General Information of the Protein
Protein ID
PT01540
Protein Name
Non-receptor tyrosine-protein kinase TYK2
Gene Name
TYK2
Sequence
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase JakB family
Function
Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:8232552, PubMed:7813427, PubMed:7657660, PubMed:10995743, PubMed:10542297). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:7813427, PubMed:10542297, PubMed:7526154, PubMed:25762719). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:7657660, PubMed:10542297, PubMed:25762719). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862).
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Uniprot ID
Primary ID:
P29597

Secondarily ID:
Q6QB10
Q96CH0
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Ensembl ID
ENSG00000105397
HGNC ID
HGNC:12440
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000077 , Ba/F3
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0957903
 Compound Info 
5-(6-acetamidopyrimidin-4-yloxy)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)indoline-1-carboxamide
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C28H30F3N7O3
  1
1
GI50 = 150 nM
 Bioactivity Info 
   TI
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CP0807417
 Compound Info 
4-(((2S,4S)-1-(4-Chlorobenzyl)-2-methylpiperidin-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
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C22H26ClN5O
  1
1
GI50 = 475 nM
 Bioactivity Info 
   TI
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CP0002393
 Compound Info 
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
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C16H20N6O
  2
1
GI50 = 1524 nM
 Bioactivity Info 
   TI
   LI
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2
IC50 = 1200 nM
 Bioactivity Info 
   TI
   LI
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CP0807413
 Compound Info 
4-((8-(4-Chlorobenzyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
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C23H26ClN5O
  1
1
GI50 = 1714 nM
 Bioactivity Info 
   TI
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CP0952685
 Compound Info 
4-((trans-1-(3-Chlorobenzyl)-2-methylpiperidin-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
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C22H26ClN5O
  1
1
GI50 = 4752 nM
 Bioactivity Info 
   TI
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CP0008628
 Compound Info 
US10112907, Example 00033
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C21H23N5O3S
  1
1
GI50 = 7191 nM
 Bioactivity Info 
   TI
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CP0807416
 Compound Info 
4-((cis-3-Fluoro-1-(3-methoxybenzyl)piperidin-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
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C22H26FN5O2
  1
1
GI50 = 9654 nM
 Bioactivity Info 
   TI
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CP0952760
 Compound Info 
4-((1-(3-Chlorobenzyl)azepan-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
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C22H26ClN5O
  1
1
GI50 > 10000 nM
 Bioactivity Info 
   TI
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CP0019908
 Compound Info 
BDBM50242742
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C30H40ClN7O3S
  1
1
IC50 = 2309 nM
 Bioactivity Info 
   TI
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CP0661487
 Compound Info 
3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea monophosphate
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C26H34Cl2N7O7P
  1
1
IC50 = 3303 nM
 Bioactivity Info 
   TI
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CP0001071
 Compound Info 
4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-[2-(dimethylamino)ethyl]thieno[3,2-c]pyridine-7-carboxamide
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C22H29N5O3S2
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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CP0001781
 Compound Info 
4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-methoxyethyl)thieno[3,2-c]pyridine-7-carboxamide
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C21H26N4O4S2
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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CP0001805
 Compound Info 
4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-morpholin-4-ylethyl)thieno[3,2-c]pyridine-7-carboxamide
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C24H31N5O4S2
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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CP0008918
