Brief Information of the Cell Line and Protein
Cell Line ID: CL000132 , NK-92
 Cell Line Info 
Synonyms
NK92
Natural Killer-92
NK-92.05
Neukoplast
aNK
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_2142
Protein ID: PT01540 , Non-receptor tyrosine-protein kinase TYK2
 Protein Info 
Gene Name TYK2
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P29597
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000132
 Cell Line Info 
 Protein ID: PT01540
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0108652
 Compound Info 
2-[4-[4-[(1R)-1-hydroxyethyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]cyclohexyl]acetonitrile
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C18H21N5O
  1
1
EC50 = 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0084964
 Compound Info 
(1R)-1-[3-[4-(2,2,2-trifluoroethylamino)cyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
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C18H22F3N5O
  1
1
EC50 = 310 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0002393
 Compound Info 
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
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C16H20N6O
  1
1
EC50 = 710 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0087139
 Compound Info 
3-[4-[4-[(1R)-1-hydroxyethyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]cyclohexyl]propanenitrile
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C19H23N5O
  1
1
EC50 = 980 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0087579
 Compound Info 
(1R)-1-[3-[(1S,3R)-3-(2,2,2-trifluoroethylamino)cyclopentyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
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C17H20F3N5O
  1
1
EC50 = 2200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0102822
 Compound Info 
4-[4-[(1R)-1-hydroxyethyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]cyclohexane-1-carbonitrile
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C17H19N5O
  1
1
EC50 = 5600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0108487
 Compound Info 
(1R)-1-[3-[(3S)-oxan-3-yl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
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C15H18N4O2
  1
1
EC50 > 5800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS