| Compound ID |
Compound Name |
Compound Formula |
|
CP0054142
|
1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
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|
C22H22F3N5O
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0101971
|
1-methyl-6-(4-(2-(1-methylpiperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C23H24F3N5O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0261638
|
6-(4-(2-(1-((3,5-dimethylisoxazol-4-yl)methyl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C28H29F3N6O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0290727
|
2-(4-(2-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl)piperidin-1-yl)-N,N-dimethylacetamide
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|
C26H29F3N6O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0214860
|
1-(4-(1H-pyrrolo[3,2-c]pyridin-3-yl)piperidin-1-yl)-3-(5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl)propan-2-ol
Show/Hide
|
C29H33F3N6O3S
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0430431
|
2-[5-[1-[2-hydroxy-3-(4-pyridin-2-ylpiperidin-1-yl)propyl]-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-[(3R)-3-hydroxypyrrolidin-1-yl]ethanone
Show/Hide
|
C33H41F3N6O5S2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0479991
|
2-(5-(1-(2-hydroxy-3-(4-(pyridin-2-yl)piperidin-1-yl)propyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-2-(trifluoromethyl)phenylthio)-1-((S)-3-hydroxypyrrolidin-1-yl)ethanone
Show/Hide
|
C33H41F3N6O5S2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0178423
|
1-(4-(1H-pyrrolo[2,3-c]pyridin-3-yl)piperidin-1-yl)-3-(5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl)propan-2-ol
Show/Hide
|
C29H33F3N6O3S
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0227274
|
1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C26H25F3N6O2
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0302135
|
1-(1-(3-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C33H47F3N6O3S2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0494060
|
2-[5-[1-[2-hydroxy-3-(4-pyridin-2-ylpiperidin-1-yl)propyl]-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-pyrrolidin-1-ylethanone
Show/Hide
|
C32H39F3N6O2S
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0095635
|
(+/-)-1-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-(4-(pyridin-2-yl)piperidin-1-yl)propan-2-ol
Show/Hide
|
C34H45F3N6O3S2
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0054137
|
6-(4-(3-(4-ethylpiperazin-1-yl)propoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C24H27F3N6O
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0302134
|
1-(1-(3-(5-(methylsulfonyl)-3-(3-(2-(pyrrolidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C32H45F3N6O3S2
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0417728
|
2-[5-[5-acetyl-1-[2-hydroxy-3-(4-methylpiperidin-1-yl)propyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-pyrrolidin-1-ylethanone
Show/Hide
|
C30H40F3N5O3S
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0364318
|
(+/-)-1-(4-cyclopentylpiperidin-1-yl)-3-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propan-2-ol
Show/Hide
|
C34H50F3N5O3S2
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0062587
|
6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C20H20F3N5O
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0043426
|
1-methyl-6-(4-(3-(pyrrolidin-1-yl)propoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C22H22F3N5O
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0159011
|
1-(4-(1H-pyrrolo[3,2-b]pyridin-3-yl)piperidin-1-yl)-3-(5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl)propan-2-ol
Show/Hide
|
C29H33F3N6O3S
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0260746
|
(+/-)-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)(pyrrolidin-1-yl)methanone
Show/Hide
|
C34H49F3N6O4S2
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0089713
|
1-methyl-6-(4-(3-(4-methylpiperazin-1-yl)propoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C23H25F3N6O
|
1
|
| 1 |
IC50 = 106 nM
|
|
|
|
CP0462928
|
1-(1-(3-(3-(3-(2-(4-methylpiperazin-1-yl)-2-oxoethylthio)-4-(trifluoromethyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C33H46F3N7O4S2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0502387
|
2-[5-[5-acetyl-1-[2-hydroxy-3-[4-(2-hydroxypropan-2-yl)piperidin-1-yl]propyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-pyrrolidin-1-ylethanone
Show/Hide
|
C32H44F3N5O4S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0233538
|
(S)-1-(3-(3-(2-(4-fluoropiperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-(piperidin-1-yl)propan-2-ol
Show/Hide
|
C29H41F4N5O3S2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0504290