 Compound Info 
4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide
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C19H22N4O3S2
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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CP0009734
 Compound Info 
4-amino-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide
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C18H18N4O2S
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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CP0388710
 Compound Info 
4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-hydroxyethyl)thieno[3,2-c]pyridine-7-carboxamide
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C20H24N4O4S2
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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CP0392929
 Compound Info 
4-amino-2-[4-(2-cyanopropan-2-yl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide
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C19H18N4OS
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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CP0392977
 Compound Info 
4-amino-N-methyl-2-phenylthieno[3,2-c]pyridine-7-carboxamide
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C15H13N3OS
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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CP0392981
 Compound Info 
4-amino-N-methyl-2-(4-methylphenyl)thieno[3,2-c]pyridine-7-carboxamide
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C16H15N3OS
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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CP0393021
 Compound Info 
4-amino-2-(4-tert-butylphenyl)-N-methylthieno[3,2-c]pyridine-7-carboxamide
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C19H21N3OS
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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CP0417017
 Compound Info 
4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-piperidin-1-ylethyl)thieno[3,2-c]pyridine-7-carboxamide
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C25H33N5O3S2
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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CP0417018
 Compound Info 
4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(3-morpholin-4-ylpropyl)thieno[3,2-c]pyridine-7-carboxamide
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C25H33N5O4S2
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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CP0441323
 Compound Info 
4-amino-N-methyl-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide
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C19H20N4O2S
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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CP0441325
 Compound Info 
4-amino-N-methyl-2-[4-(trifluoromethoxy)phenyl]thieno[3,2-c]pyridine-7-carboxamide
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C16H12F3N3O2S
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000001 , Jurkat
 Cell Line Info 
Cell Line ID: CL000132 , NK-92
 Cell Line Info 
Cell Line ID: CL000752 , PBMC iPSC #1
 Cell Line Info 
Cell Line ID: CL000012 , Sf21
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0002393
 Compound Info 
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
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C16H20N6O
  21
1 EC50 < 5 nM
2 IC50 = 3.6 nM
3 IC50 = 9 nM
4 IC50 = 10.1 nM
5 IC50 = 10.38 nM
6 IC50 = 12.8 nM
7 IC50 = 24 nM
8 IC50 = 32.3 nM
9 IC50 = 34 nM
10 IC50 = 72 nM
11 IC50 = 112 nM
12 IC50 = 260 nM
13 IC50 = 489 nM
14 Kd = 4.8 nM
15 Kd = 250 nM
16 Kd = 620 nM
17 Kd > 10000 nM
18 Ki = 4.39 nM
19 Ki = 4.4 nM
20 Ki = 7.3 nM
21 Ki = 7.8 nM
CP0004109
 Compound Info 
Bms-986165
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C20H22N8O3
  3
1 IC50 = 0.2 nM
2 IC50 > 10000 nM
3 Ki = 0.02 nM
CP0012129
 Compound Info 
INCB-018424
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C17H18N6
  11
1 IC50 = 0.4 nM
2 IC50 = 0.72 nM
3 IC50 = 10.3 nM
4 IC50 = 11 nM
5 IC50 = 19 nM
6 IC50 = 30 nM
7 IC50 = 30.1 nM
8 Kd = 0.9 nM
9 Kd = 1400 nM
10 Ki = 0.5 nM
11 Ki = 0.55 nM
CP0133018
 Compound Info 
3-amino-5-[(2S)-3-methylbutan-2-yl]-7-(1-methyl-5-morpholin-4-ylpyrazol-3-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
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C19H27N7O2
  1
1 IC50 = 0.55 nM
CP0079054
 Compound Info 
3-amino-5-[(2S)-3-methylbutan-2-yl]-7-(5-morpholin-4-ylpyridin-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
