General Information of the Protein
Protein ID
PT01028
Protein Name
Ephrin type-B receptor 4
Secondarily
Protein Name
Hepatoma transmembrane kinase
Tyrosine-protein kinase TYRO11
Gene Name
EPHB4
Secondarily
Gene Name
HTK
MYK1
TYRO11
Sequence
MELRVLLCWASLAAALEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEVCDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDADTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCREDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSAVCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALRCRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPVPFEPVNVTTDREVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLALIAGTAVVGVVLVLVVIVVAVLCLRKQSNGREAEYSDKHGQYLIGHGTKVYIDPFTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLDQRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKKILASVQHMKSQAKPGTPGGTGGPAPQY
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Eph family
Function
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.
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Uniprot ID
Primary ID:
P54760

Secondarily ID:
B5A970
B5A971
B5A972
Q7Z635
Q9BTA5
Q9BXP0
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Ensembl ID
ENSG00000196411
HGNC ID
HGNC:3395
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000045 , A-375
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0672877
 Compound Info 
1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea
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C23H29FN6O
  1
1
IC50 = 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000077 , Ba/F3
 Cell Line Info 
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Cell Line ID: CL001056 , MEF-1 [Mouse fibroblast]
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0019908
 Compound Info 
BDBM50242742
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C30H40ClN7O3S
  2
1 EC50 > 1000 nM
2 Kd = 750 nM
CP0233572
 Compound Info 
2-N-(2,6-dimorpholin-4-ylpyridin-4-yl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamine
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C25H29N9O2
  1
1 IC50 = 0.9 nM
CP0554480
 Compound Info 
3-(4-(5-chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)-5-(methylsulfonamido)benzenesulfonamide
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C18H17ClN6O6S2
  1
1 IC50 = 1 nM
CP0116958
 Compound Info 
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamine
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C26H30N8O2
  1
1 IC50 = 1.3 nM
CP0039399
 Compound Info 
8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydroxyphenyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
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C22H19N5O4
  2
1 IC50 = 1.6 nM
2 IC50 = 5 nM
CP0127575
 Compound Info 
4-N-(5-chloro-1,3-benzodioxol-4-yl)-2-N-(3,5-dimorpholin-4-ylphenyl)pyrimidine-2,4-diamine
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C25H27ClN6O4
  2
1 IC50 = 2 nM
2 IC50 = 4 nM
CP0352321
 Compound Info 
4-N-(5-chloro-1,3-benzodioxol-4-yl)-2-N-(3-methylsulfonyl-5-morpholin-4-ylphenyl)pyrimidine-2,4-diamine
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C22H22ClN5O5S
  1
1 IC50 = 2 nM
CP0352322
 Compound Info 
N-[3-[[4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-morpholin-4-ylphenyl]methanesulfonamide
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C22H23ClN6O5S
  1
1 IC50 = 2 nM
CP0135850
 Compound Info 
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(3-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine
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C26H32N6O3
  1
1 IC50 = 2 nM
CP0135851
 Compound Info 
(3-(isopropyl(2-(3-(methylsulfonyl)-5-morpholinophenylamino)pyrimidin-4-yl)amino)-4-methylphenyl)methanol
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C26H33N5O4S
  1
1 IC50 = 2 nM
CP0207638
 Compound Info 
(2-chloro-5-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)phenyl)methanol
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C26H31ClN6O3
  1
1 IC50 = 2 nM
CP0219293
 Compound Info 
(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-5-methoxyphenyl)methanol
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C27H34N6O4
  1
1 IC50 = 2 nM
CP0253191
 Compound Info 
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(5-methoxypyridin-3-yl)-4-N-methylpyrimidine-2,4-diamine
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C25H31N7O3
  1
1 IC50 = 2 nM
CP0116959
 Compound Info 
2-N-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamine
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C24H28N10O2
  1
1 IC50 = 2.6 nM
CP0207621
 Compound Info 
(4-methyl-3-(methyl(2-(3-(methylsulfonyl)-5-morpholinophenylamino)pyrimidin-4-yl)amino)phenyl)methanol
