General Information of the Protein
Protein ID
PT05484
Protein Name
C-C chemokine receptor type 10
Secondarily
Protein Name
G-protein coupled receptor 2
Gene Name
CCR10
Secondarily
Gene Name
GPR2
Sequence
MGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Function
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
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Uniprot ID
Primary ID:
P46092

Secondarily ID:
Q4V749
Q6T7X2
Q9NZG2
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Ensembl ID
ENSG00000184451
HGNC ID
HGNC:4474
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000077 , Ba/F3
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0067951
 Compound Info 
N-[4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-1H-indole-4-sulfonamide
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C23H27N5O3S
  1
1
IC50 = 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0447538
 Compound Info 
N-[4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-1H-indole-5-sulfonamide
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C23H27N5O3S
  1
1
IC50 = 12.59 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0065780
 Compound Info 
4-amino-3,5-dichloro-N-[4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]benzenesulfonamide
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C21H25Cl2N5O3S
  1
1
IC50 = 15.85 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0445928
 Compound Info 
N-[4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-1H-indole-6-sulfonamide
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C23H27N5O3S
  1
1
IC50 = 15.85 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0419712
 Compound Info 
3-amino-N-[4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-2,4-dimethylbenzenesulfonamide
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C23H31N5O3S
  1
1
IC50 = 79.43 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0534634
 Compound Info 
4-amino-3,5-dichloro-N-[4-(2-chloroimidazol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]benzenesulfonamide
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C19H24Cl3N5O3S
  1
1
IC50 = 251.19 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0427286
 Compound Info 
4-amino-3,5-dichloro-N-[(2R)-1-(4-methylpiperidin-1-yl)-1-oxo-4-phenylbutan-2-yl]benzenesulfonamide
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C22H27Cl2N3O3S
  1
1
IC50 = 501.19 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0419711
 Compound Info 
4-amino-3,5-dichloro-N-[1-(4-methylpiperidin-1-yl)-1-oxo-4-pyrazol-1-ylbutan-2-yl]benzenesulfonamide
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C19H25Cl2N5O3S
  1
1
IC50 = 1258.93 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0427285
 Compound Info 
4-amino-3,5-dichloro-N-[1-(4-methylpiperidin-1-yl)-1-oxo-4-(triazol-2-yl)butan-2-yl]benzenesulfonamide
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C18H24Cl2N6O3S
  1
1
IC50 = 1258.93 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519192
 Compound Info 
4-amino-3,5-dichloro-N-[(2S)-1-(4-methylpiperidin-1-yl)-1-oxo-4-phenylbutan-2-yl]benzenesulfonamide
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C22H27Cl2N3O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000043 , U2OS
 Cell Line Info