General Information of the Cell Line
Cell Line ID
CL000146
Cell Line Name
S21
Category
Transformed cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_K245
Tissue Information
Bone marrow
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01033, Serine/threonine protein kinase PIK3CB
 Protein Info 
Compound ID Compound Name Compound Formula
CP0248363
 Compound Info 
2-[(5-fluoro-4-phenyl-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C22H19FN4O3
  1
1
IC50 = 8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0253245
 Compound Info 
4-morpholin-4-yl-2-[(4-phenyl-1H-benzimidazol-2-yl)methyl]-1H-pyrimidin-6-one
   Show/Hide
C22H21N5O2
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169944
 Compound Info 
4-morpholin-4-yl-2-[(4-phenyl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
   Show/Hide
C22H20N4O3
  1
1
IC50 = 19 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0084873
 Compound Info 
8-(1-anilinoethyl)-6-methyl-2-morpholin-4-ylchromen-4-one
   Show/Hide
C22H24N2O3
  1
1
IC50 = 28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0322768
 Compound Info 
2-[(1-cyclopropyl-5-fluorobenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C19H20FN5O2
  1
1
IC50 = 29 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0003061
 Compound Info 
9-(1-anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one
   Show/Hide
C21H24N4O2
  1
1
IC50 = 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0322769
 Compound Info 
2-[(6-fluoro-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C16H16FN5O2
  1
1
IC50 = 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0439702
 Compound Info 
8-(4-fluoro-2-methylphenoxy)-2-morpholin-4-yl-1H-quinolin-4-one
   Show/Hide
C20H19FN2O3
  1
1
IC50 = 32 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0186648
 Compound Info 
2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)-N-phenylacetamide
   Show/Hide
C16H18N4O3
  1
1
IC50 = 42 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169941
 Compound Info 
4-morpholin-4-yl-2-[(4-thiophen-2-yl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
   Show/Hide
C20H18N4O3S
  1
1
IC50 = 46 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0204632
 Compound Info 
2-[(5-fluoro-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C16H15FN4O3
  1
1
IC50 = 46 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0262695
 Compound Info 
2-[(1-methyl-4-phenylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C23H23N5O2
  1
1
IC50 = 57 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169945
 Compound Info 
2-[(1-methyl-7-phenylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C23H23N5O2
  1
1
IC50 = 60 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0362462
 Compound Info 
2-[(1-ethylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C18H21N5O2
  1
1
IC50 = 72 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0188427
 Compound Info 
4-morpholin-4-yl-2-[(1-phenylbenzimidazol-2-yl)methyl]-1H-pyrimidin-6-one
   Show/Hide
C22H21N5O2
  1
1
IC50 = 75 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0261386
 Compound Info 
2-[(5-fluoro-1-methylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C17H18FN5O2
  1
1
IC50 = 82 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0295019
 Compound Info 
2-(1,3-benzoxazol-2-ylmethyl)-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C16H16N4O3
  1
1
IC50 = 82 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169943
 Compound Info 
4-morpholin-4-yl-2-[(7-phenyl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
   Show/Hide
C22H20N4O3
  1
1
IC50 = 90 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0204633
 Compound Info 
2-[(1-cyclohexylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C22H27N5O2
  1
1
IC50 = 90 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169946
 Compound Info 
2-[(6-bromo-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C16H16BrN5O2
  1
1
IC50 = 91 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0111428
 Compound Info 
2-[(1-methylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C17H19N5O2
  1
1
IC50 = 99 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0298910
 Compound Info 
2-[(6-chloro-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C16H16ClN5O2
  1
1
IC50 = 99 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0147436
 Compound Info 
2-[(1-benzylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C23H23N5O2
  1
1
IC50 = 111 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0322766
 Compound Info 
2-[(6-fluoro-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C16H15FN4O3
  1
1
IC50 = 126 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0322764
 Compound Info 
4-morpholin-4-yl-2-[(4-pyridin-3-yl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
   Show/Hide
C21H19N5O3
  1
1
IC50 = 156 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0238398
 Compound Info 
4-morpholin-4-yl-2-[(4-pyridin-4-yl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
   Show/Hide
C21H19N5O3
  1
1
IC50 = 158 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0362464
 Compound Info 
2-(1H-benzimidazol-2-ylmethyl)-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C16H17N5O2
  1
1
IC50 = 158 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0248389
 Compound Info 
2-[(6-methoxy-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C17H19N5O3
  1
1
IC50 = 193 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0295159
 Compound Info 
2-[[5-fluoro-1-(2-methoxyethyl)benzimidazol-2-yl]methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C19H22FN5O3
  1
1
IC50 = 205 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0341821
