General Information of the Cell Line
Cell Line ID
CL000012
Cell Line Name
Sf21
Synonyms
SF21
Sf-21
SF-21
IPLB-SF-21-AE
IPLB-Sf21-AE
IPLB-SF21-AE
IPLB-SF 21AE
IPLB-Sf21AE
IPLB-SF21AE
IPLB-SF-21
IPLB-Sf-21
IPLB-SF 21
IPLB-Sf21
IPLB-SF21
Category
Spontaneously immortalized cell line
Organism
Spodoptera frugiperda (Fall armyworm)
Cellosaurus ID
CVCL_0518
Tissue Information
Ovary
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01305, 3',5'-cyclic-AMP phosphodiesterase 4B
Compound ID Compound Name Compound Formula
CP0015304
2-cycloheptyl-5-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4,4-dimethylpyrazol-3-one
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C30H38N6O4
 1
1
IC50 = 4.6 nM
   TI
   LI
   LO
   TS
CP0038742
1-(3,4-Dihydroxy-phenyl)-2-(2,5-dimethyl-3-phenyl-pyrazolo[1,5-a]pyrimidin-7-ylsulfanyl)-ethanone
   Show/Hide
C22H19N3O3S
 1
1
IC50 = 5000 nM
   TI
   LI
   LO
   TS
CP0519735
1-morpholin-4-yl-4-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanylbutan-1-one
   Show/Hide
C20H21N3O2S2
 1
1
IC50 = 14000 nM
   TI
   LI
   LO
   TS
CP0449722
3-(3-oxo-3-piperidin-1-ylpropyl)-1-(2-phenylethyl)quinoxalin-2-one
   Show/Hide
C24H27N3O2
 1
1
IC50 = 15000 nM
   TI
   LI
   LO
   TS
CP0418440
N-cyclopropyl-4-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-(furan-2-ylmethyl)butanamide
   Show/Hide
C24H22N2O4
 1
1
IC50 = 16000 nM
   TI
   LI
   LO
   TS
CP0500801
5-[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl-3-methyl-7-(2-methylpropyl)-1-propylpyrimido[4,5-d]pyrimidine-2,4-dione
   Show/Hide
C22H25ClN4O3S
 1
1
IC50 = 26000 nM
   TI
   LI
   LO
   TS
CP0438413
N-[[4-(1,2,4-triazol-1-ylmethyl)phenyl]methyl]-6,7,8,9-tetrahydro-5H-carbazole-3-carboxamide
   Show/Hide
C23H23N5O
 1
1
IC50 = 68000 nM
   TI
   LI
   LO
   TS
CP0035728
3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
   Show/Hide
C17H14Cl2F2N2O3
 1
1
Ki = 0.3981 nM
   TI
   LI
   LO
   TS
CP0014732
(4aS,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one
   Show/Hide
C33H40N6O4
 1
1
Ki = 0.631 nM
   TI
   LI
   LO
   TS
CP0408772
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]benzonitrile
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C29H31N3O2
 1
1
Ki = 31.62 nM
   TI
   LI
   LO
   TS
CP0491376
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]benzamide
   Show/Hide
C29H33N3O3
 1
1
Ki = 158.49 nM
   TI
   LI
   LO
   TS
CP0408769
(4aS,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-(4-oxoimidazolidine-1-carbonyl)phenyl]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one
   Show/Hide
C32H36N4O4
 1
1
Ki = 630.96 nM
   TI
   LI
   LO
   TS
CP0511661
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-(3-amino-3-oxopropyl)benzamide
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C32H38N4O4
 1
1
Ki = 1000 nM
   TI
   LI
   LO
   TS
CP0234672
4-[5-[(4aR,8aS)-4-oxo-3-propan-2-yl-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-(2-amino-2-oxoethyl)benzamide
   Show/Hide
C27H30N4O4
 1
1
Ki = 1995.26 nM
   TI
   LI
   LO
   TS
CP0404148
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-(2-methoxyethyl)benzamide
   Show/Hide
C32H39N3O4
 1
1
Ki = 1995.26 nM
   TI
   LI
   LO
   TS
CP0511657
(4aS,8aR)-2-cycloheptyl-4-[3-[4-[(3R)-3-hydroxypyrrolidine-1-carbonyl]phenyl]-4-methoxyphenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one
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C33H39N3O4
 1
1
Ki = 1995.26 nM
   TI
   LI
   LO
   TS
CP0404147
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-(2-amino-2-oxoethyl)-N-methylbenzamide
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C32H38N4O4
 1
1
Ki = 2511.89 nM
   TI
   LI
   LO
   TS
CP0482148
(4aS,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-(3-methyl-4-oxoimidazolidine-1-carbonyl)phenyl]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one
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C33H38N4O4
 1
1
Ki = 2511.89 nM
   TI
   LI
   LO
   TS
CP0550300
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-[2-(methylamino)-2-oxoethyl]benzamide
   Show/Hide
C32H38N4O4
 1
1
Ki = 2511.89 nM
   TI
   LI
   LO
   TS
CP0404125
(4aS,8aR)-4-[3-[4-[(3R)-3-hydroxypyrrolidine-1-carbonyl]phenyl]-4-methoxyphenyl]-2-propan-2-yl-4a,5,8,8a-tetrahydrophthalazin-1-one
   Show/Hide
C29H33N3O4
 1
1
Ki = 3162.28 nM
   TI
   LI
   LO
   TS
CP0482143
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-[2-(2-hydroxyethylamino)-2-oxoethyl]benzamide
   Show/Hide
C33H40N4O5
 1
1
Ki = 3162.28 nM
   TI
   LI
   LO
   TS
CP0560123
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-[2-(dimethylamino)-2-oxoethyl]benzamide
   Show/Hide
C33H40N4O4
 1
1
Ki = 3162.28 nM
   TI
   LI
   LO
   TS
CP0569359
(4aS,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-(3-oxopyrrolidine-1-carbonyl)phenyl]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one
   Show/Hide
C33H37N3O4
 1
1
Ki = 3162.28 nM
   TI
   LI
   LO
   TS
CP0408770
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-[2-(2-methoxyethylamino)-2-oxoethyl]benzamide
   Show/Hide
C34H42N4O5
 1
1
Ki = 3981.07 nM
   TI
   LI
   LO
   TS
CP0529366
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-(2-acetamidoethyl)benzamide
   Show/Hide
C33H40N4O4
 1
1
Ki = 3981.07 nM
   TI
   LI
   LO
   TS
CP0511659
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-[2-oxo-2-(propan-2-ylamino)ethyl]benzamide
   Show/Hide
C34H42N4O4
 1
1
Ki = 6309.57 nM
   TI
   LI
   LO
   TS
CP0557344
(2R)-1-[4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]benzoyl]pyrrolidine-2-carboxamide
   Show/Hide
C34H40N4O4
 1
1
Ki = 6309.57 nM
   TI
   LI
   LO
   TS
CP0491377
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]benzoic acid
   Show/Hide
C29H32N2O4
 1
1
Ki = 7943.28 nM
   TI
   LI
   LO
   TS
CP0550299
(2R)-1-[4-[5-[(4aR,8aS)-4-oxo-3-propan-2-yl-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]benzoyl]pyrrolidine-2-carboxamide
   Show/Hide
C30H34N4O4
 1
1
Ki = 10000 nM
   TI
   LI
   LO
   TS
CP0511660
3-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]benzoic acid
   Show/Hide
C29H32N2O4
 1
1
Ki = 12589.25 nM
   TI
   LI
   LO
   TS
CP0408771
4-[5-[(4aS,8aR)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-(2-amino-2-oxoethyl)benzamide
   Show/Hide
C31H36N4O4
 1
1
Ki = 50118.72 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Ovary)
Cell Line Name Organism Disease
SW626 Homo sapiens (Human) Colon adenocarcinoma
FU-OV-1 Homo sapiens (Human) High grade ovarian serous adenocarcinoma