|
2-[5-[1-[2-hydroxy-3-[4-(2-methoxyphenyl)piperidin-1-yl]propyl]-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-pyrrolidin-1-ylethanone
Show/Hide
|
C34H42F3N5O3S
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0054150
|
1-methyl-6-(4-(2-(1-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C26H26F3N7O2
|
1
|
| 1 |
IC50 = 123 nM
|
|
|
|
CP0062141
|
1-(1-(3-(3-(3-(2-(4-methylpiperazin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C33H48F3N7O3S2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0308787
|
1-(4-(1H-pyrrolo[3,2-c]pyridin-3-yl)piperidin-1-yl)-3-(3-(4-bromophenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl)propan-2-ol
Show/Hide
|
C28H33BrN6O3S
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0307757
|
(+/-)-1-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C33H47F3N6O4S2
|
1
|
| 1 |
IC50 = 152 nM
|
|
|
|
CP0095325
|
(+/-)-2-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)benzonitrile
Show/Hide
|
C36H45F3N6O3S2
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0522054
|
2-hydroxy-1-[1-[2-hydroxy-3-(4-pyridin-2-ylpiperidin-1-yl)propyl]-3-[3-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone
Show/Hide
|
C34H41F3N6O5S
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0270778
|
(S)-2-(3-(3-(2-(4-fluoropiperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-1-(2-hydroxy-3-(piperidin-1-yl)propyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-2-oxoacetamide
Show/Hide
|
C30H40F4N6O3S
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0462930
|
2-[5-[1-[2-hydroxy-3-[4-(2-methoxyphenyl)piperidin-1-yl]propyl]-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-morpholin-4-ylethanone
Show/Hide
|
C35H44F3N5O6S2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0530082
|
(S)-1-(4,4'-bipiperidin-1-yl)-3-(3-(4-chloro-3-((4-chlorophenyl)ethynyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propan-2-ol
Show/Hide
|
C34H41Cl2N5O3S
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0270776
|
3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-1-(3-piperidin-1-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
Show/Hide
|
C37H40Cl2N6O
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0136628
|
4-(1-(3-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one
Show/Hide
|
C37H47F3N6O4S2
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0293907
|
(+/-)-1-(4-cyclopropylpiperazin-1-yl)-3-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propan-2-ol
Show/Hide
|
C31H45F3N6O3S2
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0224911
|
6-(4-(2-(1-acetylpiperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C24H24F3N5O2
|
1
|
| 1 |
IC50 = 235 nM
|
|
|
|
CP0370561
|
1-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-3-[4-(5-oxy-1H-pyrrolo[3,2-c]pyridin-3-yl)-piperidin-1-yl]-propan-2-ol
Show/Hide
|
C29H33F3N6O4S
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0043424
|
1-(3-(dimethylamino)propyl)-6-(4-ethoxy-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C21H22F3N5O
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0035631
|
1-methyl-6-(4-(2-(6-methylpyridin-2-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C23H18F3N5O
|
1
|
| 1 |
IC50 = 267 nM
|
|
|
|
CP0239592
|
2-[3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-1-(3-thiomorpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoacetamide
Show/Hide
|
C37H38Cl2N6O2S
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0479989
|
2-[5-[5-methylsulfonyl-1-[3-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]propyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-pyrrolidin-1-ylethanone
Show/Hide
|
C33H45F3N6O4S2
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0283409
|
1-methyl-6-(4-(2-(1-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C26H26F3N7O2
|
1
|
| 1 |
IC50 = 294 nM
|
|
|
|
CP0185712
|
2-[3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-1-(3-piperidin-1-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoacetamide
Show/Hide
|
C38H40Cl2N6O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0316229
|
5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-1-(3-(4-(pyrrolidin-1-yl)piperidin-1-yl)propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine
Show/Hide
|
C33H49F3N6O2S2
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0297790
|
(S)-(3-(3-(2-(4-fluoropiperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-1-(2-hydroxy-3-(piperidin-1-yl)propyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)(1H-1,2,4-triazol-3-yl)methanone
Show/Hide
|
C31H40F4N8O2S
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
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CP0062143
