General Information of the Cell Line
Cell Line ID
CL000045
Cell Line Name
A-375
Synonyms
A 375
A375
A375-MEL
A375-mel
A375mel
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0132
Tissue Information
Skin
Disease
Amelanotic melanoma (NCIt: C3802)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT04305, Acid ceramidase
 Protein Info 
Compound ID Compound Name Compound Formula
CP0357130
 Compound Info 
N-(4-phenylbutyl)benzimidazole-1-carboxamide
   Show/Hide
C18H19N3O
  1
1
IC50 = 75.6 nM
 Bioactivity Info 
   TI
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CP0043665
 Compound Info 
CARMOFUR
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C11H16FN3O3
  1
1
IC50 = 190.8 nM
 Bioactivity Info 
   TI
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CP0416939
 Compound Info 
N-[(4-methylphenyl)methyl]benzimidazole-1-carboxamide
   Show/Hide
C16H15N3O
  1
1
IC50 = 505.3 nM
 Bioactivity Info 
   TI
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CP0416938
 Compound Info 
2-methoxy-N-(4-phenylbutyl)benzimidazole-1-carboxamide
   Show/Hide
C19H21N3O2
  1
1
IC50 = 966.9 nM
 Bioactivity Info 
   TI
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CP0534764
 Compound Info 
N-benzylbenzimidazole-1-carboxamide
   Show/Hide
C15H13N3O
  1
1
IC50 = 1061.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT02611, Ceramide glucosyltransferase
 Protein Info 
Protein ID: PT02203, eIF-2-alpha kinase GCN2
 Protein Info 
Protein ID: PT01335, Ephrin type-A receptor 2
 Protein Info 
Protein ID: PT01028, Ephrin type-B receptor 4
 Protein Info 
Protein ID: PT01080, ERK activator kinase 1
 Protein Info 
Protein ID: PT01478, Heat shock protein HSP 90-beta
 Protein Info 
Protein ID: PT01557, Indoleamine 2,3-dioxygenase 1
 Protein Info 
Protein ID: PT01422, Interleukin-1 receptor-associated kinase 1
 Protein Info 
Protein ID: PT02501, Kinase homologous to SPS1/STE20
 Protein Info 
Protein ID: PT02330, MAPK/ERK kinase 5
 Protein Info 
Protein ID: PT00911, Melanocyte-stimulating hormone receptor
 Protein Info 
Protein ID: PT00850, Mitogen-activated protein kinase 1
 Protein Info 
Protein ID: PT02262, Mitogen-activated protein kinase kinase kinase 1
 Protein Info 
Protein ID: PT01059, Mitogen-activated protein kinase kinase kinase 20
 Protein Info 
Protein ID: PT02218, Protein arginine N-methyltransferase 1
 Protein Info 
Protein ID: PT02223, Protein arginine N-methyltransferase 6
 Protein Info 
Protein ID: PT00879, Proto-oncogene tyrosine-protein kinase Src
 Protein Info 
Protein ID: PT01116, RAF proto-oncogene serine/threonine-protein kinase
 Protein Info 
Protein ID: PT03251, Serine/threonine-protein kinase A-Raf
 Protein Info 
Protein ID: PT01381, Serine/threonine-protein kinase B-raf
 Protein Info 
Protein ID: PT01071, Tyrosine-protein kinase ABL1
 Protein Info 
Protein ID: PT01262, Tyrosine-protein kinase CSK
 Protein Info 
Protein ID: PT01237, Tyrosine-protein kinase Fyn
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0002211
 Compound Info 
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
   Show/Hide
 C22H27FN4O2  1
1
IC50 = 5400 nM
   TI
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CP0002420
 Compound Info 
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
   Show/Hide
 C19H17NO3  1
1
IC50 = 8400 nM
   TI
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CP0006321
 Compound Info 
PLX-4032
   Show/Hide
 C23H18ClF2N3O3S  1
1
IC50 = 170 nM
   TI
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   TS
CP0018477
 Compound Info 
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
   Show/Hide
 C21H16ClF3N4O3  1
1
IC50 = 2200 nM
   TI
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CP0022357
 Compound Info 
N-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-2-(oxan-4-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamide
   Show/Hide
 C21H25ClFN5O3  1
1
EC50 = 390 nM
   TI
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CP0026977
 Compound Info 
SB-590885
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 C27H27N5O2  1
1
IC50 = 370 nM
   TI
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CP0029366
 Compound Info 
US8497274, 32
   Show/Hide
 C27H18F4N4O3S  1
1
GI50 = 66 nM
   TI
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CP0034613
 Compound Info 
N-[(2S,3R,4R,6R,18S)-18-hydroxy-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide
   Show/Hide
 C35H30N4O5  1
1
IC50 = 530 nM
   TI
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CP0034949
 Compound Info 
4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide
   Show/Hide
 C31H42N6O4  1
1
IC50 > 10000 nM
   TI
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CP0034962
 Compound Info 
16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one
   Show/Hide
 C26H21N3O4  1
1
IC50 = 32 nM
   TI
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CP0036068
 Compound Info 
1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine
   Show/Hide
 C24H16F6N6O  1
1
IC50 = 40 nM
   TI
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CP0039596
 Compound Info 
3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol
   Show/Hide
 C29H26N6O  1
1
IC50 = 77 nM
   TI
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CP0050822
 Compound Info 
7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(2-methylpropyl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one
   Show/Hide
 C27H29N5O2  1
1
EC50 = 70 nM
   TI
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CP0051080
 Compound Info 
3-{6-bromo-2-methylimidazo[1,2-a]pyridin-3-yl}-1-[(2-methyl-5-nitrobenzene)sulfonyl]-1H-pyrazole
   Show/Hide
 C18H14BrN5O4S  1
1
IC50 = 730 nM
   TI
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CP0051081
 Compound Info 
1-[(4-fluorobenzene)sulfonyl]-3-{2-methylimidazo[1,2-a]pyridin-3-yl}-1H-pyrazole
   Show/Hide
 C17H13FN4O2S  1
1
IC50 = 23000 nM
   TI
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CP0061810
 Compound Info 
4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1H-indazole-5-carboxamide
   Show/Hide
 C16H14FIN4O3  1
1
EC50 = 2 nM
   TI
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CP0066396
 Compound Info 
N-hydroxy-4-[2-methoxy-5-[methyl-(2-methylquinazolin-4-yl)amino]phenoxy]butanamide
   Show/Hide
 C21H24N4O4  1
1
IC50 = 45 nM
   TI
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CP0072527
 Compound Info 
SCH772984
   Show/Hide
 C33H33N9O2  1
1
IC50 = 70 nM
   TI
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CP0086818
 Compound Info 
ethyl 7-[3-[[3-(trifluoromethyl)benzoyl]amino]phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxylate
   Show/Hide
 C23H17F3N4O3  1
1
IC50 = 3800 nM
   TI
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CP0108813
 Compound Info 
N-hydroxy-2-[4-[methyl(quinazolin-4-yl)amino]phenoxy]acetamide
   Show/Hide
 C17H16N4O3  1
1
IC50 = 432 nM
   TI
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CP0113988
 Compound Info 
CEP-32496
   Show/Hide
 C24H22F3N5O5  1
1
IC50 = 78 nM
   TI
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CP0115031
 Compound Info 
N-[2-[[5-chloro-2-[[4-(dimethylamino)cyclohexyl]amino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
   Show/Hide
 C21H27ClN6O  1
1
IC50 = 120 nM
   TI
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CP0116131
 Compound Info 
7-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,2-benzothiazole-6-carboxamide
   Show/Hide
 C16H13FIN3O3S  1
1
EC50 = 7 nM
   TI
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CP0139017
 Compound Info 
2-[10-(2-methoxyethyl)-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl]-N-(piperidin-4-ylmethyl)quinolin-8-amine