 Compound Info 
2-[(6-fluoro-1-methylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C17H18FN5O2
  1
1
IC50 = 290 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0248388
 Compound Info 
4-morpholin-4-yl-2-[(4-pyridin-2-yl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
   Show/Hide
C21H19N5O3
  1
1
IC50 = 336 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0295157
 Compound Info 
2-[(7-fluoro-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C16H15FN4O3
  1
1
IC50 = 373 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0341819
 Compound Info 
4-morpholin-4-yl-2-[[6-(trifluoromethyl)-1H-benzimidazol-2-yl]methyl]-1H-pyrimidin-6-one
   Show/Hide
C17H16F3N5O2
  1
1
IC50 = 386 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0303999
 Compound Info 
2-[(7-methyl-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C17H18N4O3
  1
1
IC50 = 425 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0341820
 Compound Info 
2-[(6-methyl-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C17H19N5O2
  1
1
IC50 = 450 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0237639
 Compound Info 
2-[(4-methyl-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C17H18N4O3
  1
1
IC50 = 461 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0322765
 Compound Info 
2-[(6-methyl-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C17H18N4O3
  1
1
IC50 = 526 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0322767
 Compound Info 
2-[(4-fluoro-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C16H15FN4O3
  1
1
IC50 = 567 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0341818
 Compound Info 
2-[(4-bromo-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C16H15BrN4O3
  1
1
IC50 = 585 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169947
 Compound Info 
2-[(6-fluoro-1H-benzimidazol-2-yl)methyl]-3-methyl-6-morpholin-4-ylpyrimidin-4-one
   Show/Hide
C17H18FN5O2
  1
1
IC50 = 739 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0317536
 Compound Info 
2-[(5-methyl-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C17H18N4O3
  1
1
IC50 = 960 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0147434
 Compound Info 
2-(1,3-benzoxazol-2-ylmethyl)-3-methyl-6-morpholin-4-ylpyrimidin-4-one
   Show/Hide
C17H18N4O3
  1
1
IC50 = 1333 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0210357
 Compound Info 
2-[(1-methyl-6-phenylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C23H23N5O2
  1
1
IC50 = 3410 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0210358
 Compound Info 
2-[(1-methyl-5-phenylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
   Show/Hide
C23H23N5O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Bone marrow)
Cell Line Name Organism Disease
NB4
 Cell Line Info 
Homo sapiens (Human) Acute promyelocytic leukemia with PML-RARA
UT-7/Epo
 Cell Line Info 
Homo sapiens (Human) Adult acute megakaryoblastic leukemia
UT-7
 Cell Line Info 
Homo sapiens (Human) Adult acute megakaryoblastic leukemia
KG-1
 Cell Line Info 
Homo sapiens (Human) Adult acute myeloid leukemia
KG-1a
 Cell Line Info 
Homo sapiens (Human) Adult acute myeloid leukemia
RS4;11
 Cell Line Info 
Homo sapiens (Human) Adult B acute lymphoblastic leukemia
Rh30
 Cell Line Info 
Homo sapiens (Human) Alveolar rhabdomyosarcoma
MEG-01
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
697
 Cell Line Info 
Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
SUP-B15
 Cell Line Info 
Homo sapiens (Human) Childhood B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1
HAP1
 Cell Line Info 
Homo sapiens (Human) Chronic myelogenous leukemia, BCR-ABL1 positive
OCI-Ly1
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma
OCI-Ly3
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
TMD8
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
OCI-Ly19
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
TF-1
 Cell Line Info 
Homo sapiens (Human) Erythroleukemia
L-540
 Cell Line Info 
Homo sapiens (Human) Hodgkin lymphoma
NCI-H345
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
NCI-H526
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
Z-138
 Cell Line Info 
Homo sapiens (Human) Mantle cell lymphoma
CAL-1 [Human melanoma]
 Cell Line Info 
Homo sapiens (Human) Melanoma
SH-SY5Y
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SH-EP1
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-BE(2)
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-SH
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-BE(2)-C
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-BE(1)
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
SK-N-AS
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
GI-CA-N
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
LSCC-HD11
 Cell Line Info 
Gallus gallus (Chicken) -
IM-9
 Cell Line Info 
Homo sapiens (Human) -
LAD 2
 Cell Line Info 
Homo sapiens (Human) -
UE6E7T-2
 Cell Line Info 
Homo sapiens (Human) -
RBC
 Cell Line Info 
Homo sapiens (Human) -
Ba/F3
 Cell Line Info 
Mus musculus (Mouse) -
FDC-P1
 Cell Line Info 
Mus musculus (Mouse) -
ANA-1 [Mouse macrophage]
 Cell Line Info 
Mus musculus (Mouse) -
Y16
 Cell Line Info 
Mus musculus (Mouse) -
32D
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 FLT3-ITD
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 c-Kit D816V
 Cell Line Info 
Mus musculus (Mouse) -
Bone marrow macrophage immortalized C57BL/6
 Cell Line Info 
Mus musculus (Mouse) -
BaF3-BCL
 Cell Line Info 
Mus musculus (Mouse) -
Ba/F3 NPM-ALK
 Cell Line Info 
Mus musculus (Mouse) -
Bone marrow macrophage immortalized BALB/c
 Cell Line Info 
Mus musculus (Mouse) -