|
1-(1-(3-(3-(3-(2-(4-tert-butylpiperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C37H55F3N6O3S2
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0307756
|
(+/-)-1-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-(piperidin-1-yl)propan-2-ol
Show/Hide
|
C29H42F3N5O3S2
|
1
|
| 1 |
IC50 = 335 nM
|
|
|
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CP0308788
|
6-fluoro-3-(1-(3-(5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)-N-(2-morpholinoethyl)benzo[b]thiophene-2-carboxamide
Show/Hide
|
C37H44F4N6O4S2
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
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CP0495885
|
1-(1-(3-(3-(3-(2-(4-(hydroxymethyl)piperidin-1-yl)-2-oxoethylthio)-4-(trifluoromethyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C34H47F3N6O5S2
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
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CP0260740
|
1-(1-(3-(3-(3-(2-(4-hydroxypiperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C33H47F3N6O4S2
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
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CP0054139
|
1-methyl-6-(4-(2-(1-(methylsulfonyl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C23H24F3N5O3S
|
1
|
| 1 |
IC50 = 353 nM
|
|
|
|
CP0254347
|
5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-1-(3-(piperidin-1-yl)propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine
Show/Hide
|
C29H42F3N5O2S2
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0508045
|
2-[5-[1-[2-hydroxy-3-(4-pyridin-2-ylpiperidin-1-yl)propyl]-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-morpholin-4-ylethanone
Show/Hide
|
C33H41F3N6O5S2
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
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CP0269813
|
(+/-)-1-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-(pyrrolidin-1-yl)propan-2-ol
Show/Hide
|
C28H40F3N5O3S2
|
1
|
| 1 |
IC50 = 401 nM
|
|
|
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CP0286273
|
ethyl 3-[1-[2-hydroxy-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1H-indole-5-carboxylate
Show/Hide
|
C33H38F3N5O5S
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
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CP0086359
|
3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
Show/Hide
|
C36H38Cl2N6O2
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0520425
|
1-(1-(3-(5-(methylsulfonyl)-3-(3-(2-morpholino-2-oxoethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C32H43F3N6O5S2
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0233536
|
(+/-)-1-(5-(methylsulfonyl)-3-(3-(2-(pyrrolidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-(piperidin-1-yl)propan-2-ol
Show/Hide
|
C28H40F3N5O3S2
|
1
|
| 1 |
IC50 = 458 nM
|
|
|
|
CP0122579
|
1-(1-(3-(5-(methylsulfonyl)-3-(3-(2-(octahydroisoquinolin-2(1H)-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C37H53F3N6O3S2
|
1
|
| 1 |
IC50 = 460 nM
|
|
|
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CP0283495
|
1-(1-(3-(3-(3-(2-(benzylamino)ethylthio)-4-(trifluoromethyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C35H45F3N6O3S2
|
1
|
| 1 |
IC50 = 460 nM
|
|
|
|
CP0095308
|
5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-1-(3-(pyrrolidin-1-yl)propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine
Show/Hide
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C28H40F3N5O2S2
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0514347
|
2-[5-[1-[2-hydroxy-3-(4-pyridin-2-ylpiperidin-1-yl)propyl]-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-pyrrolidin-1-ylethanone
Show/Hide
|
C33H41F3N6O4S2
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0479992
|
2-hydroxy-1-[1-[2-hydroxy-3-[4-(2-methoxyphenyl)piperidin-1-yl]propyl]-3-[3-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone
Show/Hide
|
C36H44F3N5O6S
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0095636
|
(+/-)-1-(3-(3-(2-(4-fluoropiperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-(piperidin-1-yl)propan-2-ol
Show/Hide
|
C29H41F4N5O3S2
|
1
|
| 1 |
IC50 = 493 nM
|
|
|
|
CP0185713
|
2-[3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoacetamide
Show/Hide
|
C37H38Cl2N6O3
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0228427
|
3-[4-chloro-3-[2-[4-chloro-3-(piperidin-3-ylmethylcarbamoyl)phenyl]ethynyl]phenyl]-1-(3-thiomorpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
Show/Hide
|
C35H41Cl2N7O2S
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0479988
|
1-[1-[3-[3-[3-[2-(3-hydroxypyrrolidin-1-yl)-2-oxoethyl]sulfanyl-4-(trifluoromethyl)phenyl]-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]pyrrolidin-2-one
Show/Hide
|
C32H43F3N6O5S2
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0188325
|
2-[3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-1-[3-(4-phenylpiperazin-1-yl)propyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoacetamide
Show/Hide
|
C43H43Cl2N7O2
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
|
CP0156115
|
3-[4-chloro-3-[2-[4-chloro-3-(2-morpholin-4-ylethylcarbamoyl)phenyl]ethynyl]phenyl]-1-(3-thiomorpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
Show/Hide
|
C35H41Cl2N7O3S
|
1
|
| 1 |
IC50 = 610 nM
|
|
|
|
CP0228429
|
3-[4-chloro-3-[2-[4-chloro-3-[[(2S)-pyrrolidin-2-yl]methylcarbamoyl]phenyl]ethynyl]phenyl]-1-(3-thiomorpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
Show/Hide
|
C34H39Cl2N7O2S
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
|
CP0188324
|
3-[4-chloro-3-[2-[4-chloro-3-(piperazine-1-carbonyl)phenyl]ethynyl]phenyl]-1-(3-thiomorpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
Show/Hide
|
C33H37Cl2N7O2S
|
1
|
| 1 |
IC50 = 630 nM
|
|
|
|
CP0095305
|
1-(1-(3-(5-(methylsulfonyl)-3-(3-(2-morpholinoethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C32H45F3N6O4S2
|
1
|
| 1 |
IC50 = 680 nM
|
|
|
|
CP0239593
|
3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-1-[3-[4-(trifluoromethyl)piperidin-1-yl]propyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
Show/Hide
|
C38H39Cl2F3N6O
|
1
|
| 1 |
IC50 = 690 nM
|
|
|
|
CP0145805
|
3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-1-[3-(4-phenylpiperazin-1-yl)propyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
Show/Hide
|
C42H43Cl2N7O
|
1
|
| 1 |
IC50 = 710 nM
|
|
|
|
CP0457759
|
(S)-1-(3-(4-chloro-3-((4-chlorophenyl)ethynyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-(1'-methyl-4,4'-bipiperidin-1-yl)propan-2-ol
Show/Hide
|
C35H43Cl2N5O3S
|
1
|
| 1 |
IC50 = 720 nM
|
|
|
|
CP0168866
|
1-(1-(3-(3-(3,4-dichlorophenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one
Show/Hide
|
C29H34Cl2N6O3S
|
1
|
| 1 |
IC50 = 800 nM
|
|
|
|
CP0179285
|
3-(5-carbamoyl-3-(4-iodophenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl)-1-(4-(2-cyanophenyl)piperazin-1-yl)propan-2-yl carbamate
Show/Hide
|
C28H31IN8O3
|
1
|
| 1 |
IC50 = 800 nM
|
|
|
|
CP0200185
|
4-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one
Show/Hide
|
C30H34F3N5O5S
|
1
|
| 1 |
IC50 = 800 nM
|
|
|
|
CP0095306
|
1-(1-(3-(3-(3-(2-(4-methylpiperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C34H49F3N6O3S2
|
1
|
| 1 |
IC50 = 810 nM
|
|
|
|
CP0305743
|
(R)-1-(3-(3-(2-(4-fluoropiperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-(piperidin-1-yl)propan-2-ol
Show/Hide
|
C29H41F4N5O3S2
|
1
|
| 1 |
IC50 = 810 nM
|
|
|
|
CP0507593
|
1-[4-[2-[2-chloro-5-[5-methylsulfonyl-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]phenyl]ethynyl]phenyl]-N-[(4-methoxyphenyl)methyl]methanamine
Show/Hide
|
C37H42ClN5O4S
|
1
|
| 1 |
IC50 = 820 nM
|
|
|
|
CP0066962
|
1-methyl-6-(4-(pyridin-2-ylmethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C21H14F3N5O
|
1
|
| 1 |
IC50 = 853 nM
|
|
|
|
CP0066950
|
1-(2-(dimethylamino)ethyl)-6-(4-ethoxy-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C20H20F3N5O
|
1
|
| 1 |
IC50 = 854 nM
|
|
|
|
CP0331268
|
1-(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidin-1-yl)-3-(5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl)propan-2-ol
Show/Hide
|
C29H33F3N6O3S
|
1
|
| 1 |
IC50 = 860 nM
|
|
|
|
CP0185711
|
3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-1-(3-thiomorpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
Show/Hide
|
C36H38Cl2N6OS
|
1
|
| 1 |
IC50 = 870 nM
|
|
|
|
CP0244589
|
(+/-)-1-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-morpholinopropan-2-ol
Show/Hide
|
C28H40F3N5O4S2
|
1
|
| 1 |
IC50 = 889 nM
|
|
|
|
CP0401381
|
2-[5-[5-acetyl-1-[2-hydroxy-3-[4-(2-methoxyphenyl)piperidin-1-yl]propyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-morpholin-4-ylethanone
Show/Hide
|
C36H44F3N5O5S
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
|
CP0518647
|
4-[1-[2-hydroxy-3-[5-methylsulfonyl-3-[3-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1,4-benzoxazin-3-one
Show/Hide
|
C36H43F3N6O7S2
|
1
|
| 1 |
IC50 = 910 nM
|
|
|
|
CP0095628
|
1-(1-(3-(5-(methylsulfonyl)-3-(3-(2-(4-phenylpiperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C39H51F3N6O3S2
|
1
|
| 1 |
IC50 = 950 nM
|
|
|
|
CP0318812
|
2-[3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-1-[3-[(3R)-3-methylmorpholin-4-yl]propyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoacetamide
Show/Hide
|
C38H40Cl2N6O3
|
1
|
| 1 |
IC50 = 960 nM
|
|
|
|
CP0496212
|
