General Information of the Cell Line
Cell Line ID
CL000423
Cell Line Name
IGROV-1
Synonyms
Igrov-1
IGROV 1
IGR-OV1
IGROV1
Igrov1
IGR.OV1
IGROV
OV1/P
OV1/p
OV1-P
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1304
Tissue Information
Ovary
Disease
Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01873, Glycinamide ribonucleotide synthetase
Compound ID Compound Name Compound Formula
CP0387048
(2S)-2-[[4-[4-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophene-2-carbonyl]amino]pentanedioic acid
   Show/Hide
C20H23N5O6S
 1
1
IC50 = 1.79 nM
   TI
   LI
   LO
   TS
CP0260881
(2S)-2-[[5-[4-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophene-3-carbonyl]amino]pentanedioic acid
   Show/Hide
C20H23N5O6S
 1
1
IC50 = 2.03 nM
   TI
   LI
   LO
   TS
CP0330758
(S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)-butyl]-thiophene-2-carbonyl}-amino)-pentanedioicAcid
   Show/Hide
C20H23N5O6S
 1
1
IC50 = 3.46 nM
   TI
   LI
   LO
   TS
CP0046082
(2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-6-yl]ethyl}phenyl)formamido]pentanedioic acid
   Show/Hide
C21H25N5O6
 1
1
IC50 = 5.77 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0003433
(Arylindolyl)maleimide deriv. 27
   Show/Hide
C21H16N4O2  1
1
LC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0003832
N'-hydroxy-N-phenyloctanediamide
   Show/Hide
C14H20N2O3  1
1
IC50 = 2200 nM
   TI
   LI
   LO
   TS
CP0006369
6-[3-[4-[1-(5-cyanopentyl)indol-3-yl]-1-hydroxy-2,5-dioxopyrrol-3-yl]indol-1-yl]hexanenitrile
   Show/Hide
C32H31N5O3  1
1
LC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0007711
(E)-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]-N'-propylprop-2-enehydrazide;2,2,2-trifluoroacetic acid
   Show/Hide
C26H31F3N4O3  2
1
GI50 = 115 nM
   TI
   LI
   LO
   TS
2
LC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0010714
N-[4-chloro-3-(trifluoromethyl)phenyl]-5-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-2-amine
   Show/Hide
C24H26ClF3N4O  1
1
GI50 = 1850 nM
   TI
   LI
   LO
   TS
CP0050307
(S)-2-(4-(4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl)benzamido)pentanedioic acid
   Show/Hide
C22H25N5O6  1
1
IC50 = 1.12 nM
   TI
   LI
   LO
   TS
CP0055020
AGF94
   Show/Hide
C19H21N5O6S  2
1
IC50 = 0.55 nM
   TI
   LI
   LO
   TS
2
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0058788
(E)-N-hydroxy-3-[4-(4-methoxyphenyl)phenyl]prop-2-enamide
   Show/Hide
C16H15NO3  2
1
IC50 = 750 nM
   TI
   LI
   LO
   TS
2
IC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0060320
(2E,4E)-N-hydroxy-5-[4-(4-methoxyphenyl)phenyl]penta-2,4-dienamide
   Show/Hide
C18H17NO3  2
1
IC50 = 570 nM
   TI
   LI
   LO
   TS
2
IC50 = 2010 nM
   TI
   LI
   LO
   TS
CP0073856
(2S)-2-[[4-[6-(2-amino-4-oxo-3H-thieno[2,3-d]pyrimidin-6-yl)hexyl]benzoyl]amino]pentanedioic acid
   Show/Hide
C24H28N4O6S  1
1
IC50 = 334 nM
   TI
   LI
   LO
   TS
CP0082019
(2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid
   Show/Hide
C22H21NO2S  1
1
GI50 = 3980 nM
   TI
   LI
   LO
   TS
CP0083588
(S)-2-(4-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl)benzamido)pentanedioic acid
   Show/Hide
C21H23N5O6  2
1
IC50 = 2.2 nM
   TI
   LI
   LO
   TS
2
IC50 = 4.1 nM
   TI
   LI
   LO
   TS
CP0091315
US9422297, AAG145-136
   Show/Hide
C17H13ClN4  1
1
GI50 = 287 nM
   TI
