General Information of the Cell Line
Cell Line ID
CL000463
Cell Line Name
A375-P
Synonyms
A-375P
A375P
A375p
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_6233
Tissue Information
Skin
Disease
Amelanotic melanoma (NCIt: C3802)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01381, Serine/threonine-protein kinase B-raf
 Protein Info 
Compound ID Compound Name Compound Formula
CP0056222
 Compound Info 
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]furan-3-sulfonamide
   Show/Hide
C20H13F2N7O3S
  1
1
EC50 = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0174728
 Compound Info 
US9216981, 14
   Show/Hide
C23H16ClF2N7O2S
  1
1
EC50 = 6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0237053
 Compound Info 
US9216981, 4
   Show/Hide
C20H13F2N7O2S2
  1
1
EC50 = 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0527381
 Compound Info 
US9216981, 17
   Show/Hide
C20H13F2N7O2S2
  1
1
EC50 = 40 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0284688
 Compound Info 
US9216981, 23
   Show/Hide
C21H15F2N7O3S
  1
1
EC50 = 60 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0090716
 Compound Info 
US9216981, 30
   Show/Hide
C21H14F2N8O2S
  1
1
EC50 = 70 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0284689
 Compound Info 
US9216981, 25
   Show/Hide
C22H17F2N7O3S
  1
1
EC50 = 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0129307
 Compound Info 
US9216981, 1
   Show/Hide
C19H17F2N7O2S
  1
1
EC50 = 120 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0503615
 Compound Info 
US9216981, 13
   Show/Hide
C23H13F6N7O2S
  1
1
EC50 = 150 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0218262
 Compound Info 
US9216981, 35
   Show/Hide
C22H15F2N7O2S
  1
1
EC50 = 160 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0214720
 Compound Info 
US9216981, 44
   Show/Hide
C20H12ClF2N7O2S2
  1
1
EC50 = 200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0419447
 Compound Info 
US9216981, 2
   Show/Hide
C23H14F5N7O2S
  1
1
EC50 = 230 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0098453
 Compound Info 
US9216981, 19
   Show/Hide
C19H15F2N7O2S
  1
1
EC50 = 250 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0265728
 Compound Info 
US9216981, 5
   Show/Hide
C19H17F2N7O2S
  1
1
EC50 = 310 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0214717
 Compound Info 
US9216981, 26
   Show/Hide
C22H14F5N7O3S
  1
1
EC50 = 330 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0261168
 Compound Info 
US9216981, 11
   Show/Hide
C22H21F2N7O2S
  1
1
EC50 = 340 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0121975
 Compound Info 
US9216981, 21
   Show/Hide
C20H18F2N8O3S
  1
1
EC50 = 360 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0284693
 Compound Info 
US9216981, 32
   Show/Hide
C22H14ClF2N7O2S
  1
1
EC50 = 440 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0526543
 Compound Info 
US9216981, 34
   Show/Hide
C22H13Cl2F2N7O2S
  1
1
EC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0342865
 Compound Info 
US9216981, 12
   Show/Hide
C23H14F5N7O3S
  1
1
EC50 = 600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0284691
 Compound Info 
US9216981, 31
   Show/Hide
C23H17F2N7O2S
  1
1
EC50 = 670 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0198807
 Compound Info 
US9216981, 20
   Show/Hide
C21H16F2N8O2S2
  1
1
EC50 = 700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0484173
 Compound Info 
US9216981, 8
   Show/Hide
C22H13ClF3N7O2S
  1
1
EC50 = 700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0218261
 Compound Info 
US9216981, 29
   Show/Hide
C22H13ClF3N7O2S
  1
1
EC50 = 720 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0132879
 Compound Info 
US9216981, 27
   Show/Hide
C23H16ClF2N7O2S
  1
1
EC50 = 760 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0198809
 Compound Info 
US9216981, 33
   Show/Hide
C22H14ClF2N7O2S
  1
1
EC50 = 770 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0129312
 Compound Info 
US9216981, 24