(+/-)-N-(4-((2-chloro-5-(5-(methylsulfonyl)-1-(3-morpholinopropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)phenyl)ethynyl)benzyl)-1-phenylethanamine
Show/Hide
|
C37H42ClN5O3S
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0470598
|
N-[[4-[2-[2-chloro-5-[5-methylsulfonyl-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]phenyl]ethynyl]phenyl]methyl]-1-(4-methylphenyl)methanamine
Show/Hide
|
C37H42ClN5O3S
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0262863
|
N-[2-[3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethyl]acetamide
Show/Hide
|
C39H42Cl2N6O3
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0340860
|
N-ethyl-6-fluoro-3-[1-[3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1-benzothiophene-2-carboxamide
Show/Hide
|
C33H37F4N5O3S2
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0099327
|
1-methyl-6-(4-(2-(2-oxopyrrolidin-1-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
Show/Hide
|
C21H18F3N5O2
|
1
|
| 1 |
IC50 = 1420 nM
|
|
|
|
CP0318813
|
1-[4-[2-[2-chloro-5-[5-methylsulfonyl-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]phenyl]ethynyl]phenyl]-N-[(4-chlorophenyl)methyl]methanamine
Show/Hide
|
C36H39Cl2N5O3S
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0509363
|
2-(5-(1-(2-hydroxy-3-(4-(pyridin-2-yl)piperidin-1-yl)propyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-2-(trifluoromethyl)phenylthio)-1-(piperidin-1-yl)ethanone
Show/Hide
|
C34H43F3N6O4S2
|
1
|
| 1 |
IC50 = 1540 nM
|
|
|
|
CP0262861
|
3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-1-[3-[(3R)-3-methylmorpholin-4-yl]propyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
Show/Hide
|
C37H40Cl2N6O2
|
1
|
| 1 |
IC50 = 1540 nM
|
|
|
|
CP0514297
|
2-[5-[1-[2-hydroxy-3-(4-pyridin-2-ylpiperidin-1-yl)propyl]-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-morpholin-4-ylethanone
Show/Hide
|
C32H39F3N6O3S
|
1
|
| 1 |
IC50 = 1680 nM
|
|
|
|
CP0538103
|
(R)-2-(4-((2-chloro-5-(5-(methylsulfonyl)-1-(3-morpholinopropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)phenyl)ethynyl)benzylamino)-2-phenylethanol
Show/Hide
|
C37H42ClN5O4S
|
1
|
| 1 |
IC50 = 1700 nM
|
|
|
|
CP0142405
|
2-[3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-N,N-dimethyl-2-oxoacetamide
Show/Hide
|
C39H42Cl2N6O3
|
1
|
| 1 |
IC50 = 1750 nM
|
|
|
|
CP0128634
|
2-[3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-1-[3-[4-(trifluoromethyl)piperidin-1-yl]propyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoacetamide
Show/Hide
|
C39H39Cl2F3N6O2
|
1
|
| 1 |
IC50 = 1770 nM
|
|
|
|
CP0293053
|
methyl 6-fluoro-3-[1-[3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1-benzothiophene-2-carboxylate
Show/Hide
|
C32H34F4N4O4S2
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0504745
|
1-[4-[2-[2-chloro-5-[5-methylsulfonyl-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]phenyl]ethynyl]phenyl]-N-[(3,4-dichlorophenyl)methyl]methanamine
Show/Hide
|
C36H38Cl3N5O3S
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0490838
|
2-[5-[1-[2-hydroxy-3-[4-(2-methoxyphenyl)piperidin-1-yl]propyl]-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-morpholin-4-ylethanone
Show/Hide
|
C34H42F3N5O4S
|
1
|
| 1 |
IC50 = 1850 nM
|
|
|
|
CP0539615
|
1-(1-(3-(5-(methylsulfonyl)-3-(3-(2-oxo-2-(pyrrolidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
Show/Hide
|
C32H43F3N6O4S2
|
1
|
| 1 |
IC50 = 1970 nM
|
|
|
|
CP0307758
|
(+/-)-1-(5-(methylsulfonyl)-3-(3-(2-morpholinoethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-(piperidin-1-yl)propan-2-ol
Show/Hide
|
C28H40F3N5O4S2
|
1
|
| 1 |
IC50 = 2517 nM
|
|
|
|
CP0539616
|
2-[5-[1-[3-[4-(2-fluorophenyl)piperidin-1-yl]-2-hydroxypropyl]-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-morpholin-4-ylethanone
Show/Hide
|
C34H41F4N5O5S2
|
1
|
| 1 |
IC50 = 3130 nM
|
|
|
|
CP0518648
|
2-[5-[1-[3-[4-(3-methyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]propyl]-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-morpholin-4-ylethanone
Show/Hide
|
C31H40F3N7O5S2
|
1
|
| 1 |
IC50 = 3460 nM
|
|
|
|
CP0095630
|
4-(3-(5-(methylsulfonyl)-3-(3-(2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)morpholine
Show/Hide
|
C28H40F3N5O3S2
|
1
|
| 1 |
IC50 = 3570 nM
|
|
|
|
CP0401380
|
1-(1-(3-(5-(methylsulfonyl)-3-(3-(2-oxo-2-(piperidin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
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C33H45F3N6O4S2
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1
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| 1 |
IC50 = 3920 nM
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CP0485730
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N-[[4-[2-[2-chloro-5-[5-methylsulfonyl-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]phenyl]ethynyl]phenyl]methyl]-1-phenylmethanamine
