
8	IC50 = 10 nM
9	IC50 = 10.68 nM
10	IC50 = 10.8 nM
11	IC50 = 11 nM
12	IC50 = 11.11 nM
13	IC50 = 11.34 nM
14	IC50 = 12 nM
15	IC50 = 13 nM
16	IC50 = 14 nM
17	IC50 = 14.15 nM
18	IC50 = 14.3 nM
19	IC50 = 14.4 nM
20	IC50 = 14.6 nM
21	IC50 = 15 nM
22	IC50 = 16 nM
23	IC50 = 17 nM
24	IC50 = 17.39 nM
25	IC50 = 18 nM
26	IC50 = 20 nM
27	IC50 = 20.9 nM
28	IC50 = 21 nM
29	IC50 = 22.37 nM
30	IC50 = 22.4 nM
31	IC50 = 22.7 nM
32	IC50 = 23 nM
33	IC50 = 25 nM
34	IC50 = 25.8 nM
35	IC50 = 27 nM
36	IC50 = 29 nM
37	IC50 = 30 nM
38	IC50 = 31 nM
39	IC50 = 33 nM
40	IC50 = 34 nM
41	IC50 = 34.6 nM
42	IC50 = 37.7 nM
43	IC50 = 38 nM
44	IC50 = 39.8 nM
45	IC50 = 39.91 nM
46	IC50 = 40 nM
47	IC50 = 41 nM
48	IC50 = 42 nM
49	IC50 = 42.5 nM
50	IC50 = 42.82 nM
51	IC50 = 43 nM
52	IC50 = 43.76 nM
53	IC50 = 43.9 nM
54	IC50 = 44 nM
55	IC50 = 45 nM
56	IC50 = 45.5 nM
57	IC50 = 46 nM
58	IC50 = 47.4 nM
59	IC50 = 47.95 nM
60	IC50 = 48 nM
61	IC50 = 49 nM
62	IC50 = 51.75 nM
63	IC50 = 52 nM
64	IC50 = 53.78 nM
65	IC50 = 54.6 nM
66	IC50 = 56 nM
67	IC50 = 59 nM
68	IC50 = 60.7 nM
69	IC50 = 61 nM
70	IC50 = 62.9 nM
71	IC50 = 65 nM
72	IC50 = 65.2 nM
73	IC50 = 65.4 nM
74	IC50 = 68 nM
75	IC50 = 68.1 nM
76	IC50 = 69 nM
77	IC50 = 71.8 nM
78	IC50 = 73 nM
79	IC50 = 75 nM
80	IC50 = 76 nM
81	IC50 = 77 nM
82	IC50 = 82 nM
83	IC50 = 87.4 nM
84	IC50 = 87.9 nM
85	IC50 = 88 nM
86	IC50 = 88.5 nM
87	IC50 = 89 nM
88	IC50 = 90 nM
89	IC50 = 91 nM
90	IC50 = 93.34 nM
91	IC50 = 93.6 nM
92	IC50 = 96 nM
93	IC50 = 101.98 nM
94	IC50 = 106 nM
95	IC50 = 110 nM
96	IC50 = 117 nM
97	IC50 = 119 nM
98	IC50 = 119.5 nM
99	IC50 = 120 nM
100	IC50 = 121 nM
101	IC50 = 131 nM
102	IC50 = 131.5 nM
103	IC50 = 136 nM
104	IC50 = 138.5 nM
105	IC50 = 140 nM
106	IC50 = 142 nM
107	IC50 = 150 nM
108	IC50 = 162.7 nM
109	IC50 = 170 nM
110	IC50 = 180 nM
111	IC50 = 180.3 nM
112	IC50 = 190 nM
113	IC50 = 200 nM
114	IC50 = 203.06 nM
115	IC50 = 219.3 nM
116	IC50 = 220 nM
117	IC50 = 236 nM
118	IC50 = 240 nM
119	IC50 = 258 nM
120	IC50 = 260 nM
121	IC50 = 270 nM
122	IC50 = 290 nM
123	IC50 = 300 nM
124	IC50 = 306 nM
125	IC50 = 310 nM
126	IC50 = 320 nM
127	IC50 = 350 nM
128	IC50 = 480 nM
129	IC50 = 600 nM
130	IC50 = 775 nM
131	Kd = 40 nM
132	Ki = 1.3 nM
133	Ki = 8 nM
134	Ki = 10 nM
135	Ki = 12 nM
136	Ki = 48 nM
137	Ki = 60 nM
138	Ki = 63 nM

