| Compound ID |
Compound Name |
Compound Formula |
|
CP0033646
|
AZD-9291
Show/Hide
|
C28H33N7O2
|
16
|
| 1 |
EC50 = 2 nM
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| 2 |
EC50 = 6 nM
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| 3 |
EC50 = 16 nM
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| 4 |
EC50 = 18 nM
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| 5 |
EC50 = 20 nM
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| 6 |
EC50 = 43 nM
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| 7 |
EC50 = 66 nM
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| 8 |
GI50 = 1 nM
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| 9 |
GI50 < 3 nM
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| 10 |
GI50 = 13 nM
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| 11 |
GI50 = 60 nM
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| 12 |
GI50 = 280 nM
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| 13 |
GI50 = 300 nM
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| 14 |
GI50 = 310 nM
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| 15 |
GI50 = 550 nM
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| 16 |
GI50 = 590 nM
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CP0431565
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[5-fluoro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C28H36FN7O4S
|
3
|
| 1 |
EC50 = 2 nM
|
|
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| 2 |
EC50 = 5 nM
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| 3 |
EC50 = 25 nM
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CP0412998
|
N-[5-[[5-chloro-4-[2-(dimethylsulfamoyl)anilino]pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C27H35ClN8O4S
|
4
|
| 1 |
EC50 = 4 nM
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|
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| 2 |
EC50 = 5 nM
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| 3 |
EC50 = 6 nM
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| 4 |
EC50 = 69 nM
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CP0412999
|
N-[5-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C28H36ClN7O4S
|
4
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| 1 |
EC50 = 4 nM
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| 2 |
EC50 = 5 nM
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| 3 |
EC50 = 6 nM
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| 4 |
EC50 = 32 nM
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CP0459363
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-[2-(dimethylsulfamoyl)anilino]-5-fluoropyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C27H35FN8O4S
|
4
|
| 1 |
EC50 = 5 nM
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| 2 |
EC50 = 6 nM
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| 3 |
EC50 = 8 nM
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| 4 |
EC50 = 31 nM
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CP0852604
|
(R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C25H24ClN7O2
|
7
|
| 1 |
EC50 = 7 nM
|
|
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| 2 |
EC50 = 70 nM
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| 3 |
GI50 = 4 nM
|
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| 4 |
GI50 = 2000 nM
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| 5 |
GI50 = 2300 nM
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| 6 |
GI50 = 4600 nM
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| 7 |
GI50 = 7900 nM
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CP0431567
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-[2-(dimethylsulfamoyl)anilino]-5-iodopyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C27H35IN8O4S
|
4
|
| 1 |
EC50 = 17 nM
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| 2 |
EC50 = 19 nM
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| 3 |
EC50 = 24 nM
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| 4 |
EC50 = 262 nM
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CP0433994
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-[2-(dimethylsulfamoyl)anilino]pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C27H36N8O4S
|
4
|
| 1 |
EC50 = 19 nM
|
|
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| 2 |
EC50 = 21 nM
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| 3 |
EC50 = 22 nM
|
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| 4 |
EC50 = 93 nM
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CP0437869
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[5-iodo-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C28H36IN7O4S
|
5
|
| 1 |
EC50 = 19 nM
|
|
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| 2 |
EC50 = 20 nM
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| 3 |
EC50 = 22 nM
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| 4 |
EC50 = 47 nM
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| 5 |
EC50 = 240 nM
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CP0384136
|
N-[5-[[5-chloro-4-(2-dimethylphosphorylanilino)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C27H35ClN7O3P
|
5
|
| 1 |
EC50 = 21 nM
|
|
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| 2 |
EC50 = 30 nM
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| 3 |
EC50 = 44 nM