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C36H40ClN5O3S
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1
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| 1 |
IC50 = 4200 nM
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CP0128637
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3-[4-chloro-3-[2-[4-[[(4-chlorophenyl)methylamino]methyl]phenyl]ethynyl]phenyl]-N,N-dimethyl-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-sulfonamide
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C37H42Cl2N6O3S
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1
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| 1 |
IC50 = 5000 nM
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CP0409174
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N-(2-aminoethyl)-6-fluoro-3-[1-[3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1-benzothiophene-2-carboxamide
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C33H38F4N6O3S2
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1
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| 1 |
IC50 = 5500 nM
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CP0494260
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N-[[4-[2-[2-chloro-5-[5-methylsulfonyl-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]phenyl]ethynyl]phenyl]methyl]-2-phenylethanamine
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C37H42ClN5O3S
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1
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| 1 |
IC50 = 5700 nM
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CP0430429
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1-(1-(3-(3-(3-(2-(2-methylpyrrolidin-1-yl)-2-oxoethylthio)-4-(trifluoromethyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
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C33H45F3N6O4S2
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1
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| 1 |
IC50 = 6000 nM
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CP0495884
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1-(1-(3-(3-(3-(2-(4-methylpiperidin-1-yl)-2-oxoethylthio)-4-(trifluoromethyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
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C34H47F3N6O4S2
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1
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| 1 |
IC50 = 8000 nM
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CP0348865
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6-fluoro-3-(1-(3-(5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)benzo[b]thiophene-2-carboxylic acid
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C31H32F4N4O4S2
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1
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| 1 |
IC50 > 10000 nM
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CP0374065
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1-(4-((2-chloro-5-(5-(methylsulfonyl)-1-(3-morpholinopropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)phenyl)ethynyl)phenyl)-N-methylmethanamine
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C30H36ClN5O3S
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1
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| 1 |
IC50 > 10000 nM
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CP0418694
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1-(3-(4-chloro-3-((4-chlorophenyl)ethynyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-morpholinopropan-2-ol
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C28H30Cl2N4O4S
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1
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| 1 |
IC50 > 10000 nM
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CP0418695
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tert-butyl 4-[3-[3-[4-chloro-3-[2-(4-chlorophenyl)ethynyl]phenyl]-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxypropyl]piperazine-1-carboxylate
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C33H39Cl2N5O5S
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1
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| 1 |
IC50 > 10000 nM
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CP0439196
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1-(3-(4-chloro-3-((4-chlorophenyl)ethynyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-(5,6-dihydropyridin-1(2H)-yl)propan-2-ol
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C29H32Cl2N4O3S
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1