Protein ID: PT03901, Histone deacetylase 1

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000160	A20 Cell Line Info	Mus musculus (Mouse)	2
1	IC50 = 112 nM Bioactivity Info	TI LI LO TS
2	Ki = 67.61 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 112 nM
2	IC50 = 112.2 nM
3	IC50 = 113.498789 nM
4	IC50 ~ 112 nM

Protein ID: PT02410, Histone deacetylase 11

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	2
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 1000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 51.3 nM
2	IC50 = 90 nM
3	IC50 = 100 nM
4	IC50 = 133 nM
5	IC50 = 200 nM
6	IC50 = 360 nM
7	IC50 = 362 nM
8	IC50 = 480 nM
9	IC50 = 5840 nM
10	IC50 = 12542 nM
11	IC50 = 34500 nM
12	IC50 = 40000 nM
13	IC50 = 73770 nM
14	IC50 > 1000 nM
15	IC50 > 5000 nM
16	IC50 > 10000 nM
17	IC50 > 100000 nM
18	Ki = 13 nM
19	Ki = 31 nM
20	Ki = 36 nM
21	Ki = 60 nM

Protein ID: PT00835, Histone deacetylase 2

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	12
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
2	IC50 = 31 nM Bioactivity Info	TI LI LO TS
3	IC50 = 51 nM Bioactivity Info	TI LI LO TS
4	IC50 = 70 nM Bioactivity Info	TI LI LO TS
5	IC50 = 91 nM Bioactivity Info	TI LI LO TS
6	IC50 = 91.6 nM Bioactivity Info	TI LI LO TS
7	IC50 = 146 nM Bioactivity Info	TI LI LO TS
8	IC50 = 174 nM Bioactivity Info	TI LI LO TS
9	IC50 = 200 nM Bioactivity Info	TI LI LO TS
10	IC50 = 214 nM Bioactivity Info	TI LI LO TS
11	IC50 = 230 nM Bioactivity Info	TI LI LO TS
12	IC50 = 398.11 nM Bioactivity Info	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 82 nM Bioactivity Info	TI LI LO TS
CL000162	HeLa S3 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 96 nM Bioactivity Info	TI LI LO TS
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 1.7 nM
2	IC50 = 10 nM
3	IC50 = 10.2 nM
4	IC50 = 11 nM
5	IC50 = 12 nM
6	IC50 = 13 nM
7	IC50 = 15 nM
8	IC50 = 16 nM
9	IC50 = 17 nM
10	IC50 = 18 nM
11	IC50 = 19 nM
12	IC50 = 21.61 nM
13	IC50 = 24 nM
14	IC50 = 26 nM
15	IC50 = 27 nM
16	IC50 = 28 nM
17	IC50 = 32 nM
18	IC50 = 33 nM
19	IC50 = 35 nM
20	IC50 = 36 nM
21	IC50 = 40 nM
22	IC50 = 52 nM
23	IC50 = 56 nM
24	IC50 = 66 nM
25	IC50 = 72 nM
26	IC50 = 73 nM
27	IC50 = 76 nM
28	IC50 = 82 nM
29	IC50 = 85.8 nM
30	IC50 = 89.23 nM
31	IC50 = 90 nM
32	IC50 = 93.22 nM
33	IC50 = 93.6 nM
34	IC50 = 96 nM
35	IC50 = 98.47 nM
36	IC50 = 100 nM
37	IC50 = 100.9 nM
38	IC50 = 110 nM
39	IC50 = 112.5 nM
40	IC50 = 114 nM
41	IC50 = 118 nM
42	IC50 = 120 nM
43	IC50 = 123.7 nM
44	IC50 = 128.9 nM
45	IC50 = 135 nM
46	IC50 = 137.2 nM
47	IC50 = 140 nM
48	IC50 = 149 nM
49	IC50 = 150 nM
50	IC50 = 153.1 nM
51	IC50 = 154.6 nM
52	IC50 = 156 nM
53	IC50 = 160 nM
54	IC50 = 163.6 nM
55	IC50 = 164 nM
56	IC50 = 167 nM
57	IC50 = 170 nM
58	IC50 = 173 nM
59	IC50 = 174.6 nM
60	IC50 = 176 nM
61	IC50 = 178 nM
62	IC50 = 180 nM
63	IC50 = 182 nM
64	IC50 = 184.7 nM
65	IC50 = 193 nM
66	IC50 = 197 nM
67	IC50 = 200 nM
68	IC50 = 210 nM
69	IC50 = 213 nM
70	IC50 = 220 nM
71	IC50 = 232 nM
72	IC50 = 240 nM
73	IC50 = 250 nM
74	IC50 = 256 nM
75	IC50 = 260 nM
76	IC50 = 280 nM
77	IC50 = 282 nM
78	IC50 = 332.65 nM
79	IC50 = 390 nM
80	IC50 = 400 nM
81	IC50 = 410 nM
82	IC50 = 411 nM
83	IC50 = 454 nM
84	IC50 = 550 nM
85	IC50 = 760 nM
86	IC50 = 780 nM
87	IC50 = 920 nM
88	IC50 = 921 nM
89	IC50 >= 50 nM
90	IC50 > 200 nM
91	Ki = 1.6 nM
92	Ki = 7 nM
93	Ki = 8 nM
94	Ki = 40 nM
95	Ki = 42 nM
96	Ki = 90 nM

