General Information of the Protein
Protein ID
PT03433
Protein Name
C-X-C chemokine receptor type 3
Secondarily
Protein Name
CKR-L2
G protein-coupled receptor 9
Interferon-inducible protein 10 receptor
Gene Name
CXCR3
Secondarily
Gene Name
GPR9
Sequence
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CXC chemokine receptor
Function
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.
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Uniprot ID
Primary ID:
P49682

Secondarily ID:
B2R982
O15185
Q7Z710
Q9P2T4
Q9P2T5
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Ensembl ID
ENSG00000186810
HGNC ID
HGNC:4540
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000077 , Ba/F3
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0496049
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-methylpyrazine-2-carboxamide
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C24H33Cl2N7O
  1
1
IC50 = 0.3 nM
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CP0524095
 Compound Info 
(S)-5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-ethylpiperazin-1-yl)-N-ethylnicotinamide
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C26H35Cl2N5O
  1
1
IC50 = 0.3 nM
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CP0524098
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-(2-hydroxypropyl)pyrazine-2-carboxamide
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C26H37Cl2N7O2
  1
1
IC50 = 0.3 nM
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CP0512121
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-(2-hydroxyethyl)pyrazine-2-carboxamide
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C25H35Cl2N7O2
  1
1
IC50 = 0.4 nM
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CP0208852
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide
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C23H31Cl2N7O
  1
1
IC50 = 0.8 nM
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CP0451228
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-(2,2,2-trifluoroethyl)pyrazine-2-carboxamide
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C25H32Cl2F3N7O
  1
1
IC50 = 0.8 nM
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CP0272580
 Compound Info 
5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-chloro-N-propan-2-ylpyrazine-2-carboxamide
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C25H34Cl2N8O2
  1
1
IC50 = 0.9 nM
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CP0533228
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-[2-(trifluoromethylsulfonylamino)ethyl]pyrazine-2-carboxamide
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C26H35Cl2F3N8O3S
  1
1
IC50 = 0.9 nM
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CP0354339
 Compound Info 
5-[(3S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-cyclopropyl-6-methylpyrazine-2-carboxamide
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C27H35ClN6O2
  1
1
IC50 = 1.1 nM
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CP0335747
 Compound Info 
5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-chloro-N-cyclopropylpyrazine-2-carboxamide
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C25H32Cl2N8O2
  1
1
IC50 = 1.2 nM
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CP0094760
 Compound Info 
5-[(2R,5S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-5-ethyl-2-methylpiperazin-1-yl]-N-cyclopropyl-6-methylpyrazine-2-carboxamide
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C28H37ClN6O2
  1
1
IC50 = 1.3 nM
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CP0248601
 Compound Info 
5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-methyl-6-(trifluoromethyl)pyrazine-2-carboxamide
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C24H30ClF3N8O2
  1
1
IC50 = 1.5 nM
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CP0275220
 Compound Info 
5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-tert-butyl-6-chloropyrazine-2-carboxamide
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C26H36Cl2N8O2
  1
1
IC50 = 1.5 nM
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CP0499555
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-[(3R)-2-oxooxolan-3-yl]pyrazine-2-carboxamide
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C27H35Cl2N7O3
  1
1
IC50 = 1.5 nM
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CP0248602
 Compound Info 
5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-cyclopropyl-6-(trifluoromethyl)pyrazine-2-carboxamide
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C26H32ClF3N8O2
  1
1
IC50 = 1.8 nM
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CP0077073
 Compound Info 
5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-cyclopropyl-6-methylpyrazine-2-carboxamide
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C26H35ClN8O2
  1
1
IC50 = 1.9 nM
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CP0272581
 Compound Info 
