General Information of the Cell Line
Cell Line ID
CL000330
Cell Line Name
CHO Pro-4 MtxRII OuaR-2-4
Synonyms
Pro-4 MtxRII OuaR 2-4
MTXRIIOuaR2-4
R2
Category
Transformed cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_C5SG
Tissue Information
Ovary
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT02379, Bifunctional purine biosynthesis protein ATIC
 Protein Info 
Compound ID Compound Name Compound Formula
CP0036197
 Compound Info 
2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
   Show/Hide
C20H22N8O5
  1
1
Ki = 880 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0882698
 Compound Info 
(5-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl)thiophene-3-carbonyl)-L-glutamic acid
   Show/Hide
C20H22N4O6S2
  1
1
Ki = 1070 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0915862
 Compound Info 
(5-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl)thiophene-2-carbonyl)-L-glutamic acid
   Show/Hide
C20H22N4O6S2
  1
1
Ki = 5150 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0915864
 Compound Info 
(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl)thiophene-2-carbonyl)-L-glutamic acid
   Show/Hide
C20H22N4O6S2
  1
1
Ki = 8030 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0915865
 Compound Info 
(5-(3-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)propyl)thiophene-3-carbonyl)-L-glutamic acid
   Show/Hide
C19H20N4O6S2
  1
1
Ki = 8370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0035062
 Compound Info 
(S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl)benzamido)pentanedioic acid
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C22H24N4O6S
  1
1
Ki = 9480 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0915863
 Compound Info 
(5-(3-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)propyl)thiophene-2-carbonyl)-L-glutamic acid
   Show/Hide
C19H20N4O6S2
  1
1
Ki = 14460 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958003
 Compound Info 
(4-(3-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)propyl)thiophene-2-carbonyl)-L-glutamic acid
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C19H20N4O6S2
  1
1
Ki = 19840 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0915866
 Compound Info 
(5-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl)furan-2-carbonyl)-L-glutamic acid
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C20H22N4O7S
  1
1
Ki = 24710 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT04881, Folate receptor alpha
 Protein Info 
Protein ID: PT06045, Folate receptor beta
 Protein Info 
Protein ID: PT05580, Proton-coupled folate transporter
 Protein Info 
Protein ID: PT05723, Reduced folate transporter
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0036197
 Compound Info 
2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
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 C20H22N8O5  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0036368
 Compound Info 
(2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid
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 C20H21N5O6  1
1
IC50 = 894 nM
   TI
   LI
   LO
   TS
CP0041026
 Compound Info 
(2S)-2-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]amino}thiophen-2-yl)formamido]pentanedioic acid
   Show/Hide
 C21H22N4O6S  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0055020
 Compound Info 
AGF94
   Show/Hide
 C19H21N5O6S  3
1
IC50 = 1.4 nM
   TI
   LI
   LO
   TS
2
IC50 = 273.5 nM
   TI
   LI
   LO
   TS
3
IC50 = 288 nM
   TI
   LI
   LO
   TS
CP0083588
 Compound Info 
(S)-2-(4-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl)benzamido)pentanedioic acid
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 C21H23N5O6  1
1
IC50 = 448 nM
   TI
   LI
   LO
   TS
CP0200251
 Compound Info 
(2S)-2-[[5-[(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)methyl]thiophene-2-carbonyl]amino]pentanedioic acid
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 C17H17N5O6S  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0204133
 Compound Info 
(S)-2-({5-[5-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)-pentyl]-thiophene-2-carbonyl}-amino)-pentanedioicAcid
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 C21H25N5O6S  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0206826
 Compound Info 
(2S)-2-[[5-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophene-3-carbonyl]amino]pentanedioic acid
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 C19H21N5O6S  1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0260881
 Compound Info 
(2S)-2-[[5-[4-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophene-3-carbonyl]amino]pentanedioic acid
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 C20H23N5O6S  2
1
IC50 = 63.82 nM
   TI
   LI
   LO
   TS
2
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0334242
 Compound Info 
(2S)-2-[9-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)nonanoylamino]pentanedioic acid
   Show/Hide
 C20H29N5O6  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0374709
 Compound Info 
(2S)-2-[[4-[3-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)propyl]thiophene-2-carbonyl]amino]pentanedioic acid
   Show/Hide
 C19H21N5O6S  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0379858
 Compound Info 
(2S)-2-[[5-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carbonyl]amino]pentanoic acid
   Show/Hide
 C19H23N5O4S  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0386883
 Compound Info 
4-[[5-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carbonyl]amino]butanoic acid
   Show/Hide
 C18H21N5O4S  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0419800
 Compound Info 
(2S)-2-[[5-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carbonyl]amino]butanedioic acid
   Show/Hide
 C18H19N5O6S  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0461015
 Compound Info 
(2S)-2-[[5-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)propyl]thiophene-2-carbonyl]amino]pentanedioic acid
   Show/Hide
 C19H21N5O6S  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Ovary)
Cell Line Name Organism Disease
SW626
 Cell Line Info 
Homo sapiens (Human) Colon adenocarcinoma
FU-OV-1
 Cell Line Info 
Homo sapiens (Human) High grade ovarian serous adenocarcinoma
TOV-21G
 Cell Line Info 
Homo sapiens (Human) Ovarian clear cell adenocarcinoma
ES-2
 Cell Line Info 
Homo sapiens (Human) Ovarian clear cell adenocarcinoma
A2780
 Cell Line Info 
Homo sapiens (Human) Ovarian endometrioid adenocarcinoma
A2780ADR
 Cell Line Info 
Homo sapiens (Human) Ovarian endometrioid adenocarcinoma
IGROV-1
 Cell Line Info 
Homo sapiens (Human) Ovarian endometrioid adenocarcinoma
CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO/Galpha16
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHOP
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
T-REx-CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
Flp-In-CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-DXB11
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-CPR C10
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
PathHunter CHO-K1 EDG1 beta-arrestin
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-S
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-7
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-T
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
ValiScreen human CRTH2
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
PathHunter CHO-K1 GLP1R beta-arrestin-1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-K1/CRE-Luc
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-hTRPV1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
Lec1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-N9
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO/IR
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-K1/Gqi5
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-K9
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-A12
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO E1a
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
PathHunter CHO-K1 CXCR7 beta-arrestin
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
R2/PCFT4
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
Chinese hamster RT16
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-A1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-D-/aequorin
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-DUKX-A2
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
Lec3.2.8.1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CellSensor NFAT-bla CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
Chinese hamster PC43-10
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-A3
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO/VR1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-hgamma
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-03
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO CGE
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-CHRM2
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO CRE-SPAP
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO 2B7
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
hMORCHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO Pro-5
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO CCR3/2
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
PPLS-HA-GPR88 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
hTRPV4/CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO 1827
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO ducX#98
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO 1829
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHO-mtAEQ
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
DHB-11 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CellSensor CRE-bla CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
PathHunter CHO-K1 GLP1R beta-arrestin-2
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm) -
Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm) -
SF-12
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm) -
Tni PRO
 Cell Line Info 
Trichoplusia ni (Cabbage looper) -