Protein ID: PT00995, Histone deacetylase 3

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	4
1	IC50 = 6.57 nM Bioactivity Info	TI LI LO TS
2	IC50 = 6.8 nM Bioactivity Info	TI LI LO TS
3	IC50 = 20 nM Bioactivity Info	TI LI LO TS
4	IC50 = 29.7 nM Bioactivity Info	TI LI LO TS
CL000162	HeLa S3 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CL000131	HEK293-F Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 29 nM Bioactivity Info	TI LI LO TS
CL000012	Sf21 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	IC50 = 37 nM Bioactivity Info	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 57 nM Bioactivity Info	TI LI LO TS
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 106 nM Bioactivity Info	TI LI LO TS
CL000023	BTI-Tn-5B1-4 Cell Line Info	Trichoplusia ni (Cabbage looper)	7
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
2	IC50 = 120 nM Bioactivity Info	TI LI LO TS
3	IC50 = 140 nM Bioactivity Info	TI LI LO TS
4	IC50 = 158.17 nM Bioactivity Info	TI LI LO TS
5	IC50 = 170 nM Bioactivity Info	TI LI LO TS
6	IC50 = 181.05 nM Bioactivity Info	TI LI LO TS
7	IC50 = 232.08 nM Bioactivity Info	TI LI LO TS
CL000034	Caco-2 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 147 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 1.4 nM
2	IC50 = 3 nM
3	IC50 = 4 nM
4	IC50 = 12.6 nM
5	IC50 = 17 nM
6	IC50 = 18 nM
7	IC50 = 18.6 nM
8	IC50 = 19.1 nM
9	IC50 = 20 nM
10	IC50 = 21 nM
11	IC50 = 21.8 nM
12	IC50 = 26 nM
13	IC50 = 28 nM
14	IC50 = 28.1 nM
15	IC50 = 29 nM
16	IC50 = 29.5 nM
17	IC50 = 30 nM
18	IC50 = 31 nM
19	IC50 = 33 nM
20	IC50 = 33.1 nM
21	IC50 = 34 nM
22	IC50 = 35 nM
23	IC50 = 37 nM
24	IC50 = 38 nM
25	IC50 = 39.6 nM
26	IC50 = 40 nM
27	IC50 = 41 nM
28	IC50 = 45 nM
29	IC50 = 46 nM
30	IC50 = 48 nM
31	IC50 = 49 nM
32	IC50 = 50 nM
33	IC50 = 51 nM
34	IC50 = 52.99 nM
35	IC50 = 55 nM
36	IC50 = 56 nM
37	IC50 = 56.56 nM
38	IC50 = 56.8 nM
39	IC50 = 57 nM
40	IC50 = 62 nM
41	IC50 = 65.18 nM
42	IC50 = 67 nM
43	IC50 = 67.1 nM
44	IC50 = 70 nM
45	IC50 = 74.4 nM
46	IC50 = 81.76 nM
47	IC50 = 87.95 nM
48	IC50 = 90 nM
49	IC50 = 90.1 nM
50	IC50 = 100 nM
51	IC50 = 106 nM
52	IC50 = 107 nM
53	IC50 = 107.2 nM
54	IC50 = 108 nM
55	IC50 = 110 nM
56	IC50 = 126 nM
57	IC50 = 130 nM
58	IC50 = 132 nM
59	IC50 = 136 nM
60	IC50 = 140 nM
61	IC50 = 144.7 nM
62	IC50 = 146 nM
63	IC50 = 150 nM
64	IC50 = 153 nM
65	IC50 = 158.17 nM
66	IC50 = 170 nM
67	IC50 = 182 nM
68	IC50 = 200 nM
69	IC50 = 250 nM
70	IC50 = 261 nM
71	IC50 = 323 nM
72	IC50 = 350 nM
73	IC50 = 460 nM
74	IC50 = 517 nM
75	Ki = 5 nM
76	Ki = 12 nM
77	Ki = 29 nM
78	Ki = 36 nM

Protein ID: PT00994, Histone deacetylase 4

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000081	Jurkat E6.1 Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
2	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CL000023	BTI-Tn-5B1-4 Cell Line Info	Trichoplusia ni (Cabbage looper)	1
1	IC50 = 353.78 nM Bioactivity Info	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	4
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 12000 nM Bioactivity Info	TI LI LO TS
3	IC50 = 30710 nM Bioactivity Info	TI LI LO TS
4	IC50 > 100000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 54.3 nM
2	IC50 = 63.2 nM
3	IC50 = 100.9 nM
4	IC50 = 113 nM
5	IC50 = 150 nM
6	IC50 = 177.81477 nM
7	IC50 = 210 nM
8	IC50 = 300 nM
9	IC50 = 340 nM
10	IC50 = 490 nM
11	IC50 = 493 nM
12	IC50 = 1140 nM
13	IC50 = 2139 nM
14	IC50 = 6200 nM
15	IC50 = 6860.1 nM
16	IC50 = 7800 nM
17	IC50 = 8800 nM
18	IC50 = 37090 nM
19	IC50 = 41000 nM
20	IC50 = 48300 nM
21	IC50 = 74000 nM
22	IC50 = 76000 nM
23	IC50 > 200 nM
24	IC50 > 1000 nM
25	IC50 > 5000 nM
26	IC50 > 10000 nM
27	IC50 > 33000 nM
28	IC50 > 33330 nM
29	IC50 > 50000 nM
30	IC50 > 100000 nM
31	Ki = 16 nM
32	Ki = 20 nM
33	Ki = 14000 nM
34	Ki = 28400 nM

Protein ID: PT00996, Histone deacetylase 5

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	2
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 10510 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 107.3 nM
2	IC50 = 150 nM
3	IC50 = 378 nM
4	IC50 = 380 nM
5	IC50 = 400 nM
6	IC50 = 2180 nM
7	IC50 = 2480 nM
8	IC50 = 2580 nM
9	IC50 = 3000 nM
10	IC50 = 4600 nM
11	IC50 = 8750 nM
12	IC50 = 11000 nM
13	IC50 = 13800 nM
14	IC50 = 15000 nM
15	IC50 = 18440 nM
16	IC50 = 20000 nM
17	IC50 = 27000 nM
18	IC50 = 27200 nM
19	IC50 = 41500 nM
20	IC50 > 200 nM
21	IC50 > 5000 nM
22	IC50 > 10000 nM
23	IC50 > 30000 nM
24	Ki = 33 nM
25	Ki = 36 nM
26	Ki = 3600 nM
27	Ki = 12000 nM

