General Information of the Protein
Protein ID
PT03813
Protein Name
Chemerin-like receptor 1
Secondarily
Protein Name
Chemokine-like receptor 1
G-protein coupled receptor ChemR23
G-protein coupled receptor DEZ
Gene Name
CMKLR1
Secondarily
Gene Name
CHEMR23
DEZ
Sequence
MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor-like
>
Chemerin receptor
Function
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis (PubMed:27716822). Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism.
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Uniprot ID
Primary ID:
Q99788

Secondarily ID:
A8K6Y5
O75748
Q3KP37
Q5U0H0
Q99789
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Ensembl ID
ENSG00000174600
HGNC ID
HGNC:2121
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000077 , Ba/F3
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0847220
 Compound Info 
(3S,4S)-N-(3-(cyclopentyloxy)-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamide
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C28H33F3N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0849596
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopentyl-5-oxopyrrolidine-3-carboxamide
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C26H28F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0851305
 Compound Info 
(3R,4S)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-3-(morpholinomethyl)-5-oxopyrrolidine-3-carboxamide
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C29H34F3N3O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0851306
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxo-3-(pyrrolidin-1-ylmethyl)pyrrolidine-3-carboxamide
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C27H29F3N4O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0851307
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-5-(2,6-dimethylphenyl)-6-oxohexahydro-1H-furo[3,4-c]pyrrole-3a-carboxamide
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C23H20F6N2O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0851308
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,4-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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C21H18F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0851309
 Compound Info 
N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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C21H18F3N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0851316
 Compound Info 
(3S,4S)-N-(3-(dimethylamino)-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamide
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C25H30F3N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0851317
 Compound Info 
1-(2-chlorophenyl)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
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C24H24ClF3N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0851318
 Compound Info 
(3S,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3,4-diethyl-5-oxopyrrolidine-3-carboxamide
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C25H26F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0851319
 Compound Info 
(3S,4S)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamide
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C26H29F3N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0851320
 Compound Info 
(3S,4S)-N-(3-chloro-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamide
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C23H24ClF3N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0851323
 Compound Info 
tert-butyl 4-(3-(3,5-bis(trifluoromethyl)phenylcarbamoyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate
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C31H33F6N3O4
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0851324
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(hydroxymethyl)-5-oxopyrrolidine-3-carboxamide
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C22H20F6N2O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0851325
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-isopropyl-5-oxo-1-o-tolylpyrrolidine-3-carboxamide
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C23H22F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0851327
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-3-((methyl(neopentyl)amino)methyl)-5-oxopyrrolidine-3-carboxamide
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C29H35F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0851328
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(((2-methoxyethyl)(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C27H31F3N4O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0862402
 Compound Info 
(3R,4S)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((ethyl(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C28H34F3N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0862403
 Compound Info 
(3R,4S)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-3-((dimethylamino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C27H32F3N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0862404
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-(dimethylamino)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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C23H23F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0862406
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-2-(2,6-dimethylphenyl)-1-oxo-1,2,3,3a,4,7a-hexahydropyrano[3,4-c]pyrrole-3a-carboxamide
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C24H20F6N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0862407
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-2-(2,6-dimethylphenyl)-1-oxooctahydro-1H-isoindole-3a-carboxamide
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C25H24F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0862410
 Compound Info 
1-(2-allylphenyl)-N-(3,5-bis(trifluoromethyl)phenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
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C25H24F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0862411
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2-fluoro-6-methylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
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C23H21F7N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0862413
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-isopropyl-5-oxo-1-(2-vinylphenyl)pyrrolidine-3-carboxamide
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C24H22F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0862456
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((ethyl(isopropyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C28H33F3N4O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0862457