   Show/Hide
 C25H30N8O2  1
1
GI50 = 21800 nM
   TI
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CP0139330
 Compound Info 
N-[(2R)-2,3-dihydroxypropoxy]-4-(2-fluoro-4-iodoanilino)-1H-indazole-5-carboxamide
   Show/Hide
 C17H16FIN4O4  1
1
EC50 = 12 nM
   TI
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CP0158116
 Compound Info 
4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl}-amino)-7-[(1E)-4-(4-ethylpiperazin-1-yl)but-1-enyl]quinoline-3-carbonitrile
   Show/Hide
 C30H32ClN7S  1
1
IC50 = 26 nM
   TI
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CP0194557
 Compound Info 
pyridylpurine aminoisoquinoline, 1
   Show/Hide
 C26H19ClN8  1
1
IC50 = 310 nM
   TI
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CP0302663
 Compound Info 
N-(4-chloro-3-methylphenyl)-4-methyl-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]benzamide
   Show/Hide
 C25H20ClN7O  1
1
IC50 = 1632 nM
   TI
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CP0319000
 Compound Info 
7-fluoro-3-(2-fluoro-4-iodoanilino)-N-[(2S)-2-hydroxypropoxy]furo[3,2-c]pyridine-2-carboxamide
   Show/Hide
 C17H14F2IN3O4  1
1
EC50 = 23 nM
   TI
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CP0351712
 Compound Info 
4-methyl-N-(3-propan-2-ylphenyl)-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]benzamide
   Show/Hide
 C27H25N7O  1
1
IC50 = 2276 nM
   TI
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CP0373796
 Compound Info 
3-[7-[2-methyl-4-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]phenyl]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl]phenol
   Show/Hide
 C30H28N6O  1
1
IC50 = 31 nM
   TI
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CP0374018
 Compound Info 
7-(4-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-fluorophenyl)-3-(3-methoxyphenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
   Show/Hide
 C29H25FN6O  1
1
IC50 = 504 nM
   TI
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CP0383792
 Compound Info 
2-chloro-5-[7-[4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl]phenol
   Show/Hide
 C30H27ClN6O  1
1
IC50 = 170 nM
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CP0416084
 Compound Info 
1-[5-(1,3- difluoro-2- methylpropan- 2- yl)isoxazol- 3-yl]-3- [3- (6,7- dimethoxy- quinazolin- 4- ylthio)phenyl] urea
   Show/Hide
 C24H23F2N5O4S  1
1
IC50 = 223 nM
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CP0418427
 Compound Info 
4-[2-[3-(4-chlorophenyl)-5-(4-piperidin-1-ylphenyl)-3,4-dihydropyrazol-2-yl]-1,3-thiazol-4-yl]benzonitrile
   Show/Hide
 C30H26ClN5S  1
1
IC50 = 38720 nM
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CP0420538
 Compound Info 
1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3- (3-(1- (trifluoromethyl) cyclobutyl) isoxazol- 5-yl)urea
   Show/Hide
 C25H22F3N5O5  1
1
IC50 = 2243 nM
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CP0420835
 Compound Info 
1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(3- (2- fluoropropan-2- yl)isoxazol- 5-yl) urea
   Show/Hide
 C23H22FN5O5  1
1
IC50 = 493 nM
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CP0432219
 Compound Info 
1-(1-benzyl- 3-tert- butyl- 1H-pyrazol- 5-yl)-3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
   Show/Hide
 C31H32N6O4  1
1
IC50 = 1869 nM
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CP0436004
 Compound Info 
1-(1-tert- butyl-1H- pyrazol-4-yl)-3- (3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
   Show/Hide
 C24H26N6O4  1
1
IC50 > 15000 nM
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CP0443926
 Compound Info 
1-[5-(1,3- difluoro-2- methylpropan-2- yl)isoxazol- 3-yl]-3-[3- (6,7- dimethoxy- quinazolin- 4- yloxy)phenyl] urea
   Show/Hide
 C24H23F2N5O5  1
1
IC50 = 145 nM
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CP0443928
