| Compound ID |
Compound Name |
Compound Formula |
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CP0365521
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N-[3-fluoro-4-[[7-(1-methylazetidin-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C31H31F2N7O4
|
1
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| 1 |
IC50 = 5.3 nM
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CP0553459
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1-cyclopentyl-N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxopyrimidine-5-carboxamide
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C36H39F2N7O4
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1
|
| 1 |
IC50 = 7.9 nM
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|
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CP0550346
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1-(cyclopropylmethyl)-N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxopyrimidine-5-carboxamide
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C35H37F2N7O4
|
1
|
| 1 |
IC50 = 8.4 nM
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|
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CP0365520
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N-[4-[[6-(cyclopropanecarbonyl)-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl]oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C30H26F2N6O5
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1
|
| 1 |
IC50 = 12 nM
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|
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CP0569553
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N-[3-fluoro-4-[[7-(1-methylpiperidin-4-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C33H35F2N7O4
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1
|
| 1 |
IC50 = 13 nM
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|
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CP0491412
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N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C34H37F2N7O4
|
1
|
| 1 |
IC50 = 15 nM
|
|
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CP0553500
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3-(4-fluorophenyl)-N-[4-[6-[[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]amino]pyrimidin-4-yl]oxyphenyl]-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C35H40FN9O5
|
1
|
| 1 |
IC50 = 15 nM
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|
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CP0568458
|
1-(cyclobutylmethyl)-N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxopyrimidine-5-carboxamide
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|
C36H39F2N7O4
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
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CP0563698
|
N-[3-fluoro-4-[[6-[2-(1-methylpiperidin-4-yl)acetyl]-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C34H35F2N7O5
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
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CP0550345
|
N-[4-[[7-[1-(cyclopropylmethyl)piperidin-4-yl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C36H39F2N7O4
|
1
|
| 1 |
IC50 = 20 nM
|
|
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CP0368963
|
N-[3-fluoro-4-[[7-[(1-methylazetidin-3-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C32H33F2N7O4
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
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CP0563696
|
1-cyclopentyl-N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(5-methylpyridin-2-yl)-2,4-dioxopyrimidine-5-carboxamide
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|
C36H41FN8O4
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
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CP0562288
|
N-[3-fluoro-4-[[7-[2-(1-methylpiperidin-4-yl)acetyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C35H37F2N7O5
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
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CP0572087
|
N-[3-fluoro-4-[[6-[(1-methylpiperidin-4-yl)methyl]-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C33H35F2N7O4
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
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CP0550347
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1-(cyclopropylmethyl)-N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(5-methylpyridin-2-yl)-2,4-dioxopyrimidine-5-carboxamide
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|
C35H39FN8O4
|
1
|
| 1 |
IC50 = 34 nM
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|
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CP0553458
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N-[3-fluoro-4-[[6-[2-(4-methylpiperazin-1-yl)acetyl]-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C33H34F2N8O5
|
1
|
| 1 |
IC50 = 42 nM
|
|
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CP0539200
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N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-1-(2-methylpropyl)-2,4-dioxopyrimidine-5-carboxamide
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|
C35H39F2N7O4
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
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CP0562289
|
1-(2-fluoroethyl)-N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxopyrimidine-5-carboxamide
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|
C33H34F3N7O4
|
1
|
| 1 |
IC50 = 49 nM
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|
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CP0568457
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N-[4-[[7-[2-(azetidin-1-yl)-2-oxoethyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C32H31F2N7O5
|
1
|
| 1 |
IC50 = 66 nM
|
|
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CP0563477
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3-(4-fluorophenyl)-N-[3-fluoro-4-[[7-(3-pyrrolidin-1-ylpropanoyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C34H35F2N7O5
|
1
|
| 1 |
IC50 = 74 nM
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|
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CP0571003
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N-[3-fluoro-4-[[7-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C34H36F2N8O5
|
1
|
| 1 |
IC50 = 78 nM
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CP0539198
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N-[3-fluoro-4-[(6-oxo-5,7-dihydropyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C26H20F2N6O5
|
1
|
| 1 |
IC50 = 84 nM
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CP0550344
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N-[3-fluoro-4-[[6-(oxan-4-ylmethyl)-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C32H32F2N6O5
|
1
|
| 1 |
IC50 = 93 nM
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CP0368962
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N-[4-[[7-(cyclobutanecarbonyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C32H30F2N6O5
|
1
|
| 1 |
IC50 = 100 nM
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|
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CP0565414
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N-[3-fluoro-4-[(7-methyl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl)oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
Show/Hide
|
C28H26F2N6O4
|
1
|
| 1 |
IC50 = 110 nM
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CP0368965
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N-[3-fluoro-4-[[7-(1-methylpiperidine-4-carbonyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
Show/Hide
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C34H35F2N7O5
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1
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| 1 |
IC50 = 120 nM
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CP0568643
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3-(4-fluorophenyl)-N-[3-fluoro-4-[[6-(3-pyrrolidin-1-ylpropanoyl)-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl]oxy]phenyl]-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C33H33F2N7O5
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1
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| 1 |
IC50 = 120 nM
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CP0539199
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N-[3-fluoro-4-[[7-(2-morpholin-4-ylacetyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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|
C33H33F2N7O6
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1
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| 1 |
IC50 = 130 nM
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CP0565415
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N-[3-fluoro-4-[(6-methyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl)oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C28H26F2N6O4
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1
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| 1 |
IC50 = 150 nM
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CP0568456
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N-[3-fluoro-4-[(6-methyl-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl)oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
Show/Hide
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C27H24F2N6O4
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1
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| 1 |
IC50 = 220 nM
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CP0564987
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N-[3-fluoro-4-[[6-(2-morpholin-4-ylacetyl)-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C32H31F2N7O6
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1
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| 1 |
IC50 = 270 nM
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CP0562062
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1-cyclopropyl-N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxopyrimidine-5-carboxamide
Show/Hide
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C34H35F2N7O4
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1
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| 1 |
IC50 = 770 nM
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