General Information of the Cell Line
Cell Line ID
CL000749
Cell Line Name
HUVEC-C
Synonyms
HUV-EC-C
HUVEC
Category
Finite cell line
Organism
Homo sapiens (Human)
Tissue Information
Umbilical vein
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01103, Bifunctional epoxide hydrolase 2
 Protein Info 
Compound ID Compound Name Compound Formula
CP0195121
 Compound Info 
US8501783, 1701
   Show/Hide
C17H29N3O3S
  1
1
IC50 = 3.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0336161
 Compound Info 
1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea
   Show/Hide
C19H19F3N4O3
  1
1
IC50 = 6.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0128937
 Compound Info 
1-(1-(isopropylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea
   Show/Hide
C16H22F3N3O3S
  1
1
IC50 = 13 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0248401
 Compound Info 
1-(1-(methylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea
   Show/Hide
C14H18F3N3O3S
  1
1
IC50 = 26 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0210899
 Compound Info 
1-cycloheptyl-3-(1-acetylpiperidin-4-yl)urea
   Show/Hide
C15H27N3O2
  1
1
IC50 = 27 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0210900
 Compound Info 
1-(1-acetylpiperidin-4-yl)-3-(4,4-dimethylcyclohexyl)urea
   Show/Hide
C16H29N3O2
  1
1
IC50 = 38 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036110
 Compound Info 
US10383835, Compound 1153
   Show/Hide
C18H29N3O2
  1
1
IC50 = 57 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0322133
 Compound Info 
3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)phenyl]urea
   Show/Hide
C15H18F3N3O3
  1
1
IC50 = 59 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0297178
 Compound Info 
1-(1-(isopropylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea
   Show/Hide
C16H22F3N3O4S
  1
1
IC50 = 64 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0371231
 Compound Info 
1-cyclohexyl-3-(1-picolinoylpiperidin-4-yl)urea
   Show/Hide
C18H26N4O2
  1
1
IC50 = 67 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0128031
 Compound Info 
1-(1-acetylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea
   Show/Hide
C15H18F3N3O2
  1
1
IC50 = 98 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0297180
 Compound Info 
1-(1-Acetyl-piperidin-4-yl)-3-bicyclo[2.2.1]hept-7-yl-urea
   Show/Hide
C15H25N3O2
  1
1
IC50 = 120 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0298232
 Compound Info 
1-(1-acetylpiperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)urea
   Show/Hide
C15H18F3N3O2
  1
1
IC50 = 226 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0265154
 Compound Info 
1-(1-acetylpiperidin-4-yl)-3-(4-tert-butylcyclohexyl)urea
   Show/Hide
C18H33N3O2
  1
1
IC50 = 270 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0226963
 Compound Info 
1-(1-Acetyl-piperidin-4-yl)-3-(4-methyl-bicyclo[2.2.2]oct-2-yl)-urea
   Show/Hide
C17H29N3O2
  1
1
IC50 = 300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT01575, Common acute lymphocytic leukemia antigen
 Protein Info 
Protein ID: PT01303, Endothelial lipase
 Protein Info 
Protein ID: PT01982, Endothelin-converting enzyme 1
 Protein Info 
Protein ID: PT01141, Focal adhesion kinase 1
 Protein Info 
Protein ID: PT01554, Integrin alpha-L
 Protein Info 
Protein ID: PT00973, Methionine aminopeptidase 2
 Protein Info 
Protein ID: PT02357, Neuropilin-1
 Protein Info 
Protein ID: PT01856, Nitric oxide synthase 3
 Protein Info 
Protein ID: PT00844, Platelet-derived growth factor receptor beta
 Protein Info 
Protein ID: PT04124, Proteinase-activated receptor 2
 Protein Info 
Protein ID: PT01033, Serine/threonine protein kinase PIK3CB
 Protein Info 
Protein ID: PT06898, Transcription factor SOX-18
 Protein Info 
Protein ID: PT02347, Tumor necrosis factor
 Protein Info 
Protein ID: PT01142, Vascular endothelial growth factor receptor 1
 Protein Info 
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
 Protein Info 
Protein ID: PT00925, Vascular endothelial growth factor receptor 3
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0002211
 Compound Info 
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
   Show/Hide
 C22H27FN4O2  1
1
IC50 = 11.8 nM
   TI
   LI
   LO
   TS
CP0012102
 Compound Info 
