Protein Information

General Information of the Protein

Protein ID	PT01103
Protein Name	Bifunctional epoxide hydrolase 2
Secondarily Protein Name	Epoxide hydratase Soluble epoxide hydrolase
Gene Name	EPHX2
Sequence	MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Protease > Serine protease > Serine protease SC clan > Serine protease S33 family
Function	Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12869654, PubMed:12574510, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:12869654, PubMed:12574510, PubMed:22798687, PubMed:21217101). Show/Hide
Uniprot ID	Primary ID: P34913 Secondarily ID: B2Z3B1 B3KTU8 B3KUA0 G3V134 J3KPH7 Q16764 Q9HBJ1 Q9HBJ2 Show/Hide
Ensembl ID	ENSG00000120915
HGNC ID	HGNC:3402
Subcellular Location	Cytoplasm Peroxisome

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000023 , BTI-Tn-5B1-4

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0043233 Compound Info	US9029401, 1728 (t-TUCB) Show/Hide	C21H21F3N2O5	3
1	IC50 = 0.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 156 nM Bioactivity Info	TI LI LO TS
3	Km > 200000 nM Bioactivity Info	TI LI LO TS
CP0107311 Compound Info	CHEMBL2397138 Show/Hide	C22H24F3N3O4	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0408751 Compound Info	2-[[4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]cyclohexyl]oxybenzoyl]amino]acetic acid Show/Hide	C23H24F3N3O6	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0416131 Compound Info	CHEMBL4207039 Show/Hide	C21H22F3N3O4	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0416132 Compound Info	1-[4-(4-hydroxyphenoxy)cyclohexyl]-3-[4-(trifluoromethoxy)phenyl]urea Show/Hide	C20H21F3N2O4	2
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
2	Ki = 9.1 nM Bioactivity Info	TI LI LO TS
CP0563295 Compound Info	US9029401, 1686 Show/Hide	C21H21F3N2O5	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0566670 Compound Info	N-(2-hydroxyethyl)-4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]cyclohexyl]oxybenzamide Show/Hide	C23H26F3N3O5	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0056943 Compound Info	4-[4-(1-adamantylcarbamoylamino)cyclohexyl]oxybenzoic acid Show/Hide	C24H32N2O4	1
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0408750 Compound Info	benzyl 4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]cyclohexyl]oxybenzoate Show/Hide	C28H27F3N2O5	2
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
2	Ki = 43 nM Bioactivity Info	TI LI LO TS
CP0415968 Compound Info	CHEMBL4203223 Show/Hide	C21H23F3N2O4	1
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0444323 Compound Info	CHEMBL4211405 Show/Hide	C21H23F3N2O4	1
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0547165 Compound Info	methyl 2-[[4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]cyclohexyl]oxybenzoyl]amino]acetate Show/Hide	C24H26F3N3O6	1
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0408749 Compound Info	CHEMBL4204023 Show/Hide	C21H21F3N2O4	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0415969 Compound Info	CHEMBL4214874 Show/Hide	C23H23F3N4O4	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0422821 Compound Info	[4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]cyclohexyl]oxyphenyl] acetate Show/Hide	C22H23F3N2O5	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0444326 Compound Info	US9029401, 2581 Show/Hide	C21H20F3N3O3	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0444328 Compound Info	N-benzyl-4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]cyclohexyl]oxybenzamide Show/Hide	C28H28F3N3O4	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0557860 Compound Info	propan-2-yl 4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]cyclohexyl]oxybenzoate Show/Hide	C24H27F3N2O5	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0560068 Compound Info	4-[4-(cyclohexylcarbamoylamino)cyclohexyl]oxybenzoic acid Show/Hide	C20H28N2O4	1
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0444325 Compound Info	4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]phenoxy]benzoic acid Show/Hide	C21H15F3N2O5	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0463816 Compound Info	CHEMBL4205926 Show/Hide	C22H23F3N2O5	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0532763 Compound Info	4-[4-[(4-chlorophenyl)carbamoylamino]cyclohexyl]oxybenzoic acid Show/Hide	C20H21ClN2O4	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0563260 Compound Info	4-[1-[[4-(trifluoromethoxy)phenyl]carbamoylamino]piperidin-4-yl]oxybenzoic acid Show/Hide	C20H20F3N3O5	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0532764 Compound Info	4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]butoxy]benzoic acid Show/Hide	C19H19F3N2O5	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0463818 Compound Info	CHEMBL4204930 Show/Hide	C20H21FN2O4	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0455937 Compound Info	CHEMBL4216616 Show/Hide	C20H22N2O4	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0042616 Compound Info	3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate Show/Hide	C20H22N2O3	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0444324 Compound Info	N-pyridin-3-yl-4-[[3-[4-(trifluoromethyl)phenoxy]phenyl]methyl]piperidine-1-carboxamide Show/Hide	C25H24F3N3O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000131 , HEK293-F