   LI
   LO
   TS
CP0128229
(2S)-2-[[4-[5-(2-amino-4-oxo-3H-thieno[2,3-d]pyrimidin-6-yl)pentyl]benzoyl]amino]pentanedioic acid
   Show/Hide
C23H26N4O6S  2
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
2
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0139226
(2E,4E)-N-hydroxy-5-(4-phenylphenyl)penta-2,4-dienamide
   Show/Hide
C17H15NO2  2
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
2
IC50 = 2400 nM
   TI
   LI
   LO
   TS
CP0148456
(2R)-2-amino-3-[(4-methoxyphenyl)-diphenylmethyl]sulfanylpropan-1-ol
   Show/Hide
C23H25NO2S  1
1
GI50 = 260 nM
   TI
   LI
   LO
   TS
CP0204133
(S)-2-({5-[5-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)-pentyl]-thiophene-2-carbonyl}-amino)-pentanedioicAcid
   Show/Hide
C21H25N5O6S  1
1
IC50 = 176 nM
   TI
   LI
   LO
   TS
CP0204175
(E)-N-hydroxy-3-[3-(4-hydroxyphenyl)phenyl]prop-2-enamide
   Show/Hide
C15H13NO3  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0206826
(2S)-2-[[5-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophene-3-carbonyl]amino]pentanedioic acid
   Show/Hide
C19H21N5O6S  2
1
IC50 = 0.77 nM
   TI
   LI
   LO
   TS
2
IC50 = 276 nM
   TI
   LI
   LO
   TS
CP0260881
(2S)-2-[[5-[4-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophene-3-carbonyl]amino]pentanedioic acid
   Show/Hide
C20H23N5O6S  1
1
IC50 = 1.4 nM
   TI
   LI
   LO
   TS
CP0294158
(2S)-2-[[4-[2-(2-amino-4-oxo-3H-thieno[2,3-d]pyrimidin-6-yl)ethyl]benzoyl]amino]pentanedioic acid
   Show/Hide
C20H20N4O6S  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0330758
(S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)-butyl]-thiophene-2-carbonyl}-amino)-pentanedioicAcid
   Show/Hide
C20H23N5O6S  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0333016
(2S)-2-[[4-[3-(2-amino-4-oxo-3H-thieno[2,3-d]pyrimidin-6-yl)propyl]benzoyl]amino]pentanedioic acid
   Show/Hide
C21H22N4O6S  2
1
IC50 = 4.7 nM
   TI
   LI
   LO
   TS
2
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0381810
(E)-N-hydroxy-3-(4-thiophen-2-ylphenyl)prop-2-enamide
   Show/Hide
C13H11NO2S  1
1
IC50 = 3200 nM
   TI
   LI
   LO
   TS
CP0381811
(E)-3-[4-(4-cyanophenyl)phenyl]-N-hydroxyprop-2-enamide
   Show/Hide
C16H12N2O2  1
1
IC50 = 2700 nM
   TI
   LI
   LO
   TS
CP0381812
5-(Biphenyl-4-yl)-pentanoic acid N-hydroxyamide
   Show/Hide
C17H19NO2  1
1
IC50 = 9100 nM
   TI
   LI
   LO
   TS
CP0381814
(E)-3-[4-(4-chlorophenyl)phenyl]-N-hydroxyprop-2-enamide
   Show/Hide
C15H12ClNO2  2
1
IC50 = 610 nM
   TI
   LI
   LO
   TS
2
IC50 = 1360 nM
   TI
   LI
   LO
   TS
CP0383884
(2S)-2-[[5-[4-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)butyl]pyridine-2-carbonyl]amino]pentanedioic acid
   Show/Hide
C21H24N6O6  1
1
IC50 = 0.68 nM
   TI
   LI
   LO
   TS
CP0387048
(2S)-2-[[4-[4-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophene-2-carbonyl]amino]pentanedioic acid
   Show/Hide
C20H23N5O6S  2
1
IC50 = 0.48 nM
   TI
   LI
   LO
   TS
2
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0387614
(E)-3-[4-[4-(dimethylamino)phenyl]phenyl]-N-hydroxyprop-2-enamide
   Show/Hide
C17H18N2O2  1
1
IC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0387825
(E)-N-hydroxy-3-[4-[4-(hydroxymethyl)phenyl]phenyl]prop-2-enamide
   Show/Hide
C16H15NO3  1
1
IC50 = 8000 nM
   TI
   LI
   LO
   TS
CP0396392