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| 4 |
EC50 = 45 nM
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| 5 |
EC50 = 68 nM
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CP0412996
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(2-dimethylphosphorylanilino)-5-iodopyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C27H35IN7O3P
|
5
|
| 1 |
EC50 = 23 nM
|
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| 2 |
EC50 = 31 nM
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| 3 |
EC50 = 32 nM
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| 4 |
EC50 = 84 nM
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| 5 |
EC50 = 96 nM
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CP0059062
|
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Show/Hide
|
C25H27ClN6O3
|
9
|
| 1 |
EC50 = 26 nM
|
|
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| 2 |
EC50 = 27 nM
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| 3 |
EC50 = 31 nM
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| 4 |
EC50 = 68 nM
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| 5 |
EC50 = 989 nM
|
|
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| 6 |
GI50 = 2.1 nM
|
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| 7 |
GI50 = 890 nM
|
|
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| 8 |
GI50 = 1300 nM
|
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| 9 |
GI50 = 2200 nM
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CP0384138
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(2-dimethylphosphorylanilino)-5-fluoropyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C27H35FN7O3P
|
5
|
| 1 |
EC50 = 68 nM
|
|
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| 2 |
EC50 = 74 nM
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| 3 |
EC50 = 157 nM
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|
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| 4 |
EC50 = 162 nM
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| 5 |
EC50 = 178 nM
|
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|
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CP0431564
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C28H37N7O4S
|
5
|
| 1 |
EC50 = 78 nM
|
|
|
| 2 |
EC50 = 158 nM
|
|
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| 3 |
EC50 = 183 nM
|
|
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| 4 |
EC50 = 195 nM
|
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| 5 |
EC50 = 827 nM
|
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CP0384137
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(2-dimethylphosphorylanilino)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C27H36N7O3P
|
5
|
| 1 |
EC50 = 236 nM
|
|
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| 2 |
EC50 = 400 nM
|
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| 3 |
EC50 = 680 nM
|
|
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| 4 |
EC50 = 830 nM
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| 5 |
EC50 = 988 nM
|
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CP0477024
|
N-[5-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]propanamide
Show/Hide
|
C28H38ClN7O4S
|
2
|
| 1 |
EC50 = 666 nM
|
|
|
| 2 |
EC50 = 972 nM
|
|
|
|
CP0013877
|
CERITINIB
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|
C28H36ClN5O3S
|
5
|
| 1 |
EC50 = 2500 nM
|
|
|
| 2 |
EC50 = 2660 nM
|
|
|
| 3 |
EC50 = 3000 nM
|
|
|
| 4 |
EC50 > 3000 nM
|
|
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| 5 |
GI50 = 780.5 nM
|
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|
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CP0486473
|
3-[4-(3-bromoanilino)-6-methoxyquinazolin-7-yl]oxypropyl 3-(prop-2-enyldisulfanyl)propanoate
Show/Hide
|
C24H26BrN3O4S2
|
4
|
| 1 |
GI50 = 6.9 nM
|
|
|
| 2 |
GI50 = 8 nM
|
|
|
| 3 |
GI50 = 6030 nM
|
|
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| 4 |
GI50 > 10000 nM
|
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CP0871866
|
N-(5-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide
Show/Hide
|
C29H36ClN7O4S
|
5
|
| 1 |
GI50 = 8 nM
|
|
|
| 2 |
GI50 = 8.5 nM
|
|
|
| 3 |
GI50 = 16 nM
|
|
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| 4 |
GI50 = 230 nM
|
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| 5 |
GI50 = 1100 nM
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CP0852601
|
(R)-1-(3-(4-Amino-3-(4-(benzyloxy)-3-chlorophenyl)-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C26H25ClN6O2
|
1
|
| 1 |
GI50 = 10 nM
|
|
|
|
CP0911710
|
N-[4-(3-Bromo-phenylamino)-quinazolin-6-yl]-2-but-3-enyldisulfanyl-acetamide
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|
C20H19BrN4OS2
|
2
|
| 1 |
GI50 = 11 nM
|
|
|
| 2 |
GI50 > 10000 nM
|
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|
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CP0871191
|
2-But-3-enyldisulfanyl-N-[4-(3-chloro-4-fluoro-phenylamino)-quinazolin-6-yl]-acetamide
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|
C20H18ClFN4OS2
|
2
|
| 1 |
GI50 = 12 nM
|
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| 2 |
GI50 > 10000 nM
|
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|
|
CP0153290
|
US8476284, 39
Show/Hide
|
C24H22N6O2
|
1
|
| 1 |
GI50 = 13 nM
|
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CP0901561