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| 1 |
IC50 > 10000 nM
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CP0452448
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(S)-methyl 2-(4-((2-chloro-5-(5-(methylsulfonyl)-1-(3-morpholinopropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)phenyl)ethynyl)benzylamino)-2-phenylacetate
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C38H42ClN5O5S
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1
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| 1 |
IC50 > 10000 nM
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CP0469732
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N-[[4-[2-[2-chloro-5-[5-methylsulfonyl-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]phenyl]ethynyl]phenyl]methyl]benzamide
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C36H38ClN5O4S
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1
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| 1 |
IC50 > 10000 nM
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CP0469745
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1-(3-(3-(4-chloro-3-((4-chlorophenyl)ethynyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-2-hydroxypropyl)piperidine-4-carboxamide
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C30H33Cl2N5O4S
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1
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| 1 |
IC50 > 10000 nM
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CP0496211
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(4-((2-chloro-5-(5-(methylsulfonyl)-1-(3-morpholinopropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)phenyl)ethynyl)phenyl)methanamine
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C29H34ClN5O3S
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1
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| 1 |
IC50 = 10000 nM
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CP0496992
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(S)-tert-butyl 1'-(3-(3-(4-chloro-3-((4-chlorophenyl)ethynyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-2-hydroxypropyl)-4,4'-bipiperidine-1-carboxylate
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C39H49Cl2N5O5S
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1
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| 1 |
IC50 > 10000 nM
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CP0509780
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(R)-methyl 2-(4-((2-chloro-5-(5-(methylsulfonyl)-1-(3-morpholinopropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)phenyl)ethynyl)benzylamino)-2-phenylacetate
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C38H42ClN5O5S
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1
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| 1 |
IC50 > 10000 nM
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CP0509781
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1-(3-(4-chloro-3-((4-chlorophenyl)ethynyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-(piperazin-1-yl)propan-2-ol
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C28H31Cl2N5O3S
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1
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| 1 |
IC50 > 10000 nM
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CP0529904
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N-[[4-[2-[2-chloro-5-[5-methylsulfonyl-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]phenyl]ethynyl]phenyl]methyl]-N-methyl-1-phenylmethanamine
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C37H42ClN5O3S
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1
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| 1 |
IC50 > 10000 nM
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CP0530081
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(S)-1-(1'-(3-(3-(4-chloro-3-((4-chlorophenyl)ethynyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-2-hydroxypropyl)-4,4'-bipiperidin-1-yl)ethanone
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C36H43Cl2N5O4S
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1
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| 1 |
IC50 = 10000 nM
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CP0534173
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methyl 1-[3-[3-[4-chloro-3-[2-(4-chlorophenyl)ethynyl]phenyl]-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxypropyl]piperidine-4-carboxylate
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C31H34Cl2N4O5S
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1
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| 1 |
