General Information of the Protein
Protein ID
PT01554
Protein Name
Integrin alpha-L
Secondarily
Protein Name
CD11 antigen-like family member A
Leukocyte adhesion glycoprotein LFA-1 alpha chain
Leukocyte function-associated molecule 1 alpha chain
Gene Name
ITGAL
Secondarily
Gene Name
CD11A
Sequence
MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
Function
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
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Uniprot ID
Primary ID:
P20701

Secondarily ID:
O43746
Q45H73
Q96HB1
Q9UBC8
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Ensembl ID
ENSG00000005844
HGNC ID
HGNC:6148
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000749 , HUVEC-C
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0094004
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]thiazole-7-carboxylic Acid
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C28H19Cl2N5O4S
  1
1
IC50 = 1.8 nM
 Bioactivity Info 
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CP0365998
 Compound Info 
4-((5S,9R)-7-(5-(1H-Tetrazol-5-yl)pyridin-2-yl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl)-benzonitrile
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C26H19Cl2N9O2
  1
1
IC50 = 1.8 nM
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CP0003162
 Compound Info 
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid
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C26H19Cl2N5O4
  1
1
IC50 = 2.5 nM
 Bioactivity Info 
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CP0300919
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)isonicotinic Acid
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C26H19Cl2N5O4
  1
1
IC50 = 3.6 nM
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CP0150410
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]oxazole-5-carboxylic Acid
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C28H19Cl2N5O5
  1
1
IC50 = 4 nM
 Bioactivity Info 
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CP0065983
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]thiazole-6-carboxylic Acid
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C28H19Cl2N5O4S
  1
1
IC50 = 4.4 nM
 Bioactivity Info 
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CP0297450
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]oxazole-7-carboxylic Acid
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C28H19Cl2N5O5
  1
1
IC50 = 4.8 nM
 Bioactivity Info 
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CP0265379
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)thiazole-5-carboxylicAcid
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C24H17Cl2N5O4S
  1
1
IC50 = 5 nM
 Bioactivity Info 
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CP0047191
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]oxazole-6-carboxylic Acid
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C28H19Cl2N5O5
  1
1
IC50 = 6 nM
 Bioactivity Info 
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CP0203549
 Compound Info 
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)pyrimidine-4-carboxylic Acid
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C25H18Cl2N6O4
  1
1
IC50 = 8 nM
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CP0115736
 Compound Info 
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinic Acid
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C27H21Cl2N5O4
  1
1
IC50 = 11 nM
 Bioactivity Info 
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CP0128627
 Compound Info 
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinonitrile
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C26H18Cl2N6O2
  1
1
IC50 = 11 nM
 Bioactivity Info 
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CP0315923
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)pyrimidine-5-carboxylic Acid
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C25H18Cl2N6O4
  1
1
IC50 = 11 nM
 Bioactivity Info 
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CP0325337
 Compound Info 
4-((5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dioxo-7-(pyridin-2-yl)-1,3,7-triazaspiro[4.4]nonan-9-yl)benzonitrile
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C25H19Cl2N5O2
  1
1
IC50 = 11 nM
 Bioactivity Info 
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CP0270351
 Compound Info 
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-2-methylnicotinic Acid
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C27H21Cl2N5O4
  1
1
IC50 = 12 nM
 Bioactivity Info 
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CP0325338
 Compound Info 
5-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)picolinonitrile
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C26H18Cl2N6O2
  1
1
IC50 = 12 nM
 Bioactivity Info 
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CP0316221
 Compound Info 
6-((5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dioxo-9-phenyl-1,3,7-triazaspiro[4.4]nonan-7-yl)pyridazine-3-carboxylic Acid
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C25H18Cl2N6O4
  1
1
IC50 = 13 nM
 Bioactivity Info 
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CP0009606
 Compound Info 
5-[(5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-DIOXO-1,3,7-TRIAZASPIRO [4.4]NON-7-YL]METHYL]-3-THIOPHENECARBOXYLICACID
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C26H20Cl2N4O4S
  1
1
IC50 = 18 nM
 Bioactivity Info 
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CP0106878
 Compound Info 
5-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)pyrazine-2-carboxylic Acid
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C25H18Cl2N6O4
  1
1