5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-(trifluoromethyl)pyrazine-2-carboxamide
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C23H28ClF3N8O2
  1
1
IC50 = 1.9 nM
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CP0482240
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-[2-(sulfamoylamino)ethyl]pyrazine-2-carboxamide
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C25H37Cl2N9O3S
  1
1
IC50 = 1.9 nM
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CP0524097
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[1-(4-chlorophenyl)-2-hydroxyethyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide
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C24H33Cl2N7O2
  1
1
IC50 = 1.9 nM
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CP0291270
 Compound Info 
5-[(3S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-ethyl-6-methylpyrazine-2-carboxamide
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C26H35ClN6O2
  1
1
IC50 = 2 nM
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CP0354333
 Compound Info 
5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N,6-dimethylpyrazine-2-carboxamide
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C24H33ClN8O2
  1
1
IC50 = 2.4 nM
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CP0337930
 Compound Info 
5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-chloropyrazine-2-carboxamide
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C22H28Cl2N8O2
  1
1
IC50 = 2.5 nM
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CP0077072
 Compound Info 
5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-chloro-N-[(2R)-2-hydroxypropyl]pyrazine-2-carboxamide
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C25H34Cl2N8O3
  1
1
IC50 = 2.9 nM
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CP0248600
 Compound Info 
5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-chloro-N-(2-hydroxyethyl)pyrazine-2-carboxamide
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C24H32Cl2N8O3
  1
1
IC50 = 2.9 nM
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CP0248599
 Compound Info 
3-amino-5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-chloro-N-(2-hydroxyethyl)pyrazine-2-carboxamide
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C24H33Cl2N9O3
  1
1
IC50 = 3.4 nM
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CP0336356
 Compound Info 
5-[(3S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-N,6-dimethylpyrazine-2-carboxamide
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C25H33ClN6O2
  1
1
IC50 = 3.6 nM
 Bioactivity Info 
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CP0524096
 Compound Info 
3-amino-6-chloro-5-[(3S)-3-ethyl-4-[1-[[4-(trifluoromethoxy)phenyl]methyl]piperidin-4-yl]piperazin-1-yl]pyrazine-2-carboxamide
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C24H31ClF3N7O2
  1
1
IC50 = 3.7 nM
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CP0336355
 Compound Info 
5-[(3S)-4-[1-(2-amino-6-chloropyridine-3-carbonyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-methylpyrazine-2-carboxamide
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C23H31ClN8O2
  1
1
IC50 = 4 nM
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CP0236774
 Compound Info 
3-amino-5-[(3S)-4-[1-[[2-[(1S)-2-amino-1-hydroxy-2-oxoethyl]-4-chlorophenyl]methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-chloropyrazine-2-carboxamide
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C25H34Cl2N8O3
  1
1
IC50 = 4.1 nM
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CP0081327
 Compound Info 
5-[(2R,5S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-5-ethyl-2-methylpiperazin-1-yl]-N,6-dimethylpyrazine-2-carboxamide
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C26H35ClN6O2
  1
1
IC50 = 4.2 nM
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CP0081319
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-[2-(methanesulfonamido)ethyl]pyrazine-2-carboxamide
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C26H38Cl2N8O3S
  1
1
IC50 = 4.4 nM
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CP0248603
 Compound Info 
5-[(2R,5S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-5-ethyl-2-methylpiperazin-1-yl]-6-methylpyrazine-2-carboxamide
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C25H33ClN6O2
  1
1
IC50 = 5.4 nM
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CP0524099
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-(2-methylsulfonylethyl)pyrazine-2-carboxamide
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C26H37Cl2N7O3S
  1
1
IC50 = 6.4 nM
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CP0496167
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-(2-hydroxy-2-methylpropyl)pyrazine-2-carboxamide
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C27H39Cl2N7O2
  1
1
IC50 = 8.4 nM
 Bioactivity Info 
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CP0499578