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C24H29N5O4S
  1
1 IC50 = 3 nM
CP0049382
 Compound Info 
(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanol
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C27H34N6O3
  1
1 IC50 = 4 nM
CP0207620
 Compound Info 
(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(ethyl)amino)-4-methylphenyl)methanol
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C28H36N6O3
  1
1 IC50 = 4 nM
CP0253757
 Compound Info 
(4-methyl-3-(methyl(2-(3-(4-methylpiperazin-1-yl)-5-morpholinophenylamino)pyrimidin-4-yl)amino)phenyl)methanol
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C28H37N7O2
  1
1 IC50 = 4 nM
CP0036684
 Compound Info 
(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(isopropyl)amino)-4-methylphenyl)methanol
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C29H38N6O3
  1
1 IC50 = 5 nM
CP0171140
 Compound Info 
(3-((2-(3-methoxy-5-morpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanol
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C24H29N5O3
  1
1 IC50 = 5 nM
CP0252942
 Compound Info 
(4-methyl-3-(methyl(2-(3-morpholino-5-(morpholinomethyl)phenylamino)pyrimidin-4-yl)amino)phenyl)methanol
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C28H36N6O3
  1
1 IC50 = 6 nM
CP0294196
 Compound Info 
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(6-methoxypyridin-2-yl)-4-N-methylpyrimidine-2,4-diamine
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C25H31N7O3
  1
1 IC50 = 6 nM
CP0300435
 Compound Info 
4-N-(3-chlorophenyl)-2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-methylpyrimidine-2,4-diamine
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C25H29ClN6O2
  1
1 IC50 = 6 nM
CP0271322
 Compound Info 
4-(3-(4-((5-(hydroxymethyl)-2-methylphenyl)(methyl)amino)pyrimidin-2-ylamino)-5-morpholinophenyl)piperazin-1-ol
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C27H35N7O3
  1
1 IC50 = 7 nM
CP0102613
 Compound Info 
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-methyl-4-N-(3-methylphenyl)pyrimidine-2,4-diamine
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C26H32N6O2
  1
1 IC50 = 8 nM
CP0135843
 Compound Info 
(4-methyl-3-(methyl(2-(3-morpholino-5-(tetrahydro-2H-pyran-4-yloxy)phenylamino)pyrimidin-4-yl)amino)phenyl)methanol
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C28H35N5O4
  1
1 IC50 = 8 nM
CP0300465
 Compound Info 
(3-((2-(3-(2-methoxyethoxy)-5-morpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanol
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C26H33N5O4
  1
1 IC50 = 8 nM
CP0255598
 Compound Info 
(4-methyl-3-(methyl(2-(3-morpholino-5-(1,4-oxazepan-4-yl)phenylamino)pyrimidin-4-yl)amino)phenyl)methanol
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C28H36N6O3
  1
1 IC50 = 9 nM
CP0164812
 Compound Info 
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-methyl-4-N-(2-methylphenyl)pyrimidine-2,4-diamine
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C26H32N6O2
  1
1 IC50 = 10 nM
CP0222563
 Compound Info 
(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)phenyl)methanol
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C26H32N6O3
  1
1 IC50 = 10 nM
CP0253439
 Compound Info 
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(5-methoxy-2-methylphenyl)-4-N-methylpyrimidine-2,4-diamine
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C27H34N6O3
  1
1 IC50 = 10 nM
CP0313104
 Compound Info 
(4-methyl-3-(methyl(2-(3-morpholino-5-(piperidin-1-yl)phenylamino)pyrimidin-4-yl)amino)phenyl)methanol
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C28H36N6O2
  1
1 IC50 = 10 nM
CP0315162
 Compound Info 
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(1H-indazol-4-yl)pyrimidine-2,4-diamine
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C25H28N8O2
  1
1 IC50 = 11 nM
CP0197707
 Compound Info 
N-[3-[[4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-methylsulfonylphenyl]methanesulfonamide
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C19H18ClN5O6S2
  1
1 IC50 = 12 nM
CP0252926
 Compound Info 
(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(2-methoxyethyl)amino)-4-methylphenyl)methanol
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C29H38N6O4
  1
1 IC50 = 12 nM
CP0336576
 Compound Info 
3-(4-(5-chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)-5-morpholinobenzamide
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C22H21ClN6O4
  1
1 IC50 = 13 nM
CP0256544
 Compound Info 
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(4-methoxypyridin-2-yl)-4-N-methylpyrimidine-2,4-diamine
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C25H31N7O3
  1
1 IC50 = 13 nM