 Compound Info 
1-(3-tert- butylphenyl)- 3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
   Show/Hide
 C27H28N4O4  1
1
IC50 = 1771 nM
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CP0470527
 Compound Info 
1-(3-(6,7- dimethoxy- quinazolin- 4-ylthio)phenyl)- 3-(5-(1- (trifluoromethyl) cyclopropyl) isoxazol-3-yl) urea
   Show/Hide
 C24H20F3N5O4S  1
1
IC50 = 222 nM
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CP0470925
 Compound Info 
2-(1,3-benzoxazol-2-yl)benzene-1,4-diol
   Show/Hide
 C13H9NO3  1
1
IC50 = 24700 nM
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CP0471461
 Compound Info 
3-(7-(4-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol
   Show/Hide
 C28H24N6O  1
1
IC50 = 300 nM
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CP0489648
 Compound Info 
3-(4-chloro-3-methoxyphenyl)-7-(4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
   Show/Hide
 C31H29ClN6O  1
1
IC50 = 630 nM
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CP0489649
 Compound Info 
3-[7-[2-chloro-4-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]phenyl]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl]phenol
   Show/Hide
 C29H25ClN6O  1
1
IC50 < 10 nM
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CP0493872
 Compound Info 
N-[4-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]phenyl]-6-methylthieno[2,3-b]quinoline-2-carboxamide
   Show/Hide
 C30H24N2O4S  1
1
IC50 = 2000 nM
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CP0497568
 Compound Info 
3-[7-[2-fluoro-4-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]phenyl]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl]phenol
   Show/Hide
 C29H25FN6O  1
1
IC50 = 12 nM
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CP0497570
 Compound Info 
7-(4-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-3-(4-fluoro-3-methoxyphenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
   Show/Hide
 C29H25FN6O  1
1
IC50 = 1200 nM
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CP0499468
 Compound Info 
3-(3-hydroxyphenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
   Show/Hide
 C30H28N6O  1
1
IC50 = 300 nM
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CP0510477
 Compound Info 
3-(2-(pyridin-4-yl)-7-(4-(quinuclidin-4-ylmethylamino)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol
   Show/Hide
 C31H30N6O  1
1
IC50 = 930 nM
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CP0510478
 Compound Info 
5-(7-(4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2-fluorophenol
   Show/Hide
 C30H27FN6O  1
1
IC50 = 200 nM
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CP0514925
 Compound Info 
US11337976, Compound P-0240
   Show/Hide
 C24H22F2N6O3S  1
1
IC50 = 170 nM
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CP0520606
 Compound Info 
1-[3-(1,3- difluoro-2- methylpropan- 2- yl)isoxazol-5- yl]-3- [3- (6,7- dimethoxy- quinazolin- 4- yloxy]phenyl) urea
   Show/Hide
 C24H23F2N5O5  1
1
IC50 = 1985 nM
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CP0528647
 Compound Info 
3-[7-[4-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-2-fluorophenyl]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl]phenol
   Show/Hide
 C28H23FN6O  1
1
IC50 = 23 nM
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CP0528648
 Compound Info 
3-(3-methoxyphenyl)-7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
   Show/Hide
 C30H28N6O  1
1
IC50 = 760 nM
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CP0528649
 Compound Info 
3-(4-fluoro-3-methoxyphenyl)-7-(2-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
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 C31H29FN6O  1
1
IC50 = 933 nM
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CP0537740
 Compound Info 
