General Information of the Cell Line
Cell Line ID
CL000077
Cell Line Name
Ba/F3
Synonyms
BA/F3
BaF3
BAF3
Baf3
Category
Factor-dependent cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_0161
Tissue Information
Bone marrow
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00840, Adenosine receptor A1
 Protein Info 
Compound ID Compound Name Compound Formula
CP0017968
 Compound Info 
3-cyano-4-[2-[2-[(2-piperidin-4-ylethylamino)methyl]pyridin-4-yl]-4-[3-(trifluoromethyl)phenyl]phenoxy]-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide
   Show/Hide
C35H32F3N7O3S2
  1
1
EC50 = 1430 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT01203, ALK tyrosine kinase receptor
 Protein Info 
Protein ID: PT06841, ALK tyrosine kinase receptor
 Protein Info 
Protein ID: PT00883, Angiopoietin-1 receptor
 Protein Info 
Protein ID: PT00649, BCR/ABL p210 fusion protein
 Protein Info 
Protein ID: PT01390, BDNF/NT-3 growth factors receptor
 Protein Info 
Protein ID: PT05484, C-C chemokine receptor type 10
 Protein Info 
Protein ID: PT01304, C-X-C chemokine receptor type 1
 Protein Info 
Protein ID: PT01013, C-X-C chemokine receptor type 2
 Protein Info 
Protein ID: PT03433, C-X-C chemokine receptor type 3
 Protein Info 
Protein ID: PT00951, Cadherin family member 12
 Protein Info 
Protein ID: PT03813, Chemerin-like receptor 1
 Protein Info 
Protein ID: PT06934, Chemerin-like receptor 1
 Protein Info 
Protein ID: PT01669, Cytoplasmic tyrosine-protein kinase BMX
 Protein Info 
Protein ID: PT06169, Cytoplasmic tyrosine-protein kinase BMX
 Protein Info 
Protein ID: PT01678, Discoidin domain-containing receptor 2
 Protein Info 
Protein ID: PT01064, Ephrin type-A receptor 1
 Protein Info 
Protein ID: PT01335, Ephrin type-A receptor 2
 Protein Info 
Protein ID: PT06860, Ephrin type-A receptor 3
 Protein Info 
Protein ID: PT02172, Ephrin type-B receptor 1
 Protein Info 
Protein ID: PT04968, Ephrin type-B receptor 2
 Protein Info 
Protein ID: PT01028, Ephrin type-B receptor 4
 Protein Info 
Protein ID: PT00922, Epidermal growth factor receptor
 Protein Info 
Protein ID: PT01605, Epidermal growth factor receptor
 Protein Info 
Protein ID: PT02113, Epithelial discoidin domain-containing receptor 1
 Protein Info 
Protein ID: PT01091, Fibroblast growth factor receptor 1
 Protein Info 
Protein ID: PT01115, Fibroblast growth factor receptor 2
 Protein Info 
Protein ID: PT01411, Fibroblast growth factor receptor 3
 Protein Info 
Protein ID: PT06924, Fibroblast growth factor receptor 3
 Protein Info 
Protein ID: PT01343, Fibroblast growth factor receptor 4
 Protein Info 
Protein ID: PT07029, Fibroblast growth factor receptor 4
 Protein Info 
Protein ID: PT01201, Hepatocyte growth factor receptor
 Protein Info 
Protein ID: PT04740, Hepatocyte growth factor receptor
 Protein Info 
Protein ID: PT00934, High affinity nerve growth factor receptor
 Protein Info 
Protein ID: PT01101, Insulin receptor
 Protein Info 
Protein ID: PT05069, Insulin receptor
 Protein Info 
Protein ID: PT01104, Insulin-like growth factor 1 receptor
 Protein Info 
Protein ID: PT06120, Insulin-like growth factor 1 receptor
 Protein Info 
Protein ID: PT02470, Lysine--tRNA ligase
 Protein Info 
Protein ID: PT01008, Macrophage colony-stimulating factor 1 receptor
 Protein Info 
Protein ID: PT02032, Macrophage colony-stimulating factor 1 receptor
 Protein Info 
Protein ID: PT00933, Macrophage-stimulating protein receptor
 Protein Info 
Protein ID: PT06925, Macrophage-stimulating protein receptor
 Protein Info 
Protein ID: PT00888, Mast/stem cell growth factor receptor Kit
 Protein Info 
Protein ID: PT06681, Mast/stem cell growth factor receptor Kit
 Protein Info 
Protein ID: PT06170, Mitogen-activated protein kinase 9
 Protein Info 
Protein ID: PT01540, Non-receptor tyrosine-protein kinase TYK2
 Protein Info 
Protein ID: PT00936, NT-3 growth factor receptor
 Protein Info 
Protein ID: PT01092, Platelet-derived growth factor receptor alpha
 Protein Info 
Protein ID: PT00832, Platelet-derived growth factor receptor beta
 Protein Info 
Protein ID: PT00844, Platelet-derived growth factor receptor beta
 Protein Info 
Protein ID: PT06733, Proto-oncogene c-Ret
 Protein Info 
Protein ID: PT01061, Proto-oncogene tyrosine-protein kinase ROS
 Protein Info 
Protein ID: PT06680, Proto-oncogene tyrosine-protein kinase ROS
 Protein Info 
Protein ID: PT00879, Proto-oncogene tyrosine-protein kinase Src
 Protein Info 
Protein ID: PT02255, Proto-oncogene tyrosine-protein kinase Src
 Protein Info 
Protein ID: PT01233, Receptor tyrosine-protein kinase erbB-2
 Protein Info 
Protein ID: PT01204, Receptor-type tyrosine-protein kinase FLT3
 Protein Info 
Protein ID: PT05302, Receptor-type tyrosine-protein kinase FLT3
 Protein Info 
Protein ID: PT06683, Ribosomal protein S6 kinase alpha-2
 Protein Info 
Protein ID: PT03681, Ribosomal protein S6 kinase alpha-3
 Protein Info 
Protein ID: PT01381, Serine/threonine-protein kinase B-raf
 Protein Info 
Protein ID: PT01017, Serine/threonine-protein kinase pim-1
 Protein Info 
Protein ID: PT06051, Thrombopoietin receptor
 Protein Info 
Protein ID: PT01071, Tyrosine-protein kinase ABL1
 Protein Info 
Protein ID: PT03338, Tyrosine-protein kinase ABL1
 Protein Info 
Protein ID: PT01654, Tyrosine-protein kinase Blk
 Protein Info 
Protein ID: PT01664, Tyrosine-protein kinase Fer
 Protein Info 
Protein ID: PT01342, Tyrosine-protein kinase Fgr
 Protein Info 
Protein ID: PT06926, Tyrosine-protein kinase Fgr
 Protein Info 
Protein ID: PT00929, Tyrosine-protein kinase HCK
 Protein Info 
Protein ID: PT01659, Tyrosine-protein kinase JAK1
 Protein Info 
Protein ID: PT01214, Tyrosine-protein kinase JAK2