Cell Line Info

Cell Line ID: CL000063 , Hep-G2

Cell Line Info

Cell Line ID: CL000749 , HUVEC-C

Cell Line Info

Cell Line ID: CL000012 , Sf21

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0123327 Compound Info	(1R,3S)-N-[[4-cyano-2-(trifluoromethyl)phenyl]methyl]-3-[[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino]cyclohexane-1-carboxamide Show/Hide	C21H24F3N7O	5
1	IC50 = 0.027 nM
2	IC50 = 0.028 nM
3	IC50 = 0.9 nM
4	IC50 = 1.585 nM
5	IC50 = 110 nM
CP0055616 Compound Info	12-[(adamantan-1-ylcarbamoyl)amino]dodecanoic acid Show/Hide	C23H40N2O3	15
1	IC50 = 0.35 nM
2	IC50 = 0.6 nM
3	IC50 = 1.6 nM
4	IC50 = 1.9 nM
5	IC50 = 3 nM
6	IC50 = 3.2 nM
7	IC50 = 6.5 nM
8	IC50 = 7.8 nM
9	IC50 = 10 nM
10	IC50 = 10.3 nM
11	IC50 = 10.9 nM
12	IC50 = 59 nM
13	IC50 = 69 nM
14	IC50 = 100 nM
15	IC50 = 4400 nM
CP0313214 Compound Info	1-(2-adamantyl)-3-(2,3,4-trifluorophenyl)urea Show/Hide	C17H19F3N2O	1
1	IC50 = 0.4 nM
CP0313245 Compound Info	1-(1-adamantyl)-3-(2,3,4-trifluorophenyl)urea Show/Hide	C17H19F3N2O	2
1	IC50 = 0.4 nM
2	IC50 = 7.7 nM
CP0043233 Compound Info	US9029401, 1728 (t-TUCB) Show/Hide	C21H21F3N2O5	3
1	IC50 = 0.4 nM
2	IC50 = 0.9 nM
3	IC50 = 1 nM
CP0056943 Compound Info	CHEMBL242459 Show/Hide	C24H32N2O4	8
1	IC50 = 0.5 nM
2	IC50 = 0.8 nM
3	IC50 = 1 nM
4	IC50 = 1.3 nM
5	IC50 = 1.5 nM
6	IC50 = 2 nM
7	IC50 = 6.7 nM
8	Ki = 1.5 nM
CP0084935 Compound Info	N-[[4-bromo-2-(trifluoromethoxy)phenyl]methyl]-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide Show/Hide	C19H22BrF3N6O2	1
1	IC50 = 0.5 nM
CP0107311 Compound Info	CHEMBL2397138 Show/Hide	C22H24F3N3O4	1
1	IC50 = 0.5 nM
CP0444326 Compound Info	US9029401, 2581 Show/Hide	C21H20F3N3O3	1
1	IC50 = 0.5 nM
CP0563295 Compound Info	US9029401, 1686 Show/Hide	C21H21F3N2O5	1
1	IC50 = 0.6 nM
CP0210899 Compound Info	1-cycloheptyl-3-(1-acetylpiperidin-4-yl)urea Show/Hide	C15H27N3O2	1
1	IC50 = 0.8 nM
CP0086790 Compound Info	2-(2,4-dichlorophenyl)-1-(6-(methylsulfonyl)spiro[chroman-2,4'-piperidine]-1'-yl)ethanone Show/Hide	C22H23Cl2NO4S	1
1	IC50 = 1 nM
CP0040387 Compound Info	N-(4-chlorophenyl)-3-(2-hydroxyethyl)-3-phenylpiperidine-1-carboxamide Show/Hide	C20H23ClN2O2	1
1	IC50 = 1 nM
CP0148992 Compound Info	3-methyl-3-phenyl-N-((1S,2R)-2-phenylcyclopropyl)piperidine-1-carboxamide Show/Hide	C22H26N2O	1
1	IC50 = 1 nM
CP0149012 Compound Info	N-(4-chlorophenyl)-3-methyl-3-phenylpiperidine-1-carboxamide Show/Hide	C19H21ClN2O	1
1	IC50 = 1 nM
CP0149014 Compound Info	3-methyl-3-phenyl-N-(4-(pyridin-2-yl)benzyl)piperidine-1-carboxamide Show/Hide	C25H27N3O	1
1	IC50 = 1 nM
CP0084940 Compound Info	N-[[4-methoxy-2-(trifluoromethyl)phenyl]methyl]-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide Show/Hide	C20H25F3N6O2	1
1	IC50 = 1 nM
CP0084944 Compound Info	1-(4-methyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Show/Hide	C22H27F3N6O2	1
1	IC50 = 1 nM
CP0107687 Compound Info	1-[4-methyl-6-(propan-2-ylamino)-1,3,5-triazin-2-yl]-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Show/Hide	C21H27F3N6O	1