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((isobutyl(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C28H33F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0864379
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-3-(((cyclopropylmethyl)(methyl)amino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C28H31F3N4O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0869133
 Compound Info 
(3R,4S)-3-((4,4-difluoropiperidin-1-yl)methyl)-1-(2,6-dimethylphenyl)-N-(3-isopropoxy-5-(trifluoromethyl)phenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C30H36F5N3O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0869134
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((4-methoxypiperidin-1-yl)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C29H33F3N4O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0869135
 Compound Info 
(3R,4S)-N-(3-chloro-5-(trifluoromethyl)phenyl)-3-((diethylamino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C26H31ClF3N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0869136
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-3-(((cyclopropylmethyl)(methyl)amino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C28H31F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0869137
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-3-((4,4-difluoropiperidin-1-yl)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C28H29F5N4O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0869139
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((ethyl(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C26H29F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0869140
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-morpholino-5-oxopyrrolidine-3-carboxamide
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C25H25F6N3O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0869141
 Compound Info 
(5S)-N-(3,5-bis(trifluoromethyl)phenyl)-2-(2,6-dimethylphenyl)-5-fluoro-1-oxooctahydrocyclopenta[c]pyrrole-3a-carboxamide
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C24H21F7N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0869144
 Compound Info 
methyl 3-(1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamido)-5-(trifluoromethyl)benzoate
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C22H21F3N2O4
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0869145
 Compound Info 
N-(3,5-difluorophenyl)-1-(2-methoxy-6-methylphenyl)-5-oxopyrrolidine-3-carboxamide
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C19H18F2N2O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0869147
 Compound Info 
3-((1H-imidazol-2-yl)methyl)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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C25H22F6N4O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0869148
 Compound Info 
(3S,4S)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxo-N-(3-(trifluoromethyl)-5-((2-(trifluoromethyl)pyrrolidin-1-yl)methyl)phenyl)pyrrolidine-3-carboxamide
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C29H33F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0869149
 Compound Info 
(R)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
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C26H29F3N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0869150
 Compound Info 
3-((1-benzylpyrrolidin-3-yl)methyl)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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C33H33F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0869151
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxo-3-tert-pentylpyrrolidine-3-carboxamide
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C26H28F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0869152
 Compound Info 
(3S,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxo-3-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carboxamide
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C27H28F6N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0869153
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-ethyl-4-methoxy-5-oxopyrrolidine-3-carboxamide
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C24H24F6N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0869155
 Compound Info 
(3S,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-ethyl-3-methyl-5-oxopyrrolidine-3-carboxamide
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C24H24F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0869156
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(3-hydroxypropyl)-5-oxopyrrolidine-3-carboxamide
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C24H24F6N2O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0869157
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxo-3-propylpyrrolidine-3-carboxamide
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C24H24F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0883058
 Compound Info 
(3S,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamide
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C24H24F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0905627
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(((1-methoxy-2-methylpropan-2-yl)(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C29H35F6N3O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0905628
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((isopropyl(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C27H31F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0905629
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-3-((diethylamino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C27H31F3N4O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0905630
 Compound Info 
(3S,4S)-N-(3-chloro-5-cyanophenyl)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamide
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C23H24ClN3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0905632
 Compound Info 
(3aR,6aS)-N-(3,5-bis(trifluoromethyl)phenyl)-5-(2,6-dimethylphenyl)-6-oxohexahydro-2H-furo[3,2-c]pyrrole-3a-carboxamide
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C23H20F6N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0905634
 Compound Info 
1-(2,6-dimethylphenyl)-N-(3-morpholino-5-(trifluoromethyl)phenyl)-5-oxopyrrolidine-3-carboxamide
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C24H26F3N3O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0905635
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2-bromo-6-methylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
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C23H21BrF6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0905636
