General Information of the Protein
Protein ID
PT06045
Protein Name
Folate receptor beta
Secondarily
Protein Name
Folate receptor 2
Folate receptor
fetal/placental
Placental folate-binding protein
Gene Name
FOLR2
Sequence
MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVNAGEMLHGTGGLLLSLALMLQLWLLG
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
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Uniprot ID
Primary ID:
P14207

Secondarily ID:
Q05CA5
Q6GTE8
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HGNC ID
HGNC:3793
Subcellular Location
Cell membrane
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000330 , CHO Pro-4 MtxRII OuaR-2-4
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0958003
 Compound Info 
(4-(3-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)propyl)thiophene-2-carbonyl)-L-glutamic acid
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C19H20N4O6S2
  1
1
IC50 = 0.24 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0915865
 Compound Info 
(5-(3-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)propyl)thiophene-3-carbonyl)-L-glutamic acid
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C19H20N4O6S2
  1
1
IC50 = 0.72 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0882698
 Compound Info 
(5-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl)thiophene-3-carbonyl)-L-glutamic acid
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C20H22N4O6S2
  1
1
IC50 = 1.21 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0915862
 Compound Info 
(5-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl)thiophene-2-carbonyl)-L-glutamic acid
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C20H22N4O6S2
  1
1
IC50 = 1.67 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0915863
 Compound Info 
(5-(3-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)propyl)thiophene-2-carbonyl)-L-glutamic acid
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C19H20N4O6S2
  1
1
IC50 = 1.75 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0915866
 Compound Info 
(5-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl)furan-2-carbonyl)-L-glutamic acid
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C20H22N4O7S
  1
1
IC50 = 2.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0915864
 Compound Info 
(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl)thiophene-2-carbonyl)-L-glutamic acid
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C20H22N4O6S2
  1
1
IC50 = 5.63 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0035062
 Compound Info 
(S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl)benzamido)pentanedioic acid
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C22H24N4O6S
  1
1
IC50 = 20 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000344 , D4 [Mouse hybridoma against human RICTOR]
 Cell Line Info 
Cell Line ID: CL000853 , HeLa R1-11
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Folate receptor beta (FOLR2) )
Target Type Literature-reported Target