General Information of the Protein
Protein ID
PT01030
Protein Name
Dual specificity protein kinase CLK1
Secondarily
Protein Name
CDC-like kinase 1
Gene Name
CLK1
Secondarily
Gene Name
CLK
Sequence
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase CLK family
Function
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1 (PubMed:10480872, PubMed:19168442). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (PubMed:19168442).
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Uniprot ID
Primary ID:
P49759

Secondarily ID:
B4DFW7
Q0P694
Q8N5V8
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Ensembl ID
ENSG00000013441
HGNC ID
HGNC:2068
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000017 , HeLa
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0312448
 Compound Info 
2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-1H-pyrimidin-4-one
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C16H17N5O2
  1
1
EC50 = 20000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000012 , Sf21
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Cell Line ID: CL000619 , SK-MEL-2
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0018471
 Compound Info 
6-N-(3-amino-5-chlorophenyl)-2-N-[(1S,2R)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamine
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C20H27ClN8
  1
1 IC50 = 21 nM
CP0030404
 Compound Info 
N-[3-[[2-[[(1S,2R)-2-aminocyclohexyl]amino]-9-propan-2-ylpurin-6-yl]amino]-5-chlorophenyl]acetamide
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C22H29ClN8O
  1
1 IC50 = 26 nM
CP0023225
 Compound Info 
6-N-(3-amino-5-chlorophenyl)-2-N-[(3S)-piperidin-3-yl]-9-propan-2-ylpurine-2,6-diamine
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C19H25ClN8
  1
1 IC50 = 31 nM
CP0022429
 Compound Info 
2-N-[(1R,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine
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C20H26ClN7
  1
1 IC50 = 38 nM
CP0018472
 Compound Info 
6-N-(3-amino-5-chlorophenyl)-2-N-[(1S,2S)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamine
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C20H27ClN8
  1
1 IC50 = 56 nM
CP0018468
 Compound Info 
6-N-(3-amino-5-chlorophenyl)-2-N-[(3R)-piperidin-3-yl]-9-propan-2-ylpurine-2,6-diamine
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C19H25ClN8
  1
1 IC50 = 66 nM
CP0025323
 Compound Info 
6-N-(3-amino-5-chlorophenyl)-9-propan-2-yl-2-N-[(3S)-pyrrolidin-3-yl]purine-2,6-diamine
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C18H23ClN8
  1
1 IC50 = 71 nM
CP0022430
 Compound Info 
2-N-[(1S,2R)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine
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C20H26ClN7
  1
1 IC50 = 74 nM
CP0022006
 Compound Info 
2-N-[(1S,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine
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C20H26ClN7
  1
1 IC50 = 78 nM
CP0016735
 Compound Info 
6-N-(3-amino-5-chlorophenyl)-9-propan-2-yl-2-N-[(3R)-pyrrolidin-3-yl]purine-2,6-diamine
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C18H23ClN8
  1
1 IC50 = 118 nM
CP0002607
 Compound Info 
2-N-[(1R,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine
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C19H24ClN7
  1
1 IC50 = 148 nM
CP0023715
 Compound Info 
6-N-(3-amino-5-chlorophenyl)-2-N-[(1R,2R)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamine
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C20H27ClN8
  1
1 IC50 = 274 nM
CP0024267
 Compound Info 
2-N-[(1S,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine
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C19H24ClN7
  1
1 IC50 = 371 nM
CP0018469
 Compound Info 
2-N-[(1R,2R)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine
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C20H26ClN7
  1
1 IC50 = 400 nM
CP0016733
 Compound Info 
2-N-[(1R,2R)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine
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C19H24ClN7
  1
1 IC50 = 868 nM
CP0004159
 Compound Info 
pyrido[4,3-h]quinazolin-2-amine
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C11H8N4
  1
1 IC50 = 1480 nM
CP0315550
 Compound Info 
(1E)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one
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C13H15NO2S
  2
1 Kd = 75 nM
2 Kd < 100 nM
Clinical Information about the Protein
Target 1 ( CDC-like kinase 1 (CLK1) )
Target Type Patented-recorded Target