3-(4-fluoro-3-methoxyphenyl)-7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
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 C30H27FN6O  1
1
IC50 = 6000 nM
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CP0543125
 Compound Info 
(S)-3-(2-(pyridin-4-yl)-7-(4-(quinuclidin-3-ylamino)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol
   Show/Hide
 C30H28N6O  1
1
IC50 = 370 nM
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CP0543126
 Compound Info 
3-[7-[2-chloro-4-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]phenyl]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl]phenol
   Show/Hide
 C28H23ClN6O  1
1
IC50 = 16 nM
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CP0552315
 Compound Info 
N-[4-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]phenyl]thieno[2,3-b]quinoline-2-carboxamide
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 C30H24N2O5S  1
1
IC50 = 4200 nM
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CP0559853
 Compound Info 
3-(2-aminopropan-2-yl)-N-[7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide
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 C29H29F3N4O3  1
1
IC50 = 200 nM
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CP0664425
 Compound Info 
1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-((S)-2-hydroxy-3,3-dimethylbutyl)urea
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 C24H30FN5O2  1
1
IC50 = 10 nM
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CP0667349
 Compound Info 
N-(2-((5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide
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 C18H20ClN5O2  1
1
IC50 = 57 nM
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CP0672877
 Compound Info 
1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea
   Show/Hide
 C23H29FN6O  1
1
IC50 = 9.2 nM
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CP0674370
 Compound Info 
N-(4-((5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)amino)pyridin-3-yl)acrylamide
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 C17H19ClN6O2  1
1
IC50 = 41 nM
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CP0677468
 Compound Info 
1-(3,3-dimethylbutyl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)urea
   Show/Hide
 C25H32FN5O2  1
1
IC50 = 34 nM
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CP0683304
 Compound Info 
1-(3-tert-butylisoxazol-5-yl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)urea
   Show/Hide
 C25H27FN6O3  1
1
IC50 = 56 nM
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CP0683654
 Compound Info 
1-(3,3-Dimethylbutyl)-3-(2-fluoro-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea
   Show/Hide
 C23H28FN5O  1
1
IC50 = 40 nM
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CP0725021
 Compound Info 
4-fluoro-N-methyl-2-(2-(tetrahydro-2H-pyran-4-ylamino)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide
   Show/Hide
 C19H20F4N4O2  1
1
IC50 = 3400 nM
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CP0733190
 Compound Info 
N-(3-(pyridin-4-yl)-1H-indazol-5-yl)ethanesulfonamide
   Show/Hide
 C14H14N4O2S  1
1
IC50 > 30000 nM
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CP0733191
 Compound Info 
3-(2-methylpyridin-4-yl)-5-(vinylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine
   Show/Hide
 C14H16N4O2S  1
1
IC50 = 1400 nM
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CP0845652
 Compound Info 
PIK-75
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 C16H15BrClN5O4S  1
1
IC50 = 58 nM
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CP0870728
 Compound Info 
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-methylisoxazol-3-yl)urea
   Show/Hide
 C21H19N5O5  1
1
IC50 > 15000 nM
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CP0873042
 Compound Info 
