General Information of the Cell Line
Cell Line ID
CL000764
Cell Line Name
Bone marrow macrophage immortalized C57BL/6
Synonyms
C57BL/6
C57BL/6 Macrophage Cell Line
Category
Transformed cell line
Organism
Mus musculus (Mouse)
Tissue Information
Bone marrow
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT05439, Nuclear receptor ROR-gamma
 Protein Info 
Compound ID Compound Name Compound Formula
CP0060047
 Compound Info 
N-[4-(5-acetamido-2-propan-2-ylpyrazol-3-yl)-2-piperidin-1-ylphenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
   Show/Hide
C27H31ClFN5O2
  1
1
EC50 = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0281549
 Compound Info 
N-[4-(5-acetamido-2-propan-2-ylpyrazol-3-yl)-2-pyrrolidin-1-ylphenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
   Show/Hide
C26H29ClFN5O2
  1
1
EC50 = 17 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0717530
 Compound Info 
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(1-isopropyl-3-propionamido-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
   Show/Hide
C28H31ClFN5O2
  1
1
EC50 = 33 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0072489
 Compound Info 
N-[5-(5-acetamido-2-propan-2-ylpyrazol-3-yl)-3-piperidin-1-ylpyridin-2-yl]-2-chloro-6-fluoro-N-methylbenzamide
   Show/Hide
C26H30ClFN6O2
  1
1
EC50 = 34 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0674649
 Compound Info 
N-(4-(3-acetamido-1-isopropyl-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2-chloro-6-fluoro-N-[2H]-methylbenzamide
   Show/Hide
C27H29ClFN5O2
  1
1
EC50 = 38 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0731677
 Compound Info 
N-(4-(3-acetamido-1-cyclopentyl-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
   Show/Hide
C29H31ClFN5O2
  1
1
EC50 = 60 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0770850
 Compound Info 
N-(4-(3-acetamido-1-isopropyl-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2,6-dichloro-N-[2H]-methylbenzamide
   Show/Hide
C27H29Cl2N5O2
  1
1
EC50 = 73 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0694116
 Compound Info 
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(3-(cyclopropanecarboxamido)-1-isopropyl-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
   Show/Hide
C29H31ClFN5O2
  1
1
EC50 = 88 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0199396
 Compound Info 
N-[4-(5-acetamido-2-propan-2-ylpyrazol-3-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl]-2-chloro-6-fluoro-N-methylbenzamide
   Show/Hide
C27H29ClFN5O2
  1
1
EC50 = 110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0806353
 Compound Info 
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(3-(2-hydroxyacetamido)-1-isopropyl-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N-[2H]-methylbenzamide
   Show/Hide
C27H29ClFN5O3
  1
1
EC50 = 120 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0849524
 Compound Info 
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(3-isobutyramido-1-isopropyl-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
   Show/Hide
C29H33ClFN5O2
  1
1
EC50 = 128 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0382327
 Compound Info 
N-[2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-[5-[(3-hydroxycyclobutanecarbonyl)amino]-2-propan-2-ylpyrazol-3-yl]phenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
   Show/Hide
C30H33ClFN5O3
  1
1
EC50 = 134 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0830825
 Compound Info 
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(3-((1r,3r)-3-hydroxycyclobutanecarboxamido)-1-isopropyl-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
   Show/Hide
C30H33ClFN5O3
  1
1
EC50 = 134 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0731675
 Compound Info 
N-(5-(3-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(2-chloro-6-fluoro-N[2H]-methylbenzamido)phenyl)-1-isopropyl-1H-pyrazol-3-yl)-2-oxa-6-azaspiro[3.3]heptane-6-carboxamide
   Show/Hide
C31H34ClFN6O3
  1
1
EC50 = 148 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0659888
 Compound Info 
N-(4-(3-acetamido-1-cyclobutyl-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
   Show/Hide
C28H29ClFN5O2
  1
1
EC50 = 199 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0674427
 Compound Info 
N-(4-(3-acetamido-1-(cyclopropylmethyl)-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
   Show/Hide
C28H29ClFN5O2
  1
1
EC50 = 201 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0770851
 Compound Info 
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(1-isopropyl-3-(3-methylureido)-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
   Show/Hide
C27H30ClFN6O2
  1
1
EC50 = 354 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0660102
 Compound Info 
N-(4-(3-acetamido-1-isopropyl-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2-fluoro-N[2H],6-dimethylbenzamide
