General Information of the Cell Line
Cell Line ID
CL000081
Cell Line Name
Jurkat E6.1
Synonyms
JurkatE6-1
Jurkat E6-1
Jurkat, Clone E6-1
Jurkat Clone E6-1
Jurkat (clone E6-1)
JURKAT E-6.1
JURKAT E-61
Jurkat-CloneE61
Jurkat-E6
Jurkat E6
J.E6-1
E6-1
Jurkat J6
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0367
Tissue Information
Peripheral blood
Disease
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01014, Cysteine protease CPP32
Compound ID Compound Name Compound Formula
CP0109684
Emricasan
   Show/Hide
C26H27F4N3O7
 1
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
CP0459236
(3S)-3-[[1-(cyclopropanecarbonyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C21H22F4N2O6
 1
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
CP0536428
(3S)-3-[[1-(cyclobutanecarbonyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C22H24F4N2O6
 1
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
CP0536429
(3S)-3-[[1-(cyclopentanecarbonyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C23H26F4N2O6
 1
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
CP0560102
(3S)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)-3-[[1-(thiophene-2-carbonyl)piperidine-4-carbonyl]amino]pentanoic acid
   Show/Hide
C22H20F4N2O6S
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0462290
(3S)-3-[[1-(2-chlorophenoxy)carbonylpiperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C24H21ClF4N2O7
 1
1
IC50 = 9 nM
   TI
   LI
   LO
   TS
CP0411317
(3S)-3-[(1-hexanoylpiperidine-4-carbonyl)amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C23H28F4N2O6
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0462254
(3S)-3-[[1-(3,3-difluorocyclobutanecarbonyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C22H22F6N2O6
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0526437
(3S)-3-[[1-(4-chlorobenzoyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C24H21ClF4N2O6
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0526440
(3S)-3-[[1-(2,2-dimethylpropanoyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C22H26F4N2O6
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0555845
(3S)-3-[[1-(2-methylpropanoyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C21H24F4N2O6
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0411315
(3S)-3-[[1-(2-methylphenoxy)carbonylpiperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C25H24F4N2O7
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0526438
(3S)-3-[(1-benzoylpiperidine-4-carbonyl)amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C24H22F4N2O6
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0536427
(3S)-3-[(1-cyclopentyloxycarbonylpiperidine-4-carbonyl)amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C23H26F4N2O7
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0555847
(3S)-4-oxo-3-[(1-phenoxycarbonylpiperidine-4-carbonyl)amino]-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C24H22F4N2O7
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0411316
(3S)-3-[[1-(2-fluorophenoxy)carbonylpiperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C24H21F5N2O7
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0521621
(3S)-3-[[1-(4,4-difluorocyclohexanecarbonyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C24H26F6N2O6
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0549825
(3S)-3-[[1-(1-benzothiophene-2-carbonyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C26H22F4N2O6S
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0526439
(3S)-3-[[1-(1,2-benzoxazole-3-carbonyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C25H21F4N3O7
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0412398
(3S)-3-[[1-(5-chlorothiophene-2-carbonyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C22H19ClF4N2O6S
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0412399
(3S)-3-[[1-(2-methoxyphenoxy)carbonylpiperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C25H24F4N2O8
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0526441
(3S)-3-[[1-(adamantane-1-carbonyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C28H32F4N2O6
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0545852