Protein ID: PT01213, Histone deacetylase 6

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 21.7 nM Bioactivity Info	TI LI LO TS
2	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CL000072	A2780 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 399.25 nM Bioactivity Info	TI LI LO TS
CL000083	MCF-7 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 430 nM Bioactivity Info	TI LI LO TS
CL000068	A-549 Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 1030 nM Bioactivity Info	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	23
1	IC50 = 2.8 nM Bioactivity Info	TI LI LO TS
2	IC50 = 5 nM Bioactivity Info	TI LI LO TS
3	IC50 = 5.8 nM Bioactivity Info	TI LI LO TS
4	IC50 = 12 nM Bioactivity Info	TI LI LO TS
5	IC50 = 12.6 nM Bioactivity Info	TI LI LO TS
6	IC50 = 13 nM Bioactivity Info	TI LI LO TS
7	IC50 = 20 nM Bioactivity Info	TI LI LO TS
8	IC50 = 21 nM Bioactivity Info	TI LI LO TS
9	IC50 = 23 nM Bioactivity Info	TI LI LO TS
10	IC50 = 24.2 nM Bioactivity Info	TI LI LO TS
11	IC50 = 31 nM Bioactivity Info	TI LI LO TS
12	IC50 = 34.3 nM Bioactivity Info	TI LI LO TS
13	IC50 = 42 nM Bioactivity Info	TI LI LO TS
14	IC50 = 50 nM Bioactivity Info	TI LI LO TS
15	IC50 = 53 nM Bioactivity Info	TI LI LO TS
16	IC50 = 55 nM Bioactivity Info	TI LI LO TS
17	IC50 = 59.3 nM Bioactivity Info	TI LI LO TS
18	IC50 = 60 nM Bioactivity Info	TI LI LO TS
19	IC50 = 83 nM Bioactivity Info	TI LI LO TS
20	IC50 = 102 nM Bioactivity Info	TI LI LO TS
21	IC50 = 108 nM Bioactivity Info	TI LI LO TS
22	IC50 = 860 nM Bioactivity Info	TI LI LO TS
23	Ki < 35 nM Bioactivity Info	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	6
1	IC50 = 19 nM Bioactivity Info	TI LI LO TS
2	IC50 = 25 nM Bioactivity Info	TI LI LO TS
3	IC50 = 43 nM Bioactivity Info	TI LI LO TS
4	IC50 = 52 nM Bioactivity Info	TI LI LO TS
5	IC50 = 140 nM Bioactivity Info	TI LI LO TS
6	IC50 = 241 nM Bioactivity Info	TI LI LO TS
CL000162	HeLa S3 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 33 nM Bioactivity Info	TI LI LO TS
CL000023	BTI-Tn-5B1-4 Cell Line Info	Trichoplusia ni (Cabbage looper)	7
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
2	IC50 = 78.98 nM Bioactivity Info	TI LI LO TS
3	IC50 = 90 nM Bioactivity Info	TI LI LO TS
4	IC50 = 105.1 nM Bioactivity Info	TI LI LO TS
5	IC50 = 120 nM Bioactivity Info	TI LI LO TS
6	IC50 = 130 nM Bioactivity Info	TI LI LO TS
7	IC50 = 179.62 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 1.4 nM
2	IC50 = 2 nM
3	IC50 = 2.71 nM
4	IC50 = 3.9 nM
5	IC50 = 4.87 nM
6	IC50 = 5 nM
7	IC50 = 6.7 nM
8	IC50 = 6.9 nM
9	IC50 = 7.25 nM
10	IC50 = 7.7 nM
11	IC50 = 7.76 nM
12	IC50 = 8.8 nM
13	IC50 = 9 nM
14	IC50 = 9.1 nM
15	IC50 = 9.2 nM
16	IC50 = 9.3 nM
17	IC50 = 9.4 nM
18	IC50 = 10 nM
19	IC50 = 10.8 nM
20	IC50 = 11 nM
21	IC50 = 12 nM
22	IC50 = 13 nM
23	IC50 = 14 nM
24	IC50 = 14.5 nM
25	IC50 = 15 nM
26	IC50 = 15.1 nM
27	IC50 = 16.3 nM
28	IC50 = 17 nM
29	IC50 = 17.2 nM
30	IC50 = 17.4 nM
31	IC50 = 18 nM
32	IC50 = 18.5 nM
33	IC50 = 19 nM
34	IC50 = 19.4 nM
35	IC50 = 19.8 nM
36	IC50 = 20 nM
37	IC50 = 20.2 nM
38	IC50 = 21 nM
39	IC50 = 21.6 nM
40	IC50 = 23 nM
41	IC50 = 24 nM
42	IC50 = 24.25 nM
43	IC50 = 24.4 nM
44	IC50 = 25 nM
45	IC50 = 25.6 nM
46	IC50 = 26 nM
47	IC50 = 26.9 nM
48	IC50 = 27 nM
49	IC50 = 28 nM
50	IC50 = 28.6 nM
51	IC50 = 28.9 nM
52	IC50 = 29 nM
53	IC50 = 29.7 nM
54	IC50 = 30 nM
55	IC50 = 31 nM
56	IC50 = 32 nM
57	IC50 = 33 nM
58	IC50 = 33.1 nM
59	IC50 = 34 nM
60	IC50 = 35 nM
61	IC50 = 36 nM
62	IC50 = 38 nM
63	IC50 = 38.9 nM
64	IC50 = 39 nM
65	IC50 = 39.9 nM
66	IC50 = 40 nM
67	IC50 = 41.9 nM
68	IC50 = 42 nM
69	IC50 = 43 nM
70	IC50 = 47 nM
71	IC50 = 49 nM
72	IC50 = 50 nM
73	IC50 = 51 nM
74	IC50 = 52 nM
75	IC50 = 53 nM
76	IC50 = 54 nM
77	IC50 = 57.3 nM
78	IC50 = 60 nM
79	IC50 = 63 nM
80	IC50 = 65 nM
81	IC50 = 70 nM
82	IC50 = 70.83 nM
83	IC50 = 71 nM
84	IC50 = 72.34 nM
85	IC50 = 74 nM
86	IC50 = 75.9 nM
87	IC50 = 78.3 nM
88	IC50 = 78.98 nM
89	IC50 = 82 nM
90	IC50 = 85 nM
91	IC50 = 85.5 nM
92	IC50 = 88 nM
93	IC50 = 90 nM
94	IC50 = 91 nM
95	IC50 = 96 nM
96	IC50 = 98 nM
97	IC50 = 100 nM
98	IC50 = 109 nM
99	IC50 = 110 nM
100	IC50 = 110.6 nM
101	IC50 = 118 nM
102	IC50 = 144 nM
103	IC50 = 160 nM
104	IC50 = 169.5 nM
105	IC50 = 195 nM
106	IC50 = 196 nM
107	IC50 = 200 nM
108	IC50 = 202.11 nM
109	IC50 = 210 nM
110	IC50 = 226 nM
111	IC50 = 250 nM
112	IC50 = 340 nM
113	IC50 = 350 nM
114	IC50 = 400 nM
115	IC50 = 800 nM
116	IC50 = 5600 nM
117	Kd = 300 nM
118	Ki = 1 nM
119	Ki = 1.6 nM
120	Ki = 18 nM
121	Ki = 20 nM
122	Ki = 21 nM
123	Ki = 22 nM
124	Ki = 29 nM
125	Ki = 126 nM