CP0252925
 Compound Info 
(3-((2-(2,6-dimorpholinopyridin-4-ylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanol
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C26H33N7O3
  1
1 IC50 = 14 nM
CP0511559
 Compound Info 
N-[3-[[4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-(methanesulfonamido)phenyl]methanesulfonamide
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C19H19ClN6O6S2
  1
1 IC50 = 15 nM
CP0315192
 Compound Info 
(3-((2-(2,6-dimorpholinopyrimidin-4-ylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanol
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C25H32N8O3
  1
1 IC50 = 15 nM
CP0271323
 Compound Info 
(4-methyl-3-(methyl(2-(3-morpholino-5-(pyrrolidin-1-yl)phenylamino)pyrimidin-4-yl)amino)phenyl)methanol
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C27H34N6O2
  1
1 IC50 = 16 nM
CP0256543
 Compound Info 
(3-(4-((5-(hydroxymethyl)-2-methylphenyl)(methyl)amino)pyrimidin-2-ylamino)-5-morpholinophenyl)(morpholino)methanone
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C28H34N6O4
  1
1 IC50 = 17 nM
CP0292022
 Compound Info 
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-methyl-4-N-phenylpyrimidine-2,4-diamine
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C25H30N6O2
  1
1 IC50 = 17 nM
CP0135844
 Compound Info 
4-N-(2,5-dimethylphenyl)-2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-methylpyrimidine-2,4-diamine
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C27H34N6O2
  1
1 IC50 = 19 nM
CP0020367
 Compound Info 
3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c]pyridin-7-yl)benzenesulfonamide
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C19H13ClFN3O2S2
  1
1 IC50 = 21 nM
CP0315164
 Compound Info 
(3-(4-((1H-indazol-4-yl)(methyl)amino)pyrimidin-2-ylamino)phenyl)methanol
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C19H18N6O
  1
1 IC50 = 21 nM
CP0206903
 Compound Info 
3-(4-(5-chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)-5-(methylsulfonyl)benzamide
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C19H16ClN5O5S
  1
1 IC50 = 23 nM
CP0091881
 Compound Info 
2,4-Pyrimidine derivative, 28
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C18H15ClN4O4S
  2
1 IC50 = 25 nM
2 IC50 = 90 nM
CP0258762
 Compound Info 
3-(4-((1H-indazol-4-yl)(methyl)amino)pyrimidin-2-ylamino)-N,N-dimethylbenzamide
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C21H21N7O
  1
1 IC50 = 29 nM
CP0116956
 Compound Info 
4-N-(1,3-benzodioxol-4-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
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C18H16N4O4S
  1
1 IC50 = 34 nM
CP0218553
 Compound Info 
1-(3-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)ethanol
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C28H36N6O3
  1
1 IC50 = 35 nM
CP0225226
 Compound Info 
4-N-(5-chloro-1,3-benzodioxol-4-yl)-4-N-methyl-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
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C19H17ClN4O4S
  1
1 IC50 = 36 nM
CP0317073
 Compound Info 
4-N-(1H-indazol-4-yl)-4-N-methyl-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
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C19H18N6O2S
  1
1 IC50 = 36 nM
CP0185785
 Compound Info 
2,4-Pyrimidine derivative, 25
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C17H14ClN5O4S
  1
1 IC50 = 40 nM
CP0511413
 Compound Info 
2-(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c]pyridin-7-yl)phenyl)acetamide
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C21H15ClFN3OS
  1
1 IC50 = 44 nM
CP0059212
 Compound Info 
3-(3-chloro-4-fluorophenyl)-7-(pyridin-3-yl)thieno[3,2-c]pyridin-4-amine
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C18H11ClFN3S
  1
1 IC50 = 51 nM
CP0317074
 Compound Info 
4-N-(3-chloro-2H-indazol-4-yl)-2-N-(3,5-dimorpholin-4-ylphenyl)pyrimidine-2,4-diamine
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C25H27ClN8O2
  1
1 IC50 = 55 nM
CP0274585
 Compound Info 
3-(3-chloro-4-fluorophenyl)-7-(3-(methylsulfonyl)phenyl)thieno[3,2-c]pyridin-4-amine
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C20H14ClFN2O2S2
  1
1 IC50 = 59 nM
CP0258760
 Compound Info 
4-N-(1H-indazol-4-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
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C18H16N6O2S
  1
1 IC50 = 61 nM
CP0258763
 Compound Info 
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(3-methyl-2H-indazol-4-yl)pyrimidine-2,4-diamine
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C26H30N8O2
  1
1 IC50 = 67 nM
CP0197708
 Compound Info 
5-(4-(5-chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)isophthalamide
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C19H15ClN6O4
