General Information of the Cell Line
Cell Line ID
CL000475
Cell Line Name
SK-N-BE(2)-C
Synonyms
SK-N-BE(2)C
SK-N-BE-2c
SK-N-BE2(c)
SK-N-BE(2C)
SK-N-BE(2c)
SK-N-BE2C
SK_N_BE2C
SKNBE2C
SKNBE(2c)
BE(2)-C
BE(2)C
Be(2)C
BE2-C
BE2_C
Be2-C
BE2C
Be2C
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0529
Tissue Information
Bone marrow
Disease
Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01020, Beta-secretase 1
 Protein Info 
Compound ID Compound Name Compound Formula
CP0143562
 Compound Info 
N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
   Show/Hide
C18H16FN5OS
  1
1
IC50 = 0.93 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0206016
 Compound Info 
N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
   Show/Hide
C17H16ClFN4OS
  1
1
IC50 = 0.93 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0559105
 Compound Info 
N-[3-[(9R)-7-amino-2,2-difluoro-9-methyl-6-thia-8-azaspiro[3.5]non-7-en-9-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
   Show/Hide
C20H19F4N5O2S
  1
1
IC50 = 1.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0137792
 Compound Info 
US9751886, Compound 2
   Show/Hide
C19H15FN8O
  1
1
IC50 = 1.202 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0135177
 Compound Info 
N-[3-[(3R)-1-amino-3-methyl-4H-pyrrolo[1,2-a]pyrazin-3-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
   Show/Hide
C21H17FN6O
  1
1
IC50 = 1.318 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0484297
 Compound Info 
N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
   Show/Hide
C17H17F2N5O2S
  1
1
IC50 = 1.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0364143
 Compound Info 
N-[3-[(4S,5R)-2-amino-4-methyl-5-(oxan-4-yl)-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
   Show/Hide
C22H25F2N5O3S
  1
1
IC50 = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0508363
 Compound Info 
N-[3-[(4S,5S)-2-amino-4-methyl-5-phenyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
   Show/Hide
C23H21F2N5O2S
  1
1
IC50 = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0243093
 Compound Info 
N-[3-[(6R)-4-amino-6-methyl-7H-pyrazolo[1,5-a]pyrazin-6-yl]phenyl]-5-cyanopyridine-2-carboxamide
   Show/Hide
C20H17N7O
  1
1
IC50 = 2.188 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0426439
 Compound Info 
N-[3-[(4S,5R)-2-amino-4-methyl-5-phenyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
   Show/Hide
C23H21F2N5O2S
  1
1
IC50 = 2.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0075806
 Compound Info 
N-[3-[(5R)-3-amino-9,9-difluoro-5-methyl-2-thia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
   Show/Hide
C22H23F4N5O2S
  1
1
IC50 = 4.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0426438
 Compound Info 
N-[3-[(4R,5R)-2-amino-5-methoxy-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
   Show/Hide
C18H19F2N5O3S
  1
1
IC50 = 4.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0365697
 Compound Info 
N-[3-[(2R,3R)-5-amino-2-(difluoromethyl)-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
   Show/Hide
C18H18F3N5O3
  1
1
IC50 = 4.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0124717
 Compound Info 
N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
   Show/Hide
C17H18FN5O2S
  1
1
IC50 = 5.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0689440
 Compound Info 
N-{3-[(2R,3R)-5-Amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-cyanopyridine-2-carboxamide
   Show/Hide
C19H15F4N5O2
  1
1
IC50 = 6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0124631
 Compound Info 
N-[3-[(6R)-8-amino-6-methyl-5H-imidazo[1,2-a]pyrazin-6-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
   Show/Hide
C20H16FN7O
  1
1
IC50 = 6.31 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0471898
 Compound Info 
N-[3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-3-chloro-5-cyanopyridine-2-carboxamide
   Show/Hide
C19H14ClF4N5O2
  1
1
IC50 = 6.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0135175
 Compound Info 
N-[3-[(6R)-8-amino-6-methyl-5H-[1,2,4]triazolo[4,3-a]pyrazin-6-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
   Show/Hide
C19H15FN8O
  1
1
IC50 = 6.607 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0265376
 Compound Info 
N-[3-[(5R)-3-amino-5-methyl-9-oxa-2-thia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