(3S)-3-[[1-(1,2-oxazole-3-carbonyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C21H19F4N3O7
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0412884
(3S)-3-[[(3R)-1-[2-(2-tert-butylanilino)-2-oxoacetyl]piperidine-3-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C29H31F4N3O7
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0545851
(3S)-3-[[1-(2-chlorobenzoyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C24H21ClF4N2O6
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0470495
(3S)-3-[[1-(3-chlorobenzoyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C24H21ClF4N2O6
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0411314
(3S)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)-3-[[1-[2-(trifluoromethyl)phenoxy]carbonylpiperidine-4-carbonyl]amino]pentanoic acid
   Show/Hide
C25H21F7N2O7
 1
1
IC50 = 24 nM
   TI
   LI
   LO
   TS
CP0383203
(3S)-4-oxo-3-[[1-[2-oxo-2-[2-(trifluoromethyl)anilino]acetyl]piperidine-4-carbonyl]amino]-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C26H22F7N3O7
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0555846
(3S)-3-[[1-(4-chlorophenoxy)carbonylpiperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C24H21ClF4N2O7
 1
1
IC50 = 26 nM
   TI
   LI
   LO
   TS
CP0462291
(3S)-3-[[1-[2-(2-cyanoanilino)-2-oxoacetyl]piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C26H22F4N4O7
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0558568
(3S)-3-[[1-[2-(2-fluoroanilino)-2-oxoacetyl]piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C25H22F5N3O7
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0462249
(3S)-3-[[1-(2-tert-butylphenoxy)carbonylpiperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C28H30F4N2O7
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0519794
(3S)-3-[[1-(cyclohexanecarbonyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C24H28F4N2O6
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0462289
(3S)-3-[[1-(3-chlorophenoxy)carbonylpiperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C24H21ClF4N2O7
 1
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0402795
(3S)-3-[[1-(2-anilino-2-oxoacetyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C25H23F4N3O7
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0459234
(3S)-3-[[1-(naphthalene-1-carbonyl)piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C28H24F4N2O6
 1
1
IC50 = 44 nM
   TI
   LI
   LO
   TS
CP0521623
(3S)-3-[[1-[2-(2-tert-butylanilino)-2-oxoacetyl]piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C29H31F4N3O7
 1
1
IC50 = 64 nM
   TI
   LI
   LO
   TS
CP0561776
(3S)-3-[[(1R,5R)-8-[2-(2-tert-butylanilino)-2-oxoacetyl]-8-azabicyclo[3.2.1]octane-2-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C31H33F4N3O7
 1
1
IC50 = 75 nM
   TI
   LI
   LO
   TS
CP0470496
(3S)-3-[[1-[2-(2-chloroanilino)-2-oxoacetyl]piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C25H22ClF4N3O7
 1
1
IC50 = 79 nM
   TI
   LI
   LO
   TS
CP0521622
(3S)-3-[[1-[2-(4-tert-butylanilino)-2-oxoacetyl]piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C29H31F4N3O7
 1
1
IC50 = 108 nM
   TI
   LI
   LO
   TS
CP0383943
(3S)-3-[[1-[2-(3-tert-butylanilino)-2-oxoacetyl]piperidine-4-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C29H31F4N3O7
 1
1
IC50 = 112 nM
   TI
   LI
   LO
   TS
CP0555848
(3S)-3-[3-[[2-(2-tert-butylanilino)-2-oxoacetyl]amino]propanoylamino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C26H27F4N3O7
 1
1
IC50 = 138 nM
   TI
   LI
   LO
   TS
CP0462292
(3S)-3-[[(3S)-1-[2-(2-tert-butylanilino)-2-oxoacetyl]piperidine-3-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C29H31F4N3O7
 1
1
IC50 = 142 nM
   TI
   LI
   LO
   TS
CP0520804
(3S)-3-[[1-[2-(2-tert-butylanilino)-2-oxoacetyl]pyrrolidine-3-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C28H29F4N3O7
 1
1
IC50 = 142 nM
   TI
   LI
   LO
   TS
CP0459273
(3S)-3-[[1-[2-(2-tert-butylanilino)-2-oxoacetyl]azetidine-3-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C27H27F4N3O7
 1
1
IC50 = 213 nM
   TI
   LI
   LO
   TS
CP0560103
(3S)-3-[[(1S,5R)-8-[2-(2-tert-butylanilino)-2-oxoacetyl]-8-azabicyclo[3.2.1]octane-3-carbonyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
   Show/Hide
C31H33F4N3O7
 1
1