1	IC50 = 1 nM
CP0180177 Compound Info	1-[4-(methylamino)-6-phenyl-1,3,5-triazin-2-yl]-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Show/Hide	C24H25F3N6O	1
1	IC50 = 1 nM
CP0245375 Compound Info	1-[4-(2-methoxyethylamino)-6-methyl-1,3,5-triazin-2-yl]-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Show/Hide	C21H27F3N6O2	1
1	IC50 = 1 nM
CP0343011 Compound Info	1-[4-(dimethylamino)-6-methyl-1,3,5-triazin-2-yl]-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Show/Hide	C20H25F3N6O	1
1	IC50 = 1 nM
CP0062136 Compound Info	N-(4-chlorophenyl)-3-(3-hydroxypropyl)-3-phenylpiperidine-1-carboxamide Show/Hide	C21H25ClN2O2	1
1	IC50 = 1.3 nM
CP0046700 Compound Info	N-(4-chlorophenyl)-3-[3-(2,3-dihydro-1H-tetrazol-5-ylamino)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide Show/Hide	C22H26ClN7O2	1
1	IC50 = 1.4 nM
CP0572660 Compound Info	(1R,3S)-N-[[4-methoxy-2-(trifluoromethyl)phenyl]methyl]-3-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]cyclohexane-1-carboxamide Show/Hide	C22H22F3N5O5	1
1	IC50 = 1.43 nM
CP0297178 Compound Info	1-(1-(isopropylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea Show/Hide	C16H22F3N3O4S	1
1	IC50 = 1.6 nM
CP0336161 Compound Info	1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea Show/Hide	C19H19F3N4O3	1
1	IC50 = 1.6 nM
CP0195121 Compound Info	US8501783, 1701 Show/Hide	C17H29N3O3S	1
1	IC50 = 1.9 nM
CP0145084 Compound Info	(6-(methylsulfonyl)spiro[chroman-2,4'-piperidine]-1'-yl)(4-(trifluoromethyl)phenyl)methanone Show/Hide	C22H22F3NO4S	1
1	IC50 = 2 nM
CP0055486 Compound Info	1-[(1S,2R)-2-phenylcyclopropyl]-3-(1-phenylpiperidin-4-yl)urea Show/Hide	C21H25N3O	1
1	IC50 = 2.291 nM
CP0546725 Compound Info	11-(1-adamantylcarbamoylamino)undecanoic acid Show/Hide	C22H38N2O3	1
1	IC50 = 2.6 nM
CP0128937 Compound Info	1-(1-(isopropylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea Show/Hide	C16H22F3N3O3S	2
1	IC50 = 2.9 nM
2	Ki = 1.17 nM
CP0136351 Compound Info	(+/-)-6-fluoro-N-((trans)-2-phenylcyclopropyl)spiro[chroman-2,4'-piperidine]-1'-carboxamide Show/Hide	C23H25FN2O2	1
1	IC50 = 3 nM
CP0145078 Compound Info	(+/-)-6-(1-methyl-1H-pyrazol-5-ylamino)-4-oxo-N-((trans)-2-phenylcyclopropyl)spiro[chroman-2,4'-piperidine]-1'-carboxamide Show/Hide	C27H29N5O3	1
1	IC50 = 3 nM
CP0145083 Compound Info	6-(methylsulfonyl)-N-((trans)-2-phenylcyclopropyl)spiro[chroman-2,4'-piperidine]-1'-carboxamide Show/Hide	C24H28N2O4S	1
1	IC50 = 3 nM
CP0075226 Compound Info	N-(4-chlorophenyl)-3-(2-cyanoethyl)-3-phenylpiperidine-1-carboxamide Show/Hide	C21H22ClN3O	1
1	IC50 = 3 nM
CP0067542 Compound Info	1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea Show/Hide	C16H20F3N3O3	3
1	IC50 = 3.7 nM
2	IC50 = 12.8 nM
3	Ki = 0.91 nM
CP0248401 Compound Info	1-(1-(methylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea Show/Hide	C14H18F3N3O3S	2
1	IC50 = 3.7 nM
2	Ki = 7.16 nM
CP0322133 Compound Info	3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)phenyl]urea Show/Hide	C15H18F3N3O3	2