N'-[(1E)-(6-cyanoimidazo[1,2-a]pyridin-3-yl)methylene]-N,2-dimethyl-5-nitrobenzenesulfonohydrazide hydrochloride
   Show/Hide
 C17H15ClN6O4S  1
1
IC50 = 33 nM
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CP0873047
 Compound Info 
N'-[(1E)-(6-trifluoromethylimidazo[1,2-a]pyridin-3-yl)methylene]-N,2-dimethyl-5-nitrobenzenesulfonohydrazidehydrochloride
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 C17H15ClF3N5O4S  1
1
IC50 = 90 nM
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CP0877558
 Compound Info 
ethyl 3-((E)-{methyl[(2-methyl-5-nitrophenyl)sulfonyl]hydrazono}methyl)imidazo[1,2-a]pyridine-6-carboxylatehydrochloride
   Show/Hide
 C19H20ClN5O6S  1
1
IC50 = 9350 nM
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CP0897964
 Compound Info 
N'-[(1E)-1-(6-bromoimidazo[1,2-a]pyridin-3-yl)ethylidene]-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
   Show/Hide
 C17H16BrN5O4S  1
1
IC50 = 20000 nM
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CP0920157
 Compound Info 
N,2-dimethyl-N'-[(1E)-(6-methylimidazo[1,2-a]pyridin-3-yl)methylene]-5-nitrobenzenesulfonohydrazide hydrochloride
   Show/Hide
 C17H18ClN5O4S  1
1
IC50 = 120 nM
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CP0942058
 Compound Info 
N'-[(1E)-1-(6-bromoimidazo[1,2-a]pyridin-3-yl)ethylidene]-2-methyl-5-nitrobenzenesulfonohydrazide
   Show/Hide
 C16H14BrN5O4S  1
1
IC50 = 12000 nM
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CP0946482
 Compound Info 
N'-[(1E)-(6-chloroimidazo[1,2-a]pyridin-3-yl)methylene]-N,2-dimethyl-5-nitrobenzenesulfonohydrazide hydrochloride
   Show/Hide
 C16H15Cl2N5O4S  1
1
IC50 = 56 nM
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CP0949871
 Compound Info 
N'-[(1E)-(6-fluoroimidazo[1,2-a]pyridin-3-yl)methylene]-N,2-dimethyl-5-nitrobenzenesulfonohydrazide hydrochloride
   Show/Hide
 C16H15ClFN5O4S  1
1
IC50 = 180 nM
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CP0968881
 Compound Info 
5-[(1S,1aS,6aR)-1-(6-Trifluoromethyl-1H-benzoimidazol-2-yl)-1a,6a-dihydro-1H-6-oxa-cyclopropa[a]inden-3-yloxy]-3,4-dihydro-1H-[1,8]naphthyridin-2-one
   Show/Hide
 C25H17F3N4O3  1
1
IC50 = 200 nM
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Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Skin)
Cell Line Name Organism Disease
A375-P
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
A375-SM
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
SK-MEL-28
 Cell Line Info 
Homo sapiens (Human) Cutaneous melanoma
EBC-1
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
WM115
 Cell Line Info 
Homo sapiens (Human) Melanoma
WM266-4
 Cell Line Info 
Homo sapiens (Human) Melanoma
G-361
 Cell Line Info 
Homo sapiens (Human) Melanoma
UACC-62
 Cell Line Info 
Homo sapiens (Human) Melanoma
SK-MEL-2
 Cell Line Info 
Homo sapiens (Human) Melanoma
Mt2-4
 Cell Line Info 
Homo sapiens (Human) Mitochondrial diabetes
NMIi005-A
 Cell Line Info 
Homo sapiens (Human) Schizophrenia
A-431
 Cell Line Info 
Homo sapiens (Human) Skin squamous cell carcinoma
FF
 Cell Line Info 
Mesocricetus auratus (Golden hamster) Hamster melanoma
B16-F10
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-BL6
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-F1
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-F0
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
HaCaT
 Cell Line Info 
Homo sapiens (Human) -
HFF
 Cell Line Info 
Homo sapiens (Human) -
S12 [Human keratinocyte]
 Cell Line Info 
Homo sapiens (Human) -
Malme-3
 Cell Line Info 
Homo sapiens (Human) -
BJ [Human fibroblast]
 Cell Line Info 
Homo sapiens (Human) -
HMEC-1
 Cell Line Info 
Homo sapiens (Human) -
297L1
 Cell Line Info 
Homo sapiens (Human) -
HaCaT-ARE-Luc
 Cell Line Info 
Homo sapiens (Human) -
Melan-a
 Cell Line Info 
Mus musculus (Mouse) -
JB6 Cl 41-5a
 Cell Line Info 
Mus musculus (Mouse) -