6-[5-[(2,4-difluorophenyl)sulfonylamino]-6-methoxypyridin-3-yl]-N-(2-morpholin-4-ylethyl)imidazo[1,2-a]pyridine-3-carboxamide
   Show/Hide
 C26H26F2N6O5S  1
1
IC50 = 2940 nM
   TI
   LI
   LO
   TS
CP0012103
 Compound Info 
6-[5-[(2,4-difluorophenyl)sulfonylamino]-6-methoxypyridin-3-yl]-N-(3-morpholin-4-ylpropyl)imidazo[1,2-a]pyridine-3-carboxamide
   Show/Hide
 C27H28F2N6O5S  1
1
IC50 = 3560 nM
   TI
   LI
   LO
   TS
CP0014985
 Compound Info 
BIBF-1120
   Show/Hide
 C31H33N5O4  2
1
EC50 = 9 nM
   TI
   LI
   LO
   TS
2
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0018963
 Compound Info 
3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]urea
   Show/Hide
 C20H13F4N5O2  1
1
IC50 = 2.6 nM
   TI
   LI
   LO
   TS
CP0024012
 Compound Info 
4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-amino)-[1,3,5]triazin-2-ol
   Show/Hide
 C20H20N6OS  1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0033646
 Compound Info 
AZD-9291
   Show/Hide
 C28H33N7O2  1
1
IC50 = 7278 nM
   TI
   LI
   LO
   TS
CP0038799
 Compound Info 
N-[6-[4-[(4-anilino-1,1,1-trifluoro-4-oxobutan-2-yl)amino]-2-fluorophenoxy]pyrimidin-4-yl]pyrrolidine-1-carboxamide
   Show/Hide
 C25H24F4N6O3  1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0039053
 Compound Info 
(R)-N-(2-(1-(2-(1-(2-fluorobenzoyl)piperidin-4-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
   Show/Hide
 C28H32F4N4O3  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0043052
 Compound Info 
FORETINIB
   Show/Hide
 C34H34F2N4O6  1
1
IC50 = 17.8 nM
   TI
   LI
   LO
   TS
CP0045281
 Compound Info 
AZD0530
   Show/Hide
 C27H32ClN5O5  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0062257
 Compound Info 
(R)-N-(2-(1-(2-(1-(2-chlorobenzoyl)piperidin-4-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
   Show/Hide
 C28H32ClF3N4O3  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0079520
 Compound Info 
1-N'-[4-[6-[3-(dimethylamino)propylcarbamoyl]-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl]oxy-3-fluorophenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
   Show/Hide
 C30H31F2N7O4  1
1
IC50 = 70.8 nM
   TI
   LI
   LO
   TS
CP0095364
 Compound Info 
(R)-N-(2-(1-(2-(1-(2,5-difluorobenzoyl)piperidin-4-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
   Show/Hide
 C28H31F5N4O3  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0095368
 Compound Info 
(R)-N-(2-(1-(2-(4-(2-chlorobenzoyl)piperazin-1-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
   Show/Hide
 C27H31ClF3N5O3  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0095877
 Compound Info 
(R)-N-(2-(1-(2-(4-(2,5-difluorobenzoyl)piperazin-1-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
   Show/Hide
 C27H30F5N5O3  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0137418
 Compound Info 
N-[4-[2-(1-ethylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2-oxoimidazolidine-1-carboxamide
   Show/Hide
 C28H22F2N6O3S  1
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
CP0159148
 Compound Info 
5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione
   Show/Hide
 C25H28N2O3S2  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0168060
 Compound Info 
(R)-N-(2-(1-(2-(4-benzoylpiperazin-1-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
   Show/Hide
 C27H32F3N5O3  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0219552
 Compound Info 
1-N'-[3-fluoro-4-[6-[2-hydroxy-3-(4-hydroxypiperidin-1-yl)propoxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
   Show/Hide
 C32H34F2N6O6  1
1
IC50 = 47.9 nM
   TI
   LI
   LO
   TS
CP0222762
 Compound Info 
N-(3,4-dichlorophenyl)-2H-chromene-3-carboxamide
   Show/Hide
 C16H11Cl2NO2  1
1
IC50 = 8400 nM
   TI
   LI
   LO
   TS
CP0396174
 Compound Info 
2-N-(4-aminocyclohexyl)-9-cyclopentyl-6-N-[4-(4-ethylpiperazin-1-yl)phenyl]purine-2,6-diamine
   Show/Hide
 C28H41N9  1
1
GI50 = 4439 nM
   TI
   LI
   LO
   TS
CP0408774
 Compound Info 
2-N-(4-aminobutyl)-9-cyclopentyl-6-N-[4-(4-ethylpiperazin-1-yl)phenyl]purine-2,6-diamine
   Show/Hide
 C26H39N9  1
1
GI50 = 11421 nM
   TI
   LI
   LO
   TS
CP0408781
 Compound Info 
CHEMBL4204373
   Show/Hide
 C27H38N8O  1
1
GI50 = 5866 nM
   TI
   LI
   LO
   TS
CP0434815
 Compound Info 
1-{2-Chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}urea
   Show/Hide