TOV-21G Homo sapiens (Human) Ovarian clear cell adenocarcinoma
ES-2 Homo sapiens (Human) Ovarian clear cell adenocarcinoma
A2780 Homo sapiens (Human) Ovarian endometrioid adenocarcinoma
A2780ADR Homo sapiens (Human) Ovarian endometrioid adenocarcinoma
IGROV-1 Homo sapiens (Human) Ovarian endometrioid adenocarcinoma
CHO Cricetulus griseus (Chinese hamster) -
CHO-K1 Cricetulus griseus (Chinese hamster) -
CHO/Galpha16 Cricetulus griseus (Chinese hamster) -
CHOP Cricetulus griseus (Chinese hamster) -
T-REx-CHO Cricetulus griseus (Chinese hamster) -
CHO Pro-4 MtxRII OuaR-2-4 Cricetulus griseus (Chinese hamster) -
Flp-In-CHO Cricetulus griseus (Chinese hamster) -
CHO-DXB11 Cricetulus griseus (Chinese hamster) -
CHO-CPR C10 Cricetulus griseus (Chinese hamster) -
PathHunter CHO-K1 EDG1 beta-arrestin Cricetulus griseus (Chinese hamster) -
CHO-S Cricetulus griseus (Chinese hamster) -
CHO-7 Cricetulus griseus (Chinese hamster) -
CHO-T Cricetulus griseus (Chinese hamster) -
ValiScreen human CRTH2 Cricetulus griseus (Chinese hamster) -
PathHunter CHO-K1 GLP1R beta-arrestin-1 Cricetulus griseus (Chinese hamster) -
CHO-K1/CRE-Luc Cricetulus griseus (Chinese hamster) -
CHO-hTRPV1 Cricetulus griseus (Chinese hamster) -
Lec1 Cricetulus griseus (Chinese hamster) -
CHO-N9 Cricetulus griseus (Chinese hamster) -
CHO/IR Cricetulus griseus (Chinese hamster) -
CHO-K1/Gqi5 Cricetulus griseus (Chinese hamster) -
CHO-K9 Cricetulus griseus (Chinese hamster) -
CHO-A12 Cricetulus griseus (Chinese hamster) -
CHO E1a Cricetulus griseus (Chinese hamster) -
PathHunter CHO-K1 CXCR7 beta-arrestin Cricetulus griseus (Chinese hamster) -
R2/PCFT4 Cricetulus griseus (Chinese hamster) -
Chinese hamster RT16 Cricetulus griseus (Chinese hamster) -
CHO-A1 Cricetulus griseus (Chinese hamster) -
CHO-D-/aequorin Cricetulus griseus (Chinese hamster) -
CHO-DUKX-A2 Cricetulus griseus (Chinese hamster) -
Lec3.2.8.1 Cricetulus griseus (Chinese hamster) -
CellSensor NFAT-bla CHO-K1 Cricetulus griseus (Chinese hamster) -
Chinese hamster PC43-10 Cricetulus griseus (Chinese hamster) -
CHO-A3 Cricetulus griseus (Chinese hamster) -
CHO/VR1 Cricetulus griseus (Chinese hamster) -
CHO-hgamma Cricetulus griseus (Chinese hamster) -
CHO-1 Cricetulus griseus (Chinese hamster) -
CHO-03 Cricetulus griseus (Chinese hamster) -
CHO CGE Cricetulus griseus (Chinese hamster) -
CHO-CHRM2 Cricetulus griseus (Chinese hamster) -
CHO CRE-SPAP Cricetulus griseus (Chinese hamster) -
CHO 2B7 Cricetulus griseus (Chinese hamster) -
hMORCHO Cricetulus griseus (Chinese hamster) -
CHO Pro-5 Cricetulus griseus (Chinese hamster) -
CHO CCR3/2 Cricetulus griseus (Chinese hamster) -
PPLS-HA-GPR88 CHO Cricetulus griseus (Chinese hamster) -
hTRPV4/CHO Cricetulus griseus (Chinese hamster) -
CHO 1827 Cricetulus griseus (Chinese hamster) -
CHO ducX#98 Cricetulus griseus (Chinese hamster) -
CHO 1829 Cricetulus griseus (Chinese hamster) -
CHO-mtAEQ Cricetulus griseus (Chinese hamster) -
DHB-11 CHO Cricetulus griseus (Chinese hamster) -
CellSensor CRE-bla CHO-K1 Cricetulus griseus (Chinese hamster) -
PathHunter CHO-K1 GLP1R beta-arrestin-2 Cricetulus griseus (Chinese hamster) -
Sf9 Spodoptera frugiperda (Fall armyworm) -
SF-12 Spodoptera frugiperda (Fall armyworm) -
Tni PRO Trichoplusia ni (Cabbage looper) -