|
(R)-1-(3-(4-Amino-3-(4-(benzyloxy)phenyl)-1H-pyrazolo[3,4-d]-pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C26H26N6O2
|
1
|
| 1 |
GI50 = 13 nM
|
|
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CP0930637
|
(R)-1-(3-(4-Amino-3-(3-chloro-4-((4-fluorobenzyl)oxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-on
Show/Hide
|
C26H24ClFN6O2
|
1
|
| 1 |
GI50 = 16 nM
|
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CP0875961
|
(R)-1-(3-(4-Amino-3-(3-chloro-4-((1-methyl-1H-imidazol-2-yl)-methoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-prop-2-en-1-one
Show/Hide
|
C24H25ClN8O2
|
1
|
| 1 |
GI50 = 37 nM
|
|
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CP0921106
|
(R)-1-(3-(4-Amino-3-(3-chloro-4-((3,4-difluorobenzyl)oxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C26H23ClF2N6O2
|
1
|
| 1 |
GI50 = 49 nM
|
|
|
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CP0961271
|
3-Allyldisulfanyl-propionic acid 3-[4-(4-bromo-phenylamino)-6-methoxy-quinazolin-7-yloxy]-propyl ester
Show/Hide
|
C24H26BrN3O4S2
|
3
|
| 1 |
GI50 = 58 nM
|
|
|
| 2 |
GI50 = 2340 nM
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| 3 |
GI50 > 10000 nM
|
|
|
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CP0137937
|
AP26113
Show/Hide
|
C26H34ClN6O2P
|
1
|
| 1 |
GI50 = 59.1 nM
|
|
|
|
CP0931082
|
(R)-1-(3-(4-Amino-3-(3-fluoro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C25H24FN7O2
|
1
|
| 1 |
GI50 = 66 nM
|
|
|
|
CP0116990
|
AP-26113
Show/Hide
|
C29H39ClN7O2P
|
1
|
| 1 |
GI50 = 67.2 nM
|
|
|
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CP0875574
|
(R)-1-(3-(4-Amino-3-(2,5-dichloro-4-((3-fluorobenzyl)oxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C26H23Cl2FN6O2
|
1
|
| 1 |
GI50 = 71 nM
|
|
|
|
CP0931083
|
(R)-1-(3-(4-Amino-3-(3-methyl-4-((6-methylpyridin-2-yl)-methoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-prop-2-en-1-one
Show/Hide
|
C27H29N7O2
|
1
|
| 1 |
GI50 = 72 nM
|
|
|
|
CP0964900
|
(S)-1-(3-(4-Amino-3-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C26H24ClFN6O2
|
1
|
| 1 |
GI50 = 97 nM
|
|
|
|
CP0909540
|
N-(4-(4-Amino-3-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)acrylamide
Show/Hide
|
C27H26ClFN6O2
|
1
|
| 1 |
GI50 = 110 nM
|
|
|
|
CP0871193
|
4-(4-{3-[4-(3-Bromo-phenylamino)-6-methoxy-quinazolin-7-yloxy]-propoxy}-phenyl)-[1,2]dithiole-3-thione
Show/Hide
|
C27H22BrN3O3S3
|
3
|
| 1 |
GI50 = 120 nM
|
|
|
| 2 |
GI50 = 3060 nM
|
|
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| 3 |
GI50 > 10000 nM
|
|
|
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CP0238950
|
AZD3463
Show/Hide
|
C24H25ClN6O
|
1
|
| 1 |
GI50 = 131.5 nM
|
|
|
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CP0875575
|
(R)-1-(3-(4-Amino-3-(3-methyl-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C26H27N7O2
|
1
|
| 1 |
GI50 = 150 nM
|
|
|
|
CP0007430
|
IBRUTINIB
Show/Hide
|
C25H24N6O2
|
1
|
| 1 |
GI50 = 160 nM
|
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CP0896986
|
(R)-1-(3-(4-Amino-3-(2-chloro-4-((3-fluorobenzyl)oxy)phenyl)-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C26H24ClFN6O2
|
1
|
| 1 |
GI50 = 170 nM
|
|
|
|
CP0871205
|
4-(4-{3-[4-(4-Bromo-phenylamino)-6-methoxy-quinazolin-7-yloxy]-propoxy}-phenyl)-[1,2]dithiole-3-thione
Show/Hide
|
C27H22BrN3O3S3
|
3
|
| 1 |
GI50 = 250 nM
|
|
|
| 2 |
GI50 = 9560 nM
|
|
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| 3 |
GI50 > 10000 nM
|
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CP0908818
|
N-(5-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)propionamide
Show/Hide
|
C29H38ClN7O4S
|
7
|
| 1 |
GI50 = 270 nM
|
|
|
| 2 |
GI50 = 290 nM
|
|
|
| 3 |
GI50 = 360 nM
|
|
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| 4 |
GI50 = 370 nM
|
|
|
| 5 |
GI50 = 800 nM
|
|
|
| 6 |
GI50 = 1500 nM
|
|
|
| 7 |
GI50 = 1700 nM
|
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CP0955273
|
4-(4-{3-[4-(3-Chloro-4-fluoro-phenylamino)-6-methoxy-quinazolin-7-yloxy]-propoxy}-phenyl)-[1,2]dithiole-3-thione
Show/Hide
|
C27H21ClFN3O3S3
|
2
|
| 1 |
GI50 = 270 nM
|
|
|
| 2 |
GI50 > 10000 nM
|
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|
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CP0871192
|
N-[4-(3-Chloro-4-fluoro-phenylamino)-quinazolin-6-yl]-2-[4-(3-oxo-3H-[1,2]dithiol-4-yl)-phenoxy]-acetamide
Show/Hide
|
C25H16ClFN4O3S2
|
3
|
| 1 |
GI50 = 290 nM
|
|
|
| 2 |
GI50 = 2490 nM
|
|
|
| 3 |
GI50 = 3160 nM
|
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|
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CP0909541
|
(R)-1-(3-(4-Amino-3-(3-chloro-4-((1-methyl-1H-indazol-3-yl)-methoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-prop-2-en-1-one
Show/Hide
|
C28H27ClN8O2
|
1
|
| 1 |
GI50 = 320 nM
|
|
|
|
CP0019908
|
BDBM50242742
Show/Hide
|
C30H40ClN7O3S
|
3
|
| 1 |
GI50 = 340.7 nM
|
|
|
| 2 |
GI50 = 420 nM
|
|
|
| 3 |
GI50 = 560 nM
|
|
|
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CP0914491
|
4-(4-{3-[6-Methoxy-4-(3-trifluoromethyl-phenylamino)-quinazolin-7-yloxy]-propoxy}-phenyl)-[1,2]dithiole-3-thione
Show/Hide
|
C28H22F3N3O3S3
|
3
|
| 1 |
GI50 = 380 nM
|
|
|
| 2 |
GI50 = 1648 nM
|
|
|
| 3 |
GI50 = 1980 nM
|
|
|
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CP0852600
|
(R,E)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-4-(dimethylamino)but-2-en-1-one
