Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[7-(difluoromethyl)-5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxo-1H-isoindol-2-yl]-2-(5,5-dimethyl-6,7-dihydropyrrolo[1,2-c]imidazol-1-yl)-N-(1,3-thiazol-2-yl)acetamide
    Show/Hide
 PubChem ID
CID: 168283722
Canonical SMILES
CC1(C)CCc2c(ncn12)C(N1Cc2c(cc(cc2C(F)F)C#Cc2ccc(CN3CCC(CO)CC3)cc2)C1=O)C(=O)Nc1nccs1
    Show/Hide
Compound Formula C37H38F2N6O3S
Compound Structure
Protein Name
 Protein Info 
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  2
1
IC50 = 4 nM
   TI
   LI
   LO
   TS
2
IC50 = 12 nM
   TI
   LI
   LO
   TS