General Information of the Protein
Protein ID
PT01873
Protein Name
Trifunctional purine biosynthetic protein adenosine-3
Secondarily
Protein Name
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
AIR synthase
Phosphoribosyl-aminoimidazole synthetase
5'-phosphoribosylglycinamide transformylase
GAR transformylase
Gene Name
GART
Secondarily
Gene Name
PGFT
PRGS
Sequence
MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISNTAISISDHTALAQFCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIPTAQWKAFTKPEEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAPQVSNDLLLKIKDTVLQRTVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNCRFGDPECQVILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTALTVVMASKGYPGDYTKGVEITGFPEAQALGLEVFHAGTALKNGKVVTHGGRVLAVTAIRENLISALEEAKKGLAAIKFEGAIYRKDVGFRAIAFLQQPRSLTYKESGVDIAAGNMLVKKIQPLAKATSRSGCKVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSVTEAVVAGIAKACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLPHLERITEGDVVVGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTRIYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPEKLGVDLDAQTWRIPRVFSWLQQEGHLSEEEMARTFNCGVGAVLVVSKEQTEQILRDIQQHKEEAWVIGSVVARAEGSPRVKVKNLIESMQINGSVLKNGSLTNHFSFEKKKARVAVLISGTGSNLQALIDSTREPNSSAQIDIVISNKAAVAGLDKAERAGIPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILSGPFVQKWNGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEAVPVKRGDTVATLSERVKLAEHKIFPAALQLVASGTVQLGENGKICWVKEE
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Ligase
Function
Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway.
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Uniprot ID
Primary ID:
P22102

Secondarily ID:
A8K945
A8KA32
D3DSF3
D3DSF4
O14659
Q52M77
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Ensembl ID
ENSG00000159131
HGNC ID
HGNC:4163
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000108 , CCRF-CEM
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0367534
 Compound Info 
(2S)-2-[[4-[2-(2-amino-4-oxo-3H-pyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoyl]amino]pentanedioic acid
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C21H21N5O6
  1
1
IC50 = 16.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000423 , IGROV-1
 Cell Line Info 
Cell Line ID: CL000220 , KB
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0046082
 Compound Info 
(2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-6-yl]ethyl}phenyl)formamido]pentanedioic acid
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C21H25N5O6
  3
1 Ki = 6 nM
2 Ki = 60 nM
3 Ki = 130 nM
CP0206826
 Compound Info 
(2S)-2-[[5-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophene-3-carbonyl]amino]pentanedioic acid
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C19H21N5O6S
  1
1 Ki = 9.1 nM
CP0374708
 Compound Info 
(2S)-2-[[4-[3-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carbonyl]amino]pentanedioic acid
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C19H21N5O6S
  1
1 Ki = 13 nM
CP0838078
 Compound Info 
(4-{[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)ethyl]amino}benzoyl)-L-glutamic Acid
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C20H22N6O6
  1
1 Ki = 59 nM
CP0036368
 Compound Info 
(2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid
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C20H21N5O6
  3
1 Ki = 65 nM
2 Ki = 380 nM
3 Ki = 1000 nM
CP0055020
 Compound Info 
AGF94
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C19H21N5O6S
  1
1 Ki = 68 nM
CP0083588
 Compound Info 
(S)-2-(4-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl)benzamido)pentanedioic acid
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C21H23N5O6
  1
1 Ki = 160 nM
CP0374709
 Compound Info 
(2S)-2-[[4-[3-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)propyl]thiophene-2-carbonyl]amino]pentanedioic acid
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C19H21N5O6S
  1
1 Ki = 5500 nM
CP0374710
 Compound Info 
(2S)-2-[[5-[3-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)propyl]thiophene-3-carbonyl]amino]pentanedioic acid
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C19H21N5O6S
  1
1 Ki = 6500 nM
Clinical Information about the Protein
Target 1 ( Glycinamide ribonucleotide formyltransferase (GART) )
Target Type Clinical trial Target