1	IC50 = 3.7 nM
2	IC50 = 12 nM
CP0316498 Compound Info	4-(2-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide Show/Hide	C20H19Cl2N3O2	1
1	IC50 = 3.9 nM
CP0069937 Compound Info	(+/-)-6-(1-methyl-1H-pyrazol-5-yl)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[chroman-2,4'-piperidine]-1'-carboxamide Show/Hide	C27H28N4O3	1
1	IC50 = 4 nM
CP0128491 Compound Info	spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl-[4-(trifluoromethyl)phenyl]methanone Show/Hide	C21H20F3NO2	1
1	IC50 = 4 nM
CP0035038 Compound Info	4-(3-(4-(methylsulfonyl)phenyl)-1,2,4-oxadiazol-5-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide Show/Hide	C24H26N4O4S	1
1	IC50 = 4 nM
CP0167547 Compound Info	N-[3-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)propyl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide Show/Hide	C24H22F4N2O4S	1
1	IC50 = 4 nM
CP0101879 Compound Info	1-[4-ethyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Show/Hide	C20H25F3N6O	1
1	IC50 = 4 nM
CP0252290 Compound Info	4-tert-butyl-N-[[2-chloro-4-(methanesulfonamido)phenyl]methyl]benzamide Show/Hide	C19H23ClN2O3S	1
1	IC50 = 4.1 nM
CP0307706 Compound Info	N-[(2,4-dichlorophenyl)methyl]-4-[4-(methylcarbamoyl)phenoxy]piperidine-1-carboxamide Show/Hide	C21H23Cl2N3O3	1
1	IC50 = 4.2 nM
CP0354376 Compound Info	4-(4-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide Show/Hide	C20H19Cl2N3O2	1
1	IC50 = 4.2 nM
CP0062445 Compound Info	N-[(2,4-dichlorophenyl)methyl]-4-phenoxypiperidine-1-carboxamide Show/Hide	C19H20Cl2N2O2	1
1	IC50 = 4.3 nM
CP0166335 Compound Info	N-[(2,4-dichlorophenyl)methyl]-4-(3-methylsulfonylphenoxy)piperidine-1-carboxamide Show/Hide	C20H22Cl2N2O4S	1
1	IC50 = 4.6 nM
CP0122841 Compound Info	N-[[2-(trifluoromethoxy)phenyl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide Show/Hide	C17H14F6N2O3	1
1	IC50 = 4.6 nM
CP0069782 Compound Info	N-[(2,4-dichlorophenyl)methyl]-4-(2-methylsulfonylphenoxy)piperidine-1-carboxamide Show/Hide	C20H22Cl2N2O4S	1
1	IC50 = 4.9 nM
CP0307705 Compound Info	4-(3-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide Show/Hide	C20H19Cl2N3O2	1
1	IC50 = 4.9 nM
CP0136346 Compound Info	N-[(1S,2R)-2-phenylcyclopropyl]spiro[3,4-dihydropyrano[3,2-b]pyridine-2,4'-piperidine]-1'-carboxamide Show/Hide	C22H25N3O2	1
1	IC50 = 5 nM
CP0108609 Compound Info	4-(5-(1-(2-phenylcyclopropylcarbamoyl)piperidin-4-yl)-1,2,4-oxadiazol-3-yl)benzoic acid Show/Hide	C24H24N4O4	1
1	IC50 = 5 nM
CP0040382 Compound Info	5-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3-yl)pentanoic acid Show/Hide	C23H27ClN2O3	1
1	IC50 = 5 nM
CP0046701 Compound Info	N-(4-chlorophenyl)-3-[3-(methylamino)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide Show/Hide	C22H26ClN3O2	1
1	IC50 = 5 nM
CP0074012 Compound Info	3-methyl-3-phenyl-N-(2-(quinoxalin-6-yl)ethyl)piperidine-1-carboxamide Show/Hide	C23H26N4O	1
1	IC50 = 5 nM
CP0096847 Compound Info	3-(3-amino-3-oxopropyl)-N-(4-chlorophenyl)-3-phenylpiperidine-1-carboxamide Show/Hide	C21H24ClN3O2	1