IC50 = 244 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Peripheral blood)
Cell Line Name Organism Disease
SET-2 Homo sapiens (Human) Adult acute megakaryoblastic leukemia
Mono-Mac-6 Homo sapiens (Human) Adult acute monocytic leukemia
HL-60 Homo sapiens (Human) Adult acute myeloid leukemia
MOLM-13 Homo sapiens (Human) Adult acute myeloid leukemia
OCI-AML-2 Homo sapiens (Human) Adult acute myeloid leukemia
HL-60/ADR Homo sapiens (Human) Adult acute myeloid leukemia
MOLM-14 Homo sapiens (Human) Adult acute myeloid leukemia
HL60/MDR Homo sapiens (Human) Adult acute myeloid leukemia
HL60/MRP Homo sapiens (Human) Adult acute myeloid leukemia
NALM-6 Homo sapiens (Human) Adult B acute lymphoblastic leukemia
MOLT-4 Homo sapiens (Human) Adult T acute lymphoblastic leukemia
MOLT-4/CCR5 Homo sapiens (Human) Adult T acute lymphoblastic leukemia
Karpas-299 Homo sapiens (Human) Anaplastic large cell lymphoma, ALK-positive
M-07e Homo sapiens (Human) Childhood acute megakaryoblastic leukemia
THP-1 Homo sapiens (Human) Childhood acute monocytic leukemia
MV4-11 Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-Dual Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-Dual KO-STING Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-Blue ISG Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-ASC-GFP Homo sapiens (Human) Childhood acute monocytic leukemia
PMNL Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-Xblue Homo sapiens (Human) Childhood acute monocytic leukemia
SEM Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
SEMK2 Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
Reh Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
Jurkat Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CCRF-CEM Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CCRF/VCR1000 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM/VLB100 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM/VLB500 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM-SS Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
HPB-ALL Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CCRF-SB Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM-T4 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
J-Lat 10.6 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
12D7-MDR1 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
MDR CCRF vcr1000 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
FGS7 Jurkat Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
EoL-1 Homo sapiens (Human) Chronic eosinophilic leukemia, not otherwise specified
CII Homo sapiens (Human) Chronic lymphocytic leukemia
Ku812 Homo sapiens (Human) Chronic myelogenous leukemia, BCR-ABL1 positive
Ri-1 Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
Daudi Homo sapiens (Human) EBV-related Burkitt lymphoma
HEL Homo sapiens (Human) Erythroleukemia
UKE-1 Homo sapiens (Human) Essential thrombocythemia
L-1236 Homo sapiens (Human) Hodgkin lymphoma
Granta-519 Homo sapiens (Human) Mantle cell lymphoma
JeKo-1 Homo sapiens (Human) Mantle cell lymphoma
Mino Homo sapiens (Human) Mantle cell lymphoma
HMC-1 Homo sapiens (Human) Mast cell leukemia
NK-92 Homo sapiens (Human) Natural killer cell lymphoblastic leukemia/lymphoma
NK Homo sapiens (Human) Natural killer cell lymphoblastic leukemia/lymphoma
KHYG-1 Homo sapiens (Human) Natural killer cell lymphoblastic leukemia/lymphoma
RPMI-8226 Homo sapiens (Human) Plasma cell myeloma
OPM-2 Homo sapiens (Human) Plasma cell myeloma
U266B1 Homo sapiens (Human) Plasma cell myeloma
KMS-18 Homo sapiens (Human) Plasma cell myeloma
MM1.S Homo sapiens (Human) Plasma cell myeloma
MM1.R Homo sapiens (Human) Plasma cell myeloma
OPM-1 Homo sapiens (Human) Plasma cell myeloma
RPMI-8226/Dox40 Homo sapiens (Human) Plasma cell myeloma
HuT 78 Homo sapiens (Human) Sezary syndrome
H9 Homo sapiens (Human) Sezary syndrome
CREM010i-SS9-1 Homo sapiens (Human) Sickle cell disease
RBL-1 Rattus norvegicus (Rat) Rat leukemia
RBL-2H3 Rattus norvegicus (Rat) Rat leukemia
LCL Orang Asli K28 Homo sapiens (Human) -
JY Homo sapiens (Human) -
C.M.L. Homo sapiens (Human) -
BON Homo sapiens (Human) -
PBMC iPSC #1 Homo sapiens (Human) -
LCL 721 Homo sapiens (Human) -