Brief Information of the Compound and Protein
Compound Name
2-[5-[2-(6-aminopyridin-3-yl)ethynyl]-7-fluoro-3-oxo-1H-isoindol-2-yl]-2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-N-(1,3-thiazol-2-yl)acetamide
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PubChem ID
CID: 168269395
Canonical SMILES
Nc1ccc(cn1)C#Cc1cc2C(=O)N(Cc2c(F)c1)C(C(=O)Nc1nccs1)c1ncn2CCCc12
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Compound Formula C26H20FN7O2S
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  2
1
IC50 = 116 nM
   TI
   LI
   LO
   TS
2
IC50 = 1100 nM
   TI
   LI
   LO
   TS