   Show/Hide
C28H32FN5O2
  1
1
EC50 = 355 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0146700
 Compound Info 
2-chloro-6-fluoro-N-[4-(1-methyl-5-propan-2-ylpyrazol-4-yl)-2-(2,2,2-trifluoroethoxy)phenyl]-N-(trideuteriomethyl)benzamide
   Show/Hide
C23H22ClF4N3O2
  1
1
EC50 = 818 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0045935
 Compound Info 
N-[4-(5-carbamoyl-2-chlorophenyl)-2-(2,2,2-trifluoroethoxy)phenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
   Show/Hide
C23H16Cl2F4N2O3
  1
1
EC50 = 895 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0199394
 Compound Info 
5-[4-[(2-chloro-6-fluorobenzoyl)-(trideuteriomethyl)amino]-3-(2,2,2-trifluoroethoxy)phenyl]-1-propan-2-ylpyrazole-3-carboxamide
   Show/Hide
C23H21ClF4N4O3
  1
1
EC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0059556
 Compound Info 
N-[4-(5-acetamido-2-propan-2-ylpyrazol-3-yl)-2-(cyclobutylmethoxy)phenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
   Show/Hide
C27H30ClFN4O3
  1
1
EC50 = 3110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT03356, NACHT, LRR and PYD domains-containing protein 3
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0084720
 Compound Info 
7-[[(3R,4R)-3-aminooxan-4-yl]amino]-5-[(3-methyl-1H-indol-7-yl)amino]-3H-pyrido[4,3-d]pyrimidin-4-one
   Show/Hide
 C21H23N7O2  1
1
IC50 = 5984 nM
   TI
   LI
   LO
   TS
CP0222796
 Compound Info 
6-[[(3R,4R)-3-aminooxan-4-yl]amino]-8-[(2-methylindazol-4-yl)amino]-2H-2,7-naphthyridin-1-one
   Show/Hide
 C21H23N7O2  1
1
IC50 = 1443 nM
   TI
   LI
   LO
   TS
CP0776455
 Compound Info 
4-(1H-indol-7-ylamino)-2-((1R,2S)-2-aminocyclohexylamino)pyrimidine-5-carboxamide
   Show/Hide
 C19H23N7O  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0796446
 Compound Info 
2-(1H-indol-7-ylamino)-6-((1R,2S)-2-aminocyclohexylamino)nicotinamide
   Show/Hide
 C20H24N6O  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Bone marrow)
Cell Line Name Organism Disease
NB4
 Cell Line Info 
Homo sapiens (Human) Acute promyelocytic leukemia with PML-RARA
UT-7/Epo
 Cell Line Info 
Homo sapiens (Human) Adult acute megakaryoblastic leukemia
UT-7
 Cell Line Info 
Homo sapiens (Human) Adult acute megakaryoblastic leukemia
KG-1
 Cell Line Info 
Homo sapiens (Human) Adult acute myeloid leukemia
KG-1a
 Cell Line Info 
Homo sapiens (Human) Adult acute myeloid leukemia
RS4;11
 Cell Line Info 
Homo sapiens (Human) Adult B acute lymphoblastic leukemia
Rh30
 Cell Line Info 
Homo sapiens (Human) Alveolar rhabdomyosarcoma
MEG-01
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
697
 Cell Line Info 
Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
SUP-B15
 Cell Line Info 
Homo sapiens (Human) Childhood B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1
HAP1
 Cell Line Info 
Homo sapiens (Human) Chronic myelogenous leukemia, BCR-ABL1 positive
OCI-Ly1
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma
OCI-Ly3
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
TMD8
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
OCI-Ly19
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
TF-1
 Cell Line Info 
Homo sapiens (Human) Erythroleukemia
L-540
 Cell Line Info 
Homo sapiens (Human) Hodgkin lymphoma
NCI-H345
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
NCI-H526
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
Z-138
 Cell Line Info 
Homo sapiens (Human) Mantle cell lymphoma
CAL-1 [Human melanoma]
 Cell Line Info 
Homo sapiens (Human) Melanoma
SH-SY5Y
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SH-EP1
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-BE(2)
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-SH
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-BE(2)-C
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-BE(1)
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-AS
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
GI-CA-N
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
LSCC-HD11
 Cell Line Info 
Gallus gallus (Chicken) -
IM-9
 Cell Line Info 
Homo sapiens (Human) -
LAD 2
 Cell Line Info 
Homo sapiens (Human) -
UE6E7T-2
 Cell Line Info 
Homo sapiens (Human) -
RBC
 Cell Line Info 
Homo sapiens (Human) -
Ba/F3
 Cell Line Info 
Mus musculus (Mouse) -
FDC-P1
 Cell Line Info 
Mus musculus (Mouse) -
S21
 Cell Line Info 
Mus musculus (Mouse) -
ANA-1 [Mouse macrophage]
 Cell Line Info 
Mus musculus (Mouse) -
Y16
 Cell Line Info 
Mus musculus (Mouse) -
32D
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 FLT3-ITD
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 c-Kit D816V
 Cell Line Info 
Mus musculus (Mouse) -
BaF3-BCL
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 NPM-ALK
 Cell Line Info 
Mus musculus (Mouse) -
Bone marrow macrophage immortalized BALB/c
 Cell Line Info 
Mus musculus (Mouse) -