Protein ID: PT01807, Histone deacetylase 7

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	3
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 35160 nM Bioactivity Info	TI LI LO TS
3	IC50 > 40000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 21.6 nM
2	IC50 = 34.4 nM
3	IC50 = 75.2 nM
4	IC50 = 102.4 nM
5	IC50 = 344 nM
6	IC50 = 500 nM
7	IC50 = 2480 nM
8	IC50 = 6110 nM
9	IC50 = 8200 nM
10	IC50 = 9600 nM
11	IC50 = 21000 nM
12	IC50 = 29290 nM
13	IC50 = 29760 nM
14	IC50 = 38900 nM
15	IC50 = 41000 nM
16	IC50 = 41800 nM
17	IC50 = 54910 nM
18	IC50 = 61020 nM
19	IC50 > 1000 nM
20	IC50 > 5000 nM
21	IC50 > 10000 nM
22	IC50 > 30000 nM
23	IC50 > 33000 nM
24	IC50 > 33330 nM
25	Kd = 36000 nM
26	Ki = 129 nM

Protein ID: PT01499, Histone deacetylase 8

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	11
1	IC50 = 8.8 nM Bioactivity Info	TI LI LO TS
2	IC50 = 44 nM Bioactivity Info	TI LI LO TS
3	IC50 = 328 nM Bioactivity Info	TI LI LO TS
4	IC50 = 497 nM Bioactivity Info	TI LI LO TS
5	IC50 = 540 nM Bioactivity Info	TI LI LO TS
6	IC50 = 543 nM Bioactivity Info	TI LI LO TS
7	IC50 = 980 nM Bioactivity Info	TI LI LO TS
8	IC50 = 1320 nM Bioactivity Info	TI LI LO TS
9	IC50 = 2139 nM Bioactivity Info	TI LI LO TS
10	IC50 = 3400.1 nM Bioactivity Info	TI LI LO TS
11	IC50 = 7300 nM Bioactivity Info	TI LI LO TS
CL000012	Sf21 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	IC50 = 1200 nM Bioactivity Info	TI LI LO TS
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 1989 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 10 nM
2	IC50 = 45 nM
3	IC50 = 82.96 nM
4	IC50 = 110 nM
5	IC50 = 119 nM
6	IC50 = 161 nM
7	IC50 = 172 nM
8	IC50 = 180 nM
9	IC50 = 188 nM
10	IC50 = 191.5 nM
11	IC50 = 193 nM
12	IC50 = 195 nM
13	IC50 = 205.2 nM
14	IC50 = 230 nM
15	IC50 = 232 nM
16	IC50 = 239 nM
17	IC50 = 240 nM
18	IC50 = 243 nM
19	IC50 = 250 nM
20	IC50 = 261 nM
21	IC50 = 272 nM
22	IC50 = 290 nM
23	IC50 = 300 nM
24	IC50 = 306 nM
25	IC50 = 310 nM
26	IC50 = 370 nM
27	IC50 = 400 nM
28	IC50 = 410 nM
29	IC50 = 425 nM
30	IC50 = 440 nM
31	IC50 = 442 nM
32	IC50 = 500 nM
33	IC50 = 540 nM
34	IC50 = 640 nM
35	IC50 = 645 nM
36	IC50 = 646 nM
37	IC50 = 660 nM
38	IC50 = 780 nM
39	IC50 = 820 nM
40	IC50 = 827 nM
41	IC50 = 960 nM
42	IC50 = 1000 nM
43	IC50 = 1020 nM
44	IC50 = 1030 nM
45	IC50 = 1100 nM
46	IC50 = 1140 nM
47	IC50 = 1152 nM
48	IC50 = 1200 nM
49	IC50 = 1260 nM
50	IC50 = 1279.3 nM
51	IC50 = 1337 nM
52	IC50 = 1350 nM
53	IC50 = 1374.7 nM
54	IC50 = 1500 nM
55	IC50 = 1524 nM
56	IC50 = 1532 nM
57	IC50 = 1600 nM
58	IC50 = 1680 nM
59	IC50 = 1700 nM
60	IC50 = 1800 nM
61	IC50 = 1860 nM
62	IC50 = 1890 nM
63	IC50 = 1989 nM
64	IC50 = 2000 nM
65	IC50 = 2185 nM
66	IC50 = 2290 nM
67	IC50 = 2736.9 nM
68	IC50 = 2800 nM
69	IC50 = 3295.01 nM
70	IC50 = 3970 nM
71	IC50 = 4300 nM
72	IC50 = 4800 nM
73	IC50 = 4890 nM
74	IC50 = 5120 nM
75	IC50 = 5300 nM
76	IC50 = 5600 nM
77	IC50 = 7468.5 nM
78	IC50 = 9590 nM
79	IC50 > 500 nM
80	IC50 > 1000 nM
81	IC50 > 5000 nM
82	IC50 > 10000 nM
83	Ka = 581395.3488 nM
84	Kd = 580 nM
85	Kd = 2900 nM
86	Ki = 173 nM
87	Ki = 205 nM
88	Ki = 396 nM
89	Ki = 480 nM
90	Ki = 700 nM
91	Ki = 5330 nM

