Brief Information of the Compound and Protein
Compound Name
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-[2-(dimethylsulfamoyl)anilino]-5-iodopyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
    Show/Hide
PubChem ID
CID: 155532442
Canonical SMILES
COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(I)c(Nc2ccccc2S(=O)(=O)N(C)C)n1
    Show/Hide
Compound Formula C27H35IN8O4S
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  4
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
2
EC50 = 19 nM
   TI
   LI
   LO
   TS
3
EC50 = 24 nM
   TI
   LI
   LO
   TS
4
EC50 = 262 nM
   TI
   LI
   LO
   TS