Show/Hide
|
C28H31ClN8O2
|
1
|
| 1 |
GI50 = 470 nM
|
|
|
|
CP0934908
|
N-(3-(4-Amino-3-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)acrylamide
Show/Hide
|
C27H20ClFN6O2
|
1
|
| 1 |
GI50 = 590 nM
|
|
|
|
CP0871203
|
4-(4-{3-[6-Methoxy-4-(4-nitro-phenylamino)-quinazolin-7-yloxy]-propoxy}-phenyl)-[1,2]dithiole-3-thione
Show/Hide
|
C27H22N4O5S3
|
3
|
| 1 |
GI50 = 600 nM
|
|
|
| 2 |
GI50 = 4080 nM
|
|
|
| 3 |
GI50 > 10000 nM
|
|
|
|
CP0911447
|
4-(4-{3-[4-(3,4-Dimethoxy-phenylamino)-6-methoxy-quinazolin-7-yloxy]-propoxy}-phenyl)-[1,2]dithiole-3-thione
Show/Hide
|
C29H27N3O5S3
|
3
|
| 1 |
GI50 = 830 nM
|
|
|
| 2 |
GI50 = 3390 nM
|
|
|
| 3 |
GI50 = 6350 nM
|
|
|
|
CP0931081
|
(R)-1-(3-(4-Amino-3-(3-chloro-4-((3-(methylsulfonyl)benzyl)oxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
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C27H27ClN6O4S
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1
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| 1 |
GI50 = 1000 nM
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CP0857303
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(R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
Show/Hide
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C25H26ClN7O2
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6
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| 1 |
GI50 = 1100 nM
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| 2 |
GI50 = 1600 nM
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| 3 |
GI50 = 3200 nM
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| 4 |
GI50 = 3700 nM
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| 5 |
GI50 = 6300 nM
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| 6 |
GI50 = 7700 nM
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CP0378420
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2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine
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C29H40N8O3S
|
1
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| 1 |
GI50 = 1508 nM
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CP0065873
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1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanone
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C26H29N7O2
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1
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| 1 |
GI50 = 1800 nM
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CP0875962
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(R)-5-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]-pyrimidin-3-yl)-2-(pyridin-2-ylmethoxy)benzonitrile
Show/Hide
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C26H24N8O2
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1
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| 1 |
GI50 = 2200 nM
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CP0949061
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(R)-1-(3-(4-Amino-3-(3-methoxy-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
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C26H27N7O3
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1
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| 1 |
GI50 = 2600 nM
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CP0224766
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4-(methylamino)-2-[4-methyl-3-(prop-2-enoylamino)anilino]-N-[2-methyl-5-[(3,4,5-trimethoxybenzoyl)amino]phenyl]pyrimidine-5-carboxamide
Show/Hide
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C33H35N7O6
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1
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| 1 |
GI50 > 10000 nM
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CP0387298
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4-(methylamino)-2-[4-methyl-3-(propanoylamino)anilino]-N-[2-methyl-5-[(3,4,5-trimethoxybenzoyl)amino]phenyl]pyrimidine-5-carboxamide
Show/Hide
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C33H37N7O6
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1
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| 1 |
GI50 > 10000 nM
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CP0387299
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4-(methylamino)-2-[4-methyl-3-(propanoylamino)anilino]-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]pyrimidine-5-carboxamide
Show/Hide
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C31H30F3N7O3
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1
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| 1 |
GI50 > 10000 nM
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CP0389976
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4-(methylamino)-2-[4-methyl-3-(prop-2-enoylamino)anilino]-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]pyrimidine-5-carboxamide
Show/Hide
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C31H28F3N7O3
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1
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| 1 |
GI50 > 10000 nM
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CP0841359
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(3-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine hydrochloride
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C16H15Cl2N3O2