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[(4-cyanophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide
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C24H31ClN8O
  1
1
IC50 = 8.5 nM
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CP0354413
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[(3,4-difluorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]-N-[2-(sulfamoylamino)ethyl]pyrazine-2-carboxamide
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C25H36ClF2N9O3S
  1
1
IC50 = 9 nM
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CP0354334
 Compound Info 
5-[(3S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]-6-methylpyrazine-2-carboxamide
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C24H31ClN6O2
  1
1
IC50 = 18 nM
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CP0399918
 Compound Info 
5-chloro-6-(4-(1-(4-cyanobenzyl)piperidin-4-yl)piperazin-1-yl)-N-(2-phenoxyethyl)nicotinamide
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C31H35ClN6O2
  4
1
IC50 = 20 nM
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2
IC50 = 45 nM
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3
IC50 = 85 nM
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4
Ki = 110 nM
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CP0400836
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide
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C23H29Cl2N7O2
  1
1
IC50 = 76 nM
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CP0253448
 Compound Info 
5-[(2R,5S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-2,5-diethylpiperazin-1-yl]-6-methylpyrazine-2-carboxamide
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C26H35ClN6O2
  1
1
IC50 = 235 nM
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CP0492369
 Compound Info 
5-[(2S,5S)-4-[1-(4-chlorobenzoyl)piperidin-4-yl]-5-ethyl-2-methylpiperazin-1-yl]-6-methylpyrazine-2-carboxamide
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C25H33ClN6O2
  1
1
IC50 > 1000 nM
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CP0534075
 Compound Info 
5-chloro-6-(4-((2S)-1-(4-chlorobenzyl)-2-methylpiperidin-4-yl)piperazin-1-yl)-N-(3,4-dichlorobenzyl)nicotinamide
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C30H33Cl4N5O
  1
1
Ki = 16 nM
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CP0417527
 Compound Info 
5-chloro-6-(4-((2S)-1-(4-chlorobenzyl)-2-methylpiperidin-4-yl)piperazin-1-yl)-N-methylnicotinamide
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C24H31Cl2N5O
  1
1
Ki = 32 nM
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CP0455180
 Compound Info 
5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)piperazin-1-yl)-N-(3,4-dichlorobenzyl)nicotinamide
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C29H31Cl4N5O
  1
1
Ki = 35 nM
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CP0455179
 Compound Info 
5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)piperazin-1-yl)-N-(2-phenoxyethyl)nicotinamide
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C30H35Cl2N5O2
  1
1
Ki = 70 nM
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CP0534073
 Compound Info 
6-(4-(1-(4-bromobenzyl)piperidin-4-yl)piperazin-1-yl)-5-chloro-N-(2-phenoxyethyl)nicotinamide
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C30H35BrClN5O2
  1
1
Ki = 85 nM
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CP0496946
 Compound Info 
(R)-5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-methylpiperazin-1-yl)-N-(3,4-dichlorobenzyl)nicotinamide
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C30H33Cl4N5O
  1
1
Ki = 86 nM
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CP0529863
 Compound Info 
5-chloro-6-(4-(1-(4-cyanobenzyl)piperidin-4-yl)piperazin-1-yl)-N-(4-fluorobenzyl)nicotinamide
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C30H32ClFN6O
  1
1
Ki = 90 nM
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CP0534322
 Compound Info 
5-chloro-6-(4-(1-(4-methoxybenzyl)piperidin-4-yl)piperazin-1-yl)-N-(2-phenoxyethyl)nicotinamide
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C31H38ClN5O3
  1
1
Ki = 120 nM
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CP0506994
 Compound Info 
N-benzyl-5-chloro-6-[4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]piperazin-1-yl]pyridine-3-carboxamide
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C29H33Cl2N5O
  1
1
Ki = 140 nM
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CP0501379
 Compound Info 
5-chloro-6-(4-(1-(4-fluorobenzyl)piperidin-4-yl)piperazin-1-yl)-N-(2-phenoxyethyl)nicotinamide
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C30H35ClFN5O2
  1
1
Ki = 160 nM
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CP0399916
 Compound Info 
5-chloro-6-(4-(1-(4-cyanobenzoyl)piperidin-4-yl)piperazin-1-yl)-N-(2-phenoxyethyl)nicotinamide
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C31H33ClN6O3
  1
1
Ki = 320 nM
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CP0529918