1	IC50 = 5 nM
CP0096854 Compound Info	3-(1-(4-chlorophenylcarbamoyl)-3-(4-(trifluoromethyl)phenyl)piperidin-3-yl)propanoic acid Show/Hide	C22H22ClF3N2O3	1
1	IC50 = 5 nM
CP0678151 Compound Info	N-(4-chlorophenyl)-3-(2-(2,3-dihydro-1H-tetrazol-5-yl)ethyl)-3-phenylpiperidine-1-carboxamide Show/Hide	C21H25ClN6O	1
1	IC50 = 5 nM
CP0307804 Compound Info	1-[2-methyl-6-(methylamino)pyrimidin-4-yl]-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Show/Hide	C20H24F3N5O	1
1	IC50 = 5 nM
CP0265634 Compound Info	N-[(2,4-dichlorophenyl)methyl]-4-[4-(methylsulfamoyl)phenoxy]piperidine-1-carboxamide Show/Hide	C20H23Cl2N3O4S	1
1	IC50 = 5.2 nM
CP0298811 Compound Info	N-[(2,4-dichlorophenyl)methyl]-4-(4-methylsulfonylphenoxy)piperidine-1-carboxamide Show/Hide	C20H22Cl2N2O4S	1
1	IC50 = 5.6 nM
CP0166334 Compound Info	4-(4-chlorophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide Show/Hide	C19H19Cl3N2O2	1
1	IC50 = 5.9 nM
CP0362371 Compound Info	N-[(3S)-3-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)propyl]-4-hydroxybenzamide Show/Hide	C23H22FNO4S	1
1	IC50 = 6 nM
CP0675924 Compound Info	4-cyano-N-[3-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)propyl]benzamide Show/Hide	C24H21FN2O3S	1
1	IC50 = 6 nM
CP0210900 Compound Info	1-(1-acetylpiperidin-4-yl)-3-(4,4-dimethylcyclohexyl)urea Show/Hide	C16H29N3O2	1
1	IC50 = 6 nM
CP0353378 Compound Info	N-[(2,4-dichlorophenyl)methyl]-4-(4-fluorophenoxy)piperidine-1-carboxamide Show/Hide	C19H19Cl2FN2O2	1
1	IC50 = 6.1 nM
CP0062447 Compound Info	4-(1-(2,4-dichlorobenzylcarbamoyl)piperidin-4-yloxy)benzoic acid Show/Hide	C20H20Cl2N2O4	1
1	IC50 = 6.4 nM
CP0371231 Compound Info	1-cyclohexyl-3-(1-picolinoylpiperidin-4-yl)urea Show/Hide	C18H26N4O2	1
1	IC50 = 6.4 nM
CP0162155 Compound Info	8-methoxy-N-[(1S,2R)-2-phenylcyclopropyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide Show/Hide	C21H23NO2	1
1	IC50 = 6.457 nM
CP0214723 Compound Info	N-[(2,4-dichlorophenyl)methyl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide Show/Hide	C15H11Cl2F3N2O2	1
1	IC50 = 6.6 nM
CP0127622 Compound Info	1-(6-fluorospiro[chroman-2,4'-piperidine]-1'-yl)-3-phenylpropan-1-one Show/Hide	C22H24FNO2	1
1	IC50 = 7 nM
CP0036110 Compound Info	US10383835, Compound 1153 Show/Hide	C18H29N3O2	5
1	IC50 = 7 nM
2	IC50 = 8 nM
3	IC50 = 13.8 nM
4	IC50 = 15 nM
5	Ki = 19.5 nM
CP0035157 Compound Info	N-(2-phenylcyclopropyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide Show/Hide	C26H25N5O2	1
1	IC50 = 7 nM
CP0035158 Compound Info	4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(4-(trifluoromethyl)phenyl)piperidine-1-carboxamide Show/Hide	C20H18F3N5O2	1
1	IC50 = 7 nM
CP0189226 Compound Info	N-(2-phenylcyclopropyl)-4-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide Show/Hide	C22H23N5O2	1
1	IC50 = 7 nM
CP0264731 Compound Info	N-[3-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)propyl]-4-methylsulfonylbenzamide Show/Hide	C24H24FNO5S2	1
1	IC50 = 7 nM