 Compound Info 
(E)-N-(3,5-bis(trifluoromethyl)phenyl)-3-isopropyl-5-oxo-1-(2-(prop-1-enyl)phenyl)pyrrolidine-3-carboxamide
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C25H24F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0905637
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(2-methylallyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C25H24F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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CP0905638
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2-cyclopropylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C25H24F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
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CP0905639
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-cyclohexyl-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H28F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0915442
 Compound Info 
(3R,4S)-3-((4,4-difluoropiperidin-1-yl)methyl)-1-(2,6-dimethylphenyl)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H29F6N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0915443
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-3-((cyclobutyl(methyl)amino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C28H31F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0915444
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((ethyl(propyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C28H33F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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CP0915445
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(((2-fluoroethyl)(isobutyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C29H34F7N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0915446
 Compound Info 
(3R,4S)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((isobutyl(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C30H38F3N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0915447
 Compound Info 
(3S,4S)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-N-(4-methyl-3-(trifluoromethyl)phenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C24H27F3N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
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   TS
CP0915448
 Compound Info 
(3S,4S)-N-(3,5-dichlorophenyl)-1-(2,6-dimethylphenyl)-3,4-dimethyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C21H22Cl2N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0915449
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2-isopropylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C22H20F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0915456
 Compound Info 
(3S,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxo-3-propylpyrrolidine-3-carboxamide
   Show/Hide
C25H26F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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CP0921703
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-3-((dimethylamino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C25H27F3N4O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0921704
 Compound Info 
(R)-N-(3,5-bis(trifluoromethyl)phenyl)-3-(dimethylamino)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C23H23F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0921705
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(methylamino)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C22H21F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0921706
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-2-(2,6-dimethylphenyl)-1-oxo-5-(pyrrolidin-1-yl)octahydrocyclopenta[c]pyrrole-3a-carboxamide
   Show/Hide
C28H29F6N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
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CP0921708
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2-(hydroxymethyl)-6-methylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C24H24F6N2O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0921709
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-((dimethylamino)methyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C24H25F6N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
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CP0921710
 Compound Info 
(3S,4S)-1-(2,6-dimethylphenyl)-3-ethyl-N-(3-fluoro-5-(trifluoromethyl)phenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C23H24F4N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
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CP0921711
 Compound Info 
(R)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C24H24F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0921712
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-cyclopentyl-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H26F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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   TS
CP0921713
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C25H26F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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CP0922630
 Compound Info 
(3R,4S)-3-((bis(2-fluoroethyl)amino)methyl)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H29F8N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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CP0922631
 Compound Info 
(3R,4S)-N-(3-chloro-5-(trifluoromethyl)phenyl)-3-((4,4-difluoropiperidin-1-yl)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H29ClF5N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
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CP0922632
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-3-(((cyclopropylmethyl)(2-fluoroethyl)amino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C29H32F7N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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CP0922633
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-3-((methyl(2,2,2-trifluoroethyl)amino)methyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H26F9N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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CP0922635
 Compound Info 
(3R,4S)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((isopropyl(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C29H36F3N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
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CP0930854
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(((4-fluorobutyl)(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C28H32F7N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0930855
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-2-(2,6-dimethylphenyl)-1-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindole-3a-carboxamide
   Show/Hide
C25H22F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0930856
 Compound Info 
(1S,5S)-N-(3,5-bis(trifluoromethyl)phenyl)-3-(2,6-dimethylphenyl)-4-oxo-3-azabicyclo[3.2.0]heptane-1-carboxamide
   Show/Hide
C23H20F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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CP0930859
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-isopropyl-1-(2-methyl-6-(morpholinomethyl)phenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C28H31F6N3O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0930860
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-butyl-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C25H26F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0930861
 Compound Info 
(3S,4S)-1-(2,6-dimethylphenyl)-N-(3-ethoxy-5-(trifluoromethyl)phenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C25H29F3N2O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0930863
 Compound Info 
(S)-N-(3-chloro-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-ethyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C22H22ClF3N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0932998
 Compound Info 
1-(2,6-dimethylphenyl)-5-oxo-N-(3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide
   Show/Hide
C24H26F3N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0932999
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(4-fluoro-2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C21H17F7N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0933019
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-3-((3,3-difluoropiperidin-1-yl)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C28H29F8N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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   TS
CP0933020
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((ethyl(2-fluoroethyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H30F7N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0941926
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-2-(2,6-dimethylphenyl)-1-oxooctahydrocyclopenta[c]pyrrole-3a-carboxamide
   Show/Hide
C24H22F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0941928
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-cyclobutyl-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C25H24F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0942371
 Compound Info 
(3R,4S)-1-(2,6-dimethylphenyl)-3-((isobutyl(methyl)amino)methyl)-N-(3-isopropoxy-5-(trifluoromethyl)phenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C30H40F3N3O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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   TS
CP0942372
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-3-((methyl(propyl)amino)methyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H31F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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   TS
CP0942373
 Compound Info 
(3R,4S)-3-((4,4-difluoropiperidin-1-yl)methyl)-1-(2,6-dimethylphenyl)-N-(3-ethyl-5-(trifluoromethyl)phenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C29H34F5N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0942374
 Compound Info 
N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxo-3-(pyrrolidin-1-ylmethyl)pyrrolidine-3-carboxamide
   Show/Hide
C28H32F3N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0942377
 Compound Info 
(5R)-N-(3,5-bis(trifluoromethyl)phenyl)-2-(2,6-dimethylphenyl)-5-fluoro-1-oxooctahydrocyclopenta[c]pyrrole-3a-carboxamide
   Show/Hide
C24H21F7N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0942378
 Compound Info 
N-(3,5-dichlorophenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C19H18Cl2N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0943493
 Compound Info 
(3R,4S)-3-(azetidin-1-ylmethyl)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H27F3N4O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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   TS
CP0943494
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(isopropylamino)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C24H25F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0943495
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-2-(2,6-dimethylphenyl)-5,5-difluoro-1-oxooctahydrocyclopenta[c]pyrrole-3a-carboxamide
   Show/Hide
C24H20F8N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0943496
 Compound Info 
(3aS,6aR)-N-(3,5-bis(trifluoromethyl)phenyl)-5-(2,6-dimethylphenyl)-4-oxohexahydro-2H-furo[2,3-c]pyrrole-6a-carboxamide
   Show/Hide
C23H20F6N2O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0943497
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-2-(2,6-dimethylphenyl)-5-hydroxy-1-oxooctahydrocyclopenta[c]pyrrole-3a-carboxamide
   Show/Hide
C24H22F6N2O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0943501
 Compound Info 
N-(3-bromo-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C23H24BrF3N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0943502
 Compound Info 
(3S,4S)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxo-N-(3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide
   Show/Hide
C27H32F3N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0943503
 Compound Info 
(3S,4R)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxo-3-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carboxamide
   Show/Hide
C27H28F6N2O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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   TS
CP0943504
 Compound Info 
(3S,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C25H26F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0943505
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(1-hydroxyethyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C23H22F6N2O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0943506
 Compound Info 
(3S,4R)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C24H24F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0943507
 Compound Info 
N-[3,5-bis(trifluoromethyl)phenyl]-1-(2,6-dimethylphenyl)-3-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-5-oxo-pyrrolidine-3-carboxamide
   Show/Hide
C26H24F6N2O4S
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0943571
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((ethyl(isobutyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C29H35F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0943572
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2-ethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C21H18F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0943573
 Compound Info 