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1
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| 1 |
IC50 = 0.8 nM
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CP0878521
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4-(3'-chloroanilino)-6,7-diethoxyquinazoline hydrochloride
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C18H19Cl2N3O2
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1
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| 1 |
IC50 = 1.2 nM
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CP0543558
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2-[4-(difluoromethyl)-6-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-7-methylindazol-2-yl]-2-spiro[6,7-dihydropyrrolo[1,2-c]imidazole-5,1'-cyclopropane]-1-yl-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C37H37F2N7O2S
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2
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| 1 |
IC50 = 2 nM
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| 2 |
IC50 = 20 nM
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CP0876117
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PD153035 (HYDROCHLORIDE)
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C16H15BrClN3O2
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1
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| 1 |
IC50 = 2.6 nM
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CP0550036
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2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxo-7-(trifluoromethyl)-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C35H33F3N6O3S
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2
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| 1 |
IC50 = 3 nM
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| 2 |
IC50 = 26 nM
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CP0574923
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2-[4-(difluoromethyl)-6-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-7-methylindazol-2-yl]-2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C35H35F2N7O2S
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2
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| 1 |
IC50 = 3 nM
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| 2 |
IC50 = 23 nM
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CP0876121
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4-(3'-bromoanilino)-6,7-diethoxyquinazoline hydrochloride
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C18H19BrClN3O2
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1
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| 1 |
IC50 = 3.2 nM
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CP0564476
|
BLU-945
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C28H37FN6O3S
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2
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| 1 |
IC50 = 3.2 nM
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| 2 |
IC50 = 40 nM
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CP0550032
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2-(7-chloro-3-oxo-1H-isoindol-2-yl)-2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C19H16ClN5O2S
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2
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| 1 |
IC50 = 4 nM
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| 2 |
IC50 = 183 nM
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CP0569563
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2-[4,7-dichloro-6-[4-(4-ethylpiperazin-1-yl)phenyl]indazol-2-yl]-2-[(6R)-6-fluoro-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C30H29Cl2FN8OS
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2
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| 1 |
IC50 = 4 nM
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| 2 |
IC50 = 15 nM
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CP0576042
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2-[7-(difluoromethyl)-5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxo-1H-isoindol-2-yl]-2-(5,5-dimethyl-6,7-dihydropyrrolo[1,2-c]imidazol-1-yl)-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C37H38F2N6O3S
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2
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| 1 |
IC50 = 4 nM
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| 2 |
IC50 = 12 nM
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CP0577198
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2-[7-(difluoromethyl)-5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxo-1H-isoindol-2-yl]-2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C35H34F2N6O3S
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2
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| 1 |
IC50 = 4 nM
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| 2 |
IC50 = 13 nM
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CP0876120
|
4-(3'-iodoanilino)-6,7-diethoxyquinazoline hydrochloride
Show/Hide
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C18H19ClIN3O2
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1
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| 1 |
IC50 = 4.6 nM
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CP0550033