 Compound Info 
3-chloro-4-(4-(1-(4-chlorobenzyl)piperidin-4-yl)piperazin-1-yl)-N-(3,4-dichlorobenzyl)benzamide
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C30H32Cl4N4O
  1
1
Ki = 330 nM
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CP0414946
 Compound Info 
N-butyl-5-chloro-6-[4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]piperazin-1-yl]pyridine-3-carboxamide
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C26H35Cl2N5O
  1
1
Ki = 370 nM
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CP0494783
 Compound Info 
5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)piperazin-1-yl)-N-(3-methoxybenzyl)nicotinamide
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C30H35Cl2N5O2
  1
1
Ki = 410 nM
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CP0529917
 Compound Info 
5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)piperazin-1-yl)-N-phenethylnicotinamide
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C30H35Cl2N5O
  1
1
Ki = 470 nM
 Bioactivity Info 
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CP0373245
 Compound Info 
5-chloro-N-(2-phenoxyethyl)-6-(4-(1-(4-(trifluoromethyl)benzyl)piperidin-4-yl)piperazin-1-yl)nicotinamide
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C31H35ClF3N5O2
  1
1
Ki = 510 nM
 Bioactivity Info 
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CP0502755
 Compound Info 
5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)piperazin-1-yl)-N-methylnicotinamide
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C23H29Cl2N5O
  1
1
Ki = 560 nM
 Bioactivity Info 
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CP0501381
 Compound Info 
1-(5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)piperazin-1-yl)pyridin-3-yl)-N-(3,4-dichlorobenzyl)methanamine
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C29H33Cl4N5
  1
1
Ki = 870 nM
 Bioactivity Info 
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CP0414945
 Compound Info 
6-(4-(1-benzylpiperidin-4-yl)piperazin-1-yl)-5-chloro-N-(2-phenoxyethyl)nicotinamide
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C30H36ClN5O2
  1
1
Ki = 1900 nM
 Bioactivity Info 
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CP0475153
 Compound Info 
N-[5-chloro-6-[4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]piperazin-1-yl]pyridin-3-yl]-2-(3,4-dichlorophenyl)acetamide
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C29H31Cl4N5O
  1
1
Ki = 1900 nM
 Bioactivity Info 
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CP0529937
 Compound Info 
5-chloro-6-(4-(3-((4-chlorophenyl)(methyl)amino)propyl)piperazin-1-yl)-N-(2-phenoxyethyl)nicotinamide
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C28H33Cl2N5O2
  1
1
Ki = 2000 nM
 Bioactivity Info 
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CP0508250
 Compound Info 
5-chloro-6-(1'-(4-chlorobenzyl)-4,4'-bipiperidin-1-yl)-N-(3,4-dichlorobenzyl)nicotinamide
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C30H32Cl4N4O
  1
1
Ki = 2700 nM
 Bioactivity Info 
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CP0496944
 Compound Info 
5-chloro-6-(4-(1-(4-(dimethylamino)benzyl)piperidin-4-yl)piperazin-1-yl)-N-(2-phenoxyethyl)nicotinamide
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C32H41ClN6O2
  1
1
Ki = 2900 nM
 Bioactivity Info 
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CP0496945
 Compound Info 
1-(5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)piperazin-1-yl)pyridin-3-yl)-N-(3,4-dichlorobenzyl)-N-methylmethanamine
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C30H35Cl4N5
  1
1
Ki = 3700 nM
 Bioactivity Info 
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CP0417526
 Compound Info 
3,4-dichloro-N-((5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)piperazin-1-yl)pyridin-3-yl)methyl)benzamide
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C29H31Cl4N5O
  1
1
Ki = 3800 nM
 Bioactivity Info 
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CP0537577
 Compound Info 
5-chloro-6-(4-(1-(3-cyanobenzyl)piperidin-4-yl)piperazin-1-yl)-N-(2-phenoxyethyl)nicotinamide
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C31H35ClN6O2
  1
1
Ki = 4100 nM
 Bioactivity Info 
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CP0529864
 Compound Info 
5-chloro-6-(4-(4-(4-chlorobenzyl)piperazin-1-yl)piperidin-1-yl)-N-(3,4-dichlorobenzyl)nicotinamide
   Show/Hide
C29H31Cl4N5O
  1
1
Ki = 4500 nM
 Bioactivity Info 
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CP0529919
 Compound Info 
6-(4-(1-(4-cyanobenzyl)piperidin-4-yl)piperazin-1-yl)-N-(4-fluorobenzyl)nicotinamide
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C30H33FN6O
  1
1
Ki = 7200 nM
 Bioactivity Info 
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CP0513994
 Compound Info 
5-chloro-6-(4-(1-(2-cyanobenzyl)piperidin-4-yl)piperazin-1-yl)-N-(2-phenoxyethyl)nicotinamide
   Show/Hide
C31H35ClN6O2
  1
1
Ki = 8900 nM
