General Information of the Protein
Protein ID
PT03110
Protein Name
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Secondarily
Protein Name
MALT lymphoma-associated translocation
Paracaspase
Gene Name
MALT1
Secondarily
Gene Name
MLT
Sequence
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Hydrolase
Function
Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753). May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475).
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Uniprot ID
Primary ID:
Q9UDY8

Secondarily ID:
Q9NTB7
Q9ULX4
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Ensembl ID
ENSG00000172175
HGNC ID
HGNC:6819
Subcellular Location
Cytoplasm
Perinuclear region
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0074453
 Compound Info 
1-(3-chloropyridin-2-yl)-N-[5-chloro-6-(triazol-2-yl)pyridin-3-yl]piperidine-4-carboxamide
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C18H17Cl2N7O
  1
1
IC50 = 90 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0536081
 Compound Info 
1-(3-aminopyridin-2-yl)-N-[5-chloro-6-(triazol-2-yl)pyridin-3-yl]piperidine-4-carboxamide
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C18H19ClN8O
  1
1
IC50 = 90 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0359950
 Compound Info 
1-(3-aminopyridin-2-yl)-N-[3-chloro-4-(triazol-2-yl)phenyl]piperidine-4-carboxamide
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C19H20ClN7O
  1
1
IC50 = 110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0389888
 Compound Info 
N-[3-chloro-4-[3-(methylcarbamoyl)-1,2,4-triazol-1-yl]phenyl]-1-(3-chloropyridin-2-yl)piperidine-4-carboxamide
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C21H21Cl2N7O2
  1
1
IC50 = 140 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0475290
 Compound Info 
N-(5-chloro-6-methoxypyridin-3-yl)-1-(3-chloropyridin-2-yl)piperidine-4-carboxamide
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C17H18Cl2N4O2
  1
1
IC50 = 190 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0261160
 Compound Info 
N-(3-chloro-4-fluorophenyl)-1-(3-chloropyrazin-2-yl)piperidine-4-carboxamide
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C16H15Cl2FN4O
  1
1
IC50 = 290 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0359945
 Compound Info 
1-(3-aminopyridin-2-yl)-N-(3-chloro-4-fluorophenyl)piperidine-4-carboxamide
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C17H18ClFN4O
  1
1
IC50 = 420 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0327620
 Compound Info 
N-[3-chloro-4-(3,5-dimethyl-1,2,4-triazol-1-yl)phenyl]-1-(3-nitropyridin-2-yl)piperidine-4-carboxamide
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C21H22ClN7O3
  1
1
IC50 = 640 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0261159
 Compound Info 
N-(3-chloro-4-fluorophenyl)-1-(3-chloropyridin-2-yl)piperidine-4-carboxamide
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C17H16Cl2FN3O
  1
1
IC50 = 1350 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0236381
 Compound Info 
N-(3-chlorophenyl)-1-(3-chloropyridin-2-yl)piperidine-4-carboxamide
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C17H17Cl2N3O
  1
1
IC50 = 1590 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0359944
 Compound Info 
N-(3-chloro-4-fluorophenyl)-1-(3-cyanopyridin-2-yl)piperidine-4-carboxamide
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C18H16ClFN4O
  1
1
IC50 = 2700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0485574
 Compound Info 
1-(3-chloropyridin-2-yl)-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]piperidine-4-carboxamide
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C22H21ClF3N5O
  1
1
IC50 = 3000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0086265
 Compound Info 
N-(3-chloro-4-fluorophenyl)-1-pyrimidin-2-ylpiperidine-4-carboxamide
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C16H16ClFN4O
  1
1
IC50 = 3100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0327621
 Compound Info 
N-(3-chloro-4-fluorophenyl)-1-phenylpiperidine-4-carboxamide
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C18H18ClFN2O
  1
1
IC50 = 3200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0359942