 Protein Info 
Protein ID: PT04886, Tyrosine-protein kinase JAK2
 Protein Info 
Protein ID: PT00892, Tyrosine-protein kinase JAK3
 Protein Info 
Protein ID: PT00876, Tyrosine-protein kinase Lck
 Protein Info 
Protein ID: PT00875, Tyrosine-protein kinase Lyn
 Protein Info 
Protein ID: PT02084, Tyrosine-protein kinase Lyn
 Protein Info 
Protein ID: PT01182, Tyrosine-protein kinase Mer
 Protein Info 
Protein ID: PT07205, Tyrosine-protein kinase Mer
 Protein Info 
Protein ID: PT01868, Tyrosine-protein kinase receptor Tie-1
 Protein Info 
Protein ID: PT06840, Tyrosine-protein kinase receptor Tie-1
 Protein Info 
Protein ID: PT01661, Tyrosine-protein kinase receptor TYRO3
 Protein Info 
Protein ID: PT01128, Tyrosine-protein kinase receptor UFO
 Protein Info 
Protein ID: PT07477, Tyrosine-protein kinase receptor UFO
 Protein Info 
Protein ID: PT01441, Tyrosine-protein kinase SYK
 Protein Info 
Protein ID: PT00846, Tyrosine-protein kinase ZAP-70
 Protein Info 
Protein ID: PT06752, Tyrosine-protein kinase ZAP-70
 Protein Info 
Protein ID: PT01142, Vascular endothelial growth factor receptor 1
 Protein Info 
Protein ID: PT02141, Vascular endothelial growth factor receptor 1
 Protein Info 
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
 Protein Info 
Protein ID: PT00925, Vascular endothelial growth factor receptor 3
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0002211
 Compound Info 
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
   Show/Hide
 C22H27FN4O2  1
1
GI50 = 4789 nM
   TI
   LI
   LO
   TS
CP0002778
 Compound Info 
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
   Show/Hide
 C29H31N7O  1
1
GI50 = 6700 nM
   TI
   LI
   LO
   TS
CP0005166
 Compound Info 
BMS-354825
   Show/Hide
 C22H26ClN7O2S  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0007430
 Compound Info 
IBRUTINIB
   Show/Hide
 C25H24N6O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0013877
 Compound Info 
CERITINIB
   Show/Hide
 C28H36ClN5O3S  1
1
IC50 = 2477 nM
   TI
   LI
   LO
   TS
CP0016677
 Compound Info 
N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide
   Show/Hide
 C35H30N4O4  1
1
GI50 = 540 nM
   TI
   LI
   LO
   TS
CP0030740
 Compound Info 
1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea
   Show/Hide
 C29H32N6O4S  9
1
GI50 < 0.3 nM
   TI
   LI
   LO
   TS
2
GI50 = 4.4 nM
   TI
   LI
   LO
   TS
3
GI50 = 17 nM
   TI
   LI
   LO
   TS
4
GI50 = 24 nM
   TI
   LI
   LO
   TS
5
GI50 = 110 nM
   TI
   LI
   LO
   TS
6
GI50 = 120 nM
   TI
   LI
   LO
   TS
7
GI50 = 400 nM
   TI
   LI
   LO
   TS
8
GI50 = 1659.5 nM
   TI
   LI
   LO
   TS
9
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0033646
 Compound Info 
AZD-9291
   Show/Hide
 C28H33N7O2  2
1
GI50 = 1200 nM
   TI
   LI
   LO
   TS
2
IC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0043225
 Compound Info 
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
   Show/Hide
 C21H15ClF4N4O3  1
1
GI50 = 9953 nM
   TI
   LI
   LO
   TS
CP0059062
 Compound Info 
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
   Show/Hide
 C25H27ClN6O3  2
1
GI50 = 2200 nM
   TI
   LI
   LO
   TS
2
GI50 = 3800 nM
   TI
   LI
   LO
   TS
CP0062729
 Compound Info 
3-(2-phenylethynyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
 C16H15N5  1
1
GI50 = 16100 nM
   TI
   LI
   LO
   TS
CP0065824
 Compound Info 
3-(5-cyclopropyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
 C14H16N6O  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0065873
 Compound Info 
1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanone
   Show/Hide
 C26H29N7O2  1
1
GI50 = 4900 nM
   TI
   LI
   LO
   TS
CP0095871
 Compound Info 
3-(5-cyclopropyl-1,2-oxazol-3-yl)-1-methylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
 C12H12N6O  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0106777
 Compound Info 
3-(1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
 C11H12N6O  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0111985
 Compound Info 
3-(4-methylimidazol-1-yl)-N-[3-[[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]-5-(trifluoromethyl)benzamide
   Show/Hide
 C31H23F3N6O2  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0116539
 Compound Info 
5-methyl-2-N-[5-methyl-4-(1-methylpiperidin-4-yl)-2-propan-2-yloxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
   Show/Hide
 C30H41N5O3S  1
1
IC50 = 4077 nM
   TI
   LI
   LO
   TS
CP0132005
 Compound Info 
2-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-N-(1-propan-2-ylpyrazol-4-yl)acetamide
   Show/Hide
 C24H25N5O4  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0139586
 Compound Info 
(10S,12Z,15S,16R)-6,15,16-trihydroxy-4-methoxy-10-methyl-9-oxatricyclo[15.3.1.02,7]henicosa-1(21),2(7),3,5,12,17,19-heptaene-8,14-dione
   Show/Hide
 C22H22O7  1
1
GI50 = 10000 nM
   TI
   LI
   LO
   TS
CP0140879
 Compound Info 
1-propan-2-yl-3-(5-pyridin-2-yl-1,2-oxazol-3-yl)pyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
 C16H15N7O  1
1
GI50 = 5300 nM
   TI
   LI
   LO
   TS
CP0160838
 Compound Info 
5-amino-1-propan-2-yl-3-(5-thiophen-2-yl-1,2-oxazol-3-yl)pyrazole-4-carboxamide
   Show/Hide
 C14H15N5O2S  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0161675
 Compound Info 
1-[4-[4-amino-3-[4-(2-morpholin-4-ylethoxy)phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea
   Show/Hide
 C31H35N9O4  8
1
GI50 < 0.3 nM
   TI
   LI
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   TS
2
GI50 = 2 nM
   TI
   LI
   LO
   TS
3
GI50 = 12 nM
   TI
   LI
   LO
   TS
4
GI50 = 46 nM
   TI
   LI
   LO
   TS
5
GI50 = 56 nM
   TI
   LI
   LO
   TS
6
GI50 = 3700 nM
   TI
   LI
   LO
   TS
7
GI50 = 6400 nM