1-[2-[4-[1-adamantyl(phenyl)methyl]phenyl]ethyl]-4-methylpiperazine
   Show/Hide
C30H40N2  1
1
GI50 = 4.29 nM
   TI
   LI
   LO
   TS
CP0408582
1-[3-[4-[1-adamantyl(phenyl)methyl]phenyl]propyl]piperazine
   Show/Hide
C30H40N2  1
1
GI50 = 3.29 nM
   TI
   LI
   LO
   TS
CP0420108
N-[3-[3-[4-(1-aminocyclobutyl)phenyl]-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-5-yl]phenyl]acetamide;hydrochloride
   Show/Hide
C29H28ClN7O  1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0425261
N-(1-benzofuran-5-yl)-N,2,6-trimethylfuro[2,3-d]pyrimidin-4-amine
   Show/Hide
C17H15N3O2  1
1
GI50 = 142 nM
   TI
   LI
   LO
   TS
CP0428395
(E)-N-hydroxy-3-[4-(4-hydroxyphenyl)cyclohexyl]prop-2-enamide
   Show/Hide
C15H19NO3  2
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
2
IC50 = 2600 nM
   TI
   LI
   LO
   TS
CP0431183
(2E,4E)-5-[4-(4-cyanophenyl)phenyl]-N-hydroxypenta-2,4-dienamide
   Show/Hide
C18H14N2O2  1
1
IC50 = 3100 nM
   TI
   LI
   LO
   TS
CP0432230
N-(2,3-dihydro-1-benzofuran-5-yl)-N,2,6-trimethylfuro[2,3-d]pyrimidin-4-amine
   Show/Hide
C17H17N3O2  1
1
GI50 = 62.9 nM
   TI
   LI
   LO
   TS
CP0439505
(E)-N-hydroxy-3-[4-(1H-indol-5-yl)phenyl]prop-2-enamide
   Show/Hide
C17H14N2O2  1
1
IC50 = 29300 nM
   TI
   LI
   LO
   TS
CP0452777
1-[3-[4-[1-adamantyl(phenyl)methyl]phenyl]propyl]-4-methylpiperazine
   Show/Hide
C31H42N2  1
1
LC50 = 74.77 nM
   TI
   LI
   LO
   TS
CP0476016
1-[4-[1-adamantyl(phenyl)methyl]phenyl]piperazine
   Show/Hide
C27H34N2  2
1
GI50 = 3320 nM
   TI
   LI
   LO
   TS
2
LC50 = 8890 nM
   TI
   LI
   LO
   TS
CP0509651
(E)-3-(4'-Hydroxy-[1,1';3',1'']terphenyl-4-yl)-acrylic acid
   Show/Hide
C21H16O3  1
1
IC50 = 19000 nM
   TI
   LI
   LO
   TS
CP0515364
(E)-3-(3'-Adamantan-1-yl-4'-hydroxy-biphenyl-4-yl)-N-(4-hydroxy-phenyl)-acrylamide
   Show/Hide
C31H31NO3  1
1
IC50 = 6600 nM
   TI
   LI
   LO
   TS
CP0522476
(E)-3-(4'-Hydroxy-biphenyl-4-yl)-acrylic acid
   Show/Hide
C15H12O3  1
1
IC50 = 89000 nM
   TI
   LI
   LO
   TS
CP0524982
1-[4-[1-adamantyl(phenyl)methyl]phenyl]-4-methylpiperazine
   Show/Hide
C28H36N2  1
1
LC50 = 100000 nM
   TI
   LI
   LO
   TS
CP0838078
(4-{[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)ethyl]amino}benzoyl)-L-glutamic Acid
   Show/Hide
C20H22N6O6  1
1
IC50 = 872 nM
   TI
   LI
   LO
   TS
CP0906523
7-Benzyl-N-(4-methoxyphenyl)-N,2,5-trimethyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine hydrochloride
   Show/Hide
C23H25ClN4O  1
1
GI50 = 95.8 nM
   TI
   LI
   LO
   TS
CP0911977
N-(4-Methoxyphenyl)-N,2-dimethyl-6,7-dihydro-5H-cyclopenta-[d]pyrimidin-4-aminium Chloride
   Show/Hide
C16H20ClN3O  1
1
GI50 = 12.8 nM
   TI
   LI
   LO
   TS
CP0915862
(5-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl)thiophene-2-carbonyl)-L-glutamic acid
   Show/Hide
C20H22N4O6S2  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0915863
(5-(3-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)propyl)thiophene-2-carbonyl)-L-glutamic acid
   Show/Hide
C19H20N4O6S2  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0915866
(5-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl)furan-2-carbonyl)-L-glutamic acid
   Show/Hide
C20H22N4O7S  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Ovary)
Cell Line Name Organism Disease
SW626 Homo sapiens (Human) Colon adenocarcinoma