 Bioactivity Info 
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CP0529865
 Compound Info 
5-chloro-6-((2-((1-(4-chlorobenzyl)piperidin-4-yl)(methyl)amino)ethyl)(methyl)amino)-N-(3,4-dichlorobenzyl)nicotinamide
   Show/Hide
C29H33Cl4N5O
  1
1
Ki = 23000 nM
 Bioactivity Info 
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CP0534074
 Compound Info 
1-(5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)piperazin-1-yl)pyridin-3-yl)-3-(3,4-dichlorophenyl)urea
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C28H30Cl4N6O
  1
1
Ki > 50000 nM
 Bioactivity Info 
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Cell Line ID: CL000064 , Chem-1
 Cell Line Info 
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Cell Line ID: CL000386 , Flp-In-CHO
 Cell Line Info 
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000233 , L1.2
 Cell Line Info 
Cell Line ID: CL000043 , U2OS
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0208852
 Compound Info 
3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide
   Show/Hide
C23H31Cl2N7O
  2
1 IC50 = 0.8 nM
2 Ki = 0.4 nM
CP0095851
 Compound Info 
(-)-(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(pyridin-3-ylmethyl)-2-(4-(trifluoromethoxy)phenyl)acetamide
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C32H28F3N5O4
  4
1 IC50 = 5 nM
2 IC50 = 8 nM
3 IC50 = 8.2 nM
4 IC50 = 49 nM
CP0359857
 Compound Info 
US9073853, 12
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C31H37ClN2O6
  1
1 IC50 = 13 nM
CP0062742
 Compound Info 
US9073853, 5
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C30H37ClN2O6
  1
1 IC50 = 19 nM
CP0132800
 Compound Info 
US9073853, 88
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C31H37ClN2O5S
  1
1 IC50 = 23 nM
CP0216561
 Compound Info 
US9073853, 14
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C31H36Cl2N2O6
  1
1 IC50 = 25 nM
CP0142156
 Compound Info 
US9073853, 148
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C31H36ClFN2O6
  1
1 IC50 = 26 nM
CP0132791
 Compound Info 
US9073853, 16
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C31H37ClN2O6
  1
1 IC50 = 35 nM
CP0428341
 Compound Info 
US9073853, 15
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C31H38N2O7S
  1
1 IC50 = 37 nM
CP0170839
 Compound Info 
US9073853, 7
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C30H37ClN2O5
  1
1 IC50 = 38 nM
CP0062744
 Compound Info 
US9073853, 17
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C32H40N2O6
  1
1 IC50 = 44 nM
CP0226371
 Compound Info 
US9073853, 30
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C31H37ClN2O5
  1
1 IC50 = 53 nM
CP0132792
 Compound Info 
US9073853, 19
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C31H38N2O8
  1
1 IC50 = 55 nM
CP0304945
 Compound Info 
US9073853, 10
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C31H37ClN2O6
  1
1 IC50 = 64 nM
CP0329331
 Compound Info 
US9073853, 37
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C31H38ClN3O6
  1
1 IC50 = 76 nM
CP0170846
 Compound Info 
US9073853, 45
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C32H39ClN2O5
  1
1 IC50 = 160 nM
CP0304775
 Compound Info 
US9073853, 71
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C32H39ClN2O5
  1
1 IC50 = 176 nM
CP0342761
 Compound Info 
(6aR,9R)-9-(4-hydroxypiperidine-1-carbonyl)-N-phenyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-7-carboxamide
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C27H28N4O3
  1
1 IC50 = 200 nM
CP0329327
 Compound Info 
US9073853, 11
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C31H37ClN2O6
  1
1 IC50 = 200 nM
CP0313657
 Compound Info 
(6aR,9R)-N-phenyl-9-(pyrrolidine-1-carbonyl)-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-7-carboxamide
   Show/Hide
C26H26N4O2
  1
1 IC50 = 700 nM
CP0132790
 Compound Info 
US9073853, 2
   Show/Hide
C32H40N2O7
  1
1 IC50 = 760 nM
CP0290839
 Compound Info 
(6aR,9R)-N-phenyl-9-(piperidine-1-carbonyl)-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-7-carboxamide
   Show/Hide
C27H28N4O2
  1
1 IC50 = 840 nM
CP0062743
 Compound Info 
US9073853, 13
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C31H37ClN2O6
  1
1 IC50 = 1660 nM
CP0758111
 Compound Info 
N-(3-(1-(2-(4-((N-benzyl-4-chlorophenylsulfonamido)methyl)benzoyl)hydrazinyl)ethyl)phenyl)acetamide
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C31H29ClN4O4S
  2
1 Ki = 211 nM
2 Ki = 348 nM
Clinical Information about the Protein
Target 1 ( C-X-C chemokine receptor type 3 (CXCR3) )
Target Type Preclinical Target
Disease 2 Target-related Diseases  2
1 Hepatic fibrosis [ICD-11: DB93.0]
2 Inflammation [ICD-11: 1A00-CA43.1]
Investigative Drug(s) 1 Investigative Drug  1
1 Sch-900875
 Drug Info 
Investigative
Inflammation
Preclinical Drug(s) 1 Preclinical Drug  1
1 dioscin
 Drug Info 
Preclinical
Hepatic fibrosis
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT05171 C-X-C chemokine receptor type 3 Mus musculus, Mouse
 Protein Info