   TI
   LI
   LO
   TS
8
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0174992
 Compound Info 
3-(5-tert-butyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
 C15H20N6O  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0176935
 Compound Info 
US8592432, 34
   Show/Hide
 C31H41N7O3S  1
1
IC50 = 2507 nM
   TI
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   TS
CP0181070
 Compound Info 
3-[5-(4-fluorophenyl)-1,2-oxazol-3-yl]-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
 C17H15FN6O  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0186358
 Compound Info 
5-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-fluoro-2-methylphenol
   Show/Hide
 C17H16FN3O3  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0192497
 Compound Info 
N-(1,3-dimethylpyrazol-4-yl)-2-[2-methoxy-4-(7-methoxyquinolin-4-yl)oxyphenyl]acetamide
   Show/Hide
 C24H24N4O4  1
1
GI50 = 4289 nM
   TI
   LI
   LO
   TS
CP0202493
 Compound Info 
(10S,12Z,14R,15R,16R)-6,14,15,16-tetrahydroxy-4-methoxy-10-methyl-9-oxatricyclo[15.3.1.02,7]henicosa-1(21),2(7),3,5,12,17,19-heptaen-8-one
   Show/Hide
 C22H24O7  1
1
GI50 > 25000 nM
   TI
   LI
   LO
   TS
CP0202494
 Compound Info 
(10S,12Z,14S,15R,16R)-14-amino-6,15,16-trihydroxy-4-methoxy-10-methyl-9-oxatricyclo[15.3.1.02,7]henicosa-1(21),2(7),3,5,12,17,19-heptaen-8-one
   Show/Hide
 C22H25NO6  1
1
GI50 > 25000 nM
   TI
   LI
   LO
   TS
CP0224766
 Compound Info 
4-(methylamino)-2-[4-methyl-3-(prop-2-enoylamino)anilino]-N-[2-methyl-5-[(3,4,5-trimethoxybenzoyl)amino]phenyl]pyrimidine-5-carboxamide
   Show/Hide
 C33H35N7O6  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0253957
 Compound Info 
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[[6-(trifluoromethyl)pyridin-3-yl]methyl]urea
   Show/Hide
 C24H21F3N6O2  1
1
EC50 = 80 nM
   TI
   LI
   LO
   TS
CP0263163
 Compound Info 
2-amino-1-ethyl-7-[(3R)-3-hydroxy-4-methoxy-3-methylbut-1-ynyl]-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide
   Show/Hide
 C18H22N4O4  1
1
GI50 > 25000 nM
   TI
   LI
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   TS
CP0272876
 Compound Info 
N-(2-hydroxyethyl)-3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide
   Show/Hide
 C20H17F3N4O3  1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0273351
 Compound Info 
3-(4-fluorophenyl)-7-(furan-2-yl)imidazo[1,2-a]pyridine
   Show/Hide
 C17H11FN2O  1
1
GI50 > 1000 nM
   TI
   LI
   LO
   TS
CP0304455
 Compound Info 
3-(5-phenyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
 C17H16N6O  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0309083
 Compound Info 
N-[3-[[1-(6-aminopyrimidin-4-yl)benzimidazol-2-yl]amino]-4-methylphenyl]-5-tert-butylthiophene-2-carboxamide
   Show/Hide
 C27H27N7OS  1
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
CP0309740
 Compound Info 
3-(5-phenyl-4,5-dihydro-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
 C17H18N6O  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0346926
 Compound Info 
5-[(Z)-[6-[3-[[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzoyl]amino]anilino]-2-oxo-1H-indol-3-ylidene]methyl]-1H-pyrrole-3-carboxylic acid
   Show/Hide
 C33H29F3N6O4  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0364644
 Compound Info 
1-[4-amino-3-(5-cyclopropyl-1,2-oxazol-3-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropan-2-ol
   Show/Hide
 C15H18N6O2  1
1
GI50 > 10000 nM
   TI
   LI
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   TS
CP0378059
 Compound Info 
N-[3-[[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]-3-(trifluoromethyl)benzamide
   Show/Hide
 C27H19F3N4O2  1
1
IC50 = 4800 nM
   TI
   LI
   LO
   TS
CP0383413
 Compound Info 
N-[2-methyl-5-(2-oxo-9-pyrazol-1-ylbenzo[h][1,6]naphthyridin-1-yl)phenyl]prop-2-enamide
   Show/Hide
 C25H19N5O2  1
1
GI50 > 10000 nM
   TI
   LI
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   TS
CP0385517
 Compound Info 
2-chloro-3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
   Show/Hide
 C16H14ClN3O3  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0385522
 Compound Info 
4-chloro-3-[(6,7-dimethoxyquinazolin-4-yl)amino]-2-fluorophenol
   Show/Hide
 C16H13ClFN3O3  1
1
IC50 > 10000 nM
   TI
   LI
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   TS
CP0385988
 Compound Info 
3-[(6,7-dimethoxyquinazolin-4-yl)amino]-2,4-difluorophenol
   Show/Hide
 C16H13F2N3O3  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0387298
 Compound Info 
4-(methylamino)-2-[4-methyl-3-(propanoylamino)anilino]-N-[2-methyl-5-[(3,4,5-trimethoxybenzoyl)amino]phenyl]pyrimidine-5-carboxamide
   Show/Hide
 C33H37N7O6  1
1
GI50 > 10000 nM
   TI
   LI
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   TS
CP0387299
 Compound Info 
4-(methylamino)-2-[4-methyl-3-(propanoylamino)anilino]-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]pyrimidine-5-carboxamide
   Show/Hide
 C31H30F3N7O3  1
1
GI50 > 10000 nM
   TI
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CP0388541
 Compound Info 
N-[4-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]phenyl]methanesulfonamide
   Show/Hide
 C18H15F3N4O3S  1
1
EC50 = 2210 nM
   TI
   LI
   LO
   TS
CP0388616
 Compound Info 
3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxy-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine
   Show/Hide
 C26H29N5O3  1
1
IC50 > 11000 nM
   TI
   LI
   LO
   TS
CP0394288
 Compound Info 
N-[4-[[5-fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yltriazol-1-yl)acetamide
   Show/Hide
 C24H26FN7O3  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0396301
 Compound Info 