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2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[7-fluoro-5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxo-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C34H33FN6O3S
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2
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| 1 |
IC50 = 5 nM
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| 2 |
IC50 = 12 nM
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CP0575817
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2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[7-fluoro-5-[2-[4-[(4-hydroxypiperidin-1-yl)methyl]phenyl]ethynyl]-3-oxo-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C33H31FN6O3S
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2
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| 1 |
IC50 = 5 nM
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| 2 |
IC50 = 33 nM
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CP0076102
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2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C19H14FN3O3S
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2
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| 1 |
IC50 = 6 nM
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| 2 |
IC50 = 460 nM
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CP0569562
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2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[4-fluoro-6-[2-[4-[(4-hydroxypiperidin-1-yl)methyl]phenyl]ethynyl]indazol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C32H30FN7O2S
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2
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| 1 |
IC50 = 6 nM
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| 2 |
IC50 = 106 nM
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CP0570370
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2-[4,7-dichloro-6-(4-morpholin-4-ylphenyl)indazol-2-yl]-2-[(6R)-6-fluoro-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C28H24Cl2FN7O2S
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2
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| 1 |
IC50 = 6 nM
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| 2 |
IC50 = 17 nM
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CP0799641
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(6,7-Dimethoxy-quinazolin-4-yl)-(3-fluoro-phenyl)-amine hydrochloride
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C16H15ClFN3O2
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1
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| 1 |
IC50 = 6.3 nM
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CP0880581
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4-(3'-iodoanilino)-6,7-dimethoxyquinazoline hydrochloride
Show/Hide
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C16H15ClIN3O2
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1
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| 1 |
IC50 = 6.4 nM
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CP0880582
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4-(3'-fluoroanilino)-6,7-diethoxyquinazoline hydrochloride
Show/Hide
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C18H19ClFN3O2
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1
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| 1 |
IC50 = 6.5 nM
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CP0876122
|
4-[(4'-fluorobenzyl)amino]-6,7-diethoxyquinazoline hydrochloride
Show/Hide
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C19H21ClFN3O2
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1
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| 1 |
IC50 = 6.6 nM
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CP0543557
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2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[7-fluoro-3-oxo-5-(2-pyridin-3-ylethynyl)-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C26H19FN6O2S
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2
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| 1 |
IC50 = 7 nM
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| 2 |
IC50 = 129 nM
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CP0567936
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2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[7-fluoro-3-oxo-5-[2-[4-(piperidin-1-ylmethyl)phenyl]ethynyl]-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C33H31FN6O2S
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2
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| 1 |
IC50 = 7 nM
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| 2 |
IC50 = 54 nM
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CP0568815
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2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[6-[4-(4-ethylpiperazin-1-yl)phenyl]-4-fluoroindazol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
|
C30H31FN8OS
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2
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| 1 |
IC50 = 7 nM
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| 2 |
IC50 = 91 nM
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CP0573237