FU-OV-1 Homo sapiens (Human) High grade ovarian serous adenocarcinoma
TOV-21G Homo sapiens (Human) Ovarian clear cell adenocarcinoma
ES-2 Homo sapiens (Human) Ovarian clear cell adenocarcinoma
A2780 Homo sapiens (Human) Ovarian endometrioid adenocarcinoma
A2780ADR Homo sapiens (Human) Ovarian endometrioid adenocarcinoma
CHO Cricetulus griseus (Chinese hamster) -
CHO-K1 Cricetulus griseus (Chinese hamster) -
CHO/Galpha16 Cricetulus griseus (Chinese hamster) -
CHOP Cricetulus griseus (Chinese hamster) -
T-REx-CHO Cricetulus griseus (Chinese hamster) -
CHO Pro-4 MtxRII OuaR-2-4 Cricetulus griseus (Chinese hamster) -
Flp-In-CHO Cricetulus griseus (Chinese hamster) -
CHO-DXB11 Cricetulus griseus (Chinese hamster) -
CHO-CPR C10 Cricetulus griseus (Chinese hamster) -
PathHunter CHO-K1 EDG1 beta-arrestin Cricetulus griseus (Chinese hamster) -
CHO-S Cricetulus griseus (Chinese hamster) -
CHO-7 Cricetulus griseus (Chinese hamster) -
CHO-T Cricetulus griseus (Chinese hamster) -
ValiScreen human CRTH2 Cricetulus griseus (Chinese hamster) -
PathHunter CHO-K1 GLP1R beta-arrestin-1 Cricetulus griseus (Chinese hamster) -
CHO-K1/CRE-Luc Cricetulus griseus (Chinese hamster) -
CHO-hTRPV1 Cricetulus griseus (Chinese hamster) -
Lec1 Cricetulus griseus (Chinese hamster) -
CHO-N9 Cricetulus griseus (Chinese hamster) -
CHO/IR Cricetulus griseus (Chinese hamster) -
CHO-K1/Gqi5 Cricetulus griseus (Chinese hamster) -
CHO-K9 Cricetulus griseus (Chinese hamster) -
CHO-A12 Cricetulus griseus (Chinese hamster) -
CHO E1a Cricetulus griseus (Chinese hamster) -
PathHunter CHO-K1 CXCR7 beta-arrestin Cricetulus griseus (Chinese hamster) -
R2/PCFT4 Cricetulus griseus (Chinese hamster) -
Chinese hamster RT16 Cricetulus griseus (Chinese hamster) -
CHO-A1 Cricetulus griseus (Chinese hamster) -
CHO-D-/aequorin Cricetulus griseus (Chinese hamster) -
CHO-DUKX-A2 Cricetulus griseus (Chinese hamster) -
Lec3.2.8.1 Cricetulus griseus (Chinese hamster) -
CellSensor NFAT-bla CHO-K1 Cricetulus griseus (Chinese hamster) -
Chinese hamster PC43-10 Cricetulus griseus (Chinese hamster) -
CHO-A3 Cricetulus griseus (Chinese hamster) -
CHO/VR1 Cricetulus griseus (Chinese hamster) -
CHO-hgamma Cricetulus griseus (Chinese hamster) -
CHO-1 Cricetulus griseus (Chinese hamster) -
CHO-03 Cricetulus griseus (Chinese hamster) -
CHO CGE Cricetulus griseus (Chinese hamster) -
CHO-CHRM2 Cricetulus griseus (Chinese hamster) -
CHO CRE-SPAP Cricetulus griseus (Chinese hamster) -
CHO 2B7 Cricetulus griseus (Chinese hamster) -
hMORCHO Cricetulus griseus (Chinese hamster) -
CHO Pro-5 Cricetulus griseus (Chinese hamster) -
CHO CCR3/2 Cricetulus griseus (Chinese hamster) -
PPLS-HA-GPR88 CHO Cricetulus griseus (Chinese hamster) -
hTRPV4/CHO Cricetulus griseus (Chinese hamster) -
CHO 1827 Cricetulus griseus (Chinese hamster) -
CHO ducX#98 Cricetulus griseus (Chinese hamster) -
CHO 1829 Cricetulus griseus (Chinese hamster) -
CHO-mtAEQ Cricetulus griseus (Chinese hamster) -
DHB-11 CHO Cricetulus griseus (Chinese hamster) -
CellSensor CRE-bla CHO-K1 Cricetulus griseus (Chinese hamster) -
PathHunter CHO-K1 GLP1R beta-arrestin-2 Cricetulus griseus (Chinese hamster) -
Sf21 Spodoptera frugiperda (Fall armyworm) -
Sf9 Spodoptera frugiperda (Fall armyworm) -
SF-12 Spodoptera frugiperda (Fall armyworm) -
Tni PRO Trichoplusia ni (Cabbage looper) -