4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-methyl-5-propan-2-yloxyphenyl]piperidin-2-one
   Show/Hide
 C28H34ClN5O4S  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0396302
 Compound Info 
5-methyl-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
   Show/Hide
 C29H39N5O3S  1
1
IC50 = 2884 nM
   TI
   LI
   LO
   TS
CP0399068
 Compound Info 
2-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-N-(1-ethylpyrazol-4-yl)acetamide
   Show/Hide
 C23H23N5O4  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0404583
 Compound Info 
2-chloro-3-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-fluorophenol
   Show/Hide
 C16H13ClFN3O3  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0404687
 Compound Info 
3-[(6,7-dimethoxyquinazolin-4-yl)amino]-5-fluoro-2-methylphenol
   Show/Hide
 C17H16FN3O3  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0407914
 Compound Info 
tert-butyl (4S)-4-amino-5-[4-methyl-3-[1-methyl-7-[4-methyl-3-(prop-2-enoylamino)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]anilino]-5-oxopentanoate
   Show/Hide
 C33H40N8O5  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0410349
 Compound Info 
N-[5-[(2-fluoro-5-methylbenzoyl)amino]-2-methylphenyl]-4-(methylamino)-2-[4-methyl-3-(prop-2-enoylamino)anilino]pyrimidine-5-carboxamide
   Show/Hide
 C31H30FN7O3  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0410351
 Compound Info 
2,5-dimethoxy-N-[4-methyl-3-[1-methyl-7-[4-methyl-3-(prop-2-enoylamino)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]benzamide
   Show/Hide
 C33H33N7O5  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0410352
 Compound Info 
N-[4-methyl-3-[1-methyl-7-[4-methyl-3-(prop-2-enoylamino)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-1,3-benzodioxole-5-carboxamide
   Show/Hide
 C32H29N7O5  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0412998
 Compound Info 
N-[5-[[5-chloro-4-[2-(dimethylsulfamoyl)anilino]pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide
   Show/Hide
 C27H35ClN8O4S  1
1
EC50 = 2904 nM
   TI
   LI
   LO
   TS
CP0418567
 Compound Info 
3-[4-amino-7-[3-(hydroxymethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-5-yl]phenol
   Show/Hide
 C17H18N4O2  1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0421953
 Compound Info 
1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[3-fluoro-4-[7-methoxy-6-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]urea
   Show/Hide
 C31H36FN5O6  1
1
IC50 = 1840 nM
   TI
   LI
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CP0431567
 Compound Info 
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-[2-(dimethylsulfamoyl)anilino]-5-iodopyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
   Show/Hide
 C27H35IN8O4S  1
1
EC50 = 2270 nM
   TI
   LI
   LO
   TS
CP0433492
 Compound Info 
2-N-[4-[1-(2-methoxyethyl)piperidin-4-yl]-5-methyl-2-propan-2-yloxyphenyl]-5-methyl-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
   Show/Hide
 C32H45N5O4S  1
1
IC50 = 4407 nM
   TI
   LI
   LO
   TS
CP0441015
 Compound Info 
N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]propanamide
   Show/Hide
 C30H31F3N6OS  1
1
GI50 = 2480 nM
   TI
   LI
   LO
   TS
CP0451734
 Compound Info 
(2S)-2-amino-4-methyl-N-[4-methyl-3-[1-methyl-7-[4-methyl-3-(prop-2-enoylamino)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]pentanamide
   Show/Hide
 C30H36N8O3  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0456713
 Compound Info 
N-[5-chloro-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-[[6-(dimethylamino)pyrimidin-4-yl]amino]benzamide
   Show/Hide
 C23H17ClF4N6OS  1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0457917
 Compound Info 
4-(6-(bis(3-hydroxypropyl)amino)pyrimidin-4-ylamino)-N-(3-(4-fluoro-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-5-yl)benzamide
   Show/Hide
 C26H25F4N7O3S  1
1
EC50 = 1400 nM
   TI
   LI
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   TS
CP0458204
 Compound Info 
7-[(2-aminocyclohexyl)amino]-8-chloro-5-(3-methylanilino)-3H-pyrido[3,4-d]pyridazin-4-one
   Show/Hide
 C20H23ClN6O  1
1
GI50 = 1500 nM
   TI
   LI
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   TS
CP0461133
 Compound Info 
4-(pyrimidin-4-ylamino)-N-(7-trifluoromethyl-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-benzamide
   Show/Hide
 C23H16F3N5O2S  1
1
EC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0461134
 Compound Info 
4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide
   Show/Hide
 C23H18F4N6OS  1
1
EC50 = 8500 nM
   TI
   LI
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   TS
CP0473492
 Compound Info 
US10266535, Compound 25
   Show/Hide
 C28H33N7O2  1
1
GI50 = 1700 nM
   TI
   LI
   LO
   TS
CP0482073
 Compound Info 
N-[1-(2-hydroxy-2-methylpropyl)benzimidazol-2-yl]-2-phenylpyridine-4-carboxamide
   Show/Hide
 C23H22N4O2  1
1
IC50 > 25000 nM
   TI
   LI
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CP0482287
 Compound Info 
7-[(2-aminocyclohexyl)amino]-5-(3-methylanilino)-3H-pyrido[3,4-d]pyridazin-4-one
   Show/Hide
 C20H24N6O  1
1
GI50 = 1500 nM
   TI
   LI
   LO
   TS
CP0482380
 Compound Info 
5-chloro-2-N-[5-methyl-4-(1-methylpiperidin-4-yl)-2-propan-2-yloxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyridine-2,4-diamine
   Show/Hide
 C30H39ClN4O3S  1
1
IC50 = 5412 nM
   TI
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   TS
CP0484608
 Compound Info 
8-bromo-3-(4-methoxyphenyl)pyrimido[1,6-a]benzimidazole
   Show/Hide
 C17H12BrN3O  1
1
IC50 > 25000 nM
   TI
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CP0484609
 Compound Info 
7-bromo-4-chloropyrazino[1,2-a]benzimidazole
   Show/Hide
 C10H5BrClN3  1
1
IC50 = 2400 nM
