General Information of the Protein
Protein ID
PT02410
Protein Name
Histone deacetylase 11
Gene Name
HDAC11
Sequence
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
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Organism
Homo sapiens, Human
Protein Classification
Epigenetic regulator
>
Eraser
>
Histone deacetylase
>
HDAC class IV
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
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Uniprot ID
Primary ID:
Q96DB2

Secondarily ID:
B4DDK1
Q9H6I7
Q9H6X3
Q9NTC9
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HGNC ID
HGNC:19086
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000023 , BTI-Tn-5B1-4
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0444962
 Compound Info 
5-cyclopropyl-N-[(1S)-1-[4-(hydroxycarbamoyl)phenyl]ethyl]-2-(5-phenyl-1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamide
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C25H22N4O3S2
  1
1
IC50 = 77.82 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0003580
 Compound Info 
Faridak
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C21H23N3O2
  1
1
IC50 = 121 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000131 , HEK293-F
 Cell Line Info 
Cell Line ID: CL000314 , HEK293T/17
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0008777
 Compound Info 
JNJ-26481585
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C21H26N6O2
  3
1 IC50 = 0.37 nM
2 Ki = 0.07 nM
3 Ki = 1300 nM
CP0003580
 Compound Info 
Faridak
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C21H23N3O2
  5
1 IC50 = 1.6 nM
2 IC50 = 2.7 nM
3 IC50 = 4112 nM
4 Ki = 3.5 nM
5 Ki = 1200 nM
CP0003676
 Compound Info 
N-hydroxy-2-[[2-(6-methoxypyridin-3-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl-methylamino]pyrimidine-5-carboxamide
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C23H24N8O4S
  2
1 IC50 = 5 nM
2 IC50 = 5.4 nM
CP0005479
 Compound Info 
CHEBI:46024
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C17H22N2O3
  9
1 IC50 = 10.6 nM
2 IC50 = 13.9 nM
3 IC50 = 15 nM
4 IC50 = 15.15 nM
5 IC50 = 15.2 nM
6 IC50 = 25 nM
7 IC50 = 31 nM
8 IC50 = 2110 nM
9 IC50 = 6830 nM
CP0003832
 Compound Info 
N'-hydroxy-N-phenyloctanediamide
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C14H20N2O3
  21
1 IC50 = 51.3 nM
2 IC50 = 90 nM
3 IC50 = 100 nM
4 IC50 = 133 nM
5 IC50 = 200 nM
6 IC50 = 360 nM
7 IC50 = 362 nM
8 IC50 = 480 nM
9 IC50 = 5840 nM
10 IC50 = 12542 nM
11 IC50 = 34500 nM
12 IC50 = 40000 nM
13 IC50 = 73770 nM
14 IC50 > 1000 nM
15 IC50 > 5000 nM
16 IC50 > 10000 nM
17 IC50 > 100000 nM
18 Ki = 13 nM
19 Ki = 31 nM
20 Ki = 36 nM
21 Ki = 60 nM
CP0016939
 Compound Info 
N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide
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C23H20N6O
  1
1 IC50 = 590 nM
CP0007846
 Compound Info 
N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide
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C20H21N3O2
  4
1 IC50 = 3790 nM
2 IC50 = 16000 nM
3 IC50 > 5000 nM
4 IC50 > 30000 nM
CP0057110
 Compound Info 
4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
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C19H23N3O3
  1
1 IC50 = 5140 nM
CP0029628
 Compound Info 
4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxybenzamide
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C17H17ClN2O2
  2
1 IC50 = 5720 nM
2 IC50 = 6000 nM
CP0004475
 Compound Info 
RICOLINOSTAT
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C24H27N5O3
  3
1 IC50 > 1000 nM
2 IC50 > 5000 nM
3 IC50 > 10000 nM
CP0544056
 Compound Info 
N-hydroxy-4-[[(2,3,4,5,6-pentafluorophenyl)sulfonylamino]methyl]benzamide
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C14H9F5N2O4S
  1
1 IC50 > 1000 nM
CP0115609
 Compound Info 
N-hydroxy-2-[2-[6-(6-methoxypyridin-3-yl)-4-methylquinazolin-8-yl]oxyethyl-methylamino]pyrimidine-5-carboxamide
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C23H23N7O4
  1
1 IC50 > 1000 nM
CP0015005
 Compound Info 
S-[(E)-4-[(4Z,7S,10S)-4-ethylidene-2,5,8,12-tetraoxo-7-propan-2-yl-9-oxa-16-thia-3,6,13,18-tetrazabicyclo[13.2.1]octadeca-1(17),15(18)-dien-10-yl]but-3-enyl] octanethioate
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C29H42N4O6S2
  1
1 IC50 > 10000 nM
CP0013041
 Compound Info 
HPOB
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C17H18N2O4
  1
1 IC50 > 10000 nM
CP0013235
 Compound Info 
(E)-3-[2-butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide
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C20H32Cl2N4O2
  1
1 Ki = 43 nM
Clinical Information about the Protein
Target 1 ( Histone deacetylase 11 (HDAC11) )
Target Type Patented-recorded Target