 C27H27ClF3N7O2  1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0449938
 Compound Info 
1-[3-[4-[1-adamantyl(phenyl)methyl]phenyl]propyl]piperidine
   Show/Hide
 C31H41N  2
1
GI50 = 3.27 nM
   TI
   LI
   LO
   TS
2
LC50 = 9.18 nM
   TI
   LI
   LO
   TS
CP0452777
 Compound Info 
1-[3-[4-[1-adamantyl(phenyl)methyl]phenyl]propyl]-4-methylpiperazine
   Show/Hide
 C31H42N2  1
1
GI50 = 2.98 nM
   TI
   LI
   LO
   TS
CP0476016
 Compound Info 
1-[4-[1-adamantyl(phenyl)methyl]phenyl]piperazine
   Show/Hide
 C27H34N2  2
1
GI50 = 4800 nM
   TI
   LI
   LO
   TS
2
LC50 = 100000 nM
   TI
   LI
   LO
   TS
CP0484791
 Compound Info 
2-N-(4-aminocyclohexyl)-9-cyclopentyl-6-N-[4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl]purine-2,6-diamine
   Show/Hide
 C27H36N8O  1
1
GI50 = 5947 nM
   TI
   LI
   LO
   TS
CP0500230
 Compound Info 
1-[[4-[1-adamantyl(phenyl)methyl]phenyl]methyl]-4-methylpiperazine
   Show/Hide
 C29H38N2  1
1
LC50 = 100 nM
   TI
   LI
   LO
   TS
CP0517268
 Compound Info 
1-[4-[1-adamantyl(phenyl)methyl]phenyl]-4-ethylpiperazine
   Show/Hide
 C29H38N2  1
1
LC50 = 9880 nM
   TI
   LI
   LO
   TS
CP0524983
 Compound Info 
1-[4-[1-adamantyl(phenyl)methyl]phenyl]-4-benzylpiperazine
   Show/Hide
 C34H40N2  1
1
LC50 = 100000 nM
   TI
   LI
   LO
   TS
CP0664754
 Compound Info 
(Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-phenylamino}-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid Methyl Ester
   Show/Hide
 C28H28N4O4  1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0674914
 Compound Info 
(Z)-3-({4-[(2-Imidazol-1-yl-acetyl)methylamino]-phenylamino}-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acidMethyl Ester
   Show/Hide
 C29H25N5O4  1
1
EC50 = 52 nM
   TI
   LI
   LO
   TS
CP0674916
 Compound Info 
(Z)-3-({4-[(2-Dimethylaminoethyl)-methanesulfonyl-amino]-phenylamino}-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic Acid Methyl Ester
   Show/Hide
 C28H30N4O5S  1
1
EC50 = 14 nM
   TI
   LI
   LO
   TS
CP0674917
 Compound Info 
(Z)-3-[(4-Dimethylaminomethyl-phenylamino)-phenyl-methylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic Acid Methyl Ester
   Show/Hide
 C26H25N3O3  1
1
EC50 = 28 nM
   TI
   LI
   LO
   TS
CP0674919
 Compound Info 
(Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic Acid Amide
   Show/Hide
 C28H28N4O2  1
1
EC50 = 342 nM
   TI
   LI
   LO
   TS
CP0675761
 Compound Info 
(Z)-3-({4-[N-Acetyl-(2-dimethylaminoethyl)-amino]-phenylamino}-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid Methyl Ester
   Show/Hide
 C29H30N4O4  1
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
CP0695291
 Compound Info 
(Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic Acid Methyl Ester
   Show/Hide
 C29H29N3O3  1
1
EC50 = 103 nM
   TI
   LI
   LO
   TS
CP0710221
 Compound Info 
(Z)-3-({4-[N-Acetyl-(3-dimethylaminopropyl)-amino]-phenylamino}-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid Methyl Ester
   Show/Hide
 C30H32N4O4  1
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
CP0731426
 Compound Info 
(Z)-6-Nitro-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-indolin-2-one
   Show/Hide
 C27H26N4O3  1
1
EC50 = 60 nM
   TI
   LI
   LO
   TS
CP0828600
 Compound Info 
(Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic Acid Isopropylamide
   Show/Hide
 C31H34N4O2  1
1
EC50 = 1070 nM
   TI
   LI
   LO
   TS
CP0858393
 Compound Info 
(Z)-6-Chloro-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-indolin-2-one
   Show/Hide
 C27H26ClN3O  1
1
EC50 = 49 nM
   TI
   LI
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   TS
CP0893260
 Compound Info 
(Z)-6-Amino-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-indolin-2-one
   Show/Hide
 C27H28N4O  1
1
EC50 = 414 nM
   TI
   LI
   LO
   TS
CP0893735
 Compound Info 
(Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic Acid Dimethylamide Hydrochloride
   Show/Hide
 C30H33ClN4O2  1
1
EC50 = 542 nM
   TI
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   TS
CP0915822
 Compound Info 
(Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic Acid Ethyl Ester
   Show/Hide
 C30H31N3O3  1
1
EC50 = 47 nM
   TI
   LI
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   TS
Protein family and CMB statistics Related to the Cell Line