   TI
   LI
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   TS
CP0485122
 Compound Info 
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[(6-methylpyridin-3-yl)methyl]urea
   Show/Hide
 C24H24N6O2  1
1
EC50 = 38 nM
   TI
   LI
   LO
   TS
CP0485126
 Compound Info 
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[(1-methylpyrazol-3-yl)methyl]urea
   Show/Hide
 C22H23N7O2  1
1
EC50 = 167 nM
   TI
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   TS
CP0494137
 Compound Info 
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-(2-methoxyphenyl)urea
   Show/Hide
 C24H23N5O3  1
1
EC50 = 116 nM
   TI
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   TS
CP0495558
 Compound Info 
1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[7-(cyclopentylmethoxy)-6-methoxyquinolin-4-yl]oxy-3-fluorophenyl]urea
   Show/Hide
 C30H33FN4O5  1
1
IC50 = 5556.1 nM
   TI
   LI
   LO
   TS
CP0507870
 Compound Info 
N-[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-5-yl]-4-[[6-(3-hydroxyazetidin-1-yl)pyrimidin-4-yl]amino]benzamide
   Show/Hide
 C23H17F4N7O2S  1
1
EC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0510287
 Compound Info 
2-(4-(4-(Trifluoromethoxy)phenylamino)-1H-pyrazolo-[3,4-d]pyrimidin-1-yl)ethanol
   Show/Hide
 C14H12F3N5O2  1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0520021
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]-4-[[6-(3-hydroxyazetidin-1-yl)pyrimidin-4-yl]amino]benzamide
   Show/Hide
 C24H18F4N6O3S  1
1
EC50 = 290 nM
   TI
   LI
   LO
   TS
CP0532732
 Compound Info 
US10266535, Compound 44
   Show/Hide
 C26H29N7O3  1
1
GI50 = 3900 nM
   TI
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   LO
   TS
CP0535683
 Compound Info 
N-[1-(2-hydroxy-2-methylpropyl)benzimidazol-2-yl]-2-(4-methoxypyridin-3-yl)pyridine-4-carboxamide
   Show/Hide
 C23H23N5O3  1
1
IC50 = 990 nM
   TI
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CP0545727
 Compound Info 
2-amino-5-(1-methyl-1H-pyrazol-4-yl)-N-((1S,2S)-2-((4&#8242;-((4-methylpiperazin-1-yl)methyl)-[1,1&#8242;-biphenyl]-4-yl)methoxy)cyclopentyl)nicotinamide
   Show/Hide
 C34H41N7O2  2
1
GI50 = 7.943 nM
   TI
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   TS
2
GI50 = 5011.87 nM
   TI
   LI
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CP0546566
 Compound Info 
US10266535, Compound 48
   Show/Hide
 C25H27N7O3  1
1
GI50 = 6500 nM
   TI
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CP0550580
 Compound Info 
US10266535, Compound 43
   Show/Hide
 C24H25N7O2  1
1
GI50 = 3800 nM
   TI
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   TS
CP0555770
 Compound Info 
N-[4-methyl-3-[1-methyl-7-[4-methyl-3-(prop-2-enoylamino)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-4-propylcyclohexane-1-carboxamide
   Show/Hide
 C34H41N7O3  1
1
GI50 = 7400 nM
   TI
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   TS
CP0558728
 Compound Info 
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[(4-fluorophenyl)methyl]urea
   Show/Hide
 C24H22FN5O2  1
1
EC50 = 46 nM
   TI
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   TS
CP0559828
 Compound Info 
4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-5-methylthiazol-2-yl)benzamide
   Show/Hide
 C24H20F4N6OS  1
1
EC50 = 1600 nM
   TI
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CP0560243
 Compound Info 
N-[5-[(3,4-dimethoxybenzoyl)amino]-2-methylphenyl]-4-(methylamino)-2-[4-methyl-3-(prop-2-enoylamino)anilino]pyrimidine-5-carboxamide
   Show/Hide
 C32H33N7O5  1
1
GI50 > 10000 nM
   TI
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CP0563815
 Compound Info 
5,26-dimethyl-7-oxa-4,5,13,20,22,27-hexazapentacyclo[22.3.1.02,6.013,21.014,19]octacosa-1(27),2(6),3,14,16,18,20,24(28),25-nonaen-23-one
   Show/Hide
 C23H24N6O2  1
1
IC50 = 1700 nM
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CP0564387
 Compound Info 
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-3-yl)pyridin-2-amine
   Show/Hide
 C21H22Cl2FN5O  1
1
IC50 = 3479 nM
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   TS
CP0569057
 Compound Info 
N-[4-methyl-3-[1-methyl-7-[4-methyl-3-(prop-2-enoylamino)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-4-(trifluoromethyl)cyclohexane-1-carboxamide
   Show/Hide
 C32H34F3N7O3  1
1
GI50 > 10000 nM
   TI
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   TS
CP0569058
 Compound Info 
N-[5-[(3-methoxybenzoyl)amino]-2-methylphenyl]-4-(methylamino)-2-[4-methyl-3-(prop-2-enoylamino)anilino]pyrimidine-5-carboxamide
   Show/Hide
 C31H31N7O4  1
1
GI50 > 10000 nM
   TI
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   TS
CP0569060
 Compound Info 
N-[5-(2,3-dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-4-(methylamino)-2-[4-methyl-3-(prop-2-enoylamino)anilino]pyrimidine-5-carboxamide
   Show/Hide
 C32H31N7O5  1
1
GI50 > 10000 nM
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   TS
CP0570367
 Compound Info 
1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[3-fluoro-4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)phenyl]urea
   Show/Hide
 C20H19FN6O3  1
1
IC50 = 2623.2 nM
   TI
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   TS
CP0573875
 Compound Info 
4-methyl-N-[4-methyl-3-[1-methyl-7-[4-methyl-3-(prop-2-enoylamino)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]cyclohexane-1-carboxamide
   Show/Hide
 C32H37N7O3  1
1
GI50 = 8810 nM
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   TS
CP0573876
 Compound Info 
N-[5-[(2-methoxybenzoyl)amino]-2-methylphenyl]-4-(methylamino)-2-[4-methyl-3-(prop-2-enoylamino)anilino]pyrimidine-5-carboxamide
   Show/Hide
 C31H31N7O4  1
1
GI50 > 10000 nM
