General Information of the Cell Line
Cell Line ID
CL000619
Cell Line Name
SK-MEL-2
Synonyms
SK-Mel-2
SK-Mel 2
SK-mel-2
SK-MEL2
SK.MEL.2
SK Mel 2
SK MEL 2
SKMEL-2
SKMEL2
SKmel2
SK-ML2
SKml2
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0069
Tissue Information
Skin
Disease
Melanoma (NCIt: C3224)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01030, Dual specificity protein kinase CLK1
 Protein Info 
Compound ID Compound Name Compound Formula
CP0550139
 Compound Info 
[(Z,2S)-5-[[4-[(2E,4E)-5-[(3R,7S)-5,5-dimethyl-1,6-dioxaspiro[2.5]octan-7-yl]-3-methylpenta-2,4-dienyl]cyclohexyl]amino]-5-oxopent-3-en-2-yl] N-methylcarbamate
   Show/Hide
C27H42N2O5
  1
1
EC50 = 800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0002607
 Compound Info 
2-N-[(1R,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine
   Show/Hide
C19H24ClN7
  1
1
EC50 = 4200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0022429
 Compound Info 
2-N-[(1R,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine
   Show/Hide
C20H26ClN7
  1
1
EC50 = 4300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0018469
 Compound Info 
2-N-[(1R,2R)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine
   Show/Hide
C20H26ClN7
  1
1
EC50 = 4500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0016733
 Compound Info 
2-N-[(1R,2R)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine
   Show/Hide
C19H24ClN7
  1
1
EC50 = 7800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0464008
 Compound Info 
methyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methylindole-2-carboxylate
   Show/Hide
C14H11Cl2N3O2
  1
1
EC50 = 8000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0023715
 Compound Info 
6-N-(3-amino-5-chlorophenyl)-2-N-[(1R,2R)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamine
   Show/Hide
C20H27ClN8
  1
1
EC50 = 9700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0022006
 Compound Info 
2-N-[(1S,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine
   Show/Hide
C20H26ClN7
  1
1
EC50 = 11700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0002596
 Compound Info 
AMINOPURVALANOL
   Show/Hide
C19H26ClN7O
  1
1
EC50 = 12000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0025323
 Compound Info 
6-N-(3-amino-5-chlorophenyl)-9-propan-2-yl-2-N-[(3S)-pyrrolidin-3-yl]purine-2,6-diamine
   Show/Hide
C18H23ClN8
  1
1
EC50 = 12000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0022430
 Compound Info 
2-N-[(1S,2R)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamine
   Show/Hide
C20H26ClN7
  1
1
EC50 = 12200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0023225
 Compound Info 
6-N-(3-amino-5-chlorophenyl)-2-N-[(3S)-piperidin-3-yl]-9-propan-2-ylpurine-2,6-diamine
   Show/Hide
C19H25ClN8
  1
1
EC50 = 12900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0018468
 Compound Info 
6-N-(3-amino-5-chlorophenyl)-2-N-[(3R)-piperidin-3-yl]-9-propan-2-ylpurine-2,6-diamine
   Show/Hide
C19H25ClN8
  1
1
EC50 = 14000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0030404
 Compound Info 
N-[3-[[2-[[(1S,2R)-2-aminocyclohexyl]amino]-9-propan-2-ylpurin-6-yl]amino]-5-chlorophenyl]acetamide
   Show/Hide
C22H29ClN8O
  1
1
EC50 = 17500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0018471
 Compound Info 
6-N-(3-amino-5-chlorophenyl)-2-N-[(1S,2R)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamine
   Show/Hide
C20H27ClN8
  1
1
EC50 = 18700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0024267
 Compound Info 
2-N-[(1S,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine
   Show/Hide
C19H24ClN7
  1
1
EC50 = 22000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0018472
 Compound Info 
6-N-(3-amino-5-chlorophenyl)-2-N-[(1S,2S)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamine
   Show/Hide
C20H27ClN8
  1
1
EC50 = 23500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0016735
 Compound Info 
6-N-(3-amino-5-chlorophenyl)-9-propan-2-yl-2-N-[(3R)-pyrrolidin-3-yl]purine-2,6-diamine
   Show/Hide
C18H23ClN8
  1
1
EC50 = 26400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT01381, Serine/threonine-protein kinase B-raf
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0002499
 Compound Info 
3,3,3-trifluoro-1-[4-[[2-[[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino]pyridin-4-yl]methyl]piperazin-1-yl]propan-1-one
   Show/Hide
 C23H23F3N8O2  1
1
IC50 = 2180 nM
   TI
   LI
   LO
   TS
CP0002500
 Compound Info 
3,3,3-trifluoro-1-[4-[(1R)-1-[2-[[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]propan-1-one
   Show/Hide
 C24H25F3N8O2  1
1
IC50 = 3530 nM
   TI
   LI
   LO
   TS
CP0003433
 Compound Info 
(Arylindolyl)maleimide deriv. 27
   Show/Hide
 C21H16N4O2  1
1
LC50 = 78500 nM
   TI
   LI
   LO
   TS
CP0010821
 Compound Info 
3,3,3-trifluoro-1-[4-[(1R)-1-[2-[[6-[6-(methoxymethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]propan-1-one
   Show/Hide
 C27H29F3N8O2  1
1
IC50 = 883 nM
   TI
   LI
   LO
   TS
CP0011730
 Compound Info 
3,3,3-trifluoro-1-[4-[(1R)-1-[2-[[6-(5-propan-2-yloxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]propan-1-one
   Show/Hide
 C28H31F3N8O2  1
1
IC50 = 3970 nM
   TI
   LI
   LO
   TS
CP0012235
 Compound Info 
1-[4-[[2-[[6-[2-(dimethylamino)pyridin-4-yl]-1H-benzimidazol-2-yl]amino]pyridin-4-yl]methyl]piperazin-1-yl]-3,3,3-trifluoropropan-1-one
   Show/Hide
 C27H29F3N8O  1
1
IC50 = 337 nM
   TI
   LI
   LO
   TS
CP0012236
 Compound Info 
1-[4-[(1R)-1-[2-[[6-[6-(cyclopropylmethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]-3,3,3-trifluoropropan-1-one
   Show/Hide
 C29H31F3N8O2  1
1
IC50 = 470 nM
   TI
   LI
   LO
   TS
CP0012237
 Compound Info 
1-[4-[(1R)-1-[2-[[6-[6-(dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]-3,3,3-trifluoropropan-1-one
   Show/Hide
 C27H30F3N9O  1
1
IC50 = 900 nM
   TI
   LI
   LO
   TS
CP0014196
 Compound Info 
3,3,3-trifluoro-1-[4-[(1R)-1-[2-[[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]propan-1-one
   Show/Hide
 C26H27F3N8O  1
1
IC50 = 476 nM
   TI
   LI
   LO
   TS
CP0014524
 Compound Info 
1-[4-[[2-[[6-[1-(cyclopropylmethyl)pyrazol-4-yl]-1H-benzimidazol-2-yl]amino]pyridin-4-yl]methyl]piperazin-1-yl]-3,3,3-trifluoropropan-1-one
   Show/Hide
 C27H29F3N8O  1
1
IC50 = 221 nM
   TI
   LI
   LO
   TS
CP0064592
 Compound Info 
[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
   Show/Hide
 C47H51NO14  1
1
GI50 = 400 nM
   TI
   LI
   LO
   TS
CP0082019
 Compound Info 
(2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid
   Show/Hide
 C22H21NO2S  1
1
GI50 = 1500 nM
   TI
   LI
   LO
   TS
CP0086475
 Compound Info 
2-[(4-methoxyphenyl)-diphenylmethyl]sulfanylethanamine
   Show/Hide
 C22H23NOS  1
1
GI50 = 60 nM
   TI
   LI
   LO
   TS
CP0090639
 Compound Info 
N-benzyl-2-[2-[methyl(5-pyrrolidin-1-ylpentyl)amino]-3-(4-phenylphenyl)-4H-quinazolin-4-yl]acetamide
   Show/Hide
 C39H45N5O  1
1
GI50 = 690 nM
   TI
   LI
   LO
   TS
CP0091315
 Compound Info 
US9422297, AAG145-136
   Show/Hide
 C17H13ClN4  1
1
GI50 = 558 nM
   TI
   LI
   LO
   TS
CP0148456
 Compound Info 
(2R)-2-amino-3-[(4-methoxyphenyl)-diphenylmethyl]sulfanylpropan-1-ol
   Show/Hide
 C23H25NO2S  1