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2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[(4-hydroxypiperidin-1-yl)methyl]phenyl]ethynyl]-3-oxo-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C33H32N6O3S
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2
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| 1 |
IC50 = 7 nM
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| 2 |
IC50 = 297 nM
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CP0576279
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2-[4-(difluoromethyl)-7-methyl-6-(4-morpholin-4-ylphenyl)indazol-2-yl]-2-[(6R)-6-fluoro-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
|
C30H28F3N7O2S
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2
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| 1 |
IC50 = 7 nM
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| 2 |
IC50 = 8 nM
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CP0534253
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2-(5-fluoro-2-hydroxyphenyl)-2-[3-oxo-5-(4-piperazin-1-ylphenyl)-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
|
C29H26FN5O3S
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2
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| 1 |
IC50 = 10 nM
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| 2 |
IC50 = 100 nM
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CP0574922
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2-[4-(difluoromethyl)-7-methyl-6-(4-morpholin-4-ylphenyl)indazol-2-yl]-2-spiro[6,7-dihydropyrrolo[1,2-c]imidazole-5,1'-cyclopropane]-1-yl-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
|
C32H31F2N7O2S
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2
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| 1 |
IC50 = 10 nM
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| 2 |
IC50 = 20 nM
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CP0878522
|
4-[(4'-fluorobenzyl)amino]-6,7-dimethoxyquinazoline hydrochloride
Show/Hide
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C17H17ClFN3O2
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1
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| 1 |
IC50 = 10.9 nM
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CP0569966
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2-[4,7-dichloro-6-[4-(4-ethylpiperazin-1-yl)phenyl]indazol-2-yl]-2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C30H30Cl2N8OS
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2
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| 1 |
IC50 = 11 nM
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| 2 |
IC50 = 22 nM
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CP0876794
|
4-(2'-fluoroanilino)-6,7-dimethoxyquinazoline hydrochloride
Show/Hide
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C16H15ClFN3O2
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1
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| 1 |
IC50 = 12.8 nM
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CP0876118
|
4-(2'-fluoroanilino)-6,7-diethoxyquinazoline hydrochloride
Show/Hide
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C18H19ClFN3O2
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1
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| 1 |
IC50 = 15.8 nM
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CP0567935
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2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
|
C19H17N5O2S
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2
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| 1 |
IC50 = 16 nM
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| 2 |
IC50 = 1700 nM
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CP0574921
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2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[3-oxo-5-[2-[4-(piperidin-1-ylmethyl)phenyl]ethynyl]-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
|
C33H32N6O2S
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2
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| 1 |
IC50 = 16 nM
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| 2 |
IC50 = 342 nM
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CP0579034
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2-[4,7-dichloro-6-[4-(4-cyclopropylpiperazin-1-yl)phenyl]indazol-2-yl]-2-[(6R)-6-fluoro-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
|
C31H29Cl2FN8OS
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2
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| 1 |
IC50 = 17 nM
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| 2 |
IC50 = 30 nM
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CP0876375
|
4-(4'-fluoroanilino)-6,7-dimethoxyquinazoline hydrochloride
Show/Hide
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C16H15ClFN3O2
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1
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| 1 |
IC50 = 19.1 nM
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CP0910373
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4-[3'-fluoro-5'-(trifluoromethyl)anilino]-6,7-dimethoxyquinazoline hydrochloride
Show/Hide
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C17H14ClF4N3O2
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1