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C20H26N6O2
  1
1 IC50 = 0.92 nM
CP0182426
 Compound Info 
3-amino-5-[(2S)-3-methylbutan-2-yl]-7-[1-methyl-5-(oxan-4-yl)pyrazol-3-yl]-1H-pyrazolo[4,3-c]pyridin-4-one
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C20H28N6O2
  1
1 IC50 = 0.98 nM
CP0122206
 Compound Info 
3-amino-7-[5-(1,1-dioxo-1,4-thiazinan-4-yl)-1-methylpyrazol-3-yl]-5-[(2S)-3-methylbutan-2-yl]-1H-pyrazolo[4,3-c]pyridin-4-one
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C19H27N7O3S
  1
1 IC50 = 1.2 nM
CP0079047
 Compound Info 
3-amino-5-(3-methylbutan-2-yl)-7-(5-morpholin-4-ylpyridin-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
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C20H26N6O2
  1
1 IC50 = 1.5 nM
CP0018829
 Compound Info 
3-amino-7-[5-(2-hydroxypropan-2-yl)-1-methylpyrazol-3-yl]-5-[(2R)-3-methylbutan-2-yl]-1H-pyrazolo[4,3-c]pyridin-4-one
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C18H26N6O2
  1
1 IC50 = 2.1 nM
CP0096531
 Compound Info 
(4R,5S)-4-cyclopropyl-3-oxo-7,12-dioxa-2,19,21,25-tetrazatetracyclo[18.3.1.12,5.114,18]hexacosa-1(24),14(25),15,17,20,22-hexaene-4-carbonitrile
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C24H27N5O3
  1
1 IC50 = 4.9 nM
CP0096534
 Compound Info 
(4R,5S,9Z)-4-cyclopropyl-3-oxo-7,12-dioxa-2,19,21,25-tetrazatetracyclo[18.3.1.12,5.114,18]hexacosa-1(24),9,14(25),15,17,20,22-heptaene-4-carbonitrile
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C24H25N5O3
  1
1 IC50 = 5.2 nM
CP0121619
 Compound Info 
3-amino-5-[(2S)-3-methylbutan-2-yl]-7-(1-methylpyrazol-3-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
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C15H20N6O
  1
1 IC50 = 5.5 nM
CP0339308
 Compound Info 
(4R,5S)-4-cyclopropyl-3,9-dioxo-7-oxa-2,10,19,21,25-pentazatetracyclo[18.3.1.12,5.114,18]hexacosa-1(24),14(25),15,17,20,22-hexaene-4-carbonitrile
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C24H26N6O3
  1
1 IC50 = 5.5 nM
CP0121622
 Compound Info 
3-amino-5-(3-methylbutan-2-yl)-7-(1-methylpyrazol-3-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
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C15H20N6O
  1
1 IC50 = 6.3 nM
CP0807417
 Compound Info 
4-(((2S,4S)-1-(4-Chlorobenzyl)-2-methylpiperidin-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
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C22H26ClN5O
  1
1 IC50 = 8.17 nM
CP0121616
 Compound Info 
3-amino-5-[(2R)-3-methylbutan-2-yl]-7-(5-morpholin-4-ylpyridin-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
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C20H26N6O2
  1
1 IC50 = 9.7 nM
CP0096528
 Compound Info 
(4R,5S,9E)-4-cyclopropyl-3-oxo-7,12-dioxa-2,19,21,25-tetrazatetracyclo[18.3.1.12,5.114,18]hexacosa-1(24),9,14(25),15,17,20,22-heptaene-4-carbonitrile
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C24H25N5O3
  1
1 IC50 = 12 nM
CP0008407
 Compound Info 
(1r,3r)-3-(Cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile
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C20H17N9
  1
1 IC50 = 17 nM
CP0133876
 Compound Info 
(4R,5S)-4-cyclopropyl-3,9-dioxo-7-oxa-2,10,18,20,24-pentazatetracyclo[17.3.1.12,5.113,17]pentacosa-1(23),13(24),14,16,19,21-hexaene-4-carbonitrile
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C23H24N6O3
  1
1 IC50 = 23 nM
CP0182423
 Compound Info 
3-amino-5-butan-2-yl-7-(1-methylpyrazol-3-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
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C14H18N6O
  1
1 IC50 = 33 nM
CP0551444
 Compound Info 
N-[3-[[4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C22H25N7O3S
  1
1 IC50 = 33 nM
CP0952760
 Compound Info 
4-((1-(3-Chlorobenzyl)azepan-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
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C22H26ClN5O
  1
1 IC50 = 59.8 nM
CP0952685
 Compound Info 
4-((trans-1-(3-Chlorobenzyl)-2-methylpiperidin-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
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C22H26ClN5O
  1
1 IC50 = 61.7 nM
CP0008628
 Compound Info 
US10112907, Example 00033
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C21H23N5O3S
  4
1 IC50 = 65.3 nM
2 IC50 = 113 nM
3 IC50 = 116 nM
4 IC50 = 2600 nM
CP0079051
 Compound Info 
3-amino-5-(2-methylpropyl)-7-(1-methylpyrazol-3-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
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C14H18N6O
  1
1 IC50 = 72 nM
CP0079048
 Compound Info 
3-amino-5-(2-methylpentan-3-yl)-7-(1-methylpyrazol-3-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
