Brief Information of the Compound and Protein
Compound Name
N-(5-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide
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PubChem ID
CID: 129281909
Canonical SMILES
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC)cc1N1CCCN(C)CC1
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Compound Formula C29H36ClN7O4S
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  5
1
GI50 = 8 nM
   TI
   LI
   LO
   TS
2
GI50 = 8.5 nM
   TI
   LI
   LO
   TS
3
GI50 = 16 nM
   TI
   LI
   LO
   TS
4
GI50 = 230 nM
   TI
   LI
   LO
   TS
5
GI50 = 1100 nM
   TI
   LI
   LO
   TS