IC50 > 10000 nM
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CP0545686
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N-[[4-[2-[2-chloro-5-[5-methylsulfonyl-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]phenyl]ethynyl]phenyl]methyl]benzenesulfonamide
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C35H38ClN5O5S2
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1
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| 1 |
IC50 > 10000 nM
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CP0260743
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N-[2-[5-[1-[2-hydroxy-3-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]propyl]-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanylethyl]-2-phenylacetamide
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C36H45F3N6O5S2
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1
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| 1 |
IC50 > 10000 nM
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CP0430430
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2-[5-[1-[2-hydroxy-3-[(2S)-2-methylpiperidin-1-yl]propyl]-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-morpholin-4-ylethanone
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C29H40F3N5O5S2
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1
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| 1 |
IC50 = 10000 nM
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CP0510117
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N-benzyl-2-[5-[5-methylsulfonyl-1-[3-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]propyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanylacetamide
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C35H43F3N6O4S2
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1
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| 1 |
IC50 = 10000 nM
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CP0234034
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6-(4-ethoxy-3-(trifluoromethyl)phenyl)-1-(2-morpholinoethyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile
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C22H22F3N5O2
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1
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| 1 |
IC50 = 10000 nM
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CP0145803
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3-[4-chloro-3-[2-[4-(pyridin-3-ylmethoxymethyl)phenyl]ethynyl]phenyl]-1-(3-thiomorpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
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C35H37ClN6O2S
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1
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| 1 |
IC50 > 10000 nM
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CP0145804
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3-[4-chloro-3-[2-[4-[[(2S)-pyrrolidin-2-yl]methylcarbamoyl]phenyl]ethynyl]phenyl]-1-(3-thiomorpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
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C34H40ClN7O2S
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1
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| 1 |
IC50 > 10000 nM
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CP0270775
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3-[4-chloro-3-[2-[4-(pyridin-3-ylmethylcarbamoyl)phenyl]ethynyl]phenyl]-1-(3-thiomorpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
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C35H36ClN7O2S
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1
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| 1 |
IC50 > 10000 nM
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CP0318809
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3-[4-chloro-3-[2-[4-(morpholin-2-ylmethoxymethyl)phenyl]ethynyl]phenyl]-1-(3-thiomorpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
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C34H41ClN6O3S
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1
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| 1 |
IC50 > 10000 nM
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CP0318810
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3-[4-chloro-3-[2-[4-[(4-chlorophenyl)methylcarbamoyl]phenyl]ethynyl]phenyl]-1-(3-thiomorpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
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C36H36Cl2N6O2S
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1
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| 1 |
IC50 > 10000 nM
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