N-(3-chloro-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C20H18ClF3N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0943575
 Compound Info 
(S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-ethyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C23H22F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0943576
 Compound Info 
(3S,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C24H24F3N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0943577
 Compound Info 
(3S,4S)-1-(2,6-dimethylphenyl)-3-ethyl-N-(3-isopropoxy-5-(trifluoromethyl)phenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H31F3N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0943578
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C24H24F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0946223
 Compound Info 
(3R,4S)-3-((cyclobutyl(methyl)amino)methyl)-1-(2,6-dimethylphenyl)-N-(3-isopropoxy-5-(trifluoromethyl)phenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C30H38F3N3O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0946225
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-3-((methyl(2,2,2-trifluoroethyl)amino)methyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H26F6N4O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0947363
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((isopropyl(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H31F3N4O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0947364
 Compound Info 
(3R,4S)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxo-3-(piperidin-1-ylmethyl)pyrrolidine-3-carboxamide
   Show/Hide
C30H36F3N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0947365
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-3-(morpholinomethyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H29F3N4O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0947383
 Compound Info 
1-(2-allyl-6-methylphenyl)-N-(3,5-bis(trifluoromethyl)phenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H26F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0949909
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(((1-hydroxy-2-methylpropan-2-yl)(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C28H33F6N3O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0949910
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-3-((4,4-difluoropiperidin-1-yl)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C28H29F8N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0949912
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,5-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C21H18F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0949914
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,3-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C21H18F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0953077
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-(3,6-dihydro-2H-thiopyran-4-yl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H24F6N2O2S
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0953079
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-(3,6-dihydro-2H-pyran-4-yl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H24F6N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0953080
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-hydroxy-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C21H18F6N2O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0953081
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-methyl-5-oxo-1-o-tolylpyrrolidine-3-carboxamide
   Show/Hide
C21H18F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0954988
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-(3,5-dimethyl-1H-pyrazol-1-yl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H24F6N4O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0954989
 Compound Info 
(3S,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3,4-dimethyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C23H22F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0954990
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isobutyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C25H26F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0954991
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C22H20F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0957606
 Compound Info 
(3S,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-3-butyl-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H28F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0957607
 Compound Info 
(R)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-ethyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C23H22F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0957881
 Compound Info 
(R)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C24H24F3N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0957882
 Compound Info 
tert-butyl 4-(3-(3,5-bis(trifluoromethyl)phenylcarbamoyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidin-3-yl)piperidine-1-carboxylate
   Show/Hide
C31H35F6N3O4
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0957883
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H27F6N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0957884
 Compound Info 
(3R,4S)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((4-fluoropiperidin-1-yl)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C30H35F4N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0957891
 Compound Info 
(3R,4S)-1-(2,6-dimethylphenyl)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-4-methyl-5-oxo-3-((4-(2,2,2-trifluoroethyl)piperazin-1-yl)methyl)pyrrolidine-3-carboxamide
   Show/Hide
C28H31F7N4O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0957893
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-3-(((2,2-difluoroethyl)(methyl)amino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H27F8N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0957912
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-3-(((R)-3-methylmorpholino)methyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C28H31F6N3O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0957956
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-3-(((R)-2-methylmorpholino)methyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C28H31F3N4O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0957957
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(((2-methoxyethyl)(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H31F6N3O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0957958
 Compound Info 
(5S)-N-(3,5-bis(trifluoromethyl)phenyl)-2-(2,6-dimethylphenyl)-5-methoxy-1-oxooctahydrocyclopenta[c]pyrrole-3a-carboxamide
   Show/Hide
C25H24F6N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0957961