CP0092619 Compound Info	3-methyl-3-phenyl-N-(3-(pyridin-3-yl)propyl)piperidine-1-carboxamide Show/Hide	C21H27N3O	1
1	IC50 = 7 nM
CP0150798 Compound Info	N-[[4-(1H-indol-5-yl)phenyl]methyl]-3-methyl-3-phenylpiperidine-1-carboxamide Show/Hide	C28H29N3O	1
1	IC50 = 7 nM
CP0035034 Compound Info	4-(benzo[d]oxazol-2-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide Show/Hide	C22H23N3O2	1
1	IC50 = 7.5 nM
CP0071452 Compound Info	4'-oxo-N-((trans)-2-phenylcyclopropyl)-3',4'-dihydrospiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide Show/Hide	C22H23N3O3	1
1	IC50 = 8 nM
CP0152588 Compound Info	4'-hydroxy-N-((trans)-2-phenylcyclopropyl)-3',4'-dihydrospiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide Show/Hide	C22H25N3O3	1
1	IC50 = 8 nM
CP0035159 Compound Info	4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)piperidine-1-carboxamide Show/Hide	C23H25N5O2	1
1	IC50 = 8 nM
CP0048984 Compound Info	(S)-4-Cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide Show/Hide	C24H21FN2O3S	1
1	IC50 = 8 nM
CP0092495 Compound Info	N-[3-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)propyl]pyridine-3-carboxamide Show/Hide	C22H21FN2O3S	1
1	IC50 = 8 nM
CP0075231 Compound Info	3-(3-(biphenyl-4-yl)-1-(4-(trifluoromethoxy)phenylcarbamoyl)piperidin-3-yl)propanoic acid Show/Hide	C28H27F3N2O4	1
1	IC50 = 8 nM
CP0096852 Compound Info	N-(4-chlorophenyl)-3-(3-morpholin-4-yl-3-oxopropyl)-3-phenylpiperidine-1-carboxamide Show/Hide	C25H30ClN3O3	1
1	IC50 = 8 nM
CP0073406 Compound Info	N-(2-phenylcyclopropyl)-4-[3-[2-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide Show/Hide	C24H23F3N4O2	1
1	IC50 = 9 nM
CP0035156 Compound Info	4-(3-(isoquinolin-1-yl)-1,2,4-oxadiazol-5-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide Show/Hide	C26H25N5O2	1
1	IC50 = 10 nM
CP0298232 Compound Info	1-(1-acetylpiperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)urea Show/Hide	C15H18F3N3O2	1
1	IC50 = 10 nM
CP0102031 Compound Info	1-[4-methyl-6-(methylamino)pyridin-2-yl]-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Show/Hide	C21H25F3N4O	1
1	IC50 = 10 nM
CP0069942 Compound Info	6'-(methylsulfonyl)-N-((trans)-2-phenylcyclopropyl)spiro[azepane-4,2'-chroman]-1-carboxamide Show/Hide	C25H30N2O4S	1
1	IC50 = 11 nM
CP0128031 Compound Info	1-(1-acetylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea Show/Hide	C15H18F3N3O2	2
1	IC50 = 11 nM
2	Ki = 14.6 nM
CP0354375 Compound Info	N-[(2,4-dichlorophenyl)methyl]-4-[4-(trifluoromethoxy)phenoxy]piperidine-1-carboxamide Show/Hide	C20H19Cl2F3N2O3	1
1	IC50 = 12 nM
CP0075224 Compound Info	4-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3-yl)butanoic acid Show/Hide	C22H25ClN2O3	1
1	IC50 = 12 nM
CP0096848 Compound Info	N-(4-chlorophenyl)-3-[2-(dimethylamino)ethyl]-3-phenylpiperidine-1-carboxamide Show/Hide	C22H28ClN3O	1
1	IC50 = 12 nM
CP0157342 Compound Info	N-[[4-(4-methylsulfonylphenyl)phenyl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide Show/Hide	C23H21F3N2O4S	1
