Brief Information of the Cell Line and Protein
Cell Line ID: CL000045 , A-375
 Cell Line Info 
Synonyms
A 375
A375
A375-MEL
A375-mel
A375mel
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0132
Protein ID: PT00911 , Melanocyte-stimulating hormone receptor
 Protein Info 
Gene Name MC1R
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q01726
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000045
 Cell Line Info 
 Protein ID: PT00911
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0388945
 Compound Info 
(3S,6S,9R,12S,15S,23S)-15-[[(2R)-2-acetamidohexanoyl]amino]-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-9-(naphthalen-2-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide
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C54H71N15O9
  2
1
EC50 = 3.3 nM
 Bioactivity Info 
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2
IC50 = 100 nM
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CP0382074
 Compound Info 
(3S,6S,9R,12S,15S,23S)-15-[[(2R)-2-acetamidohexanoyl]amino]-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-1,4,7,13-tetramethyl-9-(naphthalen-2-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide
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C58H79N15O9
  2
1
EC50 = 20 nM
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2
IC50 = 8.7 nM
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CP0382073
 Compound Info 
(3S,6S,9R,12S,15S,23S)-15-[[(2R)-2-acetamidohexanoyl]amino]-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-7,13-dimethyl-9-(naphthalen-2-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide
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C56H75N15O9
  2
1
EC50 = 22 nM
 Bioactivity Info 
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2
IC50 = 14.8 nM
 Bioactivity Info 
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CP0091326
 Compound Info 
(3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexanoylamino)-9-benzyl-6-(3-guanidino-propyl)-12-(3H-imidazol-4-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18hexaaza-cyclotricosane-23-carboxylic acid amide
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C50H69N15O9
  2
1
EC50 = 110 nM
 Bioactivity Info 
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2
IC50 = 6.7 nM
 Bioactivity Info 
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