Protein ID: PT01946, Histone deacetylase 9

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	3
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 15830 nM Bioactivity Info	TI LI LO TS
3	IC50 = 32260 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 20 nM
2	IC50 = 38 nM
3	IC50 = 107.2 nM
4	IC50 = 200 nM
5	IC50 = 316 nM
6	IC50 = 320 nM
7	IC50 = 3570 nM
8	IC50 = 7372.8 nM
9	IC50 = 22800 nM
10	IC50 = 49000 nM
11	IC50 = 51290 nM
12	IC50 = 64000 nM
13	IC50 = 80030 nM
14	IC50 > 5000 nM
15	IC50 > 10000 nM
16	IC50 > 33000 nM
17	IC50 > 33330 nM
18	Ki = 49 nM
19	Ki = 65 nM
20	Ki = 2000 nM

Protein ID: PT04880, Nuclear receptor subfamily 1 group I member 2

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000063	Hep-G2 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 2500 nM Bioactivity Info	TI LI LO TS

Protein ID: PT01552, Nuclear receptor subfamily 1 group I member 2

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000514	DPX2 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 35500 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	EC50 = 25100 nM

Protein ID: PT06124, Paired box protein Pax-8

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000097	RMG-I Cell Line Info	Homo sapiens (Human)	1
1	AC50 = 4580 nM Bioactivity Info	TI LI LO TS

Protein ID: PT01443, Polyamine deacetylase HDAC10

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 1258.93 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 47.5 nM
2	IC50 = 50 nM
3	IC50 = 58 nM
4	IC50 = 64 nM
5	IC50 = 68.4 nM
6	IC50 = 70 nM
7	IC50 = 72 nM
8	IC50 = 80 nM
9	IC50 = 91.8 nM
10	IC50 = 97 nM
11	IC50 = 100 nM
12	IC50 = 150 nM
13	IC50 = 170 nM
14	IC50 = 199.53 nM
15	IC50 = 200 nM
16	IC50 = 210 nM
17	IC50 = 238.1 nM
18	IC50 = 278 nM
19	IC50 = 430 nM
20	IC50 = 432 nM
21	IC50 = 456 nM
22	IC50 = 460 nM
23	IC50 = 686 nM
24	IC50 = 982 nM
25	Ki = 40 nM
26	Ki = 50 nM
27	Ki = 60 nM

Protein ID: PT02585, Proteasome subunit beta type-5

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000164	SEM Cell Line Info	Homo sapiens (Human)	1
1	IC50 > 25000 nM Bioactivity Info	TI LI LO TS
CL000165	SUP-B15 Cell Line Info	Homo sapiens (Human)	1
1	IC50 > 25000 nM Bioactivity Info	TI LI LO TS
CL000018	HL-60 Cell Line Info	Homo sapiens (Human)	1
1	IC50 > 25000 nM Bioactivity Info	TI LI LO TS

Protein ID: PT04279, Protein Tat

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000852	J-Lat 10.6 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 2300 nM Bioactivity Info	TI LI LO TS