   Show/Hide
C23H17F2N7O5S
  1
1
EC50 = 800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0443371
 Compound Info 
US9216981, 37
   Show/Hide
C24H15F2N7O3S
  1
1
EC50 = 810 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0512129
 Compound Info 
US9216981, 22
   Show/Hide
C20H15F2N9O2S
  1
1
EC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0325790
 Compound Info 
US9216981, 43
   Show/Hide
C20H15F2N9O2S
  1
1
EC50 = 1370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0284690
 Compound Info 
US9216981, 28
   Show/Hide
C22H13ClF3N7O2S
  1
1
EC50 = 1930 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0218260
 Compound Info 
US9216981, 6
   Show/Hide
C22H13Cl2F2N7O2S
  1
1
EC50 = 2800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0406867
 Compound Info 
US9216981, 39
   Show/Hide
C24H16F2N8O2S2
  1
1
EC50 = 2930 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0129313
 Compound Info 
US9216981, 41
   Show/Hide
C25H18F2N8O2S
  1
1
EC50 = 4200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0284686
 Compound Info 
US9216981, 7
   Show/Hide
C24H15F2N7O3S
  1
1
EC50 = 4300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0284685
 Compound Info 
US9216981, 3
   Show/Hide
C23H14F5N7O2S
  1
1
EC50 = 5200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0218263
 Compound Info 
US9216981, 42
   Show/Hide
C25H18F2N8O2S
  1
1
EC50 = 5870 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0443372
 Compound Info 
US9216981, 38
   Show/Hide
C25H19F2N7O3S
  1
1
EC50 = 7190 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0318172
 Compound Info 
US9216981, 36
   Show/Hide
C24H17F2N7O3S
  1
1
EC50 = 8370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0284687
 Compound Info 
US9216981, 16
   Show/Hide
C22H15F2N7O4S2
  1
1
EC50 = 9600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0516190
 Compound Info 
US9216981, 10
   Show/Hide
C24H19F2N7O4S
  1
1
EC50 = 10200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0341112
 Compound Info 
US9216981, 15
   Show/Hide
C20H13F2N7O3S
  1
1
EC50 = 11000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0342864
 Compound Info 
US9216981, 9
   Show/Hide
C23H16F2N8O4S
  1
1
EC50 = 11200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0292511
 Compound Info 
US9216981, 40
   Show/Hide
C25H18F2N8O2S
  1
1
EC50 > 15000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Skin)
Cell Line Name Organism Disease
A-375
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
A375-SM
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
SK-MEL-28
 Cell Line Info 
Homo sapiens (Human) Cutaneous melanoma
EBC-1
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
WM115
 Cell Line Info 
Homo sapiens (Human) Melanoma
WM266-4
 Cell Line Info 
Homo sapiens (Human) Melanoma
G-361
 Cell Line Info 
Homo sapiens (Human) Melanoma
UACC-62
 Cell Line Info 
Homo sapiens (Human) Melanoma
SK-MEL-2
 Cell Line Info 
Homo sapiens (Human) Melanoma
Mt2-4
 Cell Line Info 
Homo sapiens (Human) Mitochondrial diabetes
NMIi005-A
 Cell Line Info 
Homo sapiens (Human) Schizophrenia
A-431
 Cell Line Info 
Homo sapiens (Human) Skin squamous cell carcinoma
FF
 Cell Line Info 
Mesocricetus auratus (Golden hamster) Hamster melanoma
B16-F10
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-BL6
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-F1
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-F0
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
HaCaT
 Cell Line Info 
Homo sapiens (Human) -
HFF
 Cell Line Info 
Homo sapiens (Human) -
S12 [Human keratinocyte]
 Cell Line Info 
Homo sapiens (Human) -
Malme-3
 Cell Line Info 
Homo sapiens (Human) -
BJ [Human fibroblast]
 Cell Line Info 
Homo sapiens (Human) -
HMEC-1
 Cell Line Info 
Homo sapiens (Human) -
297L1
 Cell Line Info 
Homo sapiens (Human) -
HaCaT-ARE-Luc
 Cell Line Info 
Homo sapiens (Human) -
Melan-a
 Cell Line Info 
Mus musculus (Mouse) -
JB6 Cl 41-5a
 Cell Line Info 
Mus musculus (Mouse) -