   Show/Hide
C21H23F2N5O3S
  1
1
IC50 = 6.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0262950
 Compound Info 
N-[3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
   Show/Hide
C18H15ClF4N4O2
  1
1
IC50 = 7.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0484295
 Compound Info 
N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-(difluoromethyl)pyrazine-2-carboxamide
   Show/Hide
C17H16F3N5OS
  1
1
IC50 = 7.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0067274
 Compound Info 
N-[3-[(2R,3R)-5-amino-2-fluoro-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
   Show/Hide
C18H15F2N5O2
  1
1
IC50 = 8.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0082231
 Compound Info 
N-[3-[(6R)-8-amino-6-methyl-5H-[1,2,4]triazolo[1,5-a]pyrazin-6-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
   Show/Hide
C19H15FN8O
  1
1
IC50 = 9.772 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0243092
 Compound Info 
N-[3-[(6R)-8-amino-6-methyl-5H-imidazo[1,2-a]pyrazin-6-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
   Show/Hide
C19H16ClFN6O
  1
1
IC50 = 10.47 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0465046
 Compound Info 
N-[3-[(2R,3R)-5-amino-2-fluoro-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-fluoropyridine-2-carboxamide
   Show/Hide
C18H14F3N5O2
  1
1
IC50 = 12.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0478213
 Compound Info 
N-[3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-(2-methoxyethoxy)pyrazine-2-carboxamide
   Show/Hide
C20H21F4N5O4
  1
1
IC50 = 12.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0198194
 Compound Info 
N-[3-[(5R)-3-amino-5-methyl-9,9-dioxo-2,9lambda6-dithia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
   Show/Hide
C21H23F2N5O4S2
  1
1
IC50 = 13 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0249063
 Compound Info 
N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide
   Show/Hide
C18H17F4N5O2S
  1
1
IC50 = 13 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0074572
 Compound Info 
N-[3-[(2R,3R)-5-amino-2-fluoro-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
   Show/Hide
C17H17F2N5O3
  1
1
IC50 = 13.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0331661
 Compound Info 
N-[3-[(2R,3R)-5-amino-2-fluoro-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-3-chloro-5-cyanopyridine-2-carboxamide
   Show/Hide
C18H14ClF2N5O2
  1
1
IC50 = 15.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0143564
 Compound Info 
N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide
   Show/Hide
C17H16F2N4OS
  1
1
IC50 = 16 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0252314
 Compound Info 
N-[3-[(6R)-8-amino-6-methyl-5H-imidazo[1,5-a]pyrazin-6-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
   Show/Hide
C20H16FN7O
  1
1
IC50 = 18.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0365698
 Compound Info 
N-[3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide
   Show/Hide
C19H16F7N5O3
  1
1
IC50 = 20.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0464951
 Compound Info 
N-[3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
   Show/Hide
C18H17F4N5O3
  1
1
IC50 = 27.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0547265
 Compound Info 
N-[3-[(3R)-5-amino-1,3-dimethyl-6-oxo-2H-pyrazin-3-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
   Show/Hide
C18H17ClFN5O2
  1
1
IC50 = 28.18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0365696
 Compound Info 
N-[3-[(5R)-3-amino-6-(difluoromethylidene)-5-methyl-2H-1,4-oxazin-5-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
   Show/Hide
C18H16F3N5O3
  1
1
IC50 = 35.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0241298
 Compound Info 
N-[3-[(3R)-5-amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-3-cyanopyridine-2-carboxamide
   Show/Hide
C18H16FN5O2
  1
1
IC50 = 40.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0241297
 Compound Info 
N-[3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-(1,1,2,2,2-pentafluoroethoxy)pyrazine-2-carboxamide
   Show/Hide
C19H14F9N5O3
  1
1
IC50 = 49 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0153818
 Compound Info 
N-[3-[(6R)-8-amino-6-methyl-5H-tetrazolo[1,5-a]pyrazin-6-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
   Show/Hide
C18H14FN9O
  1
1
IC50 = 97.72 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0365700
 Compound Info 
N-[3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-(azetidin-1-yl)pyrazine-2-carboxamide
   Show/Hide
C20H20F4N6O2
  1
1
IC50 = 115 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0548266
 Compound Info 
6-[(E)-2-[3-[(3R)-5-amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluoroanilino]ethenyl]pyridine-3-carbonitrile
   Show/Hide
C19H18FN5O
  1
1
IC50 = 251 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0365699
 Compound Info 
N-[3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-(cyclopropylamino)pyrazine-2-carboxamide
   Show/Hide
C20H20F4N6O2
  1
1
IC50 = 603 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0365701
 Compound Info 
N-[3-[(3R)-5-amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]pyrimidine-5-carboxamide
   Show/Hide
C16H16FN5O2
  1
1
IC50 = 631 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0262951
 Compound Info 
N-[3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-(2,2,2-trifluoroethylamino)pyrazine-2-carboxamide
   Show/Hide
C19H17F7N6O2
  1
1
IC50 = 4500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT01521, Solute carrier family 6 member 5
 Protein Info 
Protein ID: PT02185, Solute carrier family 6 member 9
 Protein Info 
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Bone marrow)
Cell Line Name Organism Disease
NB4
 Cell Line Info 
Homo sapiens (Human) Acute promyelocytic leukemia with PML-RARA
UT-7/Epo
 Cell Line Info 
Homo sapiens (Human) Adult acute megakaryoblastic leukemia
UT-7
 Cell Line Info 
Homo sapiens (Human) Adult acute megakaryoblastic leukemia
KG-1
 Cell Line Info 
Homo sapiens (Human) Adult acute myeloid leukemia
KG-1a
 Cell Line Info 
Homo sapiens (Human) Adult acute myeloid leukemia
RS4;11
 Cell Line Info 
Homo sapiens (Human) Adult B acute lymphoblastic leukemia
Rh30
 Cell Line Info 
Homo sapiens (Human) Alveolar rhabdomyosarcoma
MEG-01
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
697
 Cell Line Info 
Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
SUP-B15
 Cell Line Info 
Homo sapiens (Human) Childhood B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1
HAP1
 Cell Line Info 
Homo sapiens (Human) Chronic myelogenous leukemia, BCR-ABL1 positive
OCI-Ly1
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma
OCI-Ly3
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
TMD8
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
OCI-Ly19
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
TF-1
 Cell Line Info 
Homo sapiens (Human) Erythroleukemia
L-540
 Cell Line Info 
Homo sapiens (Human) Hodgkin lymphoma
NCI-H345
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
NCI-H526
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
Z-138
 Cell Line Info 
Homo sapiens (Human) Mantle cell lymphoma
CAL-1 [Human melanoma]
 Cell Line Info 
Homo sapiens (Human) Melanoma
SH-SY5Y
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SH-EP1
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-BE(2)
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-SH
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-BE(1)
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-AS
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
GI-CA-N
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
LSCC-HD11
 Cell Line Info 
Gallus gallus (Chicken) -
IM-9
 Cell Line Info 
Homo sapiens (Human) -
LAD 2
 Cell Line Info 
Homo sapiens (Human) -
UE6E7T-2
 Cell Line Info 
Homo sapiens (Human) -
RBC
 Cell Line Info 
Homo sapiens (Human) -
Ba/F3
 Cell Line Info 
Mus musculus (Mouse) -
FDC-P1
 Cell Line Info 
Mus musculus (Mouse) -
S21
 Cell Line Info 
Mus musculus (Mouse) -
ANA-1 [Mouse macrophage]
 Cell Line Info 
Mus musculus (Mouse) -
Y16
 Cell Line Info 
Mus musculus (Mouse) -
32D
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 FLT3-ITD
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 c-Kit D816V
 Cell Line Info 
Mus musculus (Mouse) -
Bone marrow macrophage immortalized C57BL/6
 Cell Line Info 
Mus musculus (Mouse) -
BaF3-BCL
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 NPM-ALK
 Cell Line Info 
Mus musculus (Mouse) -
Bone marrow macrophage immortalized BALB/c
 Cell Line Info 
Mus musculus (Mouse) -