Brief Information of the Compound and Protein
Compound Name
2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[3-oxo-5-(2-pyridin-3-ylethynyl)-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
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PubChem ID
CID: 168270755
Canonical SMILES
O=C(Nc1nccs1)C(N1Cc2ccc(cc2C1=O)C#Cc1cccnc1)c1ncn2CCCc12
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Compound Formula C26H20N6O2S
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  2
1
IC50 = 460 nM
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
   TI
   LI
   LO
   TS