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C16H22N6O
  1
1 IC50 = 91 nM
CP0807416
 Compound Info 
4-((cis-3-Fluoro-1-(3-methoxybenzyl)piperidin-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
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C22H26FN5O2
  1
1 IC50 = 116 nM
CP0552840
 Compound Info 
(4R,5S)-4-cyclopropyl-3,9-dioxo-7-oxa-2,10,17,19,23-pentazatetracyclo[16.3.1.12,5.112,16]tetracosa-1(22),12(23),13,15,18,20-hexaene-4-carbonitrile
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C22H22N6O3
  1
1 IC50 = 130 nM
CP0807413
 Compound Info 
4-((8-(4-Chlorobenzyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
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C23H26ClN5O
  1
1 IC50 = 134 nM
CP0275670
 Compound Info 
4-[[[2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C22H26N6O3S
  1
1 IC50 = 276 nM
CP0054852
 Compound Info 
1-(2-aminoethyl)-2-piperidin-4-ylbenzimidazole-5-carboxamide
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C15H21N5O
  1
1 IC50 = 3700 nM
CP0014937
 Compound Info 
6-(cyclopropanecarbonylamino)-4-[3-[[4-[[(2S)-1,4-dioxan-2-yl]methylamino]phenyl]carbamoyl]-2-methoxyanilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
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C29H33N7O6
  1
1 IC50 > 1000 nM
CP0661487
 Compound Info 
3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea monophosphate
   Show/Hide
C26H34Cl2N7O7P
  1
1 IC50 > 10000 nM
CP0670126
 Compound Info 
1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
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C15H19N5O
  1
1 IC50 > 10000 nM
CP0019908
 Compound Info 
BDBM50242742
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C30H40ClN7O3S
  2
1 Kd = 77 nM
2 Kd = 1900 nM
CP0528258
 Compound Info 
US10196390, Compound I-182
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C23H19F4N5O
  1
1 Ki = 0.081 nM
CP0014588
 Compound Info 
US10196390, Compound I-136
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C21H17F2N5O2
  1
1 Ki = 0.15 nM
CP0562828
 Compound Info 
US10196390, Compound I-147
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C23H21F2N5O2
  1
1 Ki = 0.21 nM
CP0543383
 Compound Info 
US10196390, Compound I-248
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C22H17F2N5O3
  1
1 Ki = 0.34 nM
CP0011836
 Compound Info 
US10196390, Compound I-231
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C24H20F2N4O3
  1
1 Ki = 0.35 nM
CP0261054
 Compound Info 
US10196390, Compound I-171
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C22H19F2N5O2
  1
1 Ki = 0.36 nM
CP0108652
 Compound Info 
CHEMBL2386635
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C18H21N5O
  1
1 Ki = 0.4 nM
CP0014097
 Compound Info 
US10336752, Compound 1
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C24H20F2N4O2
  1
1 Ki = 0.51 nM
CP0357732
 Compound Info 
US10196390, Compound I-88
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C22H19F2N5O2
  1
1 Ki = 1.3 nM
CP0087139
 Compound Info 
CHEMBL2386636
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C19H23N5O
  1
1 Ki = 1.7 nM
CP0084964
 Compound Info 
CHEMBL2386629
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C18H22F3N5O
  1
1 Ki = 3.4 nM
CP0066334
 Compound Info 
2,6-dichloro-N-[2-(cyclopropanecarbonylamino)pyridin-4-yl]benzamide
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C16H13Cl2N3O2
  1
1 Ki = 4.8 nM
CP0543382
 Compound Info 
US10196390, Compound I-80
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C22H19F2N5O2
  1
1 Ki = 7.8 nM
CP0102822
 Compound Info 
CHEMBL2386633
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C17H19N5O
  1
1 Ki = 12 nM
CP0087579
 Compound Info 
(1R)-1-[3-[(1S,3R)-3-(2,2,2-trifluoroethylamino)cyclopentyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
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C17H20F3N5O
  1
1 Ki = 20 nM
CP0108487
 Compound Info 
(1R)-1-[3-[(3S)-oxan-3-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
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C15H18N4O2
  1
1 Ki = 31 nM
Clinical Information about the Protein
Target 1 ( TYK2 tyrosine kinase (TYK2) )
Target Type Successful Target
Disease 3 Target-related Diseases  3
1 Plaque psoriasis [ICD-11: EA90.0]
2 Psoriatic arthritis [ICD-11: FA21]
3 Asthma [ICD-11: CA23]
Approved Drug(s) 1 Approved Drug  1
1 Deucravacitinib
 Drug Info 
Approved
Plaque psoriasis
Clinical Trial Drug(s) 2 Clinical Trial Drugs  2
1 NDI-034858
 Drug Info 
Phase 2
Psoriatic arthritis
2 PF-06700841
 Drug Info 
Phase 2
Asthma