1	IC50 = 12 nM
CP0157343 Compound Info	N-[[4-bromo-2-(trifluoromethoxy)phenyl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide Show/Hide	C17H13BrF6N2O3	1
1	IC50 = 12 nM
CP0035052 Compound Info	N-(2-phenylcyclopropyl)-4-(3-pyrazin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide Show/Hide	C21H22N6O2	1
1	IC50 = 13 nM
CP0265154 Compound Info	1-(1-acetylpiperidin-4-yl)-3-(4-tert-butylcyclohexyl)urea Show/Hide	C18H33N3O2	1
1	IC50 = 13 nM
CP0035051 Compound Info	N-(2-phenylcyclopropyl)-4-(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide Show/Hide	C22H23N5O2	1
1	IC50 = 14 nM
CP0035162 Compound Info	N-[(1R,2S)-2-phenylcyclopropyl]-4-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide Show/Hide	C22H23N5O2	1
1	IC50 = 14 nM
CP0167548 Compound Info	(R)-4-Cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide Show/Hide	C24H21FN2O3S	1
1	IC50 = 14 nM
CP0201666 Compound Info	N-[(2-chloro-4-cyanophenyl)methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide Show/Hide	C17H13ClF3N3O2	1
1	IC50 = 14 nM
CP0226507 Compound Info	N-[[2-chloro-4-(methylsulfamoyl)phenyl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide Show/Hide	C17H17ClF3N3O4S	1
1	IC50 = 14 nM
CP0297180 Compound Info	1-(1-Acetyl-piperidin-4-yl)-3-bicyclo[2.2.1]hept-7-yl-urea Show/Hide	C15H25N3O2	1
1	IC50 = 14 nM
CP0069816 Compound Info	N-[(2,4-dichlorophenyl)methyl]-4-pyrimidin-2-yloxypiperidine-1-carboxamide Show/Hide	C17H18Cl2N4O2	3
1	IC50 = 15 nM
2	IC50 = 18 nM
3	IC50 = 63 nM
CP0214722 Compound Info	N-[(2-chloro-4-methylsulfonylphenyl)methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide Show/Hide	C17H16ClF3N2O4S	1
1	IC50 = 15 nM
CP0793909 Compound Info	N-[3-(4-Fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-hydroxy-nicotinamide Show/Hide	C22H21FN2O4S	1
1	IC50 = 16 nM
CP0277957 Compound Info	3-(1-(4-chlorophenylcarbamoyl)-3-(2-(trifluoromethyl)phenyl)piperidin-3-yl)propanoic acid Show/Hide	C22H22ClF3N2O3	1
1	IC50 = 16 nM
CP0069941 Compound Info	(+/-)-N-(2,3-dihydro-1H-inden-1-yl)-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxamide Show/Hide	C23H24N2O3	1
1	IC50 = 20 nM
CP0224412 Compound Info	1-[4,6-bis(methylamino)-1,3,5-triazin-2-yl]-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Show/Hide	C19H24F3N7O	1
1	IC50 = 20 nM
CP0124002 Compound Info	N-[[2-chloro-4-(tetrazol-1-yl)phenyl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide Show/Hide	C17H14ClF3N6O2	1
1	IC50 = 21 nM
CP0136208 Compound Info	N-[(3R)-3-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)propyl]-4-hydroxybenzamide Show/Hide	C23H22FNO4S	1
1	IC50 = 23 nM
CP0230275 Compound Info	1-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-3-(3,4-dichlorophenyl)urea Show/Hide	C22H17Cl2N3O2S	1
1	IC50 = 23 nM
CP0226963 Compound Info	1-(1-Acetyl-piperidin-4-yl)-3-(4-methyl-bicyclo[2.2.2]oct-2-yl)-urea Show/Hide	C17H29N3O2	1
1	IC50 = 25 nM
CP0035032 Compound Info	4-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide Show/Hide	C18H22N4O2	1