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CP0574765
 Compound Info 
6-N-[5-methyl-4-(1-methylpiperidin-4-yl)-2-propan-2-yloxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1H-pyrrolo[2,3-b]pyridine-4,6-diamine
   Show/Hide
 C32H41N5O3S  1
1
IC50 = 4912 nM
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   TS
CP0576189
 Compound Info 
1-[4-[3-[4-amino-5-(4-hydroxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanone
   Show/Hide
 C22H26N6O2  1
1
IC50 > 10000 nM
   TI
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CP0851621
 Compound Info 
Ripretinib
   Show/Hide
 C24H21BrFN5O2  1
1
GI50 = 8037 nM
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   TS
CP0851623
 Compound Info 
N-(4-((5,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(4-isopropyl-1H-1,2,3-triazol-1-yl)acetamide
   Show/Hide
 C23H24N6O4  1
1
GI50 > 10000 nM
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CP0852509
 Compound Info 
1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(1-(2-chloro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea
   Show/Hide
 C28H32ClN7O3  1
1
GI50 = 2044.5 nM
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CP0852601
 Compound Info 
(R)-1-(3-(4-Amino-3-(4-(benzyloxy)-3-chlorophenyl)-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
   Show/Hide
 C26H25ClN6O2  1
1
GI50 = 4800 nM
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   TS
CP0854595
 Compound Info 
3-Acrylamido-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-5-(trifluoromethyl)benzamide
   Show/Hide
 C27H21F3N6O2  1
1
GI50 = 5460 nM
   TI
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   TS
CP0855257
 Compound Info 
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(4-isopropyl-1H-1,2,3-triazol-1-yl)acetamide
   Show/Hide
 C23H24N6O4  1
1
GI50 > 10000 nM
   TI
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CP0855258
 Compound Info 
2-(5-(6,7-dimethoxyquinazolin-4-yloxy)-3-methoxypyridin-2-yl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide
   Show/Hide
 C24H26N6O5  1
1
GI50 > 10000 nM
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   TS
CP0855259
 Compound Info 
2-(4-(6,7-dimethoxyquinolin-4-yloxy)-2-methoxyphenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide
   Show/Hide
 C26H28N4O5  1
1
GI50 > 10000 nM
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CP0857303
 Compound Info 
(R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
   Show/Hide
 C25H26ClN7O2  1
1
GI50 > 10000 nM
   TI
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CP0860121
 Compound Info 
(5-(tert-butyl)isoxazol-3-yl)-3-(4-(1-(4-(2-morpholinoethoxy)-3-nitrophenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea
   Show/Hide
 C28H32N8O6  1
1
GI50 > 3000 nM
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   TS
CP0862401
 Compound Info 
(R)-1-(1-(Methylsulfonyl)pyrrolidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
 C22H22N6O3S  1
1
GI50 > 10000 nM
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CP0864071
 Compound Info 
4-((N-Isopentylacrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
   Show/Hide
 C32H34N6O2  1
1
GI50 = 5620 nM
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CP0864256
 Compound Info 
N-{4-[(5,7-Dimethoxyquinazolin-4-yl)amino]phenyl}-2-[4-(propan-2-yl)-1H-1,2,3-triazol-1-yl]acetamide
   Show/Hide
 C23H25N7O3  1
1
GI50 > 10000 nM
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CP0864259
 Compound Info 
N-{4-[(5-Fluoro-7-methoxyquinazolin-4-yl)amino]phenyl}-2-[4-(propan-2-yl)-1H-1,2,3-triazol-1-yl]acetamide
   Show/Hide
 C22H22FN7O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0864261
 Compound Info 
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)-2-methoxyphenyl)-2-(1-ethyl-1H-pyrazol-4-yl)acetamide
   Show/Hide
 C24H25N5O5  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0866565
 Compound Info 
1-(5-(tert-butyl)isoxazol-3-yl)-3-(2-chloro-4-(1-(4-(2-morpholinoethoxy)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea
   Show/Hide
 C28H32ClN7O4  1
1
GI50 > 3000 nM
   TI
   LI
   LO
   TS
CP0867289
 Compound Info 
(E)-N1-(2-Fluorophenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)malonamide
   Show/Hide
 C23H18FN5O2  1
1
GI50 = 5090 nM
   TI
   LI
   LO
   TS
CP0871877
 Compound Info 
N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-6-yl)malonamide
   Show/Hide
 C21H16ClF3N6O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0874420
 Compound Info 
4-((2-(Dimethylamino)-N-(2-(dimethylamino)ethyl)acetamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
   Show/Hide
 C32H38N8O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0875470
 Compound Info 
N-(4-((4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)-N-(2-(pyrrolidin-1-yl)ethyl)nicotinamide
   Show/Hide
 C36H36N8O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0875962
 Compound Info 
(R)-5-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]-pyrimidin-3-yl)-2-(pyridin-2-ylmethoxy)benzonitrile
   Show/Hide
 C26H24N8O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0883780
 Compound Info 
4-(((2-(Dimethylamino)ethyl)amino)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
   Show/Hide
 C28H31N7O  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0887633
 Compound Info 
N-(5-((6,7-Dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2-(1-isopropyl-1H-pyrazol-4-yl)acetamide
   Show/Hide
 C24H25N5O4  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0888593
 Compound Info 
3-Fluoro-N-(4-methyl-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)-5-(trifluoromethyl)benzamide
   Show/Hide
 C26H23F4N3O3  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0890942