1
GI50 = 240 nM
   TI
   LI
   LO
   TS
CP0370065
 Compound Info 
5-(4-chlorophenyl)-2-(4-methoxyphenyl)-[1,3]thiazolo[3,2-b][1,2,4]triazole
   Show/Hide
 C17H12ClN3OS  1
1
GI50 > 50000 nM
   TI
   LI
   LO
   TS
CP0378573
 Compound Info 
N-benzyl-2-[2-[5-(dimethylamino)pentyl-methylamino]-3-(4-phenylphenyl)-4H-quinazolin-4-yl]acetamide
   Show/Hide
 C37H43N5O  1
1
GI50 = 480 nM
   TI
   LI
   LO
   TS
CP0383276
 Compound Info 
N-(4-methoxyphenyl)-N,2,6-trimethylfuro[2,3-d]pyrimidin-4-amine
   Show/Hide
 C16H17N3O2  1
1
GI50 = 33.9 nM
   TI
   LI
   LO
   TS
CP0421176
 Compound Info 
tert-butyl N-[5-[4-[2-(benzylamino)-2-oxoethyl]-2-(4-phenylanilino)-4H-quinazolin-3-yl]pentyl]carbamate
   Show/Hide
 C39H45N5O3  1
1
GI50 = 1590 nM
   TI
   LI
   LO
   TS
CP0421570
 Compound Info 
N-(5-methoxynaphthalen-2-yl)-N,2-dimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine
   Show/Hide
 C20H21N3O  1
1
GI50 < 10 nM
   TI
   LI
   LO
   TS
CP0461401
 Compound Info 
2-(2-(dimethylamino)-3-phenyl-3,4-dihydroquinazolin-4-yl)-N-(4-(4-methylphenylsulfonamido)benzyl)acetamide
   Show/Hide
 C32H33N5O3S  1
1
GI50 = 8530 nM
   TI
   LI
   LO
   TS
CP0465282
 Compound Info 
4-N-(4-methoxyphenyl)-4-N-methyl-9H-pyrimido[4,5-b]indole-2,4-diamine
   Show/Hide
 C18H17N5O  1
1
GI50 = 19.7 nM
   TI
   LI
   LO
   TS
CP0485975
 Compound Info 
methyl 2-[3-(5-aminopentyl)-2-(4-phenylanilino)-4H-quinazolin-4-yl]acetate
   Show/Hide
 C28H32N4O2  1
1
GI50 = 1800 nM
   TI
   LI
   LO
   TS
CP0497857
 Compound Info 
N-[(4-aminophenyl)methyl]-2-[2-(dimethylamino)-3-phenyl-4H-quinazolin-4-yl]acetamide
   Show/Hide
 C25H27N5O  1
1
GI50 = 43950 nM
   TI
   LI
   LO
   TS
CP0504395
 Compound Info 
tert-butyl N-[5-[[4-[2-(benzylamino)-2-oxoethyl]-3-phenyl-1,4-dihydroquinazolin-2-ylidene]amino]pentyl]carbamate
   Show/Hide
 C33H41N5O3  1
1
GI50 = 2020 nM
   TI
   LI
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   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Skin)
Cell Line Name Organism Disease
A-375
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
A375-P
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
A375-SM
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
SK-MEL-28
 Cell Line Info 
Homo sapiens (Human) Cutaneous melanoma
EBC-1
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
WM115
 Cell Line Info 
Homo sapiens (Human) Melanoma
WM266-4
 Cell Line Info 
Homo sapiens (Human) Melanoma
G-361
 Cell Line Info 
Homo sapiens (Human) Melanoma
UACC-62
 Cell Line Info 
Homo sapiens (Human) Melanoma
Mt2-4
 Cell Line Info 
Homo sapiens (Human) Mitochondrial diabetes
NMIi005-A
 Cell Line Info 
Homo sapiens (Human) Schizophrenia
A-431
 Cell Line Info 
Homo sapiens (Human) Skin squamous cell carcinoma
FF
 Cell Line Info 
Mesocricetus auratus (Golden hamster) Hamster melanoma
B16-F10
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-BL6
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-F1
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-F0
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
HaCaT
 Cell Line Info 
Homo sapiens (Human) -
HFF
 Cell Line Info 
Homo sapiens (Human) -
S12 [Human keratinocyte]
 Cell Line Info 
Homo sapiens (Human) -
Malme-3
 Cell Line Info 
Homo sapiens (Human) -
BJ [Human fibroblast]
 Cell Line Info 
Homo sapiens (Human) -
HMEC-1
 Cell Line Info 
Homo sapiens (Human) -
297L1
 Cell Line Info 
Homo sapiens (Human) -
HaCaT-ARE-Luc
 Cell Line Info 
Homo sapiens (Human) -
Melan-a
 Cell Line Info 
Mus musculus (Mouse) -
JB6 Cl 41-5a
 Cell Line Info 
Mus musculus (Mouse) -