IC50 = 19 nM
 Bioactivity Info 
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CP0150409
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)pyrimidine-4-carboxylic Acid
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C25H18Cl2N6O4
  1
1
IC50 = 26 nM
 Bioactivity Info 
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CP0065984
 Compound Info 
4-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)picolinic Acid
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C26H19Cl2N5O4
  1
1
IC50 = 56 nM
 Bioactivity Info 
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CP0115737
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)oxazole-4-carboxylic Acid
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C24H17Cl2N5O5
  1
1
IC50 = 58 nM
 Bioactivity Info 
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CP0150411
 Compound Info 
4,4'-((5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,9-diyl)dibenzonitrile
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C27H19Cl2N5O2
  1
1
IC50 = 60 nM
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Cell Line ID: CL000147 , JY
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0300919
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)isonicotinic Acid
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C26H19Cl2N5O4
  1
1 IC50 = 50 nM
CP0003162
 Compound Info 
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid
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C26H19Cl2N5O4
  2
1 IC50 = 60 nM
2 IC50 = 276 nM
CP0297450
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]oxazole-7-carboxylic Acid
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C28H19Cl2N5O5
  1
1 IC50 = 70 nM
CP0094004
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]thiazole-7-carboxylic Acid
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C28H19Cl2N5O4S
  1
1 IC50 = 80 nM
CP0128627
 Compound Info 
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinonitrile
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C26H18Cl2N6O2
  1
1 IC50 = 80 nM
CP0365998
 Compound Info 
4-((5S,9R)-7-(5-(1H-Tetrazol-5-yl)pyridin-2-yl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl)-benzonitrile
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C26H19Cl2N9O2
  1
1 IC50 = 80 nM
CP0203549
 Compound Info 
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)pyrimidine-4-carboxylic Acid
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C25H18Cl2N6O4
  1
1 IC50 = 100 nM
CP0065984
 Compound Info 
4-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)picolinic Acid
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C26H19Cl2N5O4
  1
1 IC50 = 140 nM
CP0325338
 Compound Info 
5-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)picolinonitrile
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C26H18Cl2N6O2
  1
1 IC50 = 140 nM
CP0265379
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)thiazole-5-carboxylicAcid
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C24H17Cl2N5O4S
  1
1 IC50 = 170 nM
CP0325337
 Compound Info 
4-((5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dioxo-7-(pyridin-2-yl)-1,3,7-triazaspiro[4.4]nonan-9-yl)benzonitrile
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C25H19Cl2N5O2
  1
1 IC50 = 200 nM
CP0115736
 Compound Info 
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinic Acid
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C27H21Cl2N5O4
  1
1 IC50 = 240 nM
CP0315923
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)pyrimidine-5-carboxylic Acid
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C25H18Cl2N6O4
  1
1 IC50 = 260 nM
CP0316221
 Compound Info 
6-((5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dioxo-9-phenyl-1,3,7-triazaspiro[4.4]nonan-7-yl)pyridazine-3-carboxylic Acid
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C25H18Cl2N6O4
  1
1 IC50 = 270 nM
CP0009606
 Compound Info 
5-[(5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-DIOXO-1,3,7-TRIAZASPIRO [4.4]NON-7-YL]METHYL]-3-THIOPHENECARBOXYLICACID
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C26H20Cl2N4O4S
  2
1 IC50 = 276 nM
2 IC50 = 280 nM
CP0065983
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]thiazole-6-carboxylic Acid
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C28H19Cl2N5O4S
  1
1 IC50 = 280 nM
CP0270351
 Compound Info 
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-2-methylnicotinic Acid
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C27H21Cl2N5O4
  1
1 IC50 = 280 nM
CP0150409
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)pyrimidine-4-carboxylic Acid
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C25H18Cl2N6O4
  1
1 IC50 = 310 nM
CP0150410
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]oxazole-5-carboxylic Acid
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C28H19Cl2N5O5
  1
1 IC50 = 400 nM
CP0047191
 Compound Info 
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]oxazole-6-carboxylic Acid
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C28H19Cl2N5O5
  1
1 IC50 = 410 nM
CP0106878
 Compound Info 
5-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)pyrazine-2-carboxylic Acid
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C25H18Cl2N6O4
  1
1 IC50 = 1260 nM
Clinical Information about the Protein
Target 1 ( Integrin alpha-L (ITGAL) )
Target Type Successful Target
Disease 2 Target-related Diseases  2
1 Dry eye disease [ICD-11: 9E1Z]
2 Psoriasis vulgaris [ICD-11: EA90]
Approved Drug(s) 1 Approved Drug  1
1 lifitegrast
 Drug Info 
Approved
Dry eye disease
Discontinued Drug(s) 1 Discontinued Drug  1
1 BMS-587101
 Drug Info 
Discontinued in Phase 2
Psoriasis vulgaris