 Compound Info 
(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2,2-dimethylpropan-1-one
   Show/Hide
 C27H30N6O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0891178
 Compound Info 
(E)-4-((N-(2-(Dimethylamino)ethyl)but-2-enamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
   Show/Hide
 C32H35N7O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0891179
 Compound Info 
N-(4-((4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)phenyl)nicotinamide
   Show/Hide
 C29H23N7O2  1
1
GI50 = 1700 nM
   TI
   LI
   LO
   TS
CP0892598
 Compound Info 
N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(3-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-indazol-6-yl)malonamide
   Show/Hide
 C29H28ClF3N6O2  1
1
GI50 = 911 nM
   TI
   LI
   LO
   TS
CP0893382
 Compound Info 
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(1-ethyl-1H-pyrazol-4-yl)acetamide
   Show/Hide
 C23H23N5O4  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0898929
 Compound Info 
(E)-N1-(3-(2-(Pyridin-2-yl)vinyl)-1H-indazol-6-yl)-N3-(3-(trifluoromethyl)phenyl)malonamide
   Show/Hide
 C24H18F3N5O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0899401
 Compound Info 
N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-3-propionamido-5-(trifluoromethyl)benzamide
   Show/Hide
 C27H23F3N6O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0901561
 Compound Info 
(R)-1-(3-(4-Amino-3-(4-(benzyloxy)phenyl)-1H-pyrazolo[3,4-d]-pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
   Show/Hide
 C26H26N6O2  1
1
GI50 = 8200 nM
   TI
   LI
   LO
   TS
CP0902838
 Compound Info 
N-(4-((4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)nicotinamide
   Show/Hide
 C30H25N7O2  1
1
GI50 = 1120 nM
   TI
   LI
   LO
   TS
CP0903100
 Compound Info 
(R)-2-Amino-1-(4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo-[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-4-methylpentan-1-one
   Show/Hide
 C28H33N7O2  1
1
GI50 = 590 nM
   TI
   LI
   LO
   TS
CP0911397
 Compound Info 
(E)-N-(4((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-4-yl)vinyl)-1H-indazol-6-yl)thio)propanamide
   Show/Hide
 C30H31F3N6OS  1
1
GI50 = 543 nM
   TI
   LI
   LO
   TS
CP0911799
 Compound Info 
4-((N-(2-(Dimethylamino)ethyl)isobutyramido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
   Show/Hide
 C32H37N7O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0913817
 Compound Info 
N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(3-(3-fluorophenyl)-1H-indazol-6-yl)malonamide
   Show/Hide
 C23H15ClF4N4O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0914113
 Compound Info 
4-Methyl-N-(4-methyl-3-((1-(thiazole-5-carbonyl)piperidin-4-yl)-oxy)phenyl)-3-(trifluoromethyl)benzamide
   Show/Hide
 C25H24F3N3O3S  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0914663
 Compound Info 
1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(1-(4-(2-morpholinoethoxy)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea
   Show/Hide
 C28H33N7O4  1
1
GI50 > 3000 nM
   TI
   LI
   LO
   TS
CP0914664
 Compound Info 
1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(1-(4-(2-morpholinoethoxy)-3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea
   Show/Hide
 C29H32F3N7O4  1
1
GI50 = 1525 nM
   TI
   LI
   LO
   TS
CP0921106
 Compound Info 
(R)-1-(3-(4-Amino-3-(3-chloro-4-((3,4-difluorobenzyl)oxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
   Show/Hide
 C26H23ClF2N6O2  1
1
GI50 = 2900 nM
   TI
   LI
   LO
   TS
CP0927905
 Compound Info 
(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-cyclopropylethanone
   Show/Hide
 C27H28N6O2  1
1
GI50 = 3600 nM
   TI
   LI
   LO
   TS
CP0927906
 Compound Info 
(R)-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)(cyclopropyl)methanone
   Show/Hide
 C26H26N6O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0930637
 Compound Info 
(R)-1-(3-(4-Amino-3-(3-chloro-4-((4-fluorobenzyl)oxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-on
   Show/Hide
 C26H24ClFN6O2  1
1
GI50 = 5600 nM
   TI
   LI
   LO
   TS
CP0930997
 Compound Info 
1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(1-(3-methyl-4-(2-morpholinoethoxy)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea
   Show/Hide
 C29H35N7O4  1
1
GI50 = 1972 nM
   TI
   LI
   LO
   TS
CP0931021
 Compound Info 
1-(5-(tert-butyl)isoxazol-3-yl)-3-(2-fluoro-4-(1-(4-(2-morpholinoethoxy)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea
   Show/Hide
 C28H32FN7O4  1
1
GI50 > 3000 nM
   TI
   LI
   LO
   TS
CP0931081
 Compound Info 
(R)-1-(3-(4-Amino-3-(3-chloro-4-((3-(methylsulfonyl)benzyl)oxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
   Show/Hide
 C27H27ClN6O4S  1
1
GI50 = 5400 nM
   TI
   LI
   LO
   TS
CP0931082
 Compound Info 
(R)-1-(3-(4-Amino-3-(3-fluoro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
   Show/Hide
 C25H24FN7O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0938607
 Compound Info 
1-(5-(tert-butyl)isoxazol-3-yl)-3-(3-fluoro-4-(1-(4-(2-morpholinoethoxy)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea
   Show/Hide
 C28H32FN7O4  1
1
GI50 > 3000 nM
   TI
   LI
   LO
   TS
CP0941817
 Compound Info 
4-((N-(2-(Dimethylamino)ethyl)butyramido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
   Show/Hide
 C32H37N7O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0942328
 Compound Info 
4-((N-(2-(Dimethylamino)ethyl)propionamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
   Show/Hide
 C31H35N7O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0943642
 Compound Info 
(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]-pyrimidin-1-yl)pyrrolidin-1-yl)-2-(dimethylamino)ethanone