  1
1 IC50 = 77 nM
CP0342841
 Compound Info 
N-[3-[[4-(1H-indazol-4-ylamino)pyrimidin-2-yl]amino]phenyl]methanesulfonamide
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C18H17N7O2S
  1
1 IC50 = 84 nM
CP0116957
 Compound Info 
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(1H-indazol-7-yl)pyrimidine-2,4-diamine
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C25H28N8O2
  1
1 IC50 = 89 nM
CP0258761
 Compound Info 
2-((5-chlorobenzo[d][1,3]dioxol-4-yl)(2-(3-(methylsulfonyl)phenylamino)pyrimidin-4-yl)amino)acetonitrile
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C20H16ClN5O4S
  1
1 IC50 = 95 nM
CP0554479
 Compound Info 
2-N-[3,5-bis(methylsulfonyl)phenyl]-4-N-(5-chloro-1,3-benzodioxol-4-yl)pyrimidine-2,4-diamine
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C19H17ClN4O6S2
  1
1 IC50 = 114 nM
CP0105791
 Compound Info 
4-N-(2H-benzotriazol-4-yl)-2-N-(3,5-dimorpholin-4-ylphenyl)pyrimidine-2,4-diamine
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C24H27N9O2
  1
1 IC50 = 115 nM
CP0369740
 Compound Info 
2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(1H-indol-4-yl)pyrimidine-2,4-diamine
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C26H29N7O2
  1
1 IC50 = 117 nM
CP0127580
 Compound Info 
2-((5-chlorobenzo[d][1,3]dioxol-4-yl)(2-(3-(methylsulfonyl)phenylamino)pyrimidin-4-yl)amino)ethanol
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C20H19ClN4O5S
  1
1 IC50 = 121 nM
CP0046280
 Compound Info 
1-amino-5-(5-hydroxy-2-methylphenyl)-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinolin-6-one
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C18H18N4O2
  2
1 IC50 = 160 nM
2 IC50 = 300 nM
CP0315163
 Compound Info 
(3-(4-(1H-indazol-4-ylamino)pyrimidin-2-ylamino)phenyl)methanol
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C18H16N6O
  1
1 IC50 = 204 nM
CP0127578
 Compound Info 
4-N-(1-benzofuran-7-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
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C19H16N4O3S
  1
1 IC50 = 205 nM
CP0317733
 Compound Info 
4-N-(1,3-benzoxazol-7-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
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C18H15N5O3S
  1
1 IC50 = 219 nM
CP0090272
 Compound Info 
3-(4-(5-chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)benzamide
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C18H14ClN5O3
  1
1 IC50 = 220 nM
CP0233571
 Compound Info 
3-(4-(1H-indazol-4-ylamino)pyrimidin-2-ylamino)-N,N-dimethylbenzamide
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C20H19N7O
  1
1 IC50 = 246 nM
CP0342840
 Compound Info 
4-N-(5-chloro-1,3-benzodioxol-4-yl)-4-N-(2-methoxyethyl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
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C21H21ClN4O5S
  1
1 IC50 = 246 nM
CP0369739
 Compound Info 
4-N-(6-chloro-1-benzofuran-7-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
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C19H15ClN4O3S
  1
1 IC50 = 300 nM
CP0344908
 Compound Info 
3-(4-(5-chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)-5-(methylsulfonamido)benzamide
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C19H17ClN6O5S
  1
1 IC50 = 370 nM
CP0342842
 Compound Info 
2-N-(4,6-dimorpholin-4-ylpyrimidin-2-yl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamine
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C24H28N10O2
  1
1 IC50 = 432 nM
CP0317072
 Compound Info 
4-N-(1,3-benzoxazol-4-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
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C18H15N5O3S
  1
1 IC50 = 549 nM
CP0086942
 Compound Info 
N-[3-[[4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]phenyl]methanesulfonamide
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C18H16ClN5O4S
  1
1 IC50 = 794 nM
CP0127579
 Compound Info 
4-N-(2,3-dihydro-1-benzofuran-7-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
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C19H18N4O3S
  1
1 IC50 = 1160 nM
CP0140813
 Compound Info 
6-butyl-4-methyl-7-phenylpurino[7,8-a]imidazole-1,3-dione
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C18H19N5O2
  2
1 IC50 = 1500 nM
2 IC50 = 8300 nM
CP0302715
 Compound Info 
8-(2-methoxyphenyl)-1-methyl-7-phenyl-1H-imidazo[1,2-f]purine-2,4(3H,8H)-dione
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C21H17N5O3
  2
1 IC50 = 3300 nM
2 IC50 = 4350 nM
Clinical Information about the Protein
Target 1 ( Ephrin type-B receptor 4 (EPHB4) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Non-small-cell lung cancer [ICD-11: 2C25.Y]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 KD019
 Drug Info 
Phase 2
Non-small-cell lung cancer