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-3-((dimethylamino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C25H27F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0957962
 Compound Info 
(R)-1-(2,6-dimethylphenyl)-N-(3-isopropoxy-5-(trifluoromethyl)phenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H31F3N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958613
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-3-(((cyclobutylmethyl)(methyl)amino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C29H33F6N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958614
 Compound Info 
(3R,4S)-N-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((isobutyl(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C28H34F5N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958615
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-3-((cyclohexyl(methyl)amino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C30H35F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958616
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((ethyl(2,2,2-trifluoroethyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H28F6N4O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958617
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(((2-fluoroethyl)(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H28F7N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958618
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((ethyl(isopropyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C28H33F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958619
 Compound Info 
(3R,4S)-3-((diethylamino)methyl)-1-(2,6-dimethylphenyl)-N-(3-isopropoxy-5-(trifluoromethyl)phenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C29H38F3N3O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958620
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-3-((3,3-difluoropyrrolidin-1-yl)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H27F5N4O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958621
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-3-(((cyclopropylmethyl)(ethyl)amino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C29H33F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958622
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-3-((3,3-difluoropyrrolidin-1-yl)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H27F8N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958623
 Compound Info 
(3R,4S)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-3-((3,3-difluoropyrrolidin-1-yl)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C29H32F5N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958624
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxo-3-(piperidin-1-ylmethyl)pyrrolidine-3-carboxamide
   Show/Hide
C28H31F3N4O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958625
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1'-(2,6-dimethylphenyl)-5'-oxo-1,3'-bipyrrolidine-3'-carboxamide
   Show/Hide
C25H25F6N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958626
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2-chloro-6-methylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C20H15ClF6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958627
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2-cyclopropyl-6-methylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C23H20F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958628
 Compound Info 
1-(2,6-dimethylphenyl)-5-oxo-N-(3-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide
   Show/Hide
C25H28F3N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958629
 Compound Info 
1-(2,6-dimethylphenyl)-N-(3-methoxy-5-(trifluoromethyl)phenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C21H21F3N2O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0958636
 Compound Info 
(R)-N-(3,5-bis(trifluoromethyl)phenyl)-3-isopropyl-1-(2-(methoxymethyl)-6-methylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C25H26F6N2O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958638
 Compound Info 
N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-3-isopropyl-5-oxo-1-o-tolylpyrrolidine-3-carboxamide
   Show/Hide
C25H27F3N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0958640
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxo-3-(tetrahydro-2H-thiopyran-4-yl)pyrrolidine-3-carboxamide
   Show/Hide
C26H26F6N2O2S
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0958641
 Compound Info 
3,4-diallyl-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H26F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0961101
 Compound Info 
(3R,4S)-3-(azetidin-1-ylmethyl)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H27F6N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0961102
 Compound Info 
(3R,4S)-N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-3-((diethylamino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C29H36F3N3O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0961104
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-5-oxo-1-o-tolylpyrrolidine-3-carboxamide
   Show/Hide
C20H16F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0961105
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C21H18F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0961107
 Compound Info 
(3S,4S)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-N-(3-methyl-5-(trifluoromethyl)phenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C24H27F3N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0962774
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((4-fluoropiperidin-1-yl)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C28H30F4N4O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0962775
 Compound Info 
(3R,4S)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((ethyl(methyl)amino)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C26H29F3N4O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0962776
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-((4-fluoropiperidin-1-yl)methyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C28H30F7N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0962777
 Compound Info 
(5R)-N-(3,5-bis(trifluoromethyl)phenyl)-2-(2,6-dimethylphenyl)-5-methoxy-1-oxooctahydrocyclopenta[c]pyrrole-3a-carboxamide
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C25H24F6N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0963003
 Compound Info 
(3S,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isobutyl-4-methyl-5-oxopyrrolidine-3-carboxamide
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C26H28F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0963004
 Compound Info 
(3S,4S)-N-(3-cyclobutoxy-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxopyrrolidine-3-carboxamide
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C27H31F3N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0963005
 Compound Info 
3-(benzyloxymethyl)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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C29H26F6N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0963006
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(2-hydroxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide
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C24H24F6N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0967678
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2-ethyl-6-methylphenyl)-5-oxopyrrolidine-3-carboxamide
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C22H20F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0967697
 Compound Info 
(3S,4S)-1-(2,6-dimethylphenyl)-3-isopropyl-N-(3-(isopropylamino)-5-(trifluoromethyl)phenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C27H34F3N3O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0967698
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2-chlorophenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
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C22H19ClF6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0967699
 Compound Info 
(3S,4S)-1-(2,6-dimethylphenyl)-3-ethyl-N-(3-methoxy-5-(trifluoromethyl)phenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C24H27F3N2O3
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0967700
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxo-3-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carboxamide
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C26H26F6N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0967701
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3,4-dimethyl-5-oxopyrrolidine-3-carboxamide
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C23H22F6N2O2
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0967702
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(methoxymethyl)-5-oxopyrrolidine-3-carboxamide
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C23H22F6N2O3
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0967703
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3,4-dimethyl-5-oxo-1-o-tolylpyrrolidine-3-carboxamide
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C22H20F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0967704
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-ethyl-5-oxopyrrolidine-3-carboxamide
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C23H22F6N2O2
  1
1
IC50 <= 30 nM
 Bioactivity Info 
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CP0847229
 Compound Info 
N-(3-chloro-5-cyanophenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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C20H18ClN3O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0847230
 Compound Info 
1-(2-ethyl-6-methylphenyl)-N-(4-fluoro-3-(trifluoromethyl)phenyl)-5-oxopyrrolidine-3-carboxamide
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C21H20F4N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0851313
 Compound Info 
N-(3-chlorophenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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C19H19ClN2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0851314
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-3-((diethylamino)methyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxopyrrolidine-3-carboxamide
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C27H31F6N3O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0851315
 Compound Info 
(3S,4S)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-5-oxo-N-(3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide
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C28H34F3N3O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0851321
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxo-3-(1-(pyrrolidin-1-yl)ethyl)pyrrolidine-3-carboxamide
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C27H29F6N3O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0851322
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-ethyl-3-methyl-5-oxopyrrolidine-3-carboxamide
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C24H24F6N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0862408
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxo-3-(pyrrolidin-1-ylmethyl)pyrrolidine-3-carboxamide
   Show/Hide
C26H27F6N3O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0862409
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2-(ethoxymethyl)-6-methylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
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C26H28F6N2O3
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0862412
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-isopropyl-1-(2-(morpholinomethyl)phenyl)-5-oxopyrrolidine-3-carboxamide
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C27H29F6N3O3
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0869146
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-3-(morpholinomethyl)-5-oxopyrrolidine-3-carboxamide
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C27H29F6N3O3
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0905631
 Compound Info 
(3aS,7aS)-N-(3,5-bis(trifluoromethyl)phenyl)-2-(2,6-dimethylphenyl)-1-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindole-3a-carboxamide
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C25H22F6N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0905633
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2-methyl-6-(methylsulfonyl)phenyl)-5-oxopyrrolidine-3-carboxamide
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C21H18F6N2O4S
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0915450
 Compound Info 
N-(3-cyanophenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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C20H19N3O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0915451
 Compound Info 
1-(2-ethyl-6-methylphenyl)-5-oxo-N-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide
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C21H21F3N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0915452
 Compound Info 
N-(3-chlorophenyl)-1-(2-fluoro-6-methylphenyl)-5-oxopyrrolidine-3-carboxamide
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C18H16ClFN2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0915453
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxo-3,3'-bipyrrolidine-3-carboxamide
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C25H25F6N3O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0915454
 Compound Info 
(3S,4S)-1-(2,6-dimethylphenyl)-3-ethyl-4-methyl-N-(3-(morpholinomethyl)-5-(trifluoromethyl)phenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C28H34F3N3O3
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0915455
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-ethyl-1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide
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C22H20F6N2O3
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0921707
 Compound Info 
1-(2-ethyl-6-methylphenyl)-N-(4-methyl-3-(trifluoromethyl)phenyl)-5-oxopyrrolidine-3-carboxamide
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C22H23F3N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0930857
 Compound Info 
N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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C23H23F3N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0930858
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-isopropyl-1-(2-methyl-6-(2-(pyrrolidin-1-yl)ethyl)phenyl)-5-oxopyrrolidine-3-carboxamide
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C29H33F6N3O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0930864
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-(1-methylpiperidin-4-yl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C27H29F6N3O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0933001
 Compound Info 
N-(2,4-dichlorophenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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C19H18Cl2N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0933002
 Compound Info 
5-oxo-1-o-tolyl-N-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide
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C19H17F3N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0933004
 Compound Info 
1-(2,6-dimethylphenyl)-N-(3-ethylphenyl)-5-oxopyrrolidine-3-carboxamide
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C21H24N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0933007
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2-(2-hydroxyethyl)-6-methylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
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C25H26F6N2O3
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0941927
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-isopropyl-1-(2-methoxy-6-methylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C24H24F6N2O3
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0941929
 Compound Info 
1-(2-ethyl-6-methylphenyl)-N-(4-methoxy-3-(trifluoromethyl)phenyl)-5-oxopyrrolidine-3-carboxamide
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C22H23F3N2O3
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0943499
 Compound Info 
N-(3,4-dichlorophenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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C19H18Cl2N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0943500
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-isopropyl-1-(2-methyl-6-(2-morpholinoethyl)phenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C29H33F6N3O3
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0943574
 Compound Info 
1-(2-bromo-6-methylphenyl)-5-oxo-N-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide
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C19H16BrF3N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0949913
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-5-oxo-1-phenylpyrrolidine-3-carboxamide
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C19H14F6N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0949916
 Compound Info 
N-(3,5-difluorophenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C19H18F2N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0953078
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxo-3-(1,2,3,6-tetrahydropyridin-4-yl)pyrrolidine-3-carboxamide
   Show/Hide
C26H25F6N3O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0957880
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-2-(2,6-dimethylphenyl)-1-oxooctahydropyrano[3,4-c]pyrrole-3a-carboxamide
   Show/Hide
C24H22F6N2O3
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0957925
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-5-oxo-3-(piperidin-1-ylmethyl)-1-o-tolylpyrrolidine-3-carboxamide
   Show/Hide
C28H31F6N3O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0958630
 Compound Info 
N-(4-chloro-3-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
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C20H18ClF3N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0958637
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-1-(2-(hydroxymethyl)phenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C23H22F6N2O3
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0958639
 Compound Info 
1-(2,6-dimethylphenyl)-3-ethyl-5-oxo-N-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide
   Show/Hide
C22H23F3N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0961103
 Compound Info 
N-(3,5-bis(trifluoromethyl)phenyl)-3-(2,6-dimethylphenyl)-4-oxo-3-azabicyclo[3.1.0]hexane-1-carboxamide
   Show/Hide
C22H18F6N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0961106
 Compound Info 
1-(2-ethyl-6-methylphenyl)-5-oxo-N-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide
   Show/Hide
C21H21F3N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0967679
 Compound Info 
1-(2,6-dimethylphenyl)-5-oxo-N-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide
   Show/Hide
C20H19F3N2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0967680
 Compound Info 
N-(3-chlorophenyl)-1-(2-ethyl-6-methylphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C20H21ClN2O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0967681
 Compound Info 
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-4-methyl-5-oxo-3-(pyrrolidin-1-ylmethyl)pyrrolidine-3-carboxamide
   Show/Hide
C27H29F6N3O2
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0967682
 Compound Info 
1-(2-bromo-6-methylphenyl)-3-isopropyl-N-(3-(2-methoxyethoxy)-5-(trifluoromethyl)phenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C25H28BrF3N2O4
  1
1
IC50 < 300 nM
 Bioactivity Info 
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CP0967696
 Compound Info 
N-(3-cyclopropyl-5-(trifluoromethyl)phenyl)-3-isopropyl-1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide
   Show/Hide
C25H27F3N2O3
  1
1
IC50 < 300 nM
 Bioactivity Info 
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Cell Line ID: CL000681 , CAL-1 [Human melanoma]
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Chemerin receptor (CMKLR1) )
Target Type Literature-reported Target