   Show/Hide
 C25H27N7O2  1
1
GI50 = 8420 nM
   TI
   LI
   LO
   TS
CP0943649
 Compound Info 
(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)butan-1-one
   Show/Hide
 C26H28N6O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0945741
 Compound Info 
(E)-N1-Phenyl-N3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)-malonamide
   Show/Hide
 C23H19N5O2  1
1
GI50 = 6720 nM
   TI
   LI
   LO
   TS
CP0948271
 Compound Info 
N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-3-(propionamidomethyl)benzamide
   Show/Hide
 C27H26N6O2  1
1
GI50 = 4750 nM
   TI
   LI
   LO
   TS
CP0948475
 Compound Info 
1-(4-(1-(2-bromo-4-(2-morpholinoethoxy)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea
   Show/Hide
 C28H32BrN7O4  1
1
GI50 = 2020 nM
   TI
   LI
   LO
   TS
CP0948476
 Compound Info 
1-(5-(tert-butyl)isoxazol-3-yl)-3-(2-methyl-4-(1-(4-(2-morpholinoethoxy)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea
   Show/Hide
 C29H35N7O4  1
1
GI50 = 2162 nM
   TI
   LI
   LO
   TS
CP0948477
 Compound Info 
1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(1-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea
   Show/Hide
 C28H32FN7O4  1
1
GI50 > 3000 nM
   TI
   LI
   LO
   TS
CP0954149
 Compound Info 
(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
   Show/Hide
 C25H26N6O2  1
1
GI50 = 3800 nM
   TI
   LI
   LO
   TS
CP0954340
 Compound Info 
3-Methoxy-N-(4-methyl-3-((1-nicotinoylpiperidin-4-yl)oxy)-phenyl)benzamide
   Show/Hide
 C26H27N3O4  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0955541
 Compound Info 
(S)-2-(6-(2-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-2-phenylethanol
   Show/Hide
 C21H20N4O2  1
1
IC50 = 134 nM
   TI
   LI
   LO
   TS
CP0963126
 Compound Info 
N-{4-Methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-3-trifluoromethyl-benzamide
   Show/Hide
 C26H18F3N5OS  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0963428
 Compound Info 
1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(1-(2-chloro-4-(3-morpholinopropoxy)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea
   Show/Hide
 C29H34ClN7O4  1
1
GI50 > 3000 nM
   TI
   LI
   LO
   TS
CP0967545
 Compound Info 
(R)-3-(4-Phenoxyphenyl)-1-(1-(propylsulfonyl)piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
 C25H28N6O3S  1
1
GI50 = 8600 nM
   TI
   LI
   LO
   TS
CP0967554
 Compound Info 
(R)-1-(1-(Ethylsulfonyl)piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
 C24H26N6O3S  1
1
GI50 = 4000 nM
   TI
   LI
   LO
   TS
CP0967555
 Compound Info 
(R,E)-1-(3-(4-Amino-3-(4-styrylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
   Show/Hide
 C27H26N6O  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Bone marrow)
Cell Line Name Organism Disease
NB4
 Cell Line Info 
Homo sapiens (Human) Acute promyelocytic leukemia with PML-RARA
UT-7/Epo
 Cell Line Info 
Homo sapiens (Human) Adult acute megakaryoblastic leukemia
UT-7
 Cell Line Info 
Homo sapiens (Human) Adult acute megakaryoblastic leukemia
KG-1
 Cell Line Info 
Homo sapiens (Human) Adult acute myeloid leukemia
KG-1a
 Cell Line Info 
Homo sapiens (Human) Adult acute myeloid leukemia
RS4;11
 Cell Line Info 
Homo sapiens (Human) Adult B acute lymphoblastic leukemia
Rh30
 Cell Line Info 
Homo sapiens (Human) Alveolar rhabdomyosarcoma
MEG-01
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
697
 Cell Line Info 
Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
SUP-B15
 Cell Line Info 
Homo sapiens (Human) Childhood B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1
HAP1
 Cell Line Info 
Homo sapiens (Human) Chronic myelogenous leukemia, BCR-ABL1 positive
OCI-Ly1
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma
OCI-Ly3
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
TMD8
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
OCI-Ly19
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
TF-1
 Cell Line Info 
Homo sapiens (Human) Erythroleukemia
L-540
 Cell Line Info 
Homo sapiens (Human) Hodgkin lymphoma
NCI-H345
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
NCI-H526
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
Z-138
 Cell Line Info 
Homo sapiens (Human) Mantle cell lymphoma
CAL-1 [Human melanoma]
 Cell Line Info 
Homo sapiens (Human) Melanoma
SH-SY5Y
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SH-EP1
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-BE(2)
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-SH
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-BE(2)-C
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-BE(1)
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-AS
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
GI-CA-N
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
LSCC-HD11
 Cell Line Info 
Gallus gallus (Chicken) -
IM-9
 Cell Line Info 
Homo sapiens (Human) -
LAD 2
 Cell Line Info 
Homo sapiens (Human) -
UE6E7T-2
 Cell Line Info 
Homo sapiens (Human) -
RBC
 Cell Line Info 
Homo sapiens (Human) -
FDC-P1
 Cell Line Info 
Mus musculus (Mouse) -
S21
 Cell Line Info 
Mus musculus (Mouse) -
ANA-1 [Mouse macrophage]
 Cell Line Info 
Mus musculus (Mouse) -
Y16
 Cell Line Info 
Mus musculus (Mouse) -
32D
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 FLT3-ITD
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 c-Kit D816V
 Cell Line Info 
Mus musculus (Mouse) -
Bone marrow macrophage immortalized C57BL/6
 Cell Line Info 
Mus musculus (Mouse) -
BaF3-BCL
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 NPM-ALK
 Cell Line Info 
Mus musculus (Mouse) -
Bone marrow macrophage immortalized BALB/c
 Cell Line Info 
Mus musculus (Mouse) -