1	IC50 = 28 nM
CP0074011 Compound Info	N-[2-(3H-benzimidazol-5-yl)ethyl]-3-methyl-3-phenylpiperidine-1-carboxamide Show/Hide	C22H26N4O	1
1	IC50 = 29 nM
CP0580240 Compound Info	N-[[4-(cyclopropylsulfonylamino)-2-(trifluoromethyl)phenyl]methyl]-1H-indole-5-carboxamide Show/Hide	C20H18F3N3O3S	1
1	IC50 = 29.4 nM
CP0108610 Compound Info	N-(2-phenylcyclopropyl)-4-(3-pyrimidin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide Show/Hide	C21H22N6O2	1
1	IC50 = 33 nM
CP0108613 Compound Info	4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)piperidine-1-carboxamide Show/Hide	C24H27N5O2	1
1	IC50 = 36 nM
CP0234730 Compound Info	1-(2-methyl-1,3-benzoxazol-5-yl)-3-[(1S,2R)-2-phenylcyclopropyl]urea Show/Hide	C18H17N3O2	1
1	IC50 = 39.81 nM
CP0231165 Compound Info	N-(benzenesulfonyl)-4-[[5-(cyclohexylcarbamoylamino)-1-methylindol-3-yl]methyl]-3-methoxybenzamide Show/Hide	C31H34N4O5S	1
1	IC50 = 43 nM
CP0095291 Compound Info	2-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3-yl)acetic acid Show/Hide	C20H21ClN2O3	1
1	IC50 = 52 nM
CP0035031 Compound Info	4-(1,2,4-oxadiazol-3-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide Show/Hide	C17H20N4O2	1
1	IC50 = 54 nM
CP0035026 Compound Info	4-(1-methyl-1H-1,2,3-triazol-4-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide Show/Hide	C18H23N5O	1
1	IC50 = 120 nM
CP0035160 Compound Info	N-(2,3-dihydro-1H-inden-2-yl)-4-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide Show/Hide	C22H23N5O2	1
1	IC50 = 130 nM
CP0073403 Compound Info	4-(1,3,4-oxadiazol-2-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide Show/Hide	C17H20N4O2	1
1	IC50 = 235 nM
CP0198883 Compound Info	N-(2-phenylcyclopropyl)-4-(triazol-1-yl)piperidine-1-carboxamide Show/Hide	C17H21N5O	1
1	IC50 = 430 nM
CP0035029 Compound Info	N-(2-phenylcyclopropyl)-4-pyrazol-1-ylpiperidine-1-carboxamide Show/Hide	C18H22N4O	1
1	IC50 = 480 nM
CP0035030 Compound Info	4-(3-hydroxy-4-methylisoxazol-5-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide Show/Hide	C19H23N3O3	1
1	IC50 = 1100 nM
CP0189223 Compound Info	N-(2-phenylcyclopropyl)-4-(1,2,4-triazol-1-yl)piperidine-1-carboxamide Show/Hide	C17H21N5O	1
1	IC50 = 1100 nM
CP0035028 Compound Info	4-(4-methyl-4H-1,2,4-triazol-3-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide Show/Hide	C18H23N5O	1
1	IC50 = 8400 nM

Clinical Information about the Protein

Target 1 ( Soluble epoxide hydrolase (EPHX2) )

Target Type	Clinical trial Target
Disease	2 Target-related Diseases				2
1	Hypertension [ICD-11: BA00-BA04]
2	Chronic obstructive pulmonary disease [ICD-11: CA22]
Clinical Trial Drug(s)	2 Clinical Trial Drugs				2
1	AR9281	Drug Info	Phase 2	Hypertension
2	GSK2256294	Drug Info	Phase 1	Chronic obstructive pulmonary disease

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT01106	Bifunctional epoxide hydrolase 2	Rattus norvegicus, Rat	Protein Info
PT01527	Bifunctional epoxide hydrolase 2	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han