Cell Viability or Cytotoxicity Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000001	Jurkat Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 590 nM	TI LI LO TS
2	IC50 = 1490 nM	TI LI LO TS
CL000002	K-562 Cell Line Info	Homo sapiens (Human)	3
1	IC50 = 650 nM	TI LI LO TS
2	IC50 = 670 nM	TI LI LO TS
3	IC50 = 1020 nM	TI LI LO TS
CL000016	IMR-32 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 620 nM	TI LI LO TS
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	3
1	CC50 = 460 nM	TI LI LO TS
2	IC50 = 1750 nM	TI LI LO TS
3	IC50 = 2200 nM	TI LI LO TS
CL000018	HL-60 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 2280 nM	TI LI LO TS
CL000048	PC-3 Cell Line Info	Homo sapiens (Human)	4
1	IC50 = 850 nM	TI LI LO TS
2	IC50 = 1210 nM	TI LI LO TS
3	IC50 = 1900 nM	TI LI LO TS
4	IC50 = 2580 nM	TI LI LO TS
CL000052	A-431 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 4200 nM	TI LI LO TS
CL000063	Hep-G2 Cell Line Info	Homo sapiens (Human)	5
1	GI50 = 21960 nM	TI LI LO TS
2	IC50 = 4100 nM	TI LI LO TS
3	IC50 = 9100 nM	TI LI LO TS
4	IC50 = 9300 nM	TI LI LO TS
5	IC50 = 23620 nM	TI LI LO TS
CL000067	HCT 116 Cell Line Info	Homo sapiens (Human)	6
1	CC50 = 1000 nM	TI LI LO TS
2	IC50 = 310 nM	TI LI LO TS
3	IC50 = 700 nM	TI LI LO TS
4	IC50 = 1310 nM	TI LI LO TS
5	IC50 = 1400 nM	TI LI LO TS
6	IC50 = 1900 nM	TI LI LO TS
CL000068	A-549 Cell Line Info	Homo sapiens (Human)	2
1	CC50 = 1800 nM	TI LI LO TS
2	IC50 = 1800 nM	TI LI LO TS
CL000073	A-498 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 25080 nM	TI LI LO TS
CL000083	MCF-7 Cell Line Info	Homo sapiens (Human)	4
1	CC50 = 3000 nM	TI LI LO TS
2	IC50 = 354 nM	TI LI LO TS
3	IC50 = 950 nM	TI LI LO TS
4	IC50 = 6700 nM	TI LI LO TS
CL000084	SK-OV-3 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 2200 nM	TI LI LO TS
CL000091	MV4-11 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 230 nM	TI LI LO TS
CL000099	SaOS-2 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 2300 nM	TI LI LO TS
CL000100	U-937 Cell Line Info	Homo sapiens (Human)	3
1	CC50 = 1050 nM	TI LI LO TS
2	EC50 = 880 nM	TI LI LO TS
3	IC50 = 4330 nM	TI LI LO TS
CL000111	MDA-MB-231 Cell Line Info	Homo sapiens (Human)	7
1	IC50 = 610 nM	TI LI LO TS
2	IC50 = 1110 nM	TI LI LO TS
3	IC50 = 1710 nM	TI LI LO TS
4	IC50 = 1730 nM	TI LI LO TS
5	IC50 = 1980 nM	TI LI LO TS
6	IC50 = 2200 nM	TI LI LO TS
7	IC50 = 7400 nM	TI LI LO TS
CL000119	DU145 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 2490 nM	TI LI LO TS
CL000141	LNCaP Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 2310 nM	TI LI LO TS
CL000145	NCI-H460 Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 1200 nM	TI LI LO TS
2	IC50 = 3400 nM	TI LI LO TS
CL000175	G-401 Cell Line Info	Homo sapiens (Human)	1
1	CC50 = 1000 nM	TI LI LO TS
CL000186	RPMI-8226 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 1250 nM	TI LI LO TS
CL000217	CAL-27 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 2640 nM	TI LI LO TS
CL000243	MCF-10A Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 420 nM	TI LI LO TS
2	IC50 = 1100 nM	TI LI LO TS
CL000261	SK-BR-3 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 2600 nM	TI LI LO TS
CL000423	IGROV-1 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 2200 nM	TI LI LO TS
CL000483	OPM-2 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 2910 nM	TI LI LO TS
CL000496	AsPC-1 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 100000 nM	TI LI LO TS
CL000591	HCT 15 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 3900 nM	TI LI LO TS
CL000627	OE19 Cell Line Info	Homo sapiens (Human)	1
1	GI50 = 1420 nM	TI LI LO TS

Clinical Information about the Compound

Drug 1 ( Vorinostat )

Drug Name	Vorinostat
Company	Merck
Indication	Cutaneous T-cell lymphoma Approved
Target(s)	Histone deacetylase 1 (HDAC1) Target Info Inhibitor

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han