 Compound Info 
N-(3-chloro-4-methylphenyl)-1-(3-chloropyridin-2-yl)piperidine-4-carboxamide
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C18H19Cl2N3O
  1
1
IC50 = 3700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000001 , Jurkat
 Cell Line Info 
Cell Line ID: CL000106 , OCI-Ly3
 Cell Line Info 
Cell Line ID: CL000222 , TMD8
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0158299
 Compound Info 
1-[7-[(1S)-1-methoxyethyl]-2-methylpyrazolo[1,5-a]pyrimidin-6-yl]-3-[5-(trifluoromethyl)pyridin-3-yl]urea
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C17H17F3N6O2
  1
1 IC50 = 0.01 nM
CP0345345
 Compound Info 
1-(5-chloro-6-methoxypyridin-3-yl)-3-[6-cyano-4-[methyl(oxan-4-yl)amino]quinolin-3-yl]urea
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C23H23ClN6O3
  1
1 IC50 = 2 nM
CP0575357
 Compound Info 
1-[2-chloro-7-(3,3-dimethylmorpholin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(5-chloro-6-methoxypyridin-3-yl)urea
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C19H21Cl2N7O3
  1
1 IC50 = 2 nM
CP0643956
 Compound Info 
NVS_MALT1
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C24H27ClF3N5O4S
  3
1 IC50 = 2.4 nM
2 IC50 ~ 2.4 nM
3 IC50 ~ 18 nM
CP0135267
 Compound Info 
(S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin-3-yl)-3-(2- chloro-7-(1- methoxyethyl)pyrazo- lo[1,5-a]pyrimidin-6- yl)urea
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C17H15Cl2N9O2
  2
1 IC50 = 3 nM
2 IC50 = 6 nM
CP0074453
 Compound Info 
1-(3-chloropyridin-2-yl)-N-[5-chloro-6-(triazol-2-yl)pyridin-3-yl]piperidine-4-carboxamide
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C18H17Cl2N7O
  1
1 IC50 = 4 nM
CP0532994
 Compound Info 
1-(5-chloro-6-methoxypyridin-3-yl)-3-[6-cyano-4-[(3S)-3-methylmorpholin-4-yl]quinolin-3-yl]urea
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C22H21ClN6O3
  1
1 IC50 = 5 nM
CP0512707
 Compound Info 
1-[2-chloro-7-(3,3-dimethylmorpholin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl]-3-[2-(trifluoromethyl)pyridin-4-yl]urea
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C19H19ClF3N7O2
  1
1 IC50 = 6 nM
CP0528642
 Compound Info 
1-[2-chloro-7-[(3S,5S)-3,5-dimethylmorpholin-4-yl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-(5-chloro-6-methoxypyridin-3-yl)urea
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C19H21Cl2N7O3
  1
1 IC50 = 6 nM
CP0554883
 Compound Info 
1-(3-chloro-4-methoxyphenyl)-3-[6-cyano-4-[(3S)-3-methylmorpholin-4-yl]quinolin-3-yl]urea
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C23H22ClN5O3
  1
1 IC50 = 6 nM
CP0536081
 Compound Info 
1-(3-aminopyridin-2-yl)-N-[5-chloro-6-(triazol-2-yl)pyridin-3-yl]piperidine-4-carboxamide
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C18H19ClN8O
  1
1 IC50 = 7 nM
CP0573419
 Compound Info 
1-(3-chloro-4-methoxyphenyl)-3-[6-cyano-4-[methyl(oxan-4-yl)amino]quinolin-3-yl]urea
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C24H24ClN5O3
  1
1 IC50 = 8 nM
CP0258300
 Compound Info 
1-[2-chloro-7-[(3S,5S)-3,5-dimethylmorpholin-4-yl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-[2-(trifluoromethyl)pyridin-4-yl]urea
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C19H19ClF3N7O2
  1
1 IC50 = 9 nM
CP0475290
 Compound Info 
N-(5-chloro-6-methoxypyridin-3-yl)-1-(3-chloropyridin-2-yl)piperidine-4-carboxamide
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C17H18Cl2N4O2
  1
1 IC50 = 13 nM
CP0554884
 Compound Info 
1-[2-bromo-7-[(3S)-3-methylmorpholin-4-yl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-(5-chloro-6-methoxypyridin-3-yl)urea
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C18H19BrClN7O3
  1
1 IC50 = 17 nM
CP0389888
 Compound Info 
N-[3-chloro-4-[3-(methylcarbamoyl)-1,2,4-triazol-1-yl]phenyl]-1-(3-chloropyridin-2-yl)piperidine-4-carboxamide
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C21H21Cl2N7O2
  1
1 IC50 = 21 nM
CP0345344
 Compound Info 
1-[(3R)-6-bromo-3,4-dihydro-2H-chromen-3-yl]-3-[3-chloro-4-(1,2,4-triazol-1-yl)phenyl]urea
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C18H15BrClN5O2
  1
1 IC50 = 26 nM
CP0261159
 Compound Info 
N-(3-chloro-4-fluorophenyl)-1-(3-chloropyridin-2-yl)piperidine-4-carboxamide
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C17H16Cl2FN3O
  1
1 IC50 = 28 nM
CP0575356
 Compound Info 
1-(6-bromo-4-chloroquinolin-3-yl)-3-(3-chloro-4-methoxyphenyl)urea
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C17H12BrCl2N3O2
  1
1 IC50 = 29 nM
CP0532993
 Compound Info 
1-(6-bromo-3,4-dihydro-2H-chromen-3-yl)-3-(5-chloro-6-methoxypyridin-3-yl)urea
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C16H15BrClN3O3
  1
1 IC50 = 31 nM
CP0359950
 Compound Info 
1-(3-aminopyridin-2-yl)-N-[3-chloro-4-(triazol-2-yl)phenyl]piperidine-4-carboxamide
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C19H20ClN7O
  1
1 IC50 = 35 nM
CP0359942
 Compound Info 
N-(3-chloro-4-methylphenyl)-1-(3-chloropyridin-2-yl)piperidine-4-carboxamide
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C18H19Cl2N3O
  1
1 IC50 = 54 nM
CP0512706
 Compound Info 
1-(3-chloro-4-methoxyphenyl)-3-(6-fluoro-3,4-dihydro-2H-chromen-3-yl)urea
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C17H16ClFN2O3
  1
1 IC50 = 57 nM
CP0261160
 Compound Info 
N-(3-chloro-4-fluorophenyl)-1-(3-chloropyrazin-2-yl)piperidine-4-carboxamide
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C16H15Cl2FN4O
  1
1 IC50 = 100 nM
CP0359945
 Compound Info 
1-(3-aminopyridin-2-yl)-N-(3-chloro-4-fluorophenyl)piperidine-4-carboxamide
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C17H18ClFN4O
  1
1 IC50 = 100 nM
CP0256471
 Compound Info 
1-(3-chloro-4-methoxyphenyl)-3-(6-fluoro-3,4-dihydro-2H-thiochromen-3-yl)urea
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C17H16ClFN2O2S
  1
1 IC50 = 145 nM
CP0565126
 Compound Info 
1-(3-chloro-4-methoxyphenyl)-3-(6-cyano-3,4-dihydro-2H-chromen-3-yl)urea
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C18H16ClN3O3
  1
1 IC50 = 150 nM
CP0327620
 Compound Info 
N-[3-chloro-4-(3,5-dimethyl-1,2,4-triazol-1-yl)phenyl]-1-(3-nitropyridin-2-yl)piperidine-4-carboxamide
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C21H22ClN7O3
  1
1 IC50 = 184 nM
CP0644231
 Compound Info 
NVS_MALT1_C
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C24H27ClF3N5O4S
  2
1 IC50 = 190 nM
2 IC50 ~ 190 nM
CP0236381
 Compound Info 
N-(3-chlorophenyl)-1-(3-chloropyridin-2-yl)piperidine-4-carboxamide
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C17H17Cl2N3O
  1
1 IC50 = 210 nM
CP0528641
 Compound Info 
1-(6-bromoquinolin-3-yl)-3-(3-chloro-4-methoxyphenyl)urea
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C17H13BrClN3O2
  1
1 IC50 = 242 nM
CP0142584
 Compound Info 
1-(3-chloro-4-methoxyphenyl)-3-(3,4-dihydro-2H-chromen-3-yl)urea
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C17H17ClN2O3
  1
1 IC50 = 245 nM
CP0550411
 Compound Info 
CHEMBL5184753
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C16H16ClF3N8
  1
1 IC50 = 300 nM
CP0485574
 Compound Info 
1-(3-chloropyridin-2-yl)-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]piperidine-4-carboxamide
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C22H21ClF3N5O
  1
1 IC50 = 340 nM
CP0359944
 Compound Info 
N-(3-chloro-4-fluorophenyl)-1-(3-cyanopyridin-2-yl)piperidine-4-carboxamide
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C18H16ClFN4O
  1
1 IC50 = 420 nM
CP0552005
 Compound Info 
CHEMBL5199890
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C17H19F3N8S
  1
1 IC50 = 800 nM
CP0327621
 Compound Info 
N-(3-chloro-4-fluorophenyl)-1-phenylpiperidine-4-carboxamide
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C18H18ClFN2O
  1
1 IC50 = 820 nM
CP0580040
 Compound Info 
CHEMBL5179449
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C16H16BrF3N8
  1
1 IC50 = 1100 nM
CP0049432
 Compound Info 
&#946;-Lapachone (A3)
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C15H14O3
  1
1 IC50 = 1200 nM
CP0086265
 Compound Info 
N-(3-chloro-4-fluorophenyl)-1-pyrimidin-2-ylpiperidine-4-carboxamide
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C16H16ClFN4O
  1
1 IC50 = 1620 nM
Clinical Information about the Protein
Target 1 ( MALT lymphoma-associated translocation (MALT1) )
Target Type Clinical trial Target