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| 1 |
IC50 = 19.1 nM
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CP0567647
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2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[3-oxo-5-(2-phenylethynyl)-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
|
C27H21N5O2S
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2
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| 1 |
IC50 = 20 nM
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| 2 |
IC50 = 850 nM
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CP0578389
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2-[4,7-dichloro-6-(4-morpholin-4-ylphenyl)indazol-2-yl]-2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
|
C28H25Cl2N7O2S
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2
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| 1 |
IC50 = 22 nM
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| 2 |
IC50 = 33 nM
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CP0965330
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2-(1-Oxoisoindolin-2-yl)-2-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-N-thiazol-2-ylacetamide
Show/Hide
|
C19H17N5O2S
|
2
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| 1 |
IC50 = 23 nM
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| 2 |
IC50 = 3200 nM
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CP0876761
|
4-(4'-fluoroanilino)-6,7-diethoxyquinazoline hydrochloride
Show/Hide
|
C18H19ClFN3O2
|
1
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| 1 |
IC50 = 23.1 nM
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CP0569186
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2-[5-[2-(6-aminopyridin-3-yl)ethynyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]-2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
|
C26H20FN7O2S
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2
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| 1 |
IC50 = 116 nM
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| 2 |
IC50 = 1100 nM
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CP0402270
|
5-benzyl-3-fluoro-8-[4-(4-methylpiperazin-1-yl)phenoxy]-11H-benzo[b][1,4]benzodiazepin-6-one
Show/Hide
|
C31H29FN4O2
|
4
|
| 1 |
IC50 = 200 nM
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| 2 |
IC50 = 360 nM
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| 3 |
IC50 = 2700 nM
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| 4 |
IC50 = 3200 nM
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CP0382934
|
(2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
|
C19H14FN3O3S
|
4
|
| 1 |
IC50 = 250 nM
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| 2 |
IC50 = 470 nM
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| 3 |
IC50 = 840 nM
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| 4 |
IC50 > 10000 nM
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CP0402271
|
5-benzyl-3-fluoro-8-(4-piperazin-1-ylphenoxy)-11H-benzo[b][1,4]benzodiazepin-6-one
Show/Hide
|
C30H27FN4O2
|
3
|
| 1 |
IC50 = 350 nM
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|
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| 2 |
IC50 = 3800 nM
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| 3 |
IC50 = 4000 nM
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CP0550031
|
2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[3-oxo-5-(2-pyridin-3-ylethynyl)-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
|
C26H20N6O2S
|
2
|
| 1 |
IC50 = 460 nM
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| 2 |
IC50 > 10000 nM
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CP0412306
|
5-benzyl-3-fluoro-8-(4-piperazin-1-ylphenyl)-11H-benzo[b][1,4]benzodiazepin-6-one
Show/Hide
|
C30H27FN4O
|
4
|
| 1 |
IC50 = 770 nM
|
|
|
| 2 |
IC50 = 930 nM
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| 3 |
IC50 = 3700 nM
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| 4 |
IC50 = 4100 nM
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CP0955274
|
2-(1-Oxoisoindolin-2-yl)-2-(1H-pyrazol-3-yl)-N-thiazol-2-yl-acetamide
Show/Hide
|
C16H13N5O2S
|
2
|
| 1 |
IC50 = 938 nM
|
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| 2 |
IC50 > 10000 nM
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|
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CP0382932
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5-benzyl-3-fluoro-11H-benzo[b][1,4]benzodiazepin-6-one
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|
C20H15FN2O
|
4
|
| 1 |
IC50 = 1200 nM
|
|
|
| 2 |
IC50 = 1500 nM
|
|
|
| 3 |
IC50 = 9700 nM
|
|
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| 4 |
IC50 > 10000 nM
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|
|
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CP0952812
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2-(4,5-Dimethyl-1H-pyrazol-3-yl)-2-(1-oxoisoindolin-2-yl)-N-thiazol-2-yl-acetamide
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|
C18H17N5O2S
|
1
|
| 1 |
IC50 > 10000 nM
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|
|
|
CP0876760
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4-[3'fluoro-5'-(trifluoromethyl)anilino)]-6,7-diethoxyquinazoline hydrochloride
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|
C19H18ClF4N3O2
|
1
|
| 1 |
IC50 > 50 nM
|
|
|
