General Information of the Cell Line
Cell Line ID
CL000222
Cell Line Name
TMD8
Synonyms
TMD-8
Tokyo Medical and Dental university 8
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_A442
Tissue Information
Bone marrow
Disease
Diffuse large B-cell lymphoma activated B-cell type (NCIt: C36081)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT03110, MALT lymphoma-associated translocation
 Protein Info 
Compound ID Compound Name Compound Formula
CP0402090
 Compound Info 
(2R,4R)-1-(3-bromopyridin-2-yl)-N-(3-chloro-4-methoxyphenyl)-2-methylpiperidine-4-carboxamide
   Show/Hide
C19H21BrClN3O2
  2
1
IC50 = 60 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0431592
 Compound Info 
1-(3-bromopyridin-2-yl)-N-(3-chloro-4-methoxyphenyl)-2-methylpiperidine-4-carboxamide
   Show/Hide
C19H21BrClN3O2
  2
1
IC50 = 250 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0402170
 Compound Info 
N-(3-chloro-4-methoxyphenyl)-2-methyl-1-(3-methylpyridin-2-yl)piperidine-4-carboxamide
   Show/Hide
C20H24ClN3O2
  2
1
IC50 = 410 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0382831
 Compound Info 
N-(3-chloro-4-methoxyphenyl)-1-(3-methylpyridin-2-yl)piperidine-4-carboxamide
   Show/Hide
C19H22ClN3O2
  2
1
IC50 = 760 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 1050 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0431590
 Compound Info 
N-(3-chloro-4-methoxyphenyl)-1-thieno[3,2-c]pyridin-4-ylpiperidine-4-carboxamide
   Show/Hide
C20H20ClN3O2S
  2
1
IC50 = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 1950 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT01308, Tyrosine-protein kinase BTK
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0393891
 Compound Info 
(12S,14S,17E)-12-(hydroxymethyl)-23-[(3-methoxyphenyl)methyl]-24-oxo-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaene-7-carbonitrile
   Show/Hide
 C33H33N7O5  1
1
GI50 = 3981.07 nM
   TI
   LI
   LO
   TS
CP0485099
 Compound Info 
CHEMBL4863078
   Show/Hide
 C26H25N5O3  1
1
IC50 = 83.9 nM
   TI
   LI
   LO
   TS
CP0521736
 Compound Info 
(12S,14S,17E)-7-chloro-12-(hydroxymethyl)-23-methyl-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
   Show/Hide
 C25H27ClN6O4  1
1
GI50 = 3981.07 nM
   TI
   LI
   LO
   TS
CP0521737
 Compound Info 
(12S,14S,17E)-7-chloro-12-(hydroxymethyl)-23-[(2-methylphenyl)methyl]-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
   Show/Hide
 C32H33ClN6O4  1
1
GI50 = 19952.62 nM
   TI
   LI
   LO
   TS
CP0543050
 Compound Info 
(12S,14S,17E)-12-(hydroxymethyl)-24-oxo-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaene-7-carbonitrile
   Show/Hide
 C25H25N7O4  1
1
GI50 = 7943.28 nM
   TI
   LI
   LO
   TS
CP0544260
 Compound Info 
(12S,14S)-7-chloro-12-(hydroxymethyl)-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,21(29),22(27)-heptaen-24-one
   Show/Hide
 C24H27ClN6O4  1
1
GI50 = 3162.28 nM
   TI
   LI
   LO
   TS
CP0549768
 Compound Info 
2-[4-(2-fluorophenoxy)phenyl]-7-(1-prop-2-ynoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide
   Show/Hide
 C26H22FN5O3  1
1
IC50 = 608 nM
   TI
   LI
   LO
   TS
CP0563463
 Compound Info 
(4-aminopiperidin-1-yl)-[4-(3-isoquinolin-6-ylimidazo[1,2-b]pyridazin-6-yl)phenyl]methanone
   Show/Hide
 C27H24N6O  1
1
IC50 = 2085 nM
   TI
   LI
   LO
   TS
CP0565911
 Compound Info 
methyl 4-[5-ethoxy-1-methyl-6-[[6-(trifluoromethyl)pyridine-2-carbonyl]amino]benzimidazol-2-yl]-2,2-dimethylbutanoate
   Show/Hide
 C24H27F3N4O4  1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Bone marrow)
Cell Line Name Organism Disease
NB4
 Cell Line Info 
Homo sapiens (Human) Acute promyelocytic leukemia with PML-RARA
UT-7/Epo
 Cell Line Info 
Homo sapiens (Human) Adult acute megakaryoblastic leukemia
UT-7
 Cell Line Info 
Homo sapiens (Human) Adult acute megakaryoblastic leukemia
KG-1
 Cell Line Info 
Homo sapiens (Human) Adult acute myeloid leukemia
KG-1a
 Cell Line Info 
Homo sapiens (Human) Adult acute myeloid leukemia
RS4;11
 Cell Line Info 
Homo sapiens (Human) Adult B acute lymphoblastic leukemia
Rh30
 Cell Line Info 
Homo sapiens (Human) Alveolar rhabdomyosarcoma
MEG-01
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
697
 Cell Line Info 
Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
SUP-B15
 Cell Line Info 
Homo sapiens (Human) Childhood B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1
HAP1
 Cell Line Info 
Homo sapiens (Human) Chronic myelogenous leukemia, BCR-ABL1 positive
OCI-Ly1
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma
OCI-Ly3
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
OCI-Ly19
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
TF-1
 Cell Line Info 
Homo sapiens (Human) Erythroleukemia
L-540
 Cell Line Info 
Homo sapiens (Human) Hodgkin lymphoma
NCI-H345
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
NCI-H526
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
Z-138
 Cell Line Info 
Homo sapiens (Human) Mantle cell lymphoma
CAL-1 [Human melanoma]
 Cell Line Info 
Homo sapiens (Human) Melanoma
SH-SY5Y
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SH-EP1
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-BE(2)
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-SH
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-BE(2)-C
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-BE(1)
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-AS
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
GI-CA-N
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
LSCC-HD11
 Cell Line Info 
Gallus gallus (Chicken) -
IM-9
 Cell Line Info 
Homo sapiens (Human) -
LAD 2
 Cell Line Info 
Homo sapiens (Human) -
UE6E7T-2
 Cell Line Info 
Homo sapiens (Human) -
RBC
 Cell Line Info 
Homo sapiens (Human) -
Ba/F3
 Cell Line Info 
Mus musculus (Mouse) -
FDC-P1
 Cell Line Info 
Mus musculus (Mouse) -
S21
 Cell Line Info 
Mus musculus (Mouse) -
ANA-1 [Mouse macrophage]
 Cell Line Info 
Mus musculus (Mouse) -
Y16
 Cell Line Info 
Mus musculus (Mouse) -
32D
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 FLT3-ITD
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 c-Kit D816V
 Cell Line Info 
Mus musculus (Mouse) -
Bone marrow macrophage immortalized C57BL/6
 Cell Line Info 
Mus musculus (Mouse) -
BaF3-BCL
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 NPM-ALK
 Cell Line Info 
Mus musculus (Mouse) -
Bone marrow macrophage immortalized BALB/c
 Cell Line Info 
Mus musculus (Mouse) -