General Information of the Compound
Compound ID
CP0957925
Compound Name
(3R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-5-oxo-3-(piperidin-1-ylmethyl)-1-o-tolylpyrrolidine-3-carboxamide
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Structure
Formula
C28H31F6N3O2
Molecular Weight
555.563
Canonical SMILES
Cc1cccc(C)c1N1C[C@@](CN2CCCCC2)(C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](C)C1=O
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InChI
InChI=1S/C28H31F6N3O2/c1-17-8-7-9-18(2)23(17)37-16-26(19(3)24(37)38,15-36-10-5-4-6-11-36)25(39)35-22-13-20(27(29,30)31)12-21(14-22)28(32,33)34/h7-9,12-14,19H,4-6,10-11,15-16H2,1-3H3,(H,35,39)/t19-,26-/m1/s1
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InChIKey
MIGYURQKDPBCPA-NIYFSFCBSA-N
Physicochemical Property
logP
6.43474
Rotatable Bonds
5
Heavy Atom Count
39
Polar Areas
52.65
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 89799825
ChEMBL ID
CHEMBL3918190
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03813, Chemerin